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高维经验似然推断AI 解读

Summary High-dimensional statistical inference with general estimating equations is challenging and remains little explored. We study two problems in the area: confidence set estimation for multiple components of the model parameters, and model specifications tests. First, we propose to construct a new set of estimating equations such that the impact from estimating the high-dimensional nuisance parameters becomes asymptotically negligible. The new construction enables us to…

寻找失落的混合时间：超高维贝叶斯变量选择的自适应 MCMCAI 解读

Summary The availability of datasets with large numbers of variables is rapidly increasing. The effective application of Bayesian variable selection methods for regression with these datasets has proved difficult since available Markov chain Monte Carlo methods do not perform well in typical problem sizes of interest. We propose new adaptive Markov chain Monte Carlo algorithms to address this shortcoming. The adaptive design of these algorithms exploits the observation that…

用半参数非线性动力系统建模时变生物标志物AI 解读

Summary Dynamical systems based on differential equations are useful for modelling the temporal evolution of biomarkers. Such systems can characterize the temporal patterns of biomarkers and inform the detection of interactions between biomarkers. Existing statistical methods for dynamical systems deal mostly with single time-course data based on a linear model or generalized additive model. Hence, they cannot adequately capture the complex interactions between biomarkers;…

具有混合偏差性质的参数刻画AI 解读

Summary We study a class of parameters with the so-called mixed bias property. For parameters with this property, the bias of the semiparametric efficient one-step estimator is equal to the mean of the product of the estimation errors of two nuisance functions. In nonparametric models, parameters with the mixed bias property admit so-called rate doubly robust estimators, i.e., estimators that are consistent and asymptotically normal when one succeeds in estimating both…

大样本平滑样条 ANOVA 模型的渐近与经验平滑参数选择AI 解读

Summary Large samples are generated routinely from various sources. Classic statistical models, such as smoothing spline ANOVA models, are not well equipped to analyse such large samples because of high computational costs. In particular, the daunting computational cost of selecting smoothing parameters renders smoothing spline ANOVA models impractical. In this article, we develop an asympirical, i.e., asymptotic and empirical, smoothing parameters selection method for…

二项响应广义线性模型中的 Jeffreys 先验惩罚、有限性与收缩AI 解读

Summary Penalization of the likelihood by Jeffreys’ invariant prior, or a positive power thereof, is shown to produce finite-valued maximum penalized likelihood estimates in a broad class of binomial generalized linear models. The class of models includes logistic regression, where the Jeffreys-prior penalty is known additionally to reduce the asymptotic bias of the maximum likelihood estimator, and models with other commonly used link functions, such as probit and log-log.…

稀疏单方程协整建模的自动化方法AI 解读

In this paper we propose the Single-equation Penalized Error Correction Selector (SPECS) as an automated estimation procedure for dynamic single-equation models with a large number of potentially (co)integrated variables. By extending the classical single-equation error correction model, SPECS enables the researcher to model large cointegrated datasets without necessitating any form of pre-testing for the order of integration or cointegrating rank. Under an asymptotic regime…

最优线性工具变量近似AI 解读

This paper studies the identification and estimation of the optimal linear approximation of a structural regression function. The parameter in the linear approximation is called the Optimal Linear Instrumental Variables Approximation (OLIVA). This paper shows that a necessary condition for standard inference on the OLIVA is also sufficient for the existence of an IV estimand in a linear model. The instrument in the IV estimand is unknown and may not be identified. A Two-Step…

具有潜在分组结构与截面依赖的非平稳面板模型AI 解读

This paper proposes a novel Lasso-based approach to handle unobserved parameter heterogeneity and cross-section dependence in nonstationary panel models. In particular, a penalized principal component (PPC) method is developed to estimate group-specific long-run relationships and unobserved common factors and jointly to identify the unknown group membership. The PPC estimators are shown to be consistent under weakly dependent innovation processes. But they suffer an…

时变参数随机波动率入均值模型中的动态收缩AI 解读

Summary Successful forecasting models strike a balance between parsimony and flexibility. This is often achieved by employing suitable shrinkage priors that penalize model complexity but also reward model fit. In this article, we modify the stochastic volatility in mean (SVM) model by introducing state‐of‐the‐art shrinkage techniques that allow for time variation in the degree of shrinkage. Using a real‐time inflation forecast exercise, we show that employing more flexible…

核矩阵的集中性及其在核谱聚类中的应用AI 解读

We study the concentration of random kernel matrices around their mean. We derive nonasymptotic exponential concentration inequalities for Lipschitz kernels assuming that the data points are independent draws from a class of multivariate distributions on $\mathbb{R}^{d}$, including the strongly log-concave distributions under affine transformations. A feature of our result is that the data points need not have identical distributions or zero mean, which is key in certain…

以分类准确率作为两样本检验的替代依据AI 解读

When data analysts train a classifier and check if its accuracy is significantly different from chance, they are implicitly performing a two-sample test. We investigate the statistical properties of this flexible approach in the high-dimensional setting. We prove two results that hold for all classifiers in any dimensions: if its true error remains $\epsilon $-better than chance for some $\epsilon >0$ as $d,n\to \infty $, then (a) the permutation-based test is consistent…

