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α -separability and adjustable combination of amplitude and phase model for functional data

函数型数据的 α 可分离性与幅度、相位的可调组合模型

Abstract We consider separating and joint modelling amplitude and phase variations for functional data in an identifiable manner. To rigorously address this separability issue, we introduce the notion of α-separability upon constructing a family of α-indexed metrics. We bridge α-separability with the uniqueness of Fréchet mean, leading to the proposed adjustable combination of amplitude and phase model. The parameter α allows user-defined modelling emphasis between vertical…

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Robust evaluation of longitudinal surrogate markers with censored data

删失数据下纵向替代指标的稳健评估

Abstract The development of statistical methods to evaluate surrogate markers is an active area of research. In many clinical settings, the surrogate marker is not simply a single measurement but is instead a longitudinal trajectory of measurements over time, e.g. fasting plasma glucose measured every 6 months for 3 years. In general, available methods developed for the single-surrogate setting cannot accommodate a longitudinal surrogate marker. Furthermore, many of the…

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Dynamic modelling of sparse longitudinal data and functional snippets with stochastic differential equations

利用随机微分方程动态建模稀疏纵向数据与函数片段

Abstract Sparse functional/longitudinal data have attracted widespread interest due to the prevalence of such data in social and life sciences. A prominent scenario where such data are routinely encountered are accelerated longitudinal studies, where subjects are enrolled in the study at a random time and are only tracked for a short amount of time relative to the domain of interest. The statistical analysis of such functional snippets is challenging since information for…

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Moving beyond population variable importance: concept, theory and applications of individual variable importance

超越总体变量重要性:个体变量重要性的概念、理论与应用

Abstract In a non-parametric regression setting, we introduce a novel concept of ‘individual variable importance’, which assesses the relevance of certain covariates to an outcome variable among individuals with specific characteristics. This concept holds practical importance for both risk assessment and association identification. For example, it can represent (i) the usefulness of expensive biomarkers in risk prediction for individuals at a specified baseline risk, or…

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Scalable couplings for the random walk Metropolis algorithm

随机游走 Metropolis 算法的可扩展耦合

Abstract There has been a recent surge of interest in coupling methods for Markov chain Monte Carlo algorithms: they facilitate convergence quantification and unbiased estimation, while exploiting embarrassingly parallel computing capabilities. Motivated by these, we consider the design and analysis of couplings of the random walk Metropolis algorithm which scale well with the dimension of the target measure. Methodologically, we introduce a low-rank modification of the…

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Adaptive conformal classification with noisy labels

含噪标签的自适应保形分类

Abstract This article develops a conformal prediction method for classification tasks that can adapt to random label contamination in the calibration sample, often leading to more informative prediction sets with stronger coverage guarantees compared to existing approaches. This is obtained through a precise characterization of the coverage inflation (or deflation) suffered by standard conformal inferences in the presence of label contamination, which is then made actionable…

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Robust angle-based transfer learning in high dimensions

高维稳健角度迁移学习

Abstract Transfer learning improves target model performance by leveraging data from related source populations, especially when target data are scarce. This study addresses the challenge of training high-dimensional regression models with limited target data in the presence of heterogeneous source populations. We focus on a practical setting where only parameter estimates of pretrained source models are available, rather than individual-level source data. For a single…

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Robustness, model checking, and hierarchical models

稳健性、模型检验与层级模型

Abstract Model checking is essential to evaluate the adequacy of statistical models and the validity of inferences drawn from them. Particularly, hierarchical models such as latent Gaussian models (LGMs) pose unique challenges as it is difficult to check assumptions on the latent parameters. Diagnostic statistics are often used to quantify the degree to which a model fit deviates from the observed data. We construct diagnostic statistics by (a) defining an alternative model…

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Adaptive functional principal components analysis

自适应函数型主成分分析

Abstract Functional data analysis almost always involves smoothing discrete observations into curves, because they are never observed in continuous time and rarely without error. Although smoothing parameters affect the subsequent inference, data-driven methods for selecting these parameters are not well-developed, frustrated by the difficulty of using all the information shared by curves while being computationally efficient. On the one hand, smoothing individual curves in…

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Causal mediation analysis: selection with asymptotically valid inference

因果中介分析:选择与渐近有效推断

Abstract Researchers are often interested in learning not only the effect of treatments on outcomes, but also the mechanisms that transmit these effects. A mediator is a variable that is affected by treatment and subsequently affects outcome. Existing methods for penalized mediation analyses may lead to ignoring important mediators and either assume that finite-dimensional linear models are sufficient to remove confounding bias, or perform no confounding control at all. In…

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Engression: extrapolation through the lens of distributional regression

Engression:从分布回归视角研究外推

Abstract Distributional regression aims to estimate the full conditional distribution of a target variable, given covariates. Popular methods include linear and tree ensemble based quantile regression. We propose a neural network-based distributional regression methodology called ‘engression’. An engression model is generative in the sense that we can sample from the fitted conditional distribution and is also suitable for high-dimensional outcomes. Furthermore, we find that…

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Frequentist inference for semi-mechanistic epidemic models with interventions

含干预的半机制流行病模型:频率学派推断

Abstract The effect of public health interventions on an epidemic are often estimated by adding the intervention to epidemic models. During the Covid-19 epidemic, numerous papers used such methods for making scenario predictions. The majority of these papers use Bayesian methods to estimate the parameters of the model. In this article, we show how to use frequentist methods for estimating these effects which avoids having to specify prior distributions. We also use…

