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稀疏分类中的错误发现率阈值法AI 解读

We study the properties of false discovery rate (FDR) thresholding, viewed as a classification procedure. The “$0$”-class (null) is assumed to have a known density while the “$1$”-class (alternative) is obtained from the “$0$”-class either by translation or by scaling. Furthermore, the “$1$”-class is assumed to have a small number of elements w.r.t. the “$0$”-class (sparsity). We focus on densities of the Subbotin family, including Gaussian and Laplace models. Nonasymptotic…

可转置数据的推断：行列相关性的建模AI 解读

Summary We consider the problem of large-scale inference on the row or column variables of data in the form of a matrix. Many of these data matrices are transposable meaning that neither the row variables nor the column variables can be considered independent instances. An example of this scenario is detecting significant genes in microarrays when the samples may be dependent because of latent variables or unknown batch effects. By modelling this matrix data by using the…

利用自助法极值相关图估计极端序列依赖AI 解读

Davis and Mikosch (2009a) introduced the extremogram as a flexible quantitative tool for measuring various types of extremal dependence in a stationary time series. There we showed some standard statistical properties of the sample extremogram. A major difficulty was the construction of credible confidence bands for the extremogram. In this paper, we employ the stationary bootstrap to overcome this problem. The use of the stationary bootstrap for the extremogram and the…

评论：错误发现比例、错误发现率与条件化的影响AI 解读

Accurate estimation of the false discovery proportion (FDP) and false discovery rate (FDR) is a problem that has been eagerly waiting for a solution. Fan, Han and Gu have found one. They have achieved this by both clarifying the concept of the problem and providing a feasible algorithmic solution. In this comment, I discuss some of the central concepts involving FDP and its estimation via conditioning in contrast with the estimators by Efron (2007) and Friguet et al. (2009).

任意协方差依赖下的错误发现比例估计AI 解读

Multiple hypothesis testing is a fundamental problem in high dimensional inference, with wide applications in many scientific fields. In genome-wide association studies, tens of thousands of tests are performed simultaneously to find if any SNPs are associated with some traits and those tests are correlated. When test statistics are correlated, false discovery control becomes very challenging under arbitrary dependence. In the current paper, we propose a novel method based…

超越面板单位根检验：用多重检验识别各序列的非平稳性AI 解读

Most panel unit root tests are designed to test the joint null hypothesis of a unit root for each individual series in a panel. After a rejection, it will often be of interest to identify which series can be deemed to be stationary and which series can be deemed nonstationary. Researchers will sometimes carry out this classification on the basis of n individual (univariate) unit root tests based on some ad hoc significance level. In this paper, we suggest and demonstrate how…

对数据选择后参数的调整贝叶斯推断AI 解读

Summary We address the problem of providing inference from a Bayesian perspective for parameters selected after viewing the data. We present a Bayesian framework for providing inference for selected parameters, based on the observation that providing Bayesian inference for selected parameters is a truncated data problem. We show that if the prior for the parameter is non-informative, or if the parameter is a ‘fixed’ unknown constant, then it is necessary to adjust the…

非参数工具变量函数估计的一致置信带AI 解读

This paper is concerned with developing uniform confidence bands for functions estimated nonparametrically with instrumental variables. We show that a sieve nonparametric instrumental variables estimator is pointwise asymptotically normally distributed. The asymptotic normality result holds in both mildly and severely ill-posed cases. We present methods to obtain a uniform confidence band and show that the bootstrap can be used to obtain the required critical values. Monte…

异方差模型中复合原假设的多重检验AI 解读

In large-scale studies, the true effect sizes often range continuously from zero to small to large, and are observed with heteroscedastic errors. In practical situations where the failure to reject small deviations from the null is inconsequential, specifying an indifference region (or forming composite null hypotheses) can greatly reduce the number of unimportant discoveries in multiple testing. The heteroscedasticity issue poses new challenges for multiple testing with…

利用重要性抽样构造保守假设检验与置信区间AI 解读

Importance sampling is a common technique for Monte Carlo approximation, including that of p-values. Here it is shown that a simple correction of the usual importance sampling p-values provides valid p-values, meaning that a hypothesis test created by rejecting the null hypothesis when the p-value is at most α will also have a Type I error rate of at most α. This correction uses the importance weight of the original observation, which gives valuable diagnostic information…

Yule–Walker估计量的同时置信带与阶数选择AI 解读

Let {Xk, k ∈ ℤ} be an autoregressive process of order q. Various estimators for the order q and the parameters Θq = (θ1, …, θq)T are known; the order is usually determined with Akaike’s criterion or related modifications, whereas Yule–Walker, Burger or maximum likelihood estimators are used for the parameters Θq. In this paper, we establish simultaneous confidence bands for the Yule–Walker estimators θ̂i; more precisely, it is shown that the limiting distribution of…

错误发现率控制与估计的自适应及动态自适应程序AI 解读

Summary Many methods for estimation or control of the false discovery rate (FDR) can be improved by incorporating information about π0, the proportion of all tested null hypotheses that are true. Estimates of π0 are often based on the number of p-values that exceed a threshold λ. We first give a finite sample proof for conservative point estimation of the FDR when the λ-parameter is fixed. Then we establish a condition under which a dynamic adaptive procedure, whose…