高维检验中渐近独立的U统计量AI 解读

Many high-dimensional hypothesis tests aim to globally examine marginal or low-dimensional features of a high-dimensional joint distribution, such as testing of mean vectors, covariance matrices and regression coefficients. This paper constructs a family of U-statistics as unbiased estimators of the $\ell_{p}$-norms of those features. We show that under the null hypothesis, the U-statistics of different finite orders are asymptotically independent and normally distributed.…

最优治疗决策的一致性与价值信息准则AI 解读

Personalized medicine is a medical procedure that receives considerable scientific and commercial attention. The goal of personalized medicine is to assign the optimal treatment regime for each individual patient, according to his/her personal prognostic information. When there are a large number of pretreatment variables, it is crucial to identify those important variables that are necessary for treatment decision making. In this paper, we study two information criteria:…

利用近似消息传递估计低秩矩阵AI 解读

Consider the problem of estimating a low-rank matrix when its entries are perturbed by Gaussian noise, a setting that is also known as “spiked model” or “deformed random matrix.” If the empirical distribution of the entries of the spikes is known, optimal estimators that exploit this knowledge can substantially outperform simple spectral approaches. Recent work characterizes the asymptotic accuracy of Bayes-optimal estimators in the high-dimensional limit. In this paper, we…

高维局部平稳过程的协方差与谱密度估计收敛性AI 解读

Covariances and spectral density functions play a fundamental role in the theory of time series. There is a well-developed asymptotic theory for their estimates for low-dimensional stationary processes. For high-dimensional nonstationary processes, however, many important problems on their asymptotic behaviors are still unanswered. This paper presents a systematic asymptotic theory for the estimates of time-varying second-order statistics for a general class of…

具有多重结构变化的高维因子模型估计与检验AI 解读

This paper considers multiple changes in the factor loadings of a high dimensional factor model occurring at dates that are unknown but common to all subjects. Since the factors are unobservable, the problem is converted to estimating and testing structural changes in the second moments of the pseudo factors. We consider both joint and sequential estimation of the change points and show that the distance between the estimated and the true change points is Op(1). We find that…

面板数据模型中的异质结构突变AI 解读

This paper develops a new model and estimation procedure for panel data that allows us to identify heterogeneous structural breaks. We model individual heterogeneity using a grouped pattern. For each group, we allow common structural breaks in the coefficients. However, the number, timing, and size of these breaks can differ across groups. We develop a hybrid estimation procedure of the grouped fixed effects approach and adaptive group fused Lasso. We show that our method…

利用高维协变量特异性治疗效应曲线估计最优个体化治疗规则AI 解读

With a large number of baseline covariates, we propose a new semiparametric modeling strategy for heterogeneous treatment effect estimation and individualized treatment selection, which are two major goals in personalized medicine. We achieve the first goal through estimating a covariate-specific treatment effect (CSTE) curve modeled as an unknown function of a weighted linear combination of all baseline covariates. The weight or the coefficient for each covariate is…

无限维、零直接样本情形的多分辨率近似理论：过渡推断与个体化预测AI 解读

Transitional inference is an empiricism concept, rooted and practiced in clinical medicine since ancient Greece. Knowledge and experiences gained from treating one entity (e.g., a disease or a group of patients) are applied to treat a related but distinctively different one (e.g., a similar disease or a new patient). This notion of “transition to the similar” renders individualized treatments an operational meaning, yet its theoretical foundation defies the familiar…

融合 GWAS 汇总统计与外部信息的多基因风险惩罚回归AI 解读

Large-scale genome-wide association studies (GWAS) provide opportunities for developing genetic risk prediction models that have the potential to improve disease prevention, intervention or treatment. The key step is to develop polygenic risk score (PRS) models with high predictive performance for a given disease, which typically requires a large training dataset for selecting truly associated single nucleotide polymorphisms (SNPs) and estimating effect sizes accurately.…

从半连续结局估计个体化处理规则的两部分框架AI 解读

Jared D. Hulinga , Maureen A. Smithb & Guanhua Chenc* a Division of Biostatistics, University of Minnesota, Minneapolis, MN; b Departments of Population Health Sciences and Family Medicine, University of Wisconsin-Madison, Madison, WI; c Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, WISupplementary materials for this article are available online. Please go to www.tandfonline.com/r/JASA.CONTACT Jared Huling huling@umn.edu…

利用纵向移动健康数据学习个性化干预策略AI 解读

Personalized policy represents a paradigm shift from one-decision-rule-for-all users to an individualized decision rule for each user. Developing personalized policy in mobile health applications imposes challenges. First, for lack of adherence, data from each user are limited. Second, unmeasured contextual factors can potentially impact on decision making. Aiming to optimize immediate rewards, we propose using a generalized linear mixed modeling framework where population…

面板数据模型的统计推断：核岭回归方法AI 解读

We propose statistical inferential procedures for nonparametric panel data models with interactive fixed effects in a kernel ridge regression framework. Compared with the traditional sieve methods, our method is automatic in the sense that it does not require the choice of basis functions and truncation parameters. The model complexity is controlled by a continuous regularization parameter which can be automatically selected by the generalized cross-validation. Based on the…