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Semiparametric inference in mixture models with predictive recursion marginal likelihood

基于预测递归边际似然的混合模型半参数推断

Predictive recursion is an accurate and computationally efficient algorithm for nonparametric estimation of mixing densities in mixture models. In semiparametric mixture models, however, the algorithm fails to account for any uncertainty in the additional unknown structural parameter. As an alternative to existing profile likelihood methods, we treat predictive recursion as a filter approximation by fitting a fully Bayes model, whereby an approximate marginal likelihood of…

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Conditional Akaike information under generalized linear and proportional hazards mixed models

广义线性与比例风险混合模型中的条件 Akaike 信息

We study model selection for clustered data, when the focus is on cluster specific inference. Such data are often modelled using random effects, and conditional Akaike information was proposed in Vaida & Blanchard (2005) and used to derive an information criterion under linear mixed models. Here we extend the approach to generalized linear and proportional hazards mixed models. Outside the normal linear mixed models, exact calculations are not available and we resort to…

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Thick Pen Transformation for Time Series

时间序列的粗笔变换

Summary Traditional visualization of time series data often consists of plotting the time series values against time and ‘connecting the dots’. We propose an alternative, multiscale visualization technique, motivated by the scale–space approach in computer vision. In brief, our method also ‘connects the dots’ but uses a range of pens of varying thicknesses for this. The resulting multiscale map, which is termed the thick pen transform, corresponds to viewing the time series…

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Adaptive Inference for the Mean of a Gaussian Process in Functional Data

函数型数据中高斯过程均值的自适应推断

Summary We propose and analyse fully data-driven methods for inference about the mean function of a Gaussian process from a sample of independent trajectories of the process, observed at random time points and corrupted by additive random error. Our methods are based on thresholded least squares estimators relative to an approximating function basis. The variable threshold levels are determined from the data and the resulting estimates adapt to the unknown sparsity of the…

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Multiscale Adaptive Regression Models for Neuroimaging Data

神经影像数据的多尺度自适应回归模型

Summary Neuroimaging studies aim to analyse imaging data with complex spatial patterns in a large number of locations (called voxels) on a two-dimensional surface or in a three-dimensional volume. Conventional analyses of imaging data include two sequential steps: spatially smoothing imaging data and then independently fitting a statistical model at each voxel. However, conventional analyses suffer from the same amount of smoothing throughout the whole image, the arbitrary…

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A control function approach for testing the usefulness of trending variables in forecast models and linear regression

检验趋势变量预测价值的控制函数方法

Many predictors employed in forecasting macroeconomic and finance variables display a great deal of persistence. Tests for determining the usefulness of these predictors are typically oversized, overstating their importance. Similarly, hypothesis tests on cointegrating vectors will typically be oversized if there is not an exact unit root. This paper uses a control variable approach where adding stationary covariates with certain properties to the model can result in…

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Variable selection, estimation and inference for multi-period forecasting problems

多期预测中的变量选择、估计与推断

This paper conducts a broad-based comparison of iterated and direct multi-period forecasting approaches applied to both univariate and multivariate models in the form of parsimonious factor-augmented vector autoregressions. To account for serial correlation in the residuals of the multi-period direct forecasting models we propose a new SURE-based estimation method and modified Akaike information criteria for model selection. Empirical analysis of the 170 variables studied by…

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How useful are no-arbitrage restrictions for forecasting the term structure of interest rates?

无套利约束对利率期限结构预测有多大用处?

We develop a general framework for analyzing the usefulness of imposing parameter restrictions on a forecasting model. We propose a measure of the usefulness of the restrictions that depends on the forecaster's loss function and that could be time varying. We show how to conduct inference about this measure. The application of our methodology to analyzing the usefulness of no-arbitrage restrictions for forecasting the term structure of interest rates reveals that: (1)Â the…

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A semiparametric panel model for unbalanced data with application to climate change in the United Kingdom

用于非平衡数据的半参数面板模型:英国气候变化应用

This paper is concerned with developing a semiparametric panel model to explain the trend in UK temperatures and other weather outcomes over the last century. We work with the monthly averaged maximum and minimum temperatures observed at the twenty six Meteorological Office stations. The data is an unbalanced panel. We allow the trend to evolve in a nonparametric way so that we obtain a fuller picture of the evolution of common temperature in the medium timescale. Profile…

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Inspired by the non-regular framework studied in Laber and Murphy (2011), we propose a family of adaptive classifiers. We discuss briefly their asymptotic properties and show that under the non-regular framework these classifiers have an "oracle property," and consequently have smaller asymptotic variance and smaller asymptotic test error variance than those of the original classifier. We also show that confidence intervals for the test error of the adaptive classifiers,…

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A Measure of Stationarity in Locally Stationary Processes With Applications to Testing

局部平稳过程的平稳性度量及检验应用

In this article we investigate the problem of measuring deviations from stationarity in locally stationary time series. Our approach is based on a direct estimate of the L2-distance between the spectral density of the locally stationary process and its best approximation by a spectral density of a stationary process. An explicit expression of the minimal distance is derived, which depends only on integrals of the spectral density of the locally stationary process and its…

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Robust, Adaptive Functional Regression in Functional Mixed Model Framework

函数混合模型框架下的稳健自适应函数回归

Functional data are increasingly encountered in scientific studies, and their high dimensionality and complexity lead to many analytical challenges. Various methods for functional data analysis have been developed, including functional response regression methods that involve regression of a functional response on univariate/multivariate predictors with nonparametrically represented functional coefficients. In existing methods, however, the functional regression can be…

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Population Value Decomposition, a Framework for the Analysis of Image Populations