利用局部极大值多重检验检测一维峰值AI 解读

A topological multiple testing scheme for one-dimensional domains is proposed where, rather than testing every spatial or temporal location for the presence of a signal, tests are performed only at the local maxima of the smoothed observed sequence. Assuming unimodal true peaks with finite support and Gaussian stationary ergodic noise, it is shown that the algorithm with Bonferroni or Benjamini-Hochberg correction provides asymptotic strong control of the family wise error…

依赖下 Westfall–Young 多重检验置换程序的渐近最优性AI 解读

Test statistics are often strongly dependent in large-scale multiple testing applications. Most corrections for multiplicity are unduly conservative for correlated test statistics, resulting in a loss of power to detect true positives. We show that the Westfall–Young permutation method has asymptotically optimal power for a broad class of testing problems with a block-dependence and sparsity structure among the tests, when the number of tests tends to infinity.

基于似然比检验的信号检测及其 FDA 药物安全数据应用AI 解读

Several statistical methods that are available in the literature to analyze postmarket safety databases, such as the U.S. Federal Drug Administration’s (FDA) adverse event reporting system (AERS), for identifying drug-event combinations with disproportionately high frequencies, are subject to high false discovery rates. Here, we propose a likelihood ratio test (LRT) based method and show, via an extensive simulation study, that the proposed method while retaining good power…

稀疏备择下的整体检验：方差分析、多重比较与 higher criticismAI 解读

Testing for the significance of a subset of regression coefficients in a linear model, a staple of statistical analysis, goes back at least to the work of Fisher who introduced the analysis of variance (ANOVA). We study this problem under the assumption that the coefficient vector is sparse, a common situation in modern high-dimensional settings. Suppose we have p covariates and that under the alternative, the response only depends upon the order of p1−α of those, 0 ≤ α ≤ 1.…

自适应推断与置信带AI 解读

The problem of existence of adaptive confidence bands for an unknown density f that belongs to a nested scale of Hölder classes over ℝ or [0, 1] is considered. Whereas honest adaptive inference in this problem is impossible already for a pair of Hölder balls Σ(r), Σ(s), r ≠ s, of fixed radius, a nonparametric distinguishability condition is introduced under which adaptive confidence bands can be shown to exist. It is further shown that this condition is necessary and…

基于离散观测过程的跳跃检验与定位AI 解读

We propose a new nonparametric test for detecting the presence of jumps in asset prices using discretely observed data. Compared with the test in Aït-Sahalia and Jacod (2009), our new test enjoys the same asymptotic properties but has smaller variance. These results are justified both theoretically and numerically. We also propose a new procedure to locate the jumps. The jump identification problem reduces to a multiple comparison problem. We employ the false discovery rate…

响应误分类下相关二元数据的边际分析方法AI 解读

Misclassification is a longstanding concern in medical research. Although there has been much research concerning error-prone covariates, relatively little work has been directed to problems with response variables subject to error. In this paper we focus on misclassification in clustered or longitudinal outcomes. We propose marginal analysis methods to handle binary responses which are subject to misclassification. The proposed methods have several appealing features,…

基于预测递归边际似然的混合模型半参数推断AI 解读

Predictive recursion is an accurate and computationally efficient algorithm for nonparametric estimation of mixing densities in mixture models. In semiparametric mixture models, however, the algorithm fails to account for any uncertainty in the additional unknown structural parameter. As an alternative to existing profile likelihood methods, we treat predictive recursion as a filter approximation by fitting a fully Bayes model, whereby an approximate marginal likelihood of…

依赖条件下错误发现比例的预测AI 解读

We present a flexible framework for predicting error measures in multiple testing situations under dependence. Our approach is based on modeling the distribution of the probit transform of the p-values by mixtures of multivariate skew-normal distributions. The model can incorporate dependence among p-values and it allows for shape restrictions on the p-value density. A nonparametric Bayesian scheme for estimating the components of the mixture model is outlined and Markov…

用非参数趋势检验分析长周期变星AI 解读

In astronomy the study of variable stars—that is, stars characterized by showing significant variation in their brightness over time—has made crucial contributions to our understanding of many phenomena, from stellar birth and evolution to the calibration of the extragalactic distance scale. In this article, we develop a method for analyzing multiple, (pseudo)-periodic time series with the goal of detecting temporal trends in their periods. We allow for nonstationary noise…

多重检验与高通量检测中的发现后验概率和预期发现率AI 解读

Technologies of measuring millions of quantities at once have been rapidly developed and used in biological and biomedical research and other fields in the past decade. Yet a key issue remains unsettled, namely, how to control spurious findings for the ensuing massive number of hypothesis tests. An emerging consensus is to control false discovery rate (FDR), with FDR defined as the expected proportion of true nulls among discoveries, and a discovery the rejection of a null…

短面板向量自回归中脉冲响应函数的渐近分布AI 解读

This paper establishes the asymptotic distributions of the impulse response functions in panel vector autoregressions with a fixed time dimension. It also proves the asymptotic validity of a bootstrap approximation to their sampling distributions. The autoregressive parameters are estimated using the GMM estimators based on the first differenced equations and the error variance is estimated using an extended analysis-of-variance type estimator. Contrary to the time series…