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逐步多重检验：将数据窥探形式化AI 解读

In econometric applications, often several hypothesis tests are carried out at once. The problem then becomes how to decide which hypotheses to reject, accounting for the multitude of tests. This paper suggests a stepwise multiple testing procedure that asymptotically controls the familywise error rate. Compared to related single-step methods, the procedure is more powerful and often will reject more false hypotheses. In addition, we advocate the use of studentization when…

稀疏纵向数据的函数型数据分析AI 解读

We propose a nonparametric method to perform functional principal components analysis for the case of sparse longitudinal data. The method aims at irregularly spaced longitudinal data, where the number of repeated measurements available per subject is small. In contrast, classical functional data analysis requires a large number of regularly spaced measurements per subject. We assume that the repeated measurements are located randomly with a random number of repetitions for…

广义函数型线性模型AI 解读

We propose a generalized functional linear regression model for a regression situation where the response variable is a scalar and the predictor is a random function. A linear predictor is obtained by forming the scalar product of the predictor function with a smooth parameter function, and the expected value of the response is related to this linear predictor via a link function. If, in addition, a variance function is specified, this leads to a functional estimating…

所选参数的错误发现率调整多重置信区间AI 解读

Often in applied research, confidence intervals (CIs) are constructed or reported only for parameters selected after viewing the data. We show that such selected intervals fail to provide the assumed coverage probability. By generalizing the false discovery rate (FDR) approach from multiple testing to selected multiple CIs, we suggest the false coverage-statement rate (FCR) as a measure of interval coverage following selection. A general procedure is then introduced,…

具有时变回归系数的Cox模型AI 解读

In the analysis of censored failure time observations, the standard Cox proportional hazards model assumes that the regression coefficients are time invariant. Often, these parameters vary over time, and the temporal covariate effects on the failure time are of great interest. In this article, following previous work of Cai and Sun, we propose a simple estimation procedure for the Cox model with time-varying coefficients based on a kernel-weighted partial likelihood…

高斯向量均值的凸假设检验及回归函数定性假设的应用AI 解读

In this paper we propose a general methodology, based on multiple testing, for testing that the mean of a Gaussian vector in ℝn belongs to a convex set. We show that the test achieves its nominal level, and characterize a class of vectors over which the tests achieve a prescribed power. In the functional regression model this general methodology is applied to test some qualitative hypotheses on the regression function. For example, we test that the regression function is…

多元失效时间数据的加性风险模型AI 解读

Marginal additive hazards models are considered for multivariate survival data in which individuals may experience events of several types and there may also be correlation between individuals. Estimators are proposed for the parameters of such models and for the baseline hazard functions. The estimators of the regression coeffcients are shown asymptotically to follow a multivariate normal distribution with a sandwich-type covariance matrix that can be consistently…

随机场的错误发现控制AI 解读

This article extends false discovery rates to random fields, for which there are uncountably many hypothesis tests. We develop a method for finding regions in the field's domain where there is a significant signal while controlling either the proportion of area or the proportion of clusters in which false rejections occur. The method produces confidence envelopes for the proportion of false discoveries as a function of the rejection threshold. From the confidence envelopes,…

高斯浓度图的模型选择AI 解读

A multivariate Gaussian graphical Markov model for an undirected graph G, also called a covariance selection model or concentration graph model, is defined in terms of the Markov properties, i.e. conditional independences associated with G, which in turn are equivalent to specified zeros among the set of pairwise partial correlation coefficients. By means of Fisher's z‐transformation and Šidák's correlation inequality, conservative simultaneous confidence intervals for the…

受试者工作特征曲线的非参数置信区间AI 解读

We study methods for constructing confidence intervals and confidence bands for estimators of receiver operating characteristics. Particular emphasis is placed on the way in which smoothing should be implemented, when estimating either the characteristic itself or its variance. We show that substantial undersmoothing is necessary if coverage properties are not to be impaired. A theoretical analysis of the problem suggests an empirical, plug‐in rule for bandwidth choice,…

模型选择后的统计推断AI 解读

Typical modeling strategies involve model selection, which has a significant effect on inference of estimated parameters. Common practice is to use a selected model ignoring uncertainty introduced by the process of model selection. This could yield overoptimistic inferences, resulting in false discovery. In this article we develop a general methodology via optimal approximation for estimating the mean and variance of complex statistics that involve the process of model…

错误发现控制的随机过程方法AI 解读

This paper extends the theory of false discovery rates (FDR) pioneered by Benjamini and Hochberg [J. Roy. Statist. Soc. Ser. B 57 (1995) 289–300]. We develop a framework in which the False Discovery Proportion (FDP)—the number of false rejections divided by the number of rejections—is treated as a stochastic process. After obtaining the limiting distribution of the process, we demonstrate the validity of a class of procedures for controlling the False Discovery Rate (the…

