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连续非线性交互作用稳健检验的交叉验证集成方法AI 解读

Gene-environment and nutrition-environment studies often involve testing of high-dimensional interactions between two sets of variables, each having potentially complex nonlinear main effects on an outcome. Construction of a valid and powerful hypothesis test for such an interaction is challenging, due to the difficulty in constructing an efficient and unbiased estimator for the complex, nonlinear main effects. In this work, we address this problem by proposing a…

匹配后的稳健统计推断AI 解读

Nearest-neighbor matching is a popular nonparametric tool to create balance between treatment and control groups in observational studies. As a preprocessing step before regression, matching reduces the dependence on parametric modeling assumptions. In current empirical practice, however, the matching step is often ignored in the calculation of standard errors and confidence intervals. In this article, we show that ignoring the matching step results in asymptotically valid…

大规模多重检验中的异方差调整排序与阈值方法AI 解读

Standardization has been a widely adopted practice in multiple testing, for it takes into account the variability in sampling and makes the test statistics comparable across different study units. However, despite conventional wisdom to the contrary, we show that there can be a significant loss in information from basing hypothesis tests on standardized statistics rather than the full data. We develop a new class of heteroscedasticity-adjusted ranking and thresholding (HART)…

具有发散尖峰的随机矩阵特征向量渐近理论AI 解读

Characterizing the asymptotic distributions of eigenvectors for large random matrices poses important challenges yet can provide useful insights into a range of statistical applications. To this end, in this paper we introduce a general framework of asymptotic theory of eigenvectors (ATE) for large spiked random matrices with diverging spikes and heterogeneous variances, and establish the asymptotic properties of the spiked eigenvectors and eigenvalues for the scenario of…

半参数 VARMA 模型的中心向外秩估计AI 解读

We propose a new class of R-estimators for semiparametric VARMA models in which the innovation density plays the role of the nuisance parameter. Our estimators are based on the novel concepts of multivariate center-outward ranks and signs. We show that these concepts, combined with Le Cam’s asymptotic theory of statistical experiments, yield a class of semiparametric estimation procedures, which are efficient (at a given reference density), root-n consistent, and…

从分散化投影学习潜在因子：因子数高估与弱因子的应用AI 解读

Estimations and applications of factor models often rely on the crucial condition that the number of latent factors is consistently estimated, which in turn also requires that factors be relatively strong, data are stationary and weakly serially dependent, and the sample size be fairly large, although in practical applications, one or several of these conditions may fail. In these cases, it is difficult to analyze the eigenvectors of the data matrix. To address this issue,…

全局假设的极小极大最优岭型集合检验及全基因组测序应用AI 解读

Testing a global hypothesis for a set of variables is a fundamental problem in statistics with a wide range of applications. A few well-known classical tests include the Hotelling’s T 2 test, the F-test, and the empirical Bayes based score test. These classical tests, however, are not robust to the signal strength and could have a substantial loss of power when signals are weak or moderate, a situation we commonly encounter in contemporary applications. In this article, we…

含大量协变量的线性回归异方差稳健推断AI 解读

We consider inference in linear regression models that is robust to heteroscedasticity and the presence of many control variables. When the number of control variables increases at the same rate as the sample size the usual heteroscedasticity-robust estimators of the covariance matrix are inconsistent. Hence, tests based on these estimators are size distorted even in large samples. An alternative covariance-matrix estimator for such a setting is presented that complements…

通过调整特征值阈值估计因子数量AI 解读

Determining the number of common factors is an important and practical topic in high dimensional factor models. The existing literatures are mainly based on the eigenvalues of the covariance matrix. Due to the incomparability of the eigenvalues of the covariance matrix caused by heterogeneous scales of observed variables, it is very difficult to give an accurate relationship between these eigenvalues and the number of common factors. To overcome this limitation, we appeal to…

协变量自适应随机实验中的未观测协变量平衡AI 解读

Balancing important covariates is often critical in clinical trials and causal inference. Stratified permuted block (STR-PB) and covariate-adaptive randomization (CAR) procedures are widely used to balance observed covariates in practice. The balance properties of these procedures with respect to the observed covariates have been well studied. However, it has been questioned whether these methods will also yield a good balance for the unobserved covariates. In this article,…

利用二次扫描统计量同时检测信号区域及全基因组关联应用AI 解读

We consider in this paper detection of signal regions associated with disease outcomes in whole genome association studies. Gene- or region-based methods have become increasingly popular in whole genome association analysis as a complementary approach to traditional individual variant analysis. However, these methods test for the association between an outcome and the genetic variants in a pre-specified region, e.g., a gene. In view of massive intergenic regions in whole…

基于模式导向抽样的大规模数据流监测AI 解读

Monitoring large-scale datastreams with limited resources has become increasingly important for real-time detection of abnormal activities in many applications. Despite the availability of large datasets, the challenges associated with designing an efficient change-detection when clustering or spatial pattern exists are not yet well addressed. In this article, a design-adaptive testing procedure is developed when only a limited number of streaming observations can be…

