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癌种特异性发病年龄外显率的贝叶斯半参数估计：Li-Fraumeni综合征应用AI 解读

Penetrance, which plays a key role in genetic research, is defined as the proportion of individuals with the genetic variants (i.e., genotype) that cause a particular trait and who have clinical symptoms of the trait (i.e., phenotype). We propose a Bayesian semiparametric approach to estimate the cancer-specific age-at-onset penetrance in the presence of the competing risk of multiple cancers. We employ a Bayesian semiparametric competing risk model to model the duration…

析因实验中的因果交互作用：联合分析应用AI 解读

We study causal interaction in factorial experiments, in which several factors, each with multiple levels, are randomized to form a large number of possible treatment combinations. Examples of such experiments include conjoint analysis, which is often used by social scientists to analyze multidimensional preferences in a population. To characterize the structure of causal interaction in factorial experiments, we propose a new causal interaction effect, called the average…

通过得分投影实现可解释的高维推断：神经影像应用AI 解读

In the fields of neuroimaging and genetics, a key goal is testing the association of a single outcome with a very high-dimensional imaging or genetic variable. Often, summary measures of the high-dimensional variable are created to sequentially test and localize the association with the outcome. In some cases, the associations between the outcome and summary measures are significant, but subsequent tests used to localize differences are underpowered and do not identify…

分布变化的序贯非参数检验：放射性异常检测应用AI 解读

We propose a sequential nonparametric test for detecting a change in distribution, based on windowed Kolmogorov–Smirnov statistics. The approach is simple, robust, highly computationally efficient, easy to calibrate, and requires no parametric assumptions about the underlying null and alternative distributions. We show that both the false-alarm rate and the power of our procedure are amenable to rigorous analysis, and that the method outperforms existing sequential testing…

基于增量倾向得分干预的非参数因果效应AI 解读

Most work in causal inference considers deterministic interventions that set each unit’s treatment to some fixed value. However, under positivity violations these interventions can lead to nonidentification, inefficiency, and effects with little practical relevance. Further, corresponding effects in longitudinal studies are highly sensitive to the curse of dimensionality, resulting in widespread use of unrealistic parametric models. We propose a novel solution to these…

变系数部分线性模型的Mallows型模型平均估计AI 解读

In the last decade, significant theoretical advances have been made in the area of frequentist model averaging (FMA); however, the majority of this work has emphasized parametric model setups. This article considers FMA for the semiparametric varying-coefficient partially linear model (VCPLM), which has gained prominence to become an extensively used modeling tool in recent years. Within this context, we develop a Mallows-type criterion for assigning model weights and prove…

高频跳跃检验的自助法AI 解读

The main contribution of this article is to propose a bootstrap test for jumps based on functions of realized volatility and bipower variation. Bootstrap intraday returns are randomly generated from a mean zero Gaussian distribution with a variance given by a local measure of integrated volatility (which we denote by {v^in}). We first discuss a set of high-level conditions on {v^in} such that any bootstrap test of this form has the correct asymptotic size and is…

通过高效数据子抽样加速 MCMCAI 解读

We propose subsampling Markov chain Monte Carlo (MCMC), an MCMC framework where the likelihood function for n observations is estimated from a random subset of m observations. We introduce a highly efficient unbiased estimator of the log-likelihood based on control variates, such that the computing cost is much smaller than that of the full log-likelihood in standard MCMC. The likelihood estimate is bias-corrected and used in two dependent pseudo-marginal algorithms to…

成对匹配观察性研究的敏感性值AI 解读

This article proposes a new quantity called the “sensitivity value,” which is defined as the minimum strength of unmeasured confounders needed to change the qualitative conclusions of a naive analysis assuming no unmeasured confounder. We establish the asymptotic normality of the sensitivity value in pair-matched observational studies. The theoretical results are then used to approximate the power of a sensitivity analysis and select the design of a study. We explore the…

高维时间序列的趋势检验AI 解读

The article considers statistical inference for trends of high-dimensional time series. Based on a modified L2 distance between parametric and nonparametric trend estimators, we propose a de-diagonalized quadratic form test statistic for testing patterns on trends, such as linear, quadratic, or parallel forms. We develop an asymptotic theory for the test statistic. A Gaussian multiplier testing procedure is proposed and it has an improved finite sample performance. Our…

含协变量的有向网络模型中的统计推断AI 解读

Ting Yana http://orcid.org/0000-0001-9830-6646, Binyan Jiangb, Stephen E. Fienbergc* & Chenlei Lengd*a Department of Statistics, Central China Normal University, Wuhan, Chinab Department of Applied Mathematics, Hong Kong Polytechnic University, Hong Kong, Chinac Department of Statistics, Heinz College, Machine Learning Department, Cylab, Carnegie Mellon University, Pittsburgh, PAd Department of Statistics, University of Warwick and Alan Turing Institute, Coventry, UKCONTACT…

无重复矩阵型数据的均值与协方差联合估计AI 解读

Michael Hornsteina*, Roger Fana, Kerby Sheddena & Shuheng Zhouaba Department of Statistics, University of Michigan, Ann Arbor, MIb Department of Statistics, University of California, Riverside, CACONTACT Michael Hornstein mdhorn@umich.edu Department of Statistics, University of Michigan, Ann Arbor, MI 48109.Color versions of one or more of the figures in the article can be found online at www.tandfonline.com/r/JASA.Supplementary materials for this article are available…