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X-vine models for multivariate extremes

多元极端事件的 X-vine 模型

Abstract Regular vine sequences permit the organization of variables in a random vector along a sequence of trees. Vine-based dependence models have become greatly popular as a way to combine arbitrary bivariate copulas into higher-dimensional ones, offering flexibility, parsimony, and tractability. In this project, we use regular vine sequences to decompose and construct the exponent measure density of a multivariate extreme value distribution, or, equivalently, the tail…

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Probabilistic Richardson extrapolation

概率化 Richardson 外推

Abstract For over a century, extrapolation methods have provided a powerful tool to improve the convergence order of a numerical method. However, these tools are not well-suited to modern computer codes, where multiple continua are discretized and convergence orders are not easily analysed. To address this challenge, we present a probabilistic perspective on Richardson extrapolation, a point of view that unifies classical extrapolation methods with modern multi-fidelity…

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A focusing framework for testing bi-directional causal effects in Mendelian randomization

孟德尔随机化中检验双向因果效应的聚焦框架

Abstract Mendelian randomization (MR) is a powerful method that uses genetic variants as instrumental variables to infer the causal effect of a modifiable exposure on an outcome. We study inference for bi-directional causal relationships and causal directions with possibly pleiotropic genetic variants. We show that assumptions for common MR methods are often impossible or too stringent given the potential bi-directional relationships. We propose a new focusing framework for…

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Conformal prediction with local weights: randomization enables robust guarantees

局部加权共形预测:随机化带来稳健保证

Abstract In this work, we consider the problem of building distribution-free prediction intervals with finite-sample conditional coverage guarantees. Conformal prediction (CP) is an increasingly popular framework for building such intervals with distribution-free guarantees, but these guarantees only ensure marginal coverage: the probability of coverage is averaged over both the training and test data, meaning that there might be substantial undercoverage within certain…

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Multiscale scanning with nuisance parameters

含干扰参数的多尺度扫描

Abstract We develop a multiscale scanning method to find anomalies in a d-dimensional random field in the presence of nuisance parameters. This covers the common situation that either the baseline-level or additional parameters such as the variance are unknown and have to be estimated from the data. We argue that state of the art approaches to determine asymptotically correct critical values for multiscale scanning statistics will in general fail when such parameters are…

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On the role of surrogates in the efficient estimation of treatment effects with limited outcome data

结果数据有限时替代指标对处理效应高效估计的作用

Abstract In many experimental and observational studies, the outcome of interest is often difficult or expensive to observe, reducing effective sample sizes for estimating average treatment effects (ATEs) even when identifiable. We study how incorporating data on units for which only surrogate outcomes not of primary interest are observed can increase the precision of ATE estimation. We refrain from imposing stringent surrogacy conditions, which permit surrogates as perfect…

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A stableness of resistance model for nonresponse adjustment with callback data

利用回访数据调整无应答的抵抗稳定性模型

Abstract Nonresponse arises frequently in surveys, and follow-ups are routinely made to increase the response rate. In order to monitor the follow-up process, callback data have been used in social sciences and survey studies for decades. In modern surveys, the availability of callback data is increasing because the response rate is decreasing, and follow-ups are essential to collect maximum information. Although callback data are helpful to reduce the bias in surveys, such…

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Long-term causal inference under persistent confounding via data combination

持续混杂下通过数据结合开展长期因果推断

Abstract We study the identification and estimation of long-term treatment effects by combining short-term experimental data and long-term observational data subject to unobserved confounding. This problem arises often when concerned with long-term treatment effects since experiments are often short-term due to operational necessity while observational data can be more easily collected over longer time frames but may be subject to confounding. In this paper, we tackle the…

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Corrected generalized cross-validation for finite ensembles of penalized estimators

有限惩罚估计集成的修正广义交叉验证

Abstract Generalized cross-validation (GCV) is a widely used method for estimating the squared out-of-sample prediction risk that employs scalar degrees of freedom adjustment (in a multiplicative sense) to the squared training error. In this paper, we examine the consistency of GCV for estimating the prediction risk of arbitrary ensembles of penalized least-squares estimators. We show that GCV is inconsistent for any finite ensemble of size greater than one. Towards…

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Robust model averaging prediction of longitudinal response with ultrahigh-dimensional covariates

超高维协变量下纵向响应的稳健模型平均预测

Abstract Model averaging is an attractive ensemble technique to construct fast and accurate prediction. Despite of having been widely practiced in cross-sectional data analysis, its application to longitudinal data is rather limited so far. We consider model averaging for longitudinal response when the number of covariates is ultrahigh. To this end, we propose a novel two-stage procedure in which variable screening is first conducted and then followed by model averaging. In…

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Nonparametric estimation via partial derivatives

利用偏导数的非参数估计

Abstract Traditional nonparametric estimation methods often lead to a slow convergence rate in large dimensions and require unrealistically large dataset sizes for reliable conclusions. We develop an approach based on partial derivatives, either observed or estimated, to effectively estimate the function at near-parametric convergence rates. This novel approach and computational algorithm could lead to methods useful to practitioners in many areas of science and engineering.…

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Isotonic subgroup selection

保序子群选择

Abstract Given a sample of covariate–response pairs, we consider the subgroup selection problem of identifying a subset of the covariate domain where the regression function exceeds a predetermined threshold. We introduce a computationally feasible approach for subgroup selection in the context of multivariate isotonic regression based on martingale tests and multiple testing procedures for logically structured hypotheses. Our proposed procedure satisfies a non-asymptotic,…

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