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Estimating False Discovery Proportion Under Arbitrary Covariance Dependence

任意协方差依赖下的错误发现比例估计

Multiple hypothesis testing is a fundamental problem in high dimensional inference, with wide applications in many scientific fields. In genome-wide association studies, tens of thousands of tests are performed simultaneously to find if any SNPs are associated with some traits and those tests are correlated. When test statistics are correlated, false discovery control becomes very challenging under arbitrary dependence. In the current paper, we propose a novel method based…

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Sharp oracle inequalities for aggregation of affine estimators

仿射估计量聚合的锐利预言不等式

We consider the problem of combining a (possibly uncountably infinite) set of affine estimators in nonparametric regression model with heteroscedastic Gaussian noise. Focusing on the exponentially weighted aggregate, we prove a PAC-Bayesian type inequality that leads to sharp oracle inequalities in discrete but also in continuous settings. The framework is general enough to cover the combinations of various procedures such as least square regression, kernel ridge regression,…

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High-dimensional semiparametric Gaussian copula graphical models

高维半参数高斯 Copula 图模型

We propose a semiparametric approach called the nonparanormal SKEPTIC for efficiently and robustly estimating high-dimensional undirected graphical models. To achieve modeling flexibility, we consider the nonparanormal graphical models proposed by Liu, Lafferty and Wasserman [J. Mach. Learn. Res. 10 (2009) 2295–2328]. To achieve estimation robustness, we exploit nonparametric rank-based correlation coefficient estimators, including Spearman’s rho and Kendall’s tau. We prove…

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Discussion: Latent variable graphical model selection via convex optimization

讨论:通过凸优化选择潜变量图模型

It is my pleasure to congratulate the authors for an innovative and inspiring piece of work.Chandrasekaran, Parrilo and Willsky (hereafter CPW) have come up with a novel approach, combining ideas from convex optimization and algebraic geometry, to the long-standing problem of Gaussian graphical model selection with latent variables.Their method is intuitive and simple to implement, based on solving a convex log-determinant program with suitable choices of regularization.In…

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Discussion: Latent variable graphical model selection via convex optimization

讨论:通过凸优化选择潜变量图模型

I want to start by congratulating Professors Chandrasekaran, Parrilo and Willsky for this fine piece of work.Their paper, hereafter referred to as CPW, addresses one of the biggest practical challenges of Gaussian graphical models-how to make inferences for a graphical model in the presence of missing variables.The difficulty comes from the fact that the validity of conditional independence relationships implied by a graphical model relies critically on the assumption that…

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Variable selection in linear mixed effects models

线性混合效应模型中的变量选择

This paper is concerned with the selection and estimation of fixed and random effects in linear mixed effects models. We propose a class of nonconcave penalized profile likelihood methods for selecting and estimating important fixed effects. To overcome the difficulty of unknown covariance matrix of random effects, we propose to use a proxy matrix in the penalized profile likelihood. We establish conditions on the choice of the proxy matrix and show that the proposed…

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Rejoinder: Latent variable graphical model selection via convex optimization

作者答复:通过凸优化选择潜变量图模型

Introduction.We thank all the discussants for their careful reading of our paper, and for their insightful critiques.We would also like to thank the editors for organizing this discussion.Our paper contributes to the area of high-dimensional statistics which has received much attention over the past several years across the statistics, machine learning and signal processing communities.In this rejoinder we clarify and comment on some of the points raised in the…

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Latent variable graphical model selection via convex optimization

通过凸优化选择潜变量图模型

Suppose we observe samples of a subset of a collection of random variables. No additional information is provided about the number of latent variables, nor of the relationship between the latent and observed variables. Is it possible to discover the number of latent components, and to learn a statistical model over the entire collection of variables? We address this question in the setting in which the latent and observed variables are jointly Gaussian, with the conditional…

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ADAPTIVE LASSO-TYPE ESTIMATION FOR MULTIVARIATE DIFFUSION PROCESSES

多元扩散过程的自适应 LASSO 型估计

The least absolute shrinkage and selection operator (LASSO) is a widely used statistical methodology for simultaneous estimation and variable selection. It is a shrinkage estimation method that allows one to select parsimonious models. In other words, this method estimates the redundant parameters as zero in the large samples and reduces variance of estimates. In recent years, many authors analyzed this technique from a theoretical and applied point of view. We introduce and…

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Global optimality of nonconvex penalized estimators

非凸惩罚估计量的全局最优性

Nonconvex penalties such as the smoothly clipped absolute deviation or minimax concave penalties have desirable properties such as the oracle property, even when the dimension of the predictive variables is large. However, checking whether a given local minimizer has such properties is not easy since there can be many local minimizers. In this paper, we give sufficient conditions under which a local minimizer is unique, and show that the oracle estimator becomes the unique…

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High Dimensional Variable Selection via Tilting

通过倾斜相关进行高维变量选择

Summary The paper considers variable selection in linear regression models where the number of covariates is possibly much larger than the number of observations. High dimensionality of the data brings in many complications, such as (possibly spurious) high correlations between the variables, which result in marginal correlation being unreliable as a measure of association between the variables and the response. We propose a new way of measuring the contribution of each…

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Flexible generalized varying coefficient regression models

灵活的广义变系数回归模型

This paper studies a very flexible model that can be used widely to analyze the relation between a response and multiple covariates. The model is nonparametric, yet renders easy interpretation for the effects of the covariates. The model accommodates both continuous and discrete random variables for the response and covariates. It is quite flexible to cover the generalized varying coefficient models and the generalized additive models as special cases. Under a weak condition…

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Robust rank correlation based screening

