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Targeted Local Support Vector Machine for Age-Dependent Classification

用于年龄依赖分类的针对性局部支持向量机

We develop methods to accurately predict whether pre-symptomatic individuals are at risk of a disease based on their various marker profiles, which offers an opportunity for early intervention well before definitive clinical diagnosis. For many diseases, existing clinical literature may suggest the risk of disease varies with some markers of biological and etiological importance, for example age. To identify effective prediction rules using nonparametric decision functions,…

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On an Additive Semigraphoid Model for Statistical Networks With Application to Pathway Analysis

统计网络的加性半图模型及其通路分析应用

We introduce a nonparametric method for estimating non-gaussian graphical models based on a new statistical relation called additive conditional independence, which is a three-way relation among random vectors that resembles the logical structure of conditional independence. Additive conditional independence allows us to use one-dimensional kernel regardless of the dimension of the graph, which not only avoids the curse of dimensionality but also simplifies computation. It…

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Functional Principal Component Analysis of Spatiotemporal Point Processes With Applications in Disease Surveillance

时空点过程的函数主成分分析及疾病监测应用

In disease surveillance applications, the disease events are modeled by spatio-temporal point processes. We propose a new class of semiparametric generalized linear mixed model for such data, where the event rate is related to some known risk factors and some unknown latent random effects. We model the latent spatio-temporal process as spatially correlated functional data, and propose Poisson maximum likelihood and composite likelihood methods based on spline approximations…

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Adaptive Confidence Bands for Nonparametric Regression Functions

非参数回归函数的自适应置信带

A new formulation for the construction of adaptive confidence bands in non-parametric function estimation problems is proposed. Confidence bands are constructed which have size that adapts to the smoothness of the function while guaranteeing that both the relative excess mass of the function lying outside the band and the measure of the set of points where the function lies outside the band are small. It is shown that the bands adapt over a maximum range of Lipschitz…

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Nonparametric Independence Screening in Sparse Ultra-High-Dimensional Varying Coefficient Models

稀疏超高维变系数模型中的非参数独立筛选

The varying-coefficient model is an important nonparametric statistical model that allows us to examine how the effects of covariates vary with exposure variables. When the number of covariates is big, the issue of variable selection arrives. In this paper, we propose and investigate marginal nonparametric screening methods to screen variables in ultra-high dimensional sparse varying-coefficient models. The proposed nonparametric independence screening (NIS) selects…

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A Bayesian Nonparametric Modeling Framework for Developmental Toxicity Studies

发育毒性研究的贝叶斯非参数混合建模框架

We develop a Bayesian nonparametric mixture modeling framework for replicated count responses in dose-response settings. We explore this methodology for modeling and risk assessment in developmental toxicity studies, where the primary objective is to determine the relationship between the level of exposure to a toxic chemical and the probability of a physiological or biochemical response, or death. Data from these experiments typically involve features that cannot be…

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Estimation and Accuracy After Model Selection

模型选择后的估计与精度评估

Classical statistical theory ignores model selection in assessing estimation accuracy. Here we consider bootstrap methods for computing standard errors and confidence intervals that take model selection into account. The methodology involves bagging, also known as bootstrap smoothing, to tame the erratic discontinuities of selection-based estimators. A useful new formula for the accuracy of bagging then provides standard errors for the smoothed estimators. Two examples,…

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A Nonparametric Test of the Predictive Regression Model

预测回归模型的非参数检验

This article considers testing the significance of a regressor with a near unit root in a predictive regression model. The procedures discussed in this article are nonparametric, so one can test the significance of a regressor without specifying a functional form. The results are used to test the null hypothesis that the entire function takes the value of zero. We show that the standardized test has a normal distribution regardless of whether there is a near unit root in the…

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Bayesian Nonparametric Instrumental Variables Regression Based on Penalized Splines and Dirichlet Process Mixtures

基于惩罚样条与狄利克雷过程混合的贝叶斯非参数工具变量回归

We propose a Bayesian nonparametric instrumental variable approach under additive separability that allows us to correct for endogeneity bias in regression models where the covariate effects enter with unknown functional form. Bias correction relies on a simultaneous equations specification with flexible modeling of the joint error distribution implemented via a Dirichlet process mixture prior. Both the structural and instrumental variable equation are specified in terms of…

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On the Estimation of Integrated Volatility With Jumps and Microstructure Noise

含跳跃与微观结构噪声的积分波动率估计

In this article, we propose a nonparametric procedure to estimate the integrated volatility of an Itô semimartingale in the presence of jumps and microstructure noise. The estimator is based on a combination of the preaveraging method and threshold technique, which serves to remove microstructure noise and jumps, respectively. The estimator is shown to work for both finite and infinite activity jumps. Furthermore, asymptotic properties of the proposed estimator, such as…

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Varying Naïve Bayes Models With Applications to Classification of Chinese Text Documents

时变朴素贝叶斯模型及其在中文文本分类中的应用

Document classification is an area of great importance for which many classification methods have been developed. However, most of these methods cannot generate time-dependent classification rules. Thus, they are not the best choices for problems with time-varying structures. To address this problem, we propose a varying naïve Bayes model, which is a natural extension of the naïve Bayes model that allows for time-dependent classification rule. The method of kernel smoothing…

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Asymptotic Efficiency of Semiparametric Two-step GMM

半参数两步 GMM 的渐近效率

Many structural economics models are semiparametric ones in which the unknown nuisance functions are identified via non-parametric conditional moment restrictions with possibly non-nested or overlapping conditioning sets, and the finite dimensional parameters of interest are over-identified via unconditional moment restrictions involving the nuisance functions. In this article we characterize the semiparametric efficiency bound for this class of models. We show that…

