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Blur-generated non-separable space–time models

模糊化生成的非可分时空模型

Summary Statistical space–time modelling has traditionally been concerned with separable covariance functions, meaning that the covariance function is a product of a purely temporal function and a purely spatial function. We draw attention to a physical dispersion model which could model phenomena such as the spread of an air pollutant. We show that this model has a non-separable covariance function. The model is well suited to a wide range of realistic problems which will…

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Almost Nonparametric Inference for Repeated Measures in Mixture Models

混合模型中重复测量的近乎非参数推断

Summary We consider ways to estimate the mixing proportions in a finite mixture distribution or to estimate the number of components of the mixture distribution without making parametric assumptions about the component distributions. We require a vector of observations on each subject. This vector is mapped into a vector of 0s and 1s and summed. The resulting distribution of sums can be modelled as a mixture of binomials. We then work with the binomial mixture. The…

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Cochran's Rule for Simple Random Sampling

简单随机抽样中的 Cochran 规则

Summary Cochran's rule for the minimum sample size to ensure adequate coverage of nominal 95% confidence intervals is derived by using the Edgeworth expansion for the distribution function of the standardized sample mean. The rule is extended for confidence intervals based on the Studentized sample mean. The performance of the rule and Edgeworth approximations for smaller sample sizes are examined by simulation.

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Regression Analysis Under Non-standard Situations: A Pairwise Pseudolikelihood Approach

非标准情形下的回归分析:成对伪似然方法

Summary Regression analysis is one of the most used statistical methods for data analysis. There are, however, many situations in which one cannot base inference solely on f(y∣x; β), the conditional probability (density) function for the response variable Y, given x, the covariates. Examples include missing data where the missingness is non-ignorable, sampling surveys in which subjects are selected on the basis of the Y-values and meta-analysis where published studies are…

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A Model for Markers and Latent Health Status

标志物与潜在健康状态的联合模型

Summary We extend the bivariate Wiener process considered by Whitmore and co-workers and model the joint process of a marker and health status. The health status process is assumed to be latent or unobservable. The time to reach the primary end point or failure (death, onset of disease, etc.) is the time when the latent health status process first crosses a failure threshold level. Inferences for the model are based on two kinds of data: censored survival data and marker…

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Confidence Intervals for Secondary Parameters Following a Sequential Test

序贯检验后次要参数的置信区间

Summary In sequential studies, formal interim analyses are usually restricted to a consideration of a single null hypothesis concerning a single parameter of interest. Valid frequentist methods of hypothesis testing and of point and interval estimation for the primary parameter have already been devised for use at the end of such a study. However, the completed data set may warrant a more detailed analysis, involving the estimation of parameters corresponding to effects that…

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A Small Sample Estimator for a Polynomial Regression with Errors in the Variables

Summary An adjusted least squares estimator, introduced by Cheng and Schneeweiss for consistently estimating a polynomial regression of any degree with errors in the variables, is modified such that it shows good results in small samples without losing its asymptotic properties for large samples. Simulation studies corroborate the theoretical findings.

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Flexible Empirical Bayes Estimation for Wavelets

灵活的小波经验贝叶斯估计

Summary Wavelet shrinkage estimation is an increasingly popular method for signal denoising and compression. Although Bayes estimators can provide excellent mean-squared error (MSE) properties, the selection of an effective prior is a difficult task. To address this problem, we propose empirical Bayes (EB) prior selection methods for various error distributions including the normal and the heavier-tailed Student t-distributions. Under such EB prior distributions, we obtain…

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Proportional Hazards Estimate of the Conditional Survival Function

条件生存函数的比例风险估计

Summary We introduce a new estimator of the conditional survival function given some subset of the covariate values under a proportional hazards regression. The new estimate does not require estimating the base-line cumulative hazard function. An estimate of the variance is given and is easy to compute, involving only those quantities that are routinely calculated in a Cox model analysis. The asymptotic normality of the new estimate is shown by using a central limit theorem…

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Failure Time Regression With Continuous Covariates Measured With Error

连续协变量存在测量误差时的失效时间回归

Summary We consider failure time regression analysis with an auxiliary variable in the presence of a validation sample. We extend the nonparametric inference procedure of Zhou and Pepe to handle a continuous auxiliary or proxy covariate. We estimate the induced relative risk function with a kernel smoother and allow the selection probability of the validation set to depend on the observed covariates. We present some asymptotic properties for the kernel estimator and provide…

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Inference in Molecular Population Genetics

分子群体遗传学中的统计推断

Summary Full likelihood-based inference for modern population genetics data presents methodological and computational challenges. The problem is of considerable practical importance and has attracted recent attention, with the development of algorithms based on importance sampling (IS) and Markov chain Monte Carlo (MCMC) sampling. Here we introduce a new IS algorithm. The optimal proposal distribution for these problems can be characterized, and we exploit a detailed…

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Improved Small Sample Inference in the Mixed Linear Model: Bartlett Correction and Adjusted Likelihood

混合线性模型的小样本推断改进:Bartlett 校正与调整似然

Summary The mixed linear model is a popular method for analysing unbalanced repeated measurement data. The classical statistical tests for parameters in this model are based on asymptotic theory that is unreliable in the small samples that are often encountered in practice. For testing a given fixed effect parameter with a small sample, we develop and investigate refined likelihood ratio (LR) tests. The refinements considered are the Bartlett correction and use of the…

