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生存结局下最优动态治疗策略的估计AI 解读

Gabrielle Simoneaua* , Erica E. M. Moodiea , Jagtar S. Nijjarb, Robert W. Platta & the Scottish Early Rheumatoid Arthritis Inception Cohort Investigatorsa Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, QC, Canada; b Department of Medicine, University of Cambridge, Cambridge, UKColor versions of one or more of the figures in the article can be found online at www.tandfonline.com/r/JASA.Supplementary materials for this article…

配对观察性研究中样本平均处理效应的学生化敏感性分析AI 解读

A fundamental limitation of causal inference in observational studies is that perceived evidence for an effect might instead be explained by factors not accounted for in the primary analysis. Methods for assessing the sensitivity of a study’s conclusions to unmeasured confounding have been established under the assumption that the treatment effect is constant across all individuals. In the potential presence of unmeasured confounding, it has been argued that certain patterns…

多模态整合分析中的协方差同时推断AI 解读

Multimodal integrative analysis fuses different types of data collected on the same set of experimental subjects. It is becoming a norm in many branches of scientific research, such as multi-omics and multimodal neuroimaging analysis. In this article, we address the problem of simultaneous covariance inference of associations between multiple modalities, which is of a vital interest in multimodal integrative analysis. Recognizing that there are few readily available…

GAP：两样本稀疏推断的信息汇聚通用框架AI 解读

Yin Xiaa, T. Tony Caib & Wenguang Sunc*a Department of Statistics, School of Management, Fudan University, Shanghai, China; b Department of Statistics, The Wharton School, University of Pennsylvania, Philadelphia, PA; c Department of Data Sciences and Operations, University of Southern California, Los Angeles, CAColor versions of one or more of the figures in the article can be found online at www.tandfonline.com/r/JASA.Supplementary materials for this article are available…

大型有向无环图的似然比检验AI 解读

Inference of directional pairwise relations between interacting units in a directed acyclic graph (DAG), such as a regulatory gene network, is common in practice, imposing challenges because of lack of inferential tools. For example, inferring a specific gene pathway of a regulatory gene network is biologically important. Yet, frequentist inference of directionality of connections remains largely unexplored for regulatory models. In this article, we propose constrained…

长度偏倚抽样与信息性删失下 Copula 及依赖度量的非参数推断AI 解读

Length-biased data are often encountered in cross-sectional surveys and prevalent-cohort studies on disease durations. Under length-biased sampling subjects with longer disease durations have greater chance to be observed. As a result, covariate values linked to the longer survivors are favored by the sampling mechanism. When the sampled durations are also subject to right censoring, the censoring is informative. Modeling dependence structure without adjusting for these…

无需预检跳跃的跳跃溢出检验AI 解读

This article develops statistical tools for testing conditional independence among the jump components of the daily quadratic variation, which we estimate using intraday data. To avoid sequential bias distortion, we do not pretest for the presence of jumps. If the null is true, our test statistic based on daily integrated jumps weakly converges to a Gaussian random variable if both assets have jumps. If instead at least one asset has no jumps, then the statistic approaches…

基于稀疏随机投影的整体定性处理效应检验AI 解读

In contrast to the classical "one size fits all" approach, precision medicine proposes the customization of individualized treatment regimes to account for patients' heterogeneity in response to treatments. Most of existing works in the literature focused on estimating optimal individualized treatment regimes. However, there has been less attention devoted to hypothesis testing regarding the existence of overall qualitative treatment effects, especially when there is a large…

合并多个观察性数据源估计因果效应AI 解读

The era of big data has witnessed an increasing availability of multiple data sources for statistical analyses. We consider estimation of causal effects combining big main data with unmeasured confounders and smaller validation data with supplementary information on these confounders. Under the unconfoundedness assumption with completely observed confounders, the smaller validation data allow for constructing consistent estimators for causal effects, but the big main data…

用 D 概率比较和加权不完美模型AI 解读

), relying on evaluating parametric models relative to a nonparametric Bayesian reference using Kullback-Leibler divergence. D-probabilities are useful in goodness-of-fit assessments, in comparing imperfect models, and in providing model weights to be used in model aggregation. D-probabilities avoid some of the disadvantages of Bayesian model probabilities, such as large sensitivity to prior choice, and tend to place higher weight on a greater diversity of models. In an…

通过机制模型分析面板数据AI 解读

Panel data, also known as longitudinal data, consist of a collection of time series. Each time series, which could itself be multivariate, comprises a sequence of measurements taken on a distinct unit. Mechanistic modeling involves writing down scientifically motivated equations describing the collection of dynamic systems giving rise to the observations on each unit. A defining characteristic of panel systems is that the dynamic interaction between units should be…

动态向量众数回归AI 解读

We study the semiparametric estimation of the conditional mode of a random vector that has a continuous conditional joint density with a well-defined global mode. A novel full-system estimator is proposed and its asymptotic properties are studied. We specifically consider the estimation of vector autoregressive conditional mode models and of systems of linear simultaneous equations defined by mode restrictions. The proposed estimator is easy to implement and simulations…

