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利用共形 p 值检验异常值AI 解读

This paper studies the construction of p-values for nonparametric outlier detection, from a multiple-testing perspective. The goal is to test whether new independent samples belong to the same distribution as a reference data set or are outliers. We propose a solution based on conformal inference, a general framework yielding p-values that are marginally valid but mutually dependent for different test points. We prove these p-values are positively dependent and enable exact…

刻画 SLOPE 的权衡：变分视角与 Donoho–Tanner 极限AI 解读

Sorted ℓ1 regularization has been incorporated into many methods for solving high-dimensional statistical estimation problems, including the SLOPE estimator in linear regression. In this paper, we study how this relatively new regularization technique improves variable selection by characterizing the optimal SLOPE trade-off between the false discovery proportion (FDP) and true positive proportion (TPP) or, equivalently, between measures of type I error and power. Assuming a…

广义区间算术中心—范围线性模型中的一致推断AI 解读

Via generalized interval arithmetic, we propose a Generalized Interval Arithmetic Center and Range (GIA-CR) model for random intervals, where parameters in the model satisfy linear inequality constraints. We construct a constrained estimator of the parameter vector and develop asymptotically uniformly valid tests for linear equality constraints on the parameters in the model. We conduct a simulation study to examine the finite sample performance of our estimator and tests.…

iProMix：利用整体蛋白质基因组数据研究 ACE2 功能的混合模型AI 解读

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused over six million deaths in the ongoing COVID-19 pandemic. SARS-CoV-2 uses ACE2 protein to enter human cells, raising a pressing need to characterize proteins/pathways interacted with ACE2. Large-scale proteomic profiling technology is not mature at single-cell resolution to examine the protein activities in disease-relevant cell types. We propose iProMix, a novel statistical framework to identify…

用于在线错误发现率控制的结构自适应序贯检验AI 解读

Consider the online testing of a stream of hypotheses where a real-time decision must be made before the next data point arrives. The error rate is required to be controlled at all decision points. Conventional simultaneous testing rules are no longer applicable due to the more stringent error constraints and absence of future data. Moreover, the online decision-making process may come to a halt when the total error budget, or alpha-wealth, is exhausted. This work develops a…

通过对称化数据聚合控制一般依赖下的错误发现率AI 解读

We develop a new class of distribution-free multiple testing rules for false discovery rate (FDR) control under general dependence. A key element in our proposal is a symmetrized data aggregation (SDA) approach to incorporating the dependence structure via sample splitting, data screening, and information pooling. The proposed SDA filter first constructs a sequence of ranking statistics that fulfill global symmetry properties, and then chooses a data-driven threshold along…

经验最佳预测量的同时推断及小区域贫困研究AI 解读

Today, generalized linear mixed models (GLMM) are broadly used in many fields. However, the development of tools for performing simultaneous inference has been largely neglected in this domain. A framework for joint inference is indispensable to carry out statistically valid multiple comparisons of parameters of interest between all or several clusters. We therefore develop simultaneous confidence intervals and multiple testing procedures for empirical best predictors under…

高维最优治疗规则的模型辅助一致诚实推断AI 解读

This article develops new tools to quantify uncertainty in optimal decision making and to gain insight into which variables one should collect information about given the potential cost of measuring a large number of variables. We investigate simultaneous inference to determine if a group of variables is relevant for estimating an optimal decision rule in a high-dimensional semiparametric framework. The unknown link function permits flexible modeling of the interactions…

利用高斯镜像控制错误发现率AI 解读

Simultaneously, finding multiple influential variables and controlling the false discovery rate (FDR) for linear regression models is a fundamental problem. We here propose the Gaussian Mirror (GM) method, which creates for each predictor variable a pair of mirror variables by adding and subtracting a randomly generated Gaussian perturbation, and proceeds with a certain regression method, such as the ordinary least-square or the Lasso (the mirror variables can also be…

基于 Bootstrap 的高维多元方差分析及函数与稀疏计数数据应用AI 解读

We propose a new approach to the problem of high-dimensional multivariate ANOVA via bootstrapping max statistics that involve the differences of sample mean vectors. The proposed method proceeds via the construction of simultaneous confidence regions for the differences of population mean vectors. It is suited to simultaneously test the equality of several pairs of mean vectors of potentially more than two populations. By exploiting the variance decay property that is a…

在保持错误发现率控制的同时筛选拒绝集合AI 解读

Scientific hypotheses in a variety of applications have domain-specific structures, such as the tree structure of the international classification of diseases (ICD), the directed acyclic graph structure of the gene ontology (GO), or the spatial structure in genome-wide association studies. In the context of multiple testing, the resulting relationships among hypotheses can create redundancies among rejections that hinder interpretability. This leads to the practice of…

基于分位数的众数回归自助法推断AI 解读

In this article, we develop uniform inference methods for the conditional mode based on quantile regression. Specifically, we propose to estimate the conditional mode by minimizing the derivative of the estimated conditional quantile function defined by smoothing the linear quantile regression estimator, and develop two bootstrap methods, a novel pivotal bootstrap and the nonparametric bootstrap, for our conditional mode estimator. Building on high-dimensional Gaussian…