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Semiparametric Inference in Dynamic Binary Choice Models

动态二元选择模型中的半参数推断

We introduce an approach for semiparametric inference in dynamic binary choice models that does not impose distributional assumptions on the state variables unobserved by the econometrician. The proposed framework combines Bayesian inference with partial identification results. The method is applicable to models with finite space of observed states. We demonstrate the method on Rust's model of bus engine replacement. The estimation experiments show that the parametric…

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Extreme-quantile tracking for financial time series

金融时间序列的极端分位数跟踪

Time series of financial asset values exhibit well-known statistical features such as heavy tails and volatility clustering. We propose a nonparametric extension of the classical Peaks-Over-Threshold method from extreme value theory to fit the time varying volatility in situations where the stationarity assumption may be violated by erratic changes of regime, say. As a result, we provide a method for estimating conditional risk measures applicable to both stationary and…

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Control functions in nonseparable simultaneous equations models

非可分联立方程模型中的控制函数

The control function approach (Heckman and Robb (1985)) in a system of linear simultaneous equations provides a convenient procedure to estimate one of the functions in the system using reduced form residuals from the other functions as additional regressors. The conditions on the structural system under which this procedure can be used in nonlinear and nonparametric simultaneous equations has thus far been unknown. In this paper, we define a new property of functions called…

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Bootstrap for the case-cohort design

病例队列设计的自助法

The case-cohort design facilitates economical investigation of risk factors in a large survival study, with covariate data collected only from the cases and a simple random subset of the full cohort. Methods that accommodate the design have been developed for various semiparametric models, but most inference procedures are based on asymptotic distribution theory. Such inference can be cumbersome to derive and implement, and does not permit confidence band construction. While…

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Testing equality of a large number of densities

大量密度函数相等性的检验

The problem of testing equality of a large number of densities is considered. The classical k-sample problem compares a small, fixed number of distributions and allows the sample size from each distribution to increase without bound. In our asymptotic analysis the number of distributions tends to infinity but the size of individual samples remains fixed. The proposed test statistic is motivated by the simple idea of comparing kernel density estimators from the various…

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Measurement bias and effect restoration in causal inference

因果推断中的测量偏差与效应恢复

This paper highlights several areas where graphical techniques can be harnessed to address the problem of measurement errors in causal inference. In particular, it discusses the control of unmeasured confounders in parametric and nonparametric models and the computational problem of obtaining bias-free effect estimates in such models. We derive new conditions under which causal effects can be restored by observing proxy variables of unmeasured confounders with/without…

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Sequential combination of weighted and nonparametric bagging for classification

用于分类的加权与非参数袋装法的序贯组合

We propose a simple sequential procedure for bagged classification, which modifies nonparametric bagging by randomizing class labels of resampled data points. The random labelling feature of the procedure also enables us to undertake unsupervised classification with the benefit of supervised learning. Theoretical properties are given for the nearest neighbour classifier in the case of supervised learning and a hard-thresholding indicator in the case of unsupervised learning,…

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Non-Parametric and Adaptive Modelling of Dynamic Periodicity and Trend with Heteroscedastic and Dependent Errors

异方差相关误差下动态周期与趋势的非参数自适应建模

Summary Periodicity and trend are features describing an observed sequence, and extracting these features is an important issue in many scientific fields. However, it is not an easy task for existing methods to analyse simultaneously the trend and dynamics of the periodicity such as time varying frequency and amplitude, and the adaptivity of the analysis to such dynamics and robustness to heteroscedastic dependent errors are not guaranteed. These tasks become even more…

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Structured Functional Additive Regression in Reproducing Kernel Hilbert Spaces

再生核希尔伯特空间中的结构化函数型加性回归

Summary Functional additive models provide a flexible yet simple framework for regressions involving functional predictors. The utilization of a data-driven basis in an additive rather than linear structure naturally extends the classical functional linear model. However, the critical issue of selecting non-linear additive components has been less studied. In this work, we propose a new regularization framework for structure estimation in the context of reproducing kernel…

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A remark on the rates of convergence for integrated volatility estimation in the presence of jumps

存在跳跃时积分波动率估计收敛速度的一点说明

The optimal rate of convergence of estimators of the integrated volatility, for a discontinuous Itô semimartingale sampled at regularly spaced times and over a fixed time interval, has been a long-standing problem, at least when the jumps are not summable. In this paper, we study this optimal rate, in the minimax sense and for appropriate “bounded” nonparametric classes of semimartingales. We show that, if the $r$th powers of the jumps are summable for some $r\in[0,2)$, the…

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The spatial distribution in infinite dimensional spaces and related quantiles and depths

无限维空间中的空间分布、分位数与深度

The spatial distribution has been widely used to develop various nonparametric procedures for finite dimensional multivariate data. In this paper, we investigate the concept of spatial distribution for data in infinite dimensional Banach spaces. Many technical difficulties are encountered in such spaces that are primarily due to the noncompactness of the closed unit ball. In this work, we prove some Glivenko–Cantelli and Donsker-type results for the empirical spatial…

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On asymptotically optimal confidence regions and tests for high-dimensional models

高维模型中渐近最优的置信区域与检验

We propose a general method for constructing confidence intervals and statistical tests for single or low-dimensional components of a large parameter vector in a high-dimensional model. It can be easily adjusted for multiplicity taking dependence among tests into account. For linear models, our method is essentially the same as in Zhang and Zhang [J. R. Stat. Soc. Ser. B Stat. Methodol. 76 (2014) 217–242]: we analyze its asymptotic properties and establish its asymptotic…

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