一类新的 Rényi 型变点检验统计量AI 解读

A new class of change point test statistics is proposed that utilizes a weighting and trimming scheme for the cumulative sum (CUSUM) process inspired by Rényi. A thorough asymptotic analysis and simulations both demonstrate that this new class of statistics possess superior power compared to traditional change point statistics based on the CUSUM process when the change point is near the beginning or end of the sample. Generalizations of these “Rényi” statistics are also…

模糊回归不连续设计的外部有效性AI 解读

Fuzzy regression discontinuity designs identify the local average treatment effect (LATE) for the subpopulation of compliers, and with forcing variable equal to the threshold. We develop methods that assess the external validity of LATE to other compliance groups at the threshold, and allow for identification away from the threshold. Specifically, we focus on the equality of outcome distributions between treated compliers and always-takers, and between untreated compliers…

双重差分的潜力与陷阱：对《16岁怀孕》及其他应用的反思AI 解读

We use the exchange between Kearney/Levine and Jaeger/Joyce/Kaestner on 16 and Pregnant to reexamine the use of DiD as a response to the failure of nature to properly design an experiment for us. We argue that (1) any DiD paper should address why the original levels of the experimental and control groups differed, and why this would not impact trends, (2) the parallel trends argument requires a justification of the chosen functional form and that the use of the interaction…

高频数据的经验似然方法AI 解读

This paper introduces empirical likelihood methods for interval estimation and hypothesis testing on volatility measures in some high frequency data environments. We propose a modified empirical likelihood statistic that is asymptotically pivotal under infill asymptotics, where the number of high frequency observations in a fixed time interval increases to infinity. The proposed statistic is extended to be robust to the presence of jumps and microstructure noise. We also…

容纳不可观测异质性的平滑转换有限混合模型AI 解读

While the smooth transition (ST) model has become popular in business and economics, the treatment of unobserved heterogeneity within these models has received limited attention. We propose a ST finite mixture (STFM) model which simultaneously estimates the presence of time-varying effects and unobserved heterogeneity in a panel data context. Our objective is to accurately recover the heterogeneous effects of our independent variables of interest while simultaneously…

介于乌托邦与反乌托邦之间：多个不可比较前景的选择AI 解读

In many fields of decision making, choices have to be made from multiple alternatives, but stochastic dominance rules do not yield a complete ordering due to incomparability of some or all of the prospects. For ranking incomparable prospects, a “Utopia Index” measuring the proximity to a lower envelope of integrated distribution functions is proposed. Economic interpretations in terms of Expected Utility are provided for the envelope and deviations from it. The analysis…

高维假设检验的灵活框架AI 解读

Summary Hypothesis testing in the linear regression model is a fundamental statistical problem. We consider linear regression in the high dimensional regime where the number of parameters exceeds the number of samples (p > n). To make informative inference, we assume that the model is approximately sparse, i.e. the effect of covariates on the response can be well approximated by conditioning on a relatively small number of covariates whose identities are unknown. We develop…

高维广义线性模型的拟合优度检验AI 解读

Summary We propose a family of tests to assess the goodness of fit of a high dimensional generalized linear model. Our framework is flexible and may be used to construct an omnibus test or directed against testing specific non-linearities and interaction effects, or for testing the significance of groups of variables. The methodology is based on extracting left-over signal in the residuals from an initial fit of a generalized linear model. This can be achieved by predicting…

因果保序回归AI 解读

Summary In observational studies, potential confounders may distort the causal relationship between an exposure and an outcome. However, under some conditions, a causal dose–response curve can be recovered by using the G-computation formula. Most classical methods for estimating such curves when the exposure is continuous rely on restrictive parametric assumptions, which carry significant risk of model misspecification. Non-parametric estimation in this context is…

通过得分贡献符号翻转实现广义线性模型的稳健检验AI 解读

Summary Generalized linear models are often misspecified because of overdispersion, heteroscedasticity and ignored nuisance variables. Existing quasi-likelihood methods for testing in misspecified models often do not provide satisfactory type I error rate control. We provide a novel semiparametric test, based on sign flipping individual score contributions. The parameter tested is allowed to be multi-dimensional and even high dimensional. Our test is often robust against the…

通过自标准化检验函数型时间序列的实质性差异AI 解读

Summary We develop methodology for testing relevant hypotheses about functional time series in a tuning-free way. Instead of testing for exact equality, e.g. for the equality of two mean functions from two independent time series, we propose to test the null hypothesis of no relevant deviation. In the two-sample problem this means that an L2-distance between the two mean functions is smaller than a prespecified threshold. For such hypotheses self-normalization, which was…

两阶段抽样设计的统计推断AI 解读

Summary Two-stage sampling designs are commonly used for household and health surveys. To produce reliable estimators with associated confidence intervals, some basic statistical properties like consistency and asymptotic normality of the Horvitz–Thompson estimator are desirable, along with the consistency of associated variance estimators. These properties have been mainly studied for single-stage sampling designs. In this work, we prove the consistency of the…