稀疏性诱导的弱因子模型推断AI 解读

In this article, we consider statistical inference for high-dimensional approximate factor models. We posit a weak factor structure, in which the factor loading matrix can be sparse and the signal eigenvalues may diverge more slowly than the cross-sectional dimension, N. We propose a novel inferential procedure to decide whether each component of the factor loadings is zero or not, and prove that this controls the false discovery rate (FDR) below a preassigned level, while…

引发攀比的比较：作为复合决策的排名与选择AI 解读

There is an innate human tendency, one might call it the “league table mentality,” to construct rankings. Schools, hospitals, sports teams, movies, and myriad other objects are ranked even though their inherent multi‐dimensionality would suggest that—at best—only partial orderings were possible. We consider a large class of elementary ranking problems in which we observe noisy, scalar measurements of merit for n objects of potentially heterogeneous precision and are asked to…

弱依赖高维动态面板中的异质性处理效应推断AI 解读

This paper provides estimation and inference methods for conditional average treatment effects (CATE) characterized by a high‐dimensional parameter in both homogeneous cross‐sectional and unit‐heterogeneous dynamic panel data settings. In our leading example, we model CATE by interacting the base treatment variable with explanatory variables. The first step of our procedure is orthogonalization, where we partial out the controls and unit effects from the outcome and the base…

依赖情形下控制错误发现率的条件校准AI 解读

We introduce a new class of methods for finite-sample false discovery rate (FDR) control in multiple testing problems with dependent test statistics where the dependence is known. Our approach separately calibrates a data-dependent p-value rejection threshold for each hypothesis, relaxing or tightening the threshold as appropriate to target exact FDR control. In addition to our general framework, we propose a concrete algorithm, the dependence-adjusted Benjamini–Hochberg…

调整Benjamini–Hochberg方法以控制knockoff变量选择的错误发现率AI 解读

Summary We consider the knockoff-based multiple testing set-up of Barber & Candès (2015). for variable selection in multiple regression. The method of Benjamini & Hochberg (1995) and an adaptive version of it are adjusted to this set-up, transforming them to valid $p$-value-based, false discovery rate-controlling methods that do not rely on specifying the correlation structure of the explanatory variables. Simulations and real data applications show that the proposed methods…

函数均值的经验似然推断及其可穿戴设备数据应用AI 解读

Abstract This paper develops a nonparametric inference framework that is applicable to occupation time curves derived from wearable device data. These curves consider all activity levels within the range of device readings, which is preferable to the practice of classifying activity into discrete categories. Motivated by certain features of these curves, we introduce a powerful likelihood ratio approach to construct confidence bands and compare functional means. Notably, our…

利用高频数据预测低频宏观事件AI 解读

Summary High‐frequency financial and economic indicators are usually time‐aggregated before computing forecasts of macroeconomic events, such as recessions. We propose a mixed‐frequency alternative that delivers high‐frequency probability forecasts (including their confidence bands) for low‐frequency events. The new approach is compared with single‐frequency alternatives using loss functions for rare‐event forecasting. We find (i) the weekly‐sampled term spread improves over…

基于多受试者时间序列的多层偏相关推断AI 解读

Partial correlations are commonly used to analyze the conditional dependence among variables. In this work, we propose a hierarchical model to study both the subject- and population-level partial correlations based on multi-subject time-series data. Multiple testing procedures adaptive to temporally dependent data with false discovery proportion control are proposed to identify the nonzero partial correlations in both the subject and population levels. A computationally…

预先多重检验估计及其在多样本协方差估计中的应用AI 解读

Multisample covariance estimation—that is, estimation of the covariance matrices associated with k distinct populations—is a classical problem in multivariate statistics. A common solution is to base estimation on the outcome of a test that these covariance matrices show some given pattern. Such a preliminary test may, for example, investigate whether or not the various covariance matrices are equal to each other (test of homogeneity), or whether or not they have common…

利用布尔矩阵逻辑检验中介效应AI 解读

A central question in high-dimensional mediation analysis is to infer the significance of individual mediators. The main challenge is that the total number of potential paths that go through any mediator is super-exponential in the number of mediators. Most existing mediation inference solutions either explicitly impose that the mediators are conditionally independent given the exposure, or ignore any potential directed paths among the mediators. In this article, we propose…

含协变量的双成分混合模型AI 解读

In this article, we study a generalization of the two-groups model in the presence of covariates—a problem that has recently received much attention in the statistical literature due to its applicability in multiple hypotheses testing problems. The model we consider allows for infinite dimensional parameters and offers flexibility in modeling the dependence of the response on the covariates. We discuss the identifiability issues arising in this model and systematically study…

多重检验与教育问责激励的分布效应AI 解读

This article proposes bootstrap-based multiple testing procedures for quantile treatment effect (QTE) heterogeneity under the assumption of selection on observables, and shows its asymptotic validity. Our procedure can be used to detect the quantiles and subgroups exhibiting treatment effect heterogeneity. We apply the multiple testing procedures to data from a large-scale Pakistani school report card experiment, and uncover evidence of policy-relevant heterogeneous effects…