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Hypothesis testing for high-dimensional sparse binary regression

高维稀疏二元回归的假设检验

In this paper, we study the detection boundary for minimax hypothesis testing in the context of high-dimensional, sparse binary regression models. Motivated by genetic sequencing association studies for rare variant effects, we investigate the complexity of the hypothesis testing problem when the design matrix is sparse. We observe a new phenomenon in the behavior of detection boundary which does not occur in the case of Gaussian linear regression. We derive the detection…

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Sparsistency and agnostic inference in sparse PCA

稀疏主成分分析中的变量选择一致性与无真值假设推断

The presence of a sparse “truth” has been a constant assumption in the theoretical analysis of sparse PCA and is often implicit in its methodological development. This naturally raises questions about the properties of sparse PCA methods and how they depend on the assumption of sparsity. Under what conditions can the relevant variables be selected consistently if the truth is assumed to be sparse? What can be said about the results of sparse PCA without assuming a sparse and…

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Universality for the largest eigenvalue of sample covariance matrices with general population

This paper is aimed at deriving the universality of the largest eigenvalue of a class of high-dimensional real or complex sample covariance matrices of the form $\mathcal{W}_{N}=\Sigma^{1/2}XX^{*}\Sigma^{1/2}$. Here, $X=(x_{ij})_{M,N}$ is an $M\times N$ random matrix with independent entries $x_{ij}$, $1\leq i\leq M$, $1\leq j\leq N$ such that $\mathbb{E}x_{ij}=0$, $\mathbb{E}|x_{ij}|^{2}=1/N$. On dimensionality, we assume that $M=M(N)$ and $N/M\rightarrow d\in(0,\infty)$ as…

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ROP: Matrix recovery via rank-one projections

ROP:通过秩一投影恢复矩阵

Estimation of low-rank matrices is of significant interest in a range of contemporary applications. In this paper, we introduce a rank-one projection model for low-rank matrix recovery and propose a constrained nuclear norm minimization method for stable recovery of low-rank matrices in the noisy case. The procedure is adaptive to the rank and robust against small perturbations. Both upper and lower bounds for the estimation accuracy under the Frobenius norm loss are…

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Homogeneity Pursuit

This paper explores the homogeneity of coefficients in high-dimensional regression, which extends the sparsity concept and is more general and suitable for many applications. Homogeneity arises when regression coefficients corresponding to neighboring geographical regions or a similar cluster of covariates are expected to be approximately the same. Sparsity corresponds to a special case of homogeneity with a large cluster of known atom zero. In this article, we propose a new…

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SPReM: Sparse Projection Regression Model For High-Dimensional Linear Regression

SPReM:高维线性回归的稀疏投影回归模型

The aim of this article is to develop a sparse projection regression modeling (SPReM) framework to perform multivariate regression modeling with a large number of responses and a multivariate covariate of interest. We propose two novel heritability ratios to simultaneously perform dimension reduction, response selection, estimation, and testing, while explicitly accounting for correlations among multivariate responses. Our SPReM is devised to specifically address the low…

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Decoupling Shrinkage and Selection in Bayesian Linear Models: A Posterior Summary Perspective

贝叶斯线性模型中收缩与选择的解耦:后验摘要视角

Selecting a subset of variables for linear models remains an active area of research. This article reviews many of the recent contributions to the Bayesian model selection and shrinkage prior literature. A posterior variable selection summary is proposed, which distills a full posterior distribution over regression coefficients into a sequence of sparse linear predictors.

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A Dynamic Directional Model for Effective Brain Connectivity Using Electrocorticographic (ECoG) Time Series

利用皮层脑电时间序列研究有效脑连接的动态方向模型

We introduce a dynamic directional model (DDM) for studying brain effective connectivity based on intracranial electrocorticographic (ECoG) time series. The DDM consists of two parts: a set of differential equations describing neuronal activity of brain components (state equations), and observation equations linking the underlying neuronal states to observed data. When applied to functional MRI or EEG data, DDMs usually have complex formulations and thus can accommodate only…

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Robust Principal Component Analysis for Power Transformed Compositional Data

幂变换成分数据的稳健主成分分析

Geochemical surveys collect sediment or rock samples, measure the concentration of chemical elements, and report these typically either in weight percent or in parts per million (ppm). There are usually a large number of elements measured and the distributions are often skewed, containing many potential outliers. We present a new robust principal component analysis (PCA) method for geochemical survey data, that involves first transforming the compositional data onto a…

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Estimating a Structured Covariance Matrix From Multilab Measurements in High-Throughput Biology

利用多实验室高通量生物测量估计结构化协方差矩阵

We consider the problem of quantifying the degree of coordination between transcription and translation, in yeast. Several studies have reported a surprising lack of coordination over the years, in organisms as different as yeast and human, using diverse technologies. However, a close look at this literature suggests that the lack of reported correlation may not reflect the biology of regulation. These reports do not control for between-study biases and structure in the…

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Tuning Parameter Selection for the Adaptive Lasso Using ERIC

使用 ERIC 选择自适应 Lasso 的调节参数

The adaptive Lasso is a commonly applied penalty for variable selection in regression modeling. Like all penalties though, its performance depends critically on the choice of the tuning parameter. One method for choosing the tuning parameter is via information criteria, such as those based on AIC and BIC. However, these criteria were developed for use with unpenalized maximum likelihood estimators, and it is not clear that they take into account the effects of penalization.…

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Risk Classification With an Adaptive Naive Bayes Kernel Machine Model

基于自适应朴素贝叶斯核机器模型的疾病风险分类

Genetic studies of complex traits have uncovered only a small number of risk markers explaining a small fraction of heritability and adding little improvement to disease risk prediction. Standard single marker methods may lack power in selecting informative markers or estimating effects. Most existing methods also typically do not account for non-linearity. Identifying markers with weak signals and estimating their joint effects among many non-informative markers remains…