总体值分解:图像总体分析的框架

Images, often stored in multidimensional arrays, are fast becoming ubiquitous in medical and public health research. Analyzing populations of images is a statistical problem that raises a host of daunting challenges. The most significant challenge is the massive size of the datasets incorporating images recorded for hundreds or thousands of subjects at multiple visits. We introduce the population value decomposition (PVD), a general method for simultaneous dimensionality…

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Linear or Nonlinear? Automatic Structure Discovery for Partially Linear Models

线性还是非线性?部分线性模型的自动结构发现

Partially linear models provide a useful class of tools for modeling complex data by naturally incorporating a combination of linear and nonlinear effects within one framework. One key question in partially linear models is the choice of model structure, that is, how to decide which covariates are linear and which are nonlinear. This is a fundamental, yet largely unsolved problem for partially linear models. In practice, one often assumes that the model structure is given or…

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Predicting False Discovery Proportion Under Dependence

依赖条件下错误发现比例的预测

We present a flexible framework for predicting error measures in multiple testing situations under dependence. Our approach is based on modeling the distribution of the probit transform of the p-values by mixtures of multivariate skew-normal distributions. The model can incorporate dependence among p-values and it allows for shape restrictions on the p-value density. A nonparametric Bayesian scheme for estimating the components of the mixture model is outlined and Markov…

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Correcting for Population Stratification in Genomewide Association Studies

全基因组关联研究中的群体分层校正

Genomewide association studies have become the primary tool for discovering the genetic basis of complex human diseases. Such studies are susceptible to the confounding effects of population stratification, in that the combination of allele-frequency heterogeneity with disease-risk heterogeneity among different ancestral subpopulations can induce spurious associations between genetic variants and disease. This article provides a statistically rigorous and computationally…

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Optimal Weight Choice for Frequentist Model Average Estimators

频率学派模型平均估计量的最优权重选择

There has been increasing interest recently in model averaging within the frequentist paradigm. The main benefit of model averaging over model selection is that it incorporates rather than ignores the uncertainty inherent in the model selection process. One of the most important, yet challenging, aspects of model averaging is how to optimally combine estimates from different models. In this work, we suggest a procedure of weight choice for frequentist model average…

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Summarizing Insurance Scores Using a Gini Index

用基尼指数概括保险评分

Individuals, corporations and government entities regularly exchange financial risks y at prices Π. Comparing distributions of risks and prices can be difficult, particularly when the financial risk distribution is complex. For example, with insurance, it is not uncommon for a risk distribution to be a mixture of 0’s (corresponding to no claims) and a right-skewed distribution with thick tails (the claims distribution). However, analysts do not work in a vacuum, and in the…

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Large Volatility Matrix Inference via Combining Low-Frequency and High-Frequency Approaches

结合低频与高频方法的大维波动矩阵推断

It is increasingly important in financial economics to estimate volatilities of asset returns. However, most of the available methods are not directly applicable when the number of assets involved is large, due to the lack of accuracy in estimating high-dimensional matrices. Therefore it is pertinent to reduce the effective size of volatility matrices in order to produce adequate estimates and forecasts. Furthermore, since high-frequency financial data for different assets…

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Nonparametric Bayes Stochastically Ordered Latent Class Models

具有随机序约束的非参数贝叶斯潜在类别模型

Latent class models (LCMs) are used increasingly for addressing a broad variety of problems, including sparse modeling of multivariate and longitudinal data, model-based clustering, and flexible inferences on predictor effects. Typical frequentist LCMs require estimation of a single finite number of classes, which does not increase with the sample size, and have a well-known sensitivity to parametric assumptions on the distributions within a class. Bayesian nonparametric…

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Hierarchical Clustering With Prototypes via Minimax Linkage

通过极小极大连接实现带原型的层次聚类

Agglomerative hierarchical clustering is a popular class of methods for understanding the structure of a dataset. The nature of the clustering depends on the choice of linkage—that is, on how one measures the distance between clusters. In this article we investigate minimax linkage, a recently introduced but little-studied linkage. Minimax linkage is unique in naturally associating a prototype chosen from the original dataset with every interior node of the dendrogram. These…

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Analysis of Long Period Variable Stars With Nonparametric Tests for Trend Detection

用非参数趋势检验分析长周期变星

In astronomy the study of variable stars—that is, stars characterized by showing significant variation in their brightness over time—has made crucial contributions to our understanding of many phenomena, from stellar birth and evolution to the calibration of the extragalactic distance scale. In this article, we develop a method for analyzing multiple, (pseudo)-periodic time series with the goal of detecting temporal trends in their periods. We allow for nonstationary noise…

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Variational Bayesian Inference for Parametric and Nonparametric Regression With Missing Data

预测变量缺失下参数与非参数回归的变分贝叶斯推断

Bayesian hierarchical models are attractive structures for conducting regression analyses when the data are subject to missingness. However, the requisite probability calculus is challenging and Monte Carlo methods typically are employed. We develop an alternative approach based on deterministic variational Bayes approximations. Both parametric and nonparametric regression are considered. Attention is restricted to the more challenging case of missing predictor data. We…

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Posterior Probability of Discovery and Expected Rate of Discovery for Multiple Hypothesis Testing and High Throughput Assays

多重检验与高通量检测中的发现后验概率和预期发现率

Technologies of measuring millions of quantities at once have been rapidly developed and used in biological and biomedical research and other fields in the past decade. Yet a key issue remains unsettled, namely, how to control spurious findings for the ensuing massive number of hypothesis tests. An emerging consensus is to control false discovery rate (FDR), with FDR defined as the expected proportion of true nulls among discoveries, and a discovery the rejection of a null…

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