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函数型时间序列动态差异的检测与定位：分子生物物理案例AI 解读

Motivated by the problem of inferring the molecular dynamics of DNA in solution, and linking them with its base-pair composition, we consider the problem of comparing the dynamics of functional time series (FTS), and of localizing any inferred differences in frequency and along curvelength. The approach we take is one of Fourier analysis, where the complete second-order structure of the FTS is encoded by its spectral density operator, indexed by frequency and curvelength.…

一般依赖下多重比较的图形化程序AI 解读

It has been more than half a century since Tukey first introduced graphical displays that relate nonoverlap of confidence intervals to statistically significant differences between parameter estimates. In this article, we show how Tukey’s graphical overlap procedure can be modified to accommodate general forms of dependence within and across samples. We also develop a procedure that can be used to more effectively resolve rankings within the tails of the distributions of…

比较回归曲线的最优设计AI 解读

We consider the optimal design problem for a comparison of two regression curves, which is used to establish the similarity between the dose response relationships of two groups. An optimal pair of designs minimizes the width of the confidence band for the difference between the two regression functions. Optimal design theory (equivalence theorems, efficiency bounds) is developed for this non-standard design problem and for some commonly used dose response models optimal…

结构脉冲响应的联合置信集AI 解读

Many questions of economic interest in structural VAR analysis involve estimates of multiple impulse response functions. Other questions relate to the shape of a given impulse response function. Answering these questions requires joint inference about sets of structural impulse responses, allowing for dependencies across time as well as across response functions. Such joint inference is complicated by the fact that the joint distribution of the structural impulse response…

This paper discusses the simultaneous inference of mean parameters in a family of distributions with quadratic variance function. We first introduce a class of semi-parametric/parametric shrinkage estimators and establish their asymptotic optimality properties. Two specific cases, the location-scale family and the natural exponential family with quadratic variance function, are then studied in detail. We conduct a comprehensive simulation study to compare the performance of…

序贯选择程序与错误发现率控制AI 解读

Summary We consider a multiple-hypothesis testing setting where the hypotheses are ordered and one is only permitted to reject an initial contiguous block H1,…,Hk of hypotheses. A rejection rule in this setting amounts to a procedure for choosing the stopping point k. This setting is inspired by the sequential nature of many model selection problems, where choosing a stopping point or a model is equivalent to rejecting all hypotheses up to that point and none thereafter. We…

非参数与半参数分位数模型推断的直接方法AI 解读

We construct a generic confidence interval for a conditional quantile via the direct approach. It avoids estimating the conditional density function of the dependent variable given the covariate and is asymptotically valid for any conditional quantile, any conditional quantile estimator, and any data structure, provided that certain weak convergence of the conditional quantile process holds for the original quantile estimator. We also construct a generic confidence band for…

In many statistical applications of one-sided tests of multiple hypotheses researchers are often concerned not only with global tests of the intersection of individual hypotheses, but also with multiple tests of individual hypotheses. For example, in clinical trial studies researchers often need to find out the efficacy of a treatment, as well as the significance of each outcome measurement (endpoint) of the treatment. This article proposes MaxT type tests aiming at…

Multiple testing of correlations arises in many applications including gene coexpression network analysis and brain connectivity analysis. In this paper, we consider large scale simultaneous testing for correlations in both the one-sample and two-sample settings. New multiple testing procedures are proposed and a bootstrap method is introduced for estimating the proportion of the nulls falsely rejected among all the true nulls. The properties of the proposed procedures are…

相关变量高维模型中的层级检验AI 解读

We propose a method for testing whether hierarchically ordered groups of potentially correlated variables are significant for explaining a response in a high-dimensional linear model. In presence of highly correlated variables, as is very common in high-dimensional data, it seems indispensable to go beyond an approach of inferring individual regression coefficients, and we show that detecting smallest groups of variables (MTDs: minimal true detections) is realistic. Thanks…

强弱截面依赖下时空分析的两阶段方法AI 解读

Summary An understanding of the spatial dimension of economic and social activity requires methods that can separate out the relationship between spatial units that is due to the effect of common factors from that which is purely spatial even in an abstract sense. The same applies to the empirical analysis of networks in general. We use cross‐unit averages to extract common factors (viewed as a source of strong cross‐sectional dependence) and compare the results with the…

高维情形下的同时变点检验AI 解读

Consider $d$ dependent change point tests, each based on a CUSUM-statistic. We provide an asymptotic theory that allows us to deal with the maximum over all test statistics as both the sample size $n$ and $d$ tend to infinity. We achieve this either by a consistent bootstrap or an appropriate limit distribution. This allows for the construction of simultaneous confidence bands for dependent change point tests, and explicitly allows us to determine the location of the change…