基于稳健秩相关的变量筛选

Independence screening is a variable selection method that uses a ranking criterion to select significant variables, particularly for statistical models with nonpolynomial dimensionality or “large $p$, small $n$” paradigms when $p$ can be as large as an exponential of the sample size $n$. In this paper we propose a robust rank correlation screening (RRCS) method to deal with ultra-high dimensional data. The new procedure is based on the Kendall $\tau$ correlation coefficient…

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Criteria for Bayesian model choice with application to variable selection

In objective Bayesian model selection, no single criterion has emerged as dominant in defining objective prior distributions. Indeed, many criteria have been separately proposed and utilized to propose differing prior choices. We first formalize the most general and compelling of the various criteria that have been suggested, together with a new criterion. We then illustrate the potential of these criteria in determining objective model selection priors by considering their…

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High-dimensional regression with noisy and missing data: Provable guarantees with nonconvexity

含噪声与缺失数据的高维回归:非凸优化下的可证明保证

Although the standard formulations of prediction problems involve fully-observed and noiseless data drawn in an i.i.d. manner, many applications involve noisy and/or missing data, possibly involving dependence, as well. We study these issues in the context of high-dimensional sparse linear regression, and propose novel estimators for the cases of noisy, missing and/or dependent data. Many standard approaches to noisy or missing data, such as those using the EM algorithm,…

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Nonconcave penalized composite conditional likelihood estimation of sparse Ising models

稀疏 Ising 模型的非凹惩罚复合条件似然估计

The Ising model is a useful tool for studying complex interactions within a system. The estimation of such a model, however, is rather challenging, especially in the presence of high-dimensional parameters. In this work, we propose efficient procedures for learning a sparse Ising model based on a penalized composite conditional likelihood with nonconcave penalties. Nonconcave penalized likelihood estimation has received a lot of attention in recent years. However, such an…

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Inference of time-varying regression models

时变回归模型的统计推断

We consider parameter estimation, hypothesis testing and variable selection for partially time-varying coefficient models. Our asymptotic theory has the useful feature that it can allow dependent, nonstationary error and covariate processes. With a two-stage method, the parametric component can be estimated with a $n^{1/2}$-convergence rate. A simulation-assisted hypothesis testing procedure is proposed for testing significance and parameter constancy. We further propose an…

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Test for bandedness of high-dimensional covariance matrices and bandwidth estimation

高维协方差矩阵的带状性检验与带宽估计

Motivated by the latest effort to employ banded matrices to estimate a high-dimensional covariance $\Sigma$, we propose a test for $\Sigma$ being banded with possible diverging bandwidth. The test is adaptive to the “large $p$, small $n$” situations without assuming a specific parametric distribution for the data. We also formulate a consistent estimator for the bandwidth of a banded high-dimensional covariance matrix. The properties of the test and the bandwidth estimator…

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High-dimensional structure estimation in Ising models: Local separation criterion

高维 Ising 模型结构估计:局部分离准则

We consider the problem of high-dimensional Ising (graphical) model selection. We propose a simple algorithm for structure estimation based on the thresholding of the empirical conditional variation distances. We introduce a novel criterion for tractable graph families, where this method is efficient, based on the presence of sparse local separators between node pairs in the underlying graph. For such graphs, the proposed algorithm has a sample complexity of $n=\Omega(J_{\min}^{-2}\log p)$…

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Estimating the effect of a variable in a high‐dimensional linear model

高维线性模型中单个变量效应的估计

A problem encountered in some empirical research, e.g. growth empirics, is that the potential number of explanatory variables is large compared to the number of observations. This makes it infeasible to condition on all variables in order to determine whether a variable of interest has an effect. We assume that the effect is identified in a high‐dimensional linear model specified by unconditional moment restrictions. We propose a new method that provides a consistent…

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Regularization of nonparametric frontier estimators

非参数前沿估计量的正则化

In production theory and efficiency analysis, we estimate the production frontier, the locus of the maximal attainable level of an output (the production), given a set of inputs (the production factors). In other setups, we estimate rather an input (or cost) frontier, the minimal level of the input (cost) attainable for a given set of outputs (goods or services produced). In both cases the problem can be viewed as estimating a surface under shape constraints (monotonicity,…

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Conditional Inference Functions for Mixed-Effects Models With Unspecified Random-Effects Distribution

随机效应分布未指定时混合效应模型的条件推断函数

In longitudinal studies, mixed-effects models are important for addressing subject-specific effects. However, most existing approaches assume a normal distribution for the random effects, and this could affect the bias and efficiency of the fixed-effects estimator. Even in cases where the estimation of the fixed effects is robust with a misspecified distribution of the random effects, the estimation of the random effects could be invalid. We propose a new approach to…

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Inverse Realized Laplace Transforms for Nonparametric Volatility Density Estimation in Jump-Diffusions

跳跃扩散中以逆已实现拉普拉斯变换估计波动率密度

This article develops a nonparametric estimator of the stochastic volatility density of a discretely observed Itô semimartingale in the setting of an increasing time span and finer mesh of the observation grid. There are two basic steps involved. The first step is aggregating the high-frequency increments into the realized Laplace transform, which is a robust nonparametric estimate of the underlying volatility Laplace transform. The second step is using a regularized kernel…

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Informative Estimation and Selection of Correlation Structure for Longitudinal Data

纵向数据相关结构的信息性估计与选择

Identifying an informative correlation structure is important in improving estimation efficiency for longitudinal data. We approximate the empirical estimator of the correlation matrix by groups of known basis matrices that represent different correlation structures, and transform the correlation structure selection problem to a covariate selection problem. To address both the complexity and the informativeness of the correlation matrix, we minimize an objective function…

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