Estimating the Null and the Proportion of Nonnull Effects in Large-Scale Multiple Comparisons
大规模多重比较中的零分布与非零效应比例估计
An important issue raised by Efron in the context of large-scale multiple comparisons is that in many applications, the usual assumption that the null distribution is known is incorrect, and seemingly negligible differences in the null may result in large differences in subsequent studies. This suggests that a careful study of estimation of the null is indispensable. In this article we consider the problem of estimating a null normal distribution, and a closely related…