效应量具有高斯先验时的最优多重检验AI 解读

We develop a new method for large-scale frequentist multiple testing with Bayesian prior information. We find optimal $p$-value weights that maximize the average power of the weighted Bonferroni method. Due to the nonconvexity of the optimization problem, previous methods that account for uncertain prior information are suitable for only a small number of tests. For a Gaussian prior on the effect sizes, we give an efficient algorithm that is guaranteed to find the optimal…

探索效应修饰的观察性研究中族错误率的强控制AI 解读

An effect modifier is a pretreatment covariate that affects the magnitude of the treatment effect or its stability. When there is effect modification, an overall test that ignores an effect modifier may be more sensitive to unmeasured bias than a test that combines results from subgroups defined by the effect modifier. If there is effect modification, one would like to identify specific subgroups for which there is evidence of effect that is insensitive to small or moderate…

变点估计：重新审视多重检验问题AI 解读

We consider large scale multiple testing for data that have locally clustered signals. With this structure, we apply techniques from changepoint analysis and propose a boundary detection algorithm so that the clustering information can be utilized. Consequently the precision of the multiple testing procedure is substantially improved. We study tests with independent as well as dependent |$p$|-values. Monte Carlo simulations suggest that the methods perform well with…

通过类别间相关性比较检验二元响应交互作用的置换方法AI 解读

To date testing interactions in high dimensions is a challenging task. Existing methods often have issues with sensitivity to modeling assumptions and heavily asymptotic nominal p-values. To help alleviate these issues, we propose a permutation-based method for testing marginal interactions with a binary response. Our method searches for pairwise correlations that differ between classes. In this article, we compare our method on real and simulated data to the standard…

高维协变量非线性交互的广义加性系数模型估计与推断AI 解读

In the low-dimensional case, the generalized additive coefficient model (GACM) proposed by Xue and Yang [Statist. Sinica 16 (2006) 1423–1446] has been demonstrated to be a powerful tool for studying nonlinear interaction effects of variables. In this paper, we propose estimation and inference procedures for the GACM when the dimension of the variables is high. Specifically, we propose a groupwise penalization based procedure to distinguish significant covariates for the…

回归函数单点的自适应检验AI 解读

We consider the problem of inference on a regression function at a point when the entire function satisfies a sign or shape restriction under the null. We propose a test that achieves the optimal minimax rate adaptively over a range of Hölder classes, up to a $\log\log n$ term, which we show to be necessary for adaptation. We apply the results to adaptive one-sided tests for the regression discontinuity parameter under a monotonicity restriction, the value of a monotone…

通过 Knockoff 变量控制错误发现率AI 解读

In many fields of science, we observe a response variable together with a large number of potential explanatory variables, and would like to be able to discover which variables are truly associated with the response. At the same time, we need to know that the false discovery rate (FDR)—the expected fraction of false discoveries among all discoveries—is not too high, in order to assure the scientist that most of the discoveries are indeed true and replicable. This paper…

高通量筛查中假阳性数量的有效估计AI 解读

This paper develops tail estimation methods to handle false positives in multiple testing problems where testing is done at extreme significance levels and with low degrees of freedom, and where the true null distribution may differ from the theoretical one. We show that the number of false positives, conditional on the total number of positives, has an approximately binomial distribution, and we find estimators of the distribution parameter. We also develop methods for…

Studies of expression quantitative trait loci (eQTLs) offer insight into the molecular mechanisms of loci that were found to be associated with complex diseases and the mechanisms can be classified into cis- and trans-acting regulation. At present, high-throughput RNA sequencing (RNA-seq) is rapidly replacing expression microarrays to assess gene expression abundance. Unlike microarrays that only measure the total expression of each gene, RNA-seq also provides information on…

同时纳入随机序与变异序的贝叶斯非参数 ROC 曲线估计AI 解读

Beom Seuk Hwang & Zhen ChenBeom Seuk Hwang is Postdoctoral Fellow (E-mail: ) and Zhen Chen is Investigator (E-mail: ), Biostatistics and Bioinformatics Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892. This research was supported by the Intramural Research Program of the Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health. This…

基于 Romano–Wolf 启发式控制错误发现比例的新程序AI 解读

The false discovery proportion (FDP) is a convenient way to account for false positives when a large number $m$ of tests are performed simultaneously. Romano and Wolf [ Ann. Statist. 35 (2007) 1378–1408] have proposed a general principle that builds FDP controlling procedures from $k$-family-wise error rate controlling procedures while incorporating dependencies in an appropriate manner; see Korn et al. [ J. Statist. Plann. Inference 124 (2004) 379–398]; Romano and Wolf…

高维 ALASSO 残差经验过程及其函数型 oracle 性质AI 解读

This paper considers post variable-selection inference in a high dimensional penalized regression model based on the ALASSO method of Zou (2006). It is shown that under suitable sparsity conditions, the residual empirical process based on the ALASSO provides valid inference methodology in very high dimensional regression problems where conventional methods fail. It is also shown that the ALASSO based residual empirical process satisfies a functional oracle property, i.e., in…