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Fast closed testing for exchangeable local tests

可交换局部检验的快速闭合检验

Summary Multiple hypothesis testing problems arise naturally in science. This note introduces a new fast closed testing method for multiple testing which controls the familywise error rate. Controlling the familywise error rate is state-of-the-art in many important application areas and is preferred over false discovery rate control for many reasons, including that it leads to stronger reproducibility. The closure principle rejects an individual hypothesis if all global…

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False Discovery and its Control in Low Rank Estimation

低秩估计中的错误发现及其控制

Summary Models specified by low rank matrices are ubiquitous in contemporary applications. In many of these problem domains, the row–column space structure of a low rank matrix carries information about some underlying phenomenon, and it is of interest in inferential settings to evaluate the extent to which the row–column spaces of an estimated low rank matrix signify discoveries about the phenomenon. However, in contrast with variable selection, we lack a formal framework…

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HONEST CONFIDENCE SETS IN NONPARAMETRIC IV REGRESSION AND OTHER ILL-POSED MODELS

非参数工具变量回归及其他病态模型中的诚实置信集

Abstract This article develops inferential methods for a very general class of ill-posed models in econometrics encompassing the nonparametric instrumental variable regression, various functional regressions, and the density deconvolution. We focus on uniform confidence sets for the parameter of interest estimated with Tikhonov regularization, as in Darolles et al. (2011, Econometrica 79, 1541–1565). Since it is impossible to have inferential methods based on the central…

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Simultaneous Covariance Inference for Multimodal Integrative Analysis

多模态整合分析中的协方差同时推断

Multimodal integrative analysis fuses different types of data collected on the same set of experimental subjects. It is becoming a norm in many branches of scientific research, such as multi-omics and multimodal neuroimaging analysis. In this article, we address the problem of simultaneous covariance inference of associations between multiple modalities, which is of a vital interest in multimodal integrative analysis. Recognizing that there are few readily available…

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GAP: A General Framework for Information Pooling in Two-Sample Sparse Inference

GAP:两样本稀疏推断的信息汇聚通用框架

Yin Xiaa, T. Tony Caib & Wenguang Sunc*a Department of Statistics, School of Management, Fudan University, Shanghai, China; b Department of Statistics, The Wharton School, University of Pennsylvania, Philadelphia, PA; c Department of Data Sciences and Operations, University of Southern California, Los Angeles, CAColor versions of one or more of the figures in the article can be found online at www.tandfonline.com/r/JASA.Supplementary materials for this article are available…

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Large sample properties of partitioning-based series estimators

基于分区的级数估计量的大样本性质

We present large sample results for partitioning-based least squares nonparametric regression, a popular method for approximating conditional expectation functions in statistics, econometrics and machine learning. First, we obtain a general characterization of their leading asymptotic bias. Second, we establish integrated mean squared error approximations for the point estimator and propose feasible tuning parameter selection. Third, we develop pointwise inference methods…

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Robust inference with knockoffs

Knockoff 方法的稳健推断

We consider the variable selection problem, which seeks to identify important variables influencing a response $Y$ out of many candidate features $X_{1},\ldots ,X_{p}$. We wish to do so while offering finite-sample guarantees about the fraction of false positives—selected variables $X_{j}$ that in fact have no effect on $Y$ after the other features are known. When the number of features $p$ is large (perhaps even larger than the sample size $n$), and we have no prior…

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Estimation and Inference for Generalized Geoadditive Models

广义地理加性模型的估计与推断

In many application areas, data are collected on a count or binary response with spatial covariate information. In this article, we introduce a new class of generalized geoadditive models (GGAMs) for spatial data distributed over complex domains. Through a link function, the proposed GGAM assumes that the mean of the discrete response variable depends on additive univariate functions of explanatory variables and a bivariate function to adjust for the spatial effect. We…

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Detecting Structural Differences in Tail Dependence of Financial Time Series

金融时间序列尾部依赖结构差异的检测

An accurate assessment of tail inequalities and tail asymmetries of financial returns is key for risk management and portfolio allocation. We propose a new test procedure for detecting the full extent of such structural differences in the dependence of bivariate extreme returns. We decompose the testing problem into piecewise multiple comparisons of Cramér–von Mises distances of tail copulas. In this way, tail regions that cause differences in extreme dependence can be…

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Functional data analysis in the Banach space of continuous functions

连续函数 Banach 空间中的函数型数据分析

Functional data analysis is typically conducted within the $L^{2}$-Hilbert space framework. There is by now a fully developed statistical toolbox allowing for the principled application of the functional data machinery to real-world problems, often based on dimension reduction techniques such as functional principal component analysis. At the same time, there have recently been a number of publications that sidestep dimension reduction steps and focus on a fully functional $L^{2}$…

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Inference on distribution functions under measurement error

测量误差下的分布函数推断

This paper is concerned with inference on the cumulative distribution function (cdf) FX∗ in the classical measurement error model X=X∗+ϵ. We consider the case where the density of the measurement error ϵ is unknown and estimated by repeated measurements, and show validity of a bootstrap approximation for the distribution of the deviation in the sup-norm between the deconvolution cdf estimator and FX∗. We allow the density of ϵ to be ordinary or super smooth. We also provide…

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ROBUST INFERENCE IN STRUCTURAL VECTOR AUTOREGRESSIONS WITH LONG-RUN RESTRICTIONS

长期限制结构向量自回归中的稳健推断

Long-run restrictions are a very popular method for identifying structural vector autoregressions, but they suffer from weak identification when the data is very persistent, i.e., when the highest autoregressive roots are near unity. Near unit roots introduce additional nuisance parameters and make standard weak-instrument-robust methods of inference inapplicable. We develop a method of inference that is robust to both weak identification and strong persistence. The method…

