论文检索

高维混频工具变量回归AI 解读

This article introduces a high-dimensional linear IV regression for the data sampled at mixed frequencies. We show that the high-dimensional slope parameter of a high-frequency covariate can be identified and accurately estimated leveraging on a low-frequency instrumental variable. The distinguishing feature of the model is that it allows handing high-dimensional datasets without imposing the approximate sparsity restrictions. We propose a Tikhonov-regularized estimator and…

使用近似共充分抽样检验拟合优度与条件独立性AI 解读

Goodness-of-fit (GoF) testing is ubiquitous in statistics, with direct ties to model selection, confidence interval construction, conditional independence testing, and multiple testing, just to name a few applications. While testing the GoF of a simple (point) null hypothesis provides an analyst great flexibility in the choice of test statistic while still ensuring validity, most GoF tests for composite null hypotheses are far more constrained, as the test statistic must…

利用正则化 Riesz 表示元对全局与局部参数进行去偏机器学习AI 解读

Summary We provide adaptive inference methods, based on $\ell _1$ regularization, for regular (semiparametric) and nonregular (nonparametric) linear functionals of the conditional expectation function. Examples of regular functionals include average treatment effects, policy effects, and derivatives. Examples of nonregular functionals include average treatment effects, policy effects, and derivatives conditional on a covariate subvector fixed at a point. We construct a…

多重检验问题的最优与最大最小程序AI 解读

Abstract Multiple testing problems (MTPs) are a staple of modern statistical analysis. The fundamental objective of MTPs is to reject as many false null hypotheses as possible (that is, maximize some notion of power), subject to controlling an overall measure of false discovery, like family-wise error rate (FWER) or false discovery rate (FDR). In this paper we provide generalizations to MTPs of the optimal Neyman-Pearson test for a single hypothesis. We show that for simple…

关于《多元依赖的多尺度 Fisher 独立性检验》的讨论AI 解读

We read with interest the work of Gorsky & Ma (2022) on statistical dependence testing using a multi-scale Fisher’s independence test, MultiFIT. The procedure consists of first transforming the data to map to the unit ball, then performing univariate Fisher’s exact tests of independence on a collection of |$2 \times 2$| contingency tables, and finally correcting for the use of multiple testing. The collection is obtained using a divide-and-conquer approach with a…

多元依赖的多尺度 Fisher 独立性检验AI 解读

Summary Identifying dependency in multivariate data is a common inference task that arises in numerous applications. However, existing nonparametric independence tests typically require computation that scales at least quadratically with the sample size, making it difficult to apply them in the presence of massive sample sizes. Moreover, resampling is usually necessary to evaluate the statistical significance of the resulting test statistics at finite sample sizes, further…

利用多环境knockoff筛选寻找稳健关联AI 解读

Summary In this article we develop a method based on model-X knockoffs to find conditional associations that are consistent across environments, while controlling the false discovery rate. The motivation for this problem is that large datasets may contain numerous associations that are statistically significant and yet misleading, as they are induced by confounders or sampling imperfections. However, associations replicated under different conditions may be more interesting.…

利用自适应筛选程序检测多个可重复信号AI 解读

Replicability is a fundamental quality of scientific discoveries: we are interested in those signals that are detectable in different laboratories, different populations, across time etc. Unlike meta-analysis which accounts for experimental variability but does not guarantee replicability, testing a partial conjunction (PC) null aims specifically to identify the signals that are discovered in multiple studies. In many contemporary applications, for example, comparing…

LAWS：空间多重检验的局部自适应加权与筛选方法AI 解读

Exploiting spatial patterns in large-scale multiple testing promises to improve both power and interpretability of false discovery rate (FDR) analyses. This article develops a new class of locally adaptive weighting and screening (LAWS) rules that directly incorporates useful local patterns into inference. The idea involves constructing robust and structure-adaptive weights according to the estimated local sparsity levels. LAWS provides a unified framework for a broad range…

多尺度分位数分段AI 解读

We introduce a new methodology for analyzing serial data by quantile regression assuming that the underlying quantile function consists of constant segments. The procedure does not rely on any distributional assumption besides serial independence. It is based on a multiscale statistic, which allows to control the (finite sample) probability for selecting the correct number of segments S at a given error level, which serves as a tuning parameter. For a proper choice of this…

基于分位数相关的变量选择AI 解读

This article is concerned with identifying important features in high-dimensional data analysis, especially when there are complex relationships among predictors. Without any specification of an actual model, we first introduce a multiple testing procedure based on the quantile correlation to select important predictors in high dimensionality. The quantile-correlation statistic is able to capture a wide range of dependence. A stepwise procedure is studied for further…

Choi 与 Wong 对《广义线性模型参数的弱假设推断》的讨论AI 解读

We congratulate the authors for major advances in the methodology of estimands, in particular assumption-lean reference for the estimands in possibly misspecified generalised linear models. Whereas the simulation studies in Section 6 indeed support the ‘assumption-lean’ claim and the authors’ software in Practice of Epidemiology187 (pp. 1079–1084, 2018) facilitates such inference, the empirical example in Section 7 seems problematic to illustrate applications of the…

