论文检索

利用存在报告延迟的实验室数据检测传染病暴发AI 解读

Many statistical surveillance systems for the timely detection of outbreaks of infectious disease operate on laboratory data. Such data typically incur reporting delays between the time at which a specimen is collected for diagnostic purposes, and the time at which the results of the laboratory analysis become available. Statistical surveillance systems currently in use usually make some ad hoc adjustment for such delays, or use counts by time of report. We propose a new…

重症脓毒症死亡率观察研究：可解释研究人群与随机化推断的离散优化AI 解读

Motivated by an observational study of the effect of hospital ward versus intensive care unit admission on severe sepsis mortality, we develop methods to address two common problems in observational studies: (1) when there is a lack of covariate overlap between the treated and control groups, how to define an interpretable study population wherein inference can be conducted without extrapolating with respect to important variables; and (2) how to use randomization inference…

聚类鼓励设计中因果机制的识别与估计：用贝叶斯主分层分解蚊帐干预效应AI 解读

Exploration of causal mechanisms is often important for researchers and policymakers to understand how an intervention works and how it can be improved. This task can be crucial in clustered encouragement designs (CED). Encouragement design studies arise frequently when the treatment cannot be enforced because of ethical or practical constrains and an encouragement intervention (information campaigns, incentives, etc) is conceived with the purpose of increasing the uptake of…

利用单调密度比模型寻找多项诊断测试的渐近最优组合AI 解读

With the advent of new technology, new biomarker studies have become essential in cancer research. To achieve optimal sensitivity and specificity, one needs to combine different diagnostic tests. The celebrated Neyman–Pearson lemma enables us to use the density ratio to optimally combine different diagnostic tests. In this article, we propose a semiparametric model by directly modeling the density ratio between the diseased and nondiseased population as an unspecified…

百万维以上数据的快速精确 Bootstrap 主成分分析AI 解读

Many have suggested a bootstrap procedure for estimating the sampling variability of principal component analysis (PCA) results. However, when the number of measurements per subject (p) is much larger than the number of subjects (n), calculating and storing the leading principal components (PCs) from each bootstrap sample can be computationally infeasible. To address this, we outline methods for fast, exact calculation of bootstrap PCs, eigenvalues, and scores. Our methods…

精细分层下的非参数方差估计：合并层方法的替代方案AI 解读

Fine stratification is commonly used to control the distribution of a sample from a finite population and to improve the precision of resulting estimators. One-per-stratum designs represent the finest possible stratification and occur in practice, but designs with very low numbers of elements per stratum (say, two or three) are also common. The classical variance estimator in this context is the collapsed stratum estimator, which relies on creating larger “pseudo-strata” and…

基于多变量符号的高维两样本位置检验AI 解读

This article concerns tests for the two-sample location problem when data dimension is larger than the sample size. Existing multivariate-sign-based procedures are not robust against high dimensionality, producing tests with Type I error rates far away from nominal levels. This is mainly due to the biases from estimating location parameters. We propose a novel test to overcome this issue by using the “leave-one-out” idea. The proposed test statistic is scalar-invariant and…

利用辅助亚组生存信息提高 Cox 模型估计效率AI 解读

With the rapidly increasing availability of data in the public domain, combining information from different sources to infer about associations or differences of interest has become an emerging challenge to researchers. This article presents a novel approach to improve efficiency in estimating the survival time distribution by synthesizing information from the individual-level data with t-year survival probabilities from external sources such as disease registries. While…

稳健正交补主成分分析AI 解读

Recently, the robustification of principal component analysis (PCA) has attracted lots of attention from statisticians, engineers, and computer scientists. In this work, we study the type of outliers that are not necessarily apparent in the original observation space but can seriously affect the principal subspace estimation. Based on a mathematical formulation of such transformed outliers, a novel robust orthogonal complement principal component analysis (ROC-PCA) is…

Spatial process models for analyzing geostatistical data entail computations that become prohibitive as the number of spatial locations become large. This article develops a class of highly scalable nearest-neighbor Gaussian process (NNGP) models to provide fully model-based inference for large geostatistical datasets. We establish that the NNGP is a well-defined spatial process providing legitimate finite-dimensional Gaussian densities with sparse precision matrices. We…

纵向数据半参数协方差分析模型的广义准似然比检验AI 解读

We model generalized longitudinal data from multiple treatment groups by a class of semiparametric analysis of covariance models, which take into account the parametric effects of time dependent covariates and the nonparametric time effects. In these models, the treatment effects are represented by nonparametric functions of time and we propose a generalized quasi-likelihood ratio test procedure to test if these functions are identical. Our estimation procedure is based on…

重复测量下含测量误差生存数据的加性风险函数校正方法AI 解读

Covariate measurement error has attracted extensive interest in survival analysis. Since Prentice, a large number of inference methods have been developed to handle error-prone data that are modulated with proportional hazards models. In contrast to proportional hazards models, additive hazards models offer a flexible tool to delineate survival processes. However, there is little research on measurement error effects under additive hazards models. In this article, we…