多个线性回归模型的多重比较AI 解读

Research on multiple comparison during the past 50 years or so has focused mainly on the comparison of several population means. Several years ago, Spurrier considered the multiple comparison of several simple linear regression lines. He constructed simultaneous confidence bands for all of the contrasts of the simple linear regression lines over the entire range (-∞, ∞) when the models have the same design matrices. This article extends Spurrier's work in several directions.…

半参数广义可加模型中的 Bootstrap 推断AI 解读

Semiparametric generalized additive models are a powerful tool in quantitative econometrics. With response Y, covariates X,T, the considered model is E(Y |X;T) = G{XTβ + α + m1(T1) + ··· + md(Td)}. Here, G is a known link, α and β are unknown parameters, and m1,…,md are unknown (smooth) functions of possibly higher dimensional covariates T1,…,Td. Estimates of m1,…,md, α, and β are presented, and asymptotic distributions are given for both the nonparametric and the parametric…

用半参数惩罚样条估计公司债利率期限结构AI 解读

This article provides a new methodology for estimating the term structure of corporate debt using a semiparametric penalized spline model. The method is applied to a case study of AT&T bonds. Typically, very few data are available on individual corporate bond prices, too little to find a nonparametric estimate of term structure from these bonds alone. This problem is solved by “borrowing strength” from Treasury bond data. More specifically, we combine a nonparametric model…

大规模同时假设检验AI 解读

Current scientific techniques in genomics and image processing routinely produce hypothesis testing problems with hundreds or thousands of cases to consider simultaneously. This poses new difficulties for the statistician, but also opens new opportunities. In particular, it allows empirical estimation of an appropriate null hypothesis. The empirical null may be considerably more dispersed than the usual theoretical null distribution that would be used for any one case…

错误发现率的强控制、保守点估计与同时保守一致性：统一方法AI 解读

Summary The false discovery rate (FDR) is a multiple hypothesis testing quantity that describes the expected proportion of false positive results among all rejected null hypotheses. Benjamini and Hochberg introduced this quantity and proved that a particular step-up p-value method controls the FDR. Storey introduced a point estimate of the FDR for fixed significance regions. The former approach conservatively controls the FDR at a fixed predetermined level, and the latter…

回归曲线及其导数的自助法置信带AI 解读

Confidence bands for regression curves and their first p derivatives are obtained via local pth order polynomial estimation. The method allows for multiparameter local likelihood estimation as well as other unbiased estimating equations. As an alternative to the confidence bands obtained by asymptotic distribution theory, we also study smoothed bootstrap confidence bands. Simulations illustrate the finite sample properties of the methodology.

正假发现率：贝叶斯解释与 q 值AI 解读

Multiple hypothesis testing is concerned with controlling the rate of false positives when testing several hypotheses simultaneously. One multiple hypothesis testing error measure is the false discovery rate (FDR), which is loosely defined to be the expected proportion of false positives among all significant hypotheses. The FDR is especially appropriate for exploratory analyses in which one is interested in finding several significant results among many tests. In this work,…

完全标记信息下多点连锁分析的渐近估计理论AI 解读

We consider estimation of a disease susceptibility locus $\tau$ at a chromosome. With perfect marker data available, the estimator $\htau_N$ of $\tau$ based on $N$-pedigrees has a rate of convergence $N^{-1}$ under mild regularity conditions. The limiting distribution is the arg max of a certain compound Poisson process. Our approach is conditional on observed phenotypes, and therefore treats parametric and nonparametric linkage, as well as quantitative trait loci methods…

利用贝叶斯模型选择识别微阵列中的差异表达基因AI 解读

DNA microarrays open up a broad new horizon for investigators interested in studying the genetic determinants of disease. The high throughput nature of these arrays, where differential expression for thousands of genes can be measured simultaneously, creates an enormous wealth of information, but also poses a challenge for data analysis because of the large multiple testing problem involved. The solution has generally been to focus on optimizing false-discovery rates while…

时间序列误差下非参数回归推断的差分方法AI 解读

Summary We show that difference-based methods can be used to construct simple and explicit estimators of error covariance and autoregressive parameters in nonparametric regression with time series errors. When the error process is Gaussian our estimators are efficient, but they are available well beyond the Gaussian case. As an illustration of their usefulness we show that difference-based estimators can be used to produce a simplified version of time series…

全基因组 DNA 匹配中的异常检测与错误发现率AI 解读

We define a statistic, called the matching statistic, for locating regions of the genome that exhibit excess similarity among cases when compared to controls. Such regions are reasonable candidates for harboring disease genes. We find the asymptotic distribution of the statistic while accounting for correlations among sampled individuals. We then use the Benjamini and Hochberg false discovery rate (FDR) method for multiple hypothesis testing to find regions of excess…

随机占优的一致检验AI 解读

Methods are proposed for testing stochastic dominance of any pre–specified order, with primary interest in the distributions of income. We consider consistent tests, that are similar to Kolmogorov–Smirnov tests, of the complete set of restrictions that relate to the various forms of stochastic dominance. For such tests, in the case of tests for stochastic dominance beyond first order, we propose and justify a variety of approaches to inference based on simulation and the…