刻画效应修饰的半参数方法AI 解读

One fundamental statistical question for research areas such as precision medicine and health disparity is about discovering effect modification of treatment or exposure by observed covariates. We propose a semiparametric framework for identifying such effect modification. Instead of using the traditional outcome models, we directly posit semiparametric models on contrasts, or expected differences of the outcome under different treatment choices or exposures. Through…

在大量测量不完整的大型系统发育树上推断表型性状演化AI 解读

Comparative biologists are often interested in inferring covariation between multiple biological traits sampled across numerous related taxa. To properly study these relationships, we must control for the shared evolutionary history of the taxa to avoid spurious inference. An additional challenge arises as obtaining a full suite of measurements becomes increasingly difficult with increasing taxa. This generally necessitates data imputation or integration, and existing…

面向多响应数据的低秩高维多元线性模型估计AI 解读

In this article, we study low rank high-dimensional multivariate linear models (LRMLM) for high-dimensional multi-response data. We propose an intuitively appealing estimation approach and develop an algorithm for implementation purposes. Asymptotic properties are established to justify the estimation procedure theoretically. Intensive simulation studies are also conducted to demonstrate performance when the sample size is finite, and a comparison is made with some popular…

基于高斯混合模型的多变量缺失数据半参数分数插补AI 解读

Item nonresponse is frequently encountered in practice. Ignoring missing data can lose efficiency and lead to misleading inference. Fractional imputation is a frequentist approach of imputation for handling missing data. However, the parametric fractional imputation may be subject to bias under model misspecification. In this article, we propose a novel semiparametric fractional imputation (SFI) method using Gaussian mixture models. The proposed method is computationally…

基于最优匹配的分布无关多样本检验及单细胞基因组学应用AI 解读

In this article, we propose a nonparametric graphical test based on optimal matching, for assessing the equality of multiple unknown multivariate probability distributions. Our procedure pools the data from the different classes to create a graph based on the minimum non-bipartite matching, and then utilizes the number of edges connecting data points from different classes to examine the closeness between the distributions. The proposed test is exactly distribution-free (the…

Hellinger 相关系数AI 解读

In this article, the defining properties of any valid measure of the dependence between two continuous random variables are revisited and complemented with two original ones, shown to imply other usual postulates. While other popular choices are proved to violate some of these requirements, a class of dependence measures satisfying all of them is identified. One particular measure, that we call the Hellinger correlation, appears as a natural choice within that class due to…

局部高斯偏相关AI 解读

It is well known in econometrics and other fields that the dependence structure for jointly Gaussian variables can be fully captured using correlations, and that the conditional dependence structure in the same way can be described using partial correlations. The partial correlation does not, however, characterize conditional dependence in many non-Gaussian populations. This article introduces the local Gaussian partial correlation (LGPC), a new measure of conditional…

可能存在水平突变时的积分阶数半参数检验AI 解读

Lobato and Robinson developed semiparametric tests for the null hypothesis that a series is weakly autocorrelated, or I(0), about a constant level, against fractionally integrated alternatives. These tests have the advantage that the user is not required to specify a parametric model for any weak autocorrelation present in the series. We extend this approach in two distinct ways. First, we show that it can be generalized to allow for testing of the null hypothesis that a…

依赖关系对欧洲市场风险的影响：非参数时变方法AI 解读

Multivariate dependence measures are crucial for risk management, where variables usually have heavy tails and non-Gaussian distributions. We propose a multivariate time varying Kendall’s tau estimator in a nonparametric context, allowing for local stationary variables. Consistency and asymptotic normality of the estimator are provided. A simulation study is conducted which supports the idea of better performance than other related methods in many complex scenarios. The…

基于广义帕累托分布的风险分析AI 解读

We compute the value-at-risk of financial losses by fitting a generalized Pareto distribution to exceedances over a threshold. Following the common practice of setting the threshold as high sample quantiles, we show that, for both independent observations and time-series data, the asymptotic variance for the maximum likelihood estimation depends on the choice of threshold, unlike the existing study of using a divergent threshold. We also propose a random weighted bootstrap…

Rao 检验的稳健推广AI 解读

This article presents new families of Rao-type test statistics based on the minimum density power divergence estimators which provide robust generalizations for testing simple and composite null hypotheses. The asymptotic null distributions of the proposed tests are obtained and their robustness properties are also theoretically studied. Numerical illustrations are provided to substantiate the theory developed. On the whole, the proposed tests are seen to be excellent…

通胀与利率的局部平稳分位数回归AI 解读

Motivated by the potential time-varying and quantile-specific relation between inflation and interest rates, we propose a locally stationary quantile regression approach to model the inflation and interest rates relation. Large sample theory for estimation and inference of quantile-varying and time-varying coefficients are established. In empirical analysis of inflation and interest rates relation, it is found that the estimated functional coefficients vary with time in a…