平滑变化均值趋势下的方差变点检测及肝脏获取应用AI 解读

Literature on change point analysis mostly requires a sudden change in the data distribution, either in a few parameters or the distribution as a whole. We are interested in the scenario, where the variance of data may make a significant jump while the mean changes in a smooth fashion. The motivation is a liver procurement experiment monitoring organ surface temperature. Blindly applying the existing methods to the example can yield erroneous change point estimates since the…

关于“不可观测选择与系数稳定性：理论与证据”及“测量不准的混杂因素放在左侧比右侧更有用”的评论AI 解读

We establish a link between the approaches proposed by Oster (2019) and Pei, Pischke, and Schwandt (2019) which contribute to the development of inferential procedures for causal effects in the challenging and empirically relevant situation where the unknown data-generation process is not included in the set of models considered by the investigator. We use the general misspecification framework recently proposed by De Luca, Magnus, and Peracchi (2018) to analyze and…

测量不准的混杂因素放在回归左侧更有用AI 解读

Researchers frequently test identifying assumptions in regression-based research designs (which include instrumental variables or difference-in-differences models) by adding additional control variables on the right-hand side of the regression. If such additions do not affect the coefficient of interest (much), a study is presumed to be reliable. We caution that such invariance may result from the fact that the observed variables used in such robustness checks are often poor…

多元跳跃扩散模型的拟合优度检验AI 解读

In this article, we develop a new goodness-of-fit test for multivariate jump diffusion models. The test statistic is constructed by a contrast between an “in-sample” likelihood (or a likelihood of observed data) and an“out-of-sample” likelihood (or a likelihood of predicted data). We show that under the null hypothesis of a jump diffusion process being correctly specified, the proposed test statistic converges in probability to a constant that equals to the number of model…

广义部分线性模型中用于假设检验的偏差分析AI 解读

In this study, we develop nonparametric analysis of deviance tools for generalized partially linear models based on local polynomial fitting. Assuming a canonical link, we propose expressions for both local and global analysis of deviance, which admit an additivity property that reduces to analysis of variance decompositions in the Gaussian case. Chi-square tests based on integrated likelihood functions are proposed to formally test whether the nonparametric term is…

跳跃事件中的秩检验AI 解读

We propose a test for the rank of a cross-section of processes at a set of jump events. The jump events are either specific known times or are random and associated with jumps of some process. The test is formed from discretely sampled data on a fixed time interval with asymptotically shrinking mesh. In the first step, we form nonparametric estimates of the jump events via thresholding techniques. We then compute the eigenvalues of the outer product of the cross-section of…

相对风险度量的统计推断AI 解读

For monitoring systemic risk from regulators’ point of view, this article proposes a relative risk measure, which is sensitive to the market comovement. The asymptotic normality of a nonparametric estimator and its smoothed version is established when the observations are independent. To effectively construct an interval without complicated asymptotic variance estimation, a jackknife empirical likelihood inference procedure based on the smoothed nonparametric estimation is…

协变量阈值引致变点的 U 过程 M 估计量AI 解读

Economic theory often predicts a “tipping point” effect due to multiple equilibria. Linear threshold regressions estimate the “tipping point” by assuming at the same time that the response variable is linear in an index of covariates. However, economic theory rarely imposes a specific functional form, but rather predicts a monotonic relationship between the response variable and the index. We propose new, rank-based, estimators for both the “tipping point” and other…

位似效率：理论与应用AI 解读

We provide a nonparametric revealed preference approach to demand analysis based on homothetic efficiency. Homotheticity is widely assumed (often implicitly) because it is a convenient and often useful restriction. However, this assumption is rarely tested, and data rarely satisfy testable conditions. To overcome this, we provide a way to estimate homothetic efficiency of consumption choices. The method provides considerably higher discriminatory power against random…

利用工具变量检验随机缺失AI 解读

This article proposes a test for missing at random (MAR). The MAR assumption is shown to be testable given instrumental variables which are independent of response given potential outcomes. A nonparametric testing procedure based on integrated squared distance is proposed. The statistic’s asymptotic distribution under the MAR hypothesis is derived. In particular, our results can be applied to testing missing completely at random (MCAR). A Monte Carlo study examines finite…

大规模两样本推断中的协变量辅助排序与筛选AI 解读

Summary Two-sample multiple testing has a wide range of applications. The conventional practice first reduces the original observations to a vector of p-values and then chooses a cut-off to adjust for multiplicity. However, this data reduction step could cause significant loss of information and thus lead to suboptimal testing procedures. We introduce a new framework for two-sample multiple testing by incorporating a carefully constructed auxiliary variable in inference to…

通过矩调整随机梯度对总体目标景观进行统计推断AI 解读

Summary Modern statistical inference tasks often require iterative optimization methods to compute the solution. Convergence analysis from an optimization viewpoint informs us only how well the solution is approximated numerically but overlooks the sampling nature of the data. In contrast, recognizing the randomness in the data, statisticians are keen to provide uncertainty quantification, or confidence, for the solution obtained by using iterative optimization methods. The…