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Regularization Methods for High-Dimensional Instrumental Variables Regression With an Application to Genetical Genomics

高维工具变量回归的正则化方法及遗传基因组学应用

In genetical genomics studies, it is important to jointly analyze gene expression data and genetic variants in exploring their associations with complex traits, where the dimensionality of gene expressions and genetic variants can both be much larger than the sample size. Motivated by such modern applications, we consider the problem of variable selection and estimation in high-dimensional sparse instrumental variables models. To overcome the difficulty of high…

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Forecasting the Distribution of Economic Variables in a Data-Rich Environment

丰富数据环境下经济变量的分布预测

This article investigates the relevance of considering a large number of macroeconomic indicators to forecast the complete distribution of a variable. The baseline time series model is a semiparametric specification based on the quantile autoregressive (QAR) model that assumes that the quantiles depend on the lagged values of the variable. We then augment the time series model with macroeconomic information from a large dataset by including principal components or a subset…

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Numerically Accelerated Importance Sampling for Nonlinear Non-Gaussian State-Space Models

非线性非高斯状态空间模型的数值加速重要性抽样

We propose a general likelihood evaluation method for nonlinear non-Gaussian state-space models using the simulation-based method of efficient importance sampling. We minimize the simulation effort by replacing some key steps of the likelihood estimation procedure by numerical integration. We refer to this method as numerically accelerated importance sampling. We show that the likelihood function for models with a high-dimensional state vector and a low-dimensional signal…

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Estimation of Hüsler–Reiss Distributions and Brown–Resnick Processes

Hüsler–Reiss分布与Brown–Resnick过程的估计

Summary Estimation of extreme value parameters from observations in the max-domain of attraction of a multivariate max-stable distribution commonly uses aggregated data such as block maxima. Multivariate peaks-over-threshold methods, in contrast, exploit additional information from the non-aggregated ‘large’ observations. We introduce an approach based on peaks over thresholds that provides several new estimators for processes η in the max-domain of attraction of the…

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Marginally Specified Priors for Non-Parametric Bayesian Estimation

非参数贝叶斯估计中的边际指定先验

Summary Prior specification for non-parametric Bayesian inference involves the difficult task of quantifying prior knowledge about a parameter of high, often infinite, dimension. A statistician is unlikely to have informed opinions about all aspects of such a parameter but will have real information about functionals of the parameter, such as the population mean or variance. The paper proposes a new framework for non-parametric Bayes inference in which the prior distribution…

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Power Enhancement in High-Dimensional Cross-Sectional Tests

高维横截面检验的功效增强

= 0 against sparse alternatives where the null hypothesis is violated only by a couple of components. Existing tests based on quadratic forms such as the Wald statistic often suffer from low powers due to the accumulation of errors in estimating high-dimensional parameters. More powerful tests for sparse alternatives such as thresholding and extreme-value tests, on the other hand, require either stringent conditions or bootstrap to derive the null distribution and often…

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Censored rank independence screening for high-dimensional survival data

高维生存数据的删失秩独立筛选

In modern statistical applications, the dimension of covariates can be much larger than the sample size. In the context of linear models, correlation screening (Fan and Lv, 2008) has been shown to reduce the dimension of such data effectively while achieving the sure screening property, i.e., all of the active variables can be retained with high probability. However, screening based on the Pearson correlation does not perform well when applied to contaminated covariates…

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Estimation of a semiparametric natural direct effect model incorporating baseline covariates

纳入基线协变量的半参数自然直接效应模型估计

Establishing cause-effect relationships is a standard goal of empirical science. Once the presence of a causal relationship is established, the precise causal mechanism involved becomes a topic of interest. A particularly popular type of mechanism analysis concerns questions of mediation, that is to what extent an effect is direct, and to what extent it is mediated by a third variable. A semiparametric theory has recently been proposed which allows multiply robust estimation…

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Robust Bayesian variable selection in linear models with spherically symmetric errors

球对称误差线性模型中的稳健贝叶斯变量选择

This paper studies Bayesian variable selection in linear models with general spherically symmetric error distributions. We construct the posterior odds based on a separable prior, which arises as a class of mixtures of Gaussian densities. The posterior odds for comparing among nonnull models are shown to be independent of the error distribution, if this is spherically symmetric. Because of this invariance, we refer to our method as a robust Bayesian variable selection…

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When does more regularization imply fewer degrees of freedom? Sufficient conditions and counterexamples

更强正则化何时意味着更少自由度?充分条件与反例

Regularization aims to improve prediction performance by trading an increase in training error for better agreement between training and prediction errors, which is often captured through decreased degrees of freedom. In this paper we give examples which show that regularization can increase the degrees of freedom in common models, including the lasso and ridge regression. In such situations, both training error and degrees of freedom increase, making the regularization…

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Variable selection in regression with compositional covariates

组成型协变量回归中的变量选择

Motivated by research problems arising in the analysis of gut microbiome and metagenomic data, we consider variable selection and estimation in high-dimensional regression with compositional covariates. We propose an ℓ1 regularization method for the linear log-contrast model that respects the unique features of compositional data. We formulate the proposed procedure as a constrained convex optimization problem and introduce a coordinate descent method of multipliers for…

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Testing independence and goodness-of-fit in linear models

线性模型中的独立性与拟合优度检验

We consider a linear regression model and propose an omnibus test to simultaneously check the assumption of independence between the error and predictor variables and the goodness-of-fit of the parametric model. Our approach is based on testing for independence between the predictor and the residual obtained from the parametric fit by using the Hilbert–Schmidt independence criterion (Gretton et al., 2008). The proposed method requires no user-defined regularization, is…

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