时间序列数据的一般回归变点检验AI 解读

This article develops a test for a single changepoint in a general setting that allows for correlated time series regression errors, a seasonal cycle, time-varying regression factors, and covariate information. Within, a changepoint statistic is constructed from likelihood ratio principles and its asymptotic distribution is derived. The asymptotic distribution of the changepoint statistic is shown to be invariant of the seasonal cycle and the covariates should the latter…

用于高维分类的贝叶斯条件张量分解AI 解读

In many application areas, data are collected on a categorical response and high-dimensional categorical predictors, with the goals being to build a parsimonious model for classification while doing inferences on the important predictors. In settings such as genomics, there can be complex interactions among the predictors. By using a carefully-structured Tucker factorization, we define a model that can characterize any conditional probability, while facilitating variable…

右删失寿命数据的经验似然AI 解读

When the empirical likelihood (EL) of a parameter θ is constructed with right censored data, literature shows that − 2log (empirical likelihood ratio) typically has an asymptotic scaled chi-squared distribution, where the scale parameter is a function of some unknown asymptotic variances. Therefore, the EL construction of confidence intervals for θ requires an additional estimation of the scale parameter. Additional estimation would reduce the coverage accuracy for θ. By…

通过辅助样本向研究样本倾斜法（AST）有效估计数据组合模型AI 解读

We propose a locally efficient estimator for a class of semiparametric data combination problems. A leading estimand in this class is the average treatment effect on the treated (ATT). Data combination problems are related to, but distinct from, the class of missing data problems with data missing at random (of which the average treatment effect (ATE) estimand is a special case). Our estimator also possesses a double robustness property. Our procedure may be used to…

分布 Granger 因果关系的非参数检验及其金融传染应用AI 解读

This article introduces a kernel-based nonparametric inferential procedure to test for Granger causality in distribution. This test is a multivariate extension of the kernel-based Granger causality test in tail event. The main advantage of this test is its ability to examine a large number of lags, with higher-order lags discounted. In addition, our test is highly flexible because it can be used to identify Granger causality in specific regions on the distribution supports,…

In fuzzy regression discontinuity (FRD) designs, the treatment effect is identified through a discontinuity in the conditional probability of treatment assignment. We show that when identification is weak (i.e., when the discontinuity is of a small magnitude), the usual t-test based on the FRD estimator and its standard error suffers from asymptotic size distortions as in a standard instrumental variables setting. This problem can be especially severe in the FRD setting…

This article proposes a class of weighted differences of averages (WDA) statistics to test and estimate possible change-points in variance for time series with weakly dependent blocks and dependent panel data without specific distributional assumptions. We derive the asymptotic distributions of the test statistics for testing the existence of a single variance change-point under the null and local alternatives. We also study the consistency of the change-point estimator.…

We develop a finite-sample procedure to test the mean-variance efficiency and spanning hypotheses, without imposing any parametric assumptions on the distribution of model disturbances. In so doing, we provide an exact distribution-free method to test uniform linear restrictions in multivariate linear regression models. The framework allows for unknown forms of nonnormalities as well as time-varying conditional variances and covariances among the model disturbances. We…

利用 Kac–Rice 公式进行自适应回归推断AI 解读

We derive an exact $p$-value for testing a global null hypothesis in a general adaptive regression setting. Our approach uses the Kac–Rice formula [as described in Random Fields and Geometry (2007) Springer, New York] applied to the problem of maximizing a Gaussian process. The resulting test statistic has a known distribution in finite samples, assuming Gaussian errors. We examine this test statistic in the case of the lasso, group lasso, principal components and matrix…

高维自协方差矩阵的大样本行为AI 解读

The existence of limiting spectral distribution (LSD) of $\hat{\Gamma}_{u}+\hat{\Gamma}_{u}^{*}$, the symmetric sum of the sample autocovariance matrix $\hat{\Gamma}_{u}$ of order $u$, is known when the observations are from an infinite dimensional vector linear process with appropriate (strong) assumptions on the coefficient matrices. Under significantly weaker conditions, we prove, in a unified way, that the LSD of any symmetric polynomial in these matrices such as $\hat{\Gamma}_{u}+\hat{\Gamma}_{u}^{*}$…

This paper discusses the simultaneous inference of mean parameters in a family of distributions with quadratic variance function. We first introduce a class of semi-parametric/parametric shrinkage estimators and establish their asymptotic optimality properties. Two specific cases, the location-scale family and the natural exponential family with quadratic variance function, are then studied in detail. We conduct a comprehensive simulation study to compare the performance of…

多元潜在结构模型的估计AI 解读

A constructive proof of identification of multilinear decompositions of multiway arrays is presented. It can be applied to show identification in a variety of multivariate latent structures. Examples are finite-mixture models and hidden Markov models. The key step to show identification is the joint diagonalization of a set of matrices in the same nonorthogonal basis. An estimator of the latent-structure model may then be based on a sample version of this…