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Quantile Function on Scalar Regression Analysis for Distributional Data

分布型数据的分位数函数对标量回归分析

Radiomics involves the study of tumor images to identify quantitative markers explaining cancer heterogeneity. The predominant approach is to extract hundreds to thousands of image features, including histogram features comprised of summaries of the marginal distribution of pixel intensities, which leads to multiple testing problems and can miss out on insights not contained in the selected features. In this paper, we present methods to model the entire marginal distribution…

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Generic Inference on Quantile and Quantile Effect Functions for Discrete Outcomes

离散结果的分位数函数与分位数效应函数的一般推断

Quantile and quantile effect functions are important tools for descriptive and causal analyses due to their natural and intuitive interpretation. Existing inference methods for these functions do not apply to discrete random variables. This paper offers a simple, practical construction of simultaneous confidence bands for quantile and quantile effect functions of possibly discrete random variables. It is based on a natural transformation of simultaneous confidence bands for…

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RANK: Large-Scale Inference With Graphical Nonlinear Knockoffs

RANK:基于图结构非线性 Knockoffs 的大规模推断

Power and reproducibility are key to enabling refined scientific discoveries in contemporary big data applications with general high-dimensional nonlinear models. In this paper, we provide theoretical foundations on the power and robustness for the model-X knockoffs procedure introduced recently in Candès, Fan, Janson and Lv (2018) in high-dimensional setting when the covariate distribution is characterized by Gaussian graphical model. We establish that under mild regularity…

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Autoregressive wild bootstrap inference for nonparametric trends

非参数趋势推断的自回归野生自助法

In this paper we propose an autoregressive wild bootstrap method to construct confidence bands around a smooth deterministic trend. The bootstrap method is easy to implement and does not require any adjustments in the presence of missing data, which makes it particularly suitable for climatological applications. We establish the asymptotic validity of the bootstrap method for both pointwise and simultaneous confidence bands under general conditions, allowing for general…

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Semiparametric estimation of structural functions in nonseparable triangular models

非可分三角模型中结构函数的半参数估计

Triangular systems with nonadditively separable unobserved heterogeneity provide a theoretically appealing framework for the modeling of complex structural relationships. However, they are not commonly used in practice due to the need for exogenous variables with large support for identification, the curse of dimensionality in estimation, and the lack of inferential tools. This paper introduces two classes of semiparametric nonseparable triangular models that address these…

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Inference on breakdown frontiers

失效边界的统计推断

Given a set of baseline assumptions, a breakdown frontier is the boundary between the set of assumptions which lead to a specific conclusion and those which do not. In a potential outcomes model with a binary treatment, we consider two conclusions: First, that ATE is at least a specific value (e.g., nonnegative) and second that the proportion of units who benefit from treatment is at least a specific value (e.g., at least 50%). For these conclusions, we derive the breakdown…

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Simultaneous control of all false discovery proportions in large-scale multiple hypothesis testing

大规模多重检验中所有假设子集的错误发现比例同时控制

Summary Closed testing procedures are classically used for familywise error rate control, but they can also be used to obtain simultaneous confidence bounds for the false discovery proportion in all subsets of the hypotheses, allowing for inference robust to post hoc selection of subsets. In this paper we investigate the special case of closed testing with Simes local tests. We construct a novel fast and exact shortcut and use it to investigate the power of this approach…

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Uniform confidence bands for nonparametric errors-in-variables regression

含解释变量测量误差的非参数回归一致置信带

This paper develops a method to construct uniform confidence bands for a nonparametric regression function where a predictor variable is subject to a measurement error. We allow for the distribution of the measurement error to be unknown, but assume the availability of validation data or repeated measurements on the latent predictor variable. The proposed confidence band builds on the deconvolution kernel estimation and a novel application of the multiplier bootstrap method.…

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FarmTest: Factor-Adjusted Robust Multiple Testing With Approximate False Discovery Control

FarmTest:具有近似错误发现控制的因子调整稳健多重检验

Large-scale multiple testing with correlated and heavy-tailed data arises in a wide range of research areas from genomics, medical imaging to finance. Conventional methods for estimating the false discovery proportion (FDP) often ignore the effect of heavy-tailedness and the dependence structure among test statistics, and thus may lead to inefficient or even inconsistent estimation. Also, the commonly imposed joint normality assumption is arguably too stringent for many…

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Uniform Inference on Quantile Effects under Sharp Regression Discontinuity Designs

尖锐断点回归设计下分位数效应的一致推断

This study develops methods for conducting uniform inference on quantile treatment effects for sharp regression discontinuity designs. We develop a score test for the treatment significance hypothesis and Wald-type tests for the hypotheses related to treatment significance, homogeneity, and unambiguity. The bias from the nonparametric estimation is studied in detail. In particular, we show that under some conditions, the asymptotic distribution of the score test is…

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A unified treatment of multiple testing with prior knowledge using the p-filter

利用 p-filter 统一处理含先验知识的多重检验

There is a significant literature on methods for incorporating knowledge into multiple testing procedures so as to improve their power and precision. Some common forms of prior knowledge include (a) beliefs about which hypotheses are null, modeled by nonuniform prior weights; (b) differing importances of hypotheses, modeled by differing penalties for false discoveries; (c) multiple arbitrary partitions of the hypotheses into (possibly overlapping) groups and (d) knowledge of…

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A knockoff filter for high-dimensional selective inference

用于高维选择后推断的knockoff过滤器

This paper develops a framework for testing for associations in a possibly high-dimensional linear model where the number of features/variables may far exceed the number of observational units. In this framework, the observations are split into two groups, where the first group is used to screen for a set of potentially relevant variables, whereas the second is used for inference over this reduced set of variables; we also develop strategies for leveraging information from…

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