使用 e 值控制错误发现率AI 解读

Abstract E-values have gained attention as potential alternatives to p-values as measures of uncertainty, significance and evidence. In brief, e-values are realized by random variables with expectation at most one under the null; examples include betting scores, (point null) Bayes factors, likelihood ratios and stopped supermartingales. We design a natural analogue of the Benjamini-Hochberg (BH) procedure for false discovery rate (FDR) control that utilizes e-values, called…

具有块结构的大规模统计推断AI 解读

The detection of weak and rare effects in large amounts of data arises in a number of modern data analysis problems. Known results show that in this situation the potential of statistical inference is severely limited by the large-scale multiple testing that is inherent in these problems. Here, we show that fundamentally more powerful statistical inference is possible when there is some structure in the signal that can be exploited, for example, if the signal is clustered in…

通过蒸馏实现快速且有力的条件随机化检验AI 解读

Summary We consider the problem of conditional independence testing: given a response $Y$ and covariates $(X,Z)$, we test the null hypothesis that $Y {\perp\!\!\!\perp} X \mid Z$. The conditional randomization test was recently proposed as a way to use distributional information about $X\mid Z$ to exactly and nonasymptotically control Type-I error using any test statistic in any dimensionality without assuming anything about $Y\mid (X,Z)$. This flexibility, in principle,…

有向无环图上的平滑嵌套检验AI 解读

Summary We consider the problem of multiple hypothesis testing when there is a logical nested structure to the hypotheses. When one hypothesis is nested inside another, the outer hypothesis must be false if the inner hypothesis is false. We model the nested structure as a directed acyclic graph, including chain and tree graphs as special cases. Each node in the graph is a hypothesis and rejecting a node requires also rejecting all of its ancestors. We propose a general…

连续处理模型中反事实分布与分位数函数的估计推断AI 解读

Donald and Hsu (2014) studied the estimation and inference for the counterfactual distribution and quantile functions in a binary treatment model. We extend their work to the continuous treatment model. Specifically, we propose a weighted regression estimator for the counterfactual distribution but we estimate the weighting function from a covariate balancing equation by maximizing a globally concave criterion function. We estimate the quantile function by inverting the…

大规模多重检验中的异方差调整排序与阈值方法AI 解读

Standardization has been a widely adopted practice in multiple testing, for it takes into account the variability in sampling and makes the test statistics comparable across different study units. However, despite conventional wisdom to the contrary, we show that there can be a significant loss in information from basing hypothesis tests on standardized statistics rather than the full data. We develop a new class of heteroscedasticity-adjusted ranking and thresholding (HART)…

利用二次扫描统计量同时检测信号区域及全基因组关联应用AI 解读

We consider in this paper detection of signal regions associated with disease outcomes in whole genome association studies. Gene- or region-based methods have become increasingly popular in whole genome association analysis as a complementary approach to traditional individual variant analysis. However, these methods test for the association between an outcome and the genetic variants in a pre-specified region, e.g., a gene. In view of massive intergenic regions in whole…

未知零假设分布下的错误发现率控制：能否模拟理想程序？AI 解读

Classical multiple testing theory prescribes the null distribution, which is often too stringent an assumption for nowadays large scale experiments. This paper presents theoretical foundations to understand the limitations caused by ignoring the null distribution, and how it can be properly learned from the same data set, when possible. We explore this issue in the setting where the null distributions are Gaussian with unknown rescaling parameters (mean and variance) whereas…

利用辅助信息的大规模多重检验最优错误发现率控制AI 解读

Large-scale multiple testing is a fundamental problem in high dimensional statistical inference. It is increasingly common that various types of auxiliary information, reflecting the structural relationship among the hypotheses, are available. Exploiting such auxiliary information can boost statistical power. To this end, we propose a framework based on a two-group mixture model with varying probabilities of being null for different hypotheses a priori, where a…

时变模型的同时推断AI 解读

A general class of non-stationary time series is considered in this paper. We estimate the time-varying coefficients by using local linear M-estimation. For these estimators, weak Bahadur representations are obtained and are used to construct simultaneous confidence bands. For practical implementation, we propose a bootstrap based method to circumvent the slow logarithmic convergence of the theoretical simultaneous bands. Our results substantially generalize and unify the…

热手谬误中的不确定性：识别偏离随机伯努利序列的连胜模式AI 解读

Abstract We study a class of permutation tests of the randomness of a collection of Bernoulli sequences and their application to analyses of the human tendency to perceive streaks of consecutive successes as overly representative of positive dependence—the hot hand fallacy. In particular, we study permutation tests of the null hypothesis of randomness (i.e. that trials are i.i.d.) based on test statistics that compare the proportion of successes that directly follow $k$ conse…

协变量自适应的错误发现率控制及组学多重检验应用AI 解读

Conventional multiple testing procedures often assume hypotheses for different features are exchangeable. However, in many scientific applications, additional covariate information regarding the patterns of signals and nulls are available. In this article, we introduce an FDR control procedure in large-scale inference problem that can incorporate covariate information. We develop a fast algorithm to implement the proposed procedure and prove its asymptotic validity even when…