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Dealing With Label Switching in Mixture Models

混合模型中标签交换问题的处理

Summary In a Bayesian analysis of finite mixture models, parameter estimation and clustering are sometimes less straightforward than might be expected. In particular, the common practice of estimating parameters by their posterior mean, and summarizing joint posterior distributions by marginal distributions, often leads to nonsensical answers. This is due to the so-called ‘label switching’ problem, which is caused by symmetry in the likelihood of the model parameters. A…

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Partial Least Squares Estimator for Single-Index Models

单指标模型的偏最小二乘估计

Summary The partial least squares (PLS) approach first constructs new explanatory variables, known as factors (or components), which are linear combinations of available predictor variables. A small subset of these factors is then chosen and retained for prediction. We study the performance of PLS in estimating single-index models, especially when the predictor variables exhibit high collinearity. We show that PLS estimates are consistent up to a constant of proportionality.…

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Semiparametric Regression for the Mean and Rate Functions of Recurrent Events

重复事件均值函数与发生率函数的半参数回归

Summary The counting process with the Cox-type intensity function has been commonly used to analyse recurrent event data. This model essentially assumes that the underlying counting process is a time-transformed Poisson process and that the covariates have multiplicative effects on the mean and rate function of the counting process. Recently, Pepe and Cai, and Lawless and co-workers have proposed semiparametric procedures for making inferences about the mean and rate…

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Median Treatment Effect in Randomized Trials

随机试验中的中位数处理效应

Summary For two response variables y t and y c corresponding to two treatments for two policies) T and C, we wish to learn about quantiles of y t−y c from the marginal quantiles of y t and y c; only one of y t and y c is observed for an individual. We find that, in general, this is difficult for quantiles other than the median unless strong assumptions are imposed on how y t is related to y c. For the median, we present conditions under which the sign of the median treatment…

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The Peculiar Shrinkage Properties of Partial Least Squares Regression

偏最小二乘回归的特殊收缩性质

Summary Partial least squares regression has been widely adopted within some areas as a useful alternative to ordinary least squares regression in the manner of other shrinkage methods such as principal components regression and ridge regression. In this paper we examine the nature of this shrinkage and demonstrate that partial least squares regression exhibits some undesirable properties.

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Generalized Spectral Tests for Serial Dependence

序列依赖的广义谱检验

Summary Two tests for serial dependence are proposed using a generalized spectral theory in combination with the empirical distribution function. The tests are generalizations of the Cramér-von Mises and Kolmogorov-Smirnov tests based on the standardized spectral distribution function. They do not involve the choice of a lag order, and they are consistent against all types of pairwise serial dependence, including those with zero autocorrelation. They also require no moment…

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Asymptotic Separability in Sensitivity Analysis

敏感性分析中的渐近可分性

Summary In an observational study in which each treated subject is matched to several untreated controls by using observed pretreatment covariates, a sensitivity analysis asks how hidden biases due to unobserved covariates might alter the conclusions. The bounds required for a sensitivity analysis are the solution to an optimization problem. In general, this optimization problem is not separable, in the sense that one cannot find the needed optimum by performing a separate…

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Expected Estimating Equations to Accommodate Covariate Measurement Error

利用期望估计方程处理协变量测量误差

Summary Estimating equations which are not necessarily likelihood-based score equations are becoming increasingly popular for estimating regression model parameters. This paper is concerned with estimation based on general estimating equations when true covariate data are missing for all the study subjects, but surrogate or mismeasured covariates are available instead. The method is motivated by the covariate measurement error problem in marginal or partly conditional…

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Mixture Kalman Filters

混合卡尔曼滤波器

Summary In treating dynamic systems, sequential Monte Carlo methods use discrete samples to represent a complicated probability distribution and use rejection sampling, importance sampling and weighted resampling to complete the on-line ‘filtering’ task. We propose a special sequential Monte Carlo method, the mixture Kalman filter, which uses a random mixture of the Gaussian distributions to approximate a target distribution. It is designed for on-line estimation and…

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A Unified Approach to Regression Analysis Under Double-Sampling Designs

双重抽样设计下回归分析的统一方法

Summary We propose a unified approach to the estimation of regression parameters under double-sampling designs, in which a primary sample consisting of data on the rough or proxy measures for the response and/or explanatory variables as well as a validation subsample consisting of data on the exact measurements are available. We assume that the validation sample is a simple random subsample from the primary sample. Our proposal utilizes a specific parametric model to extract…

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On Variable Bandwidth Selection in Local Polynomial Regression

局部多项式回归的可变带宽选择

Summary The performances of data-driven bandwidth selection procedures in local polynomial regression are investigated by using asymptotic methods and simulation. The bandwidth selection procedures considered are based on minimizing ‘prelimit’ approximations to the (conditional) mean-squared error (MSE) when the MSE is considered as a function of the bandwidth h. We first consider approximations to the MSE that are based on Taylor expansions around h=0 of the bias part of…

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Importance of Interpolation When Constructing Double-Bootstrap Confidence Intervals

构造双重自助法置信区间时插值的重要性

Summary We show that, in the context of double-bootstrap confidence intervals, linear interpolation at the second level of the double bootstrap can reduce the simulation error component of coverage error by an order of magnitude. Intervals that are indistinguishable in terms of coverage error with theoretical, infinite simulation, double-bootstrap confidence intervals may be obtained at substantially less computational expense than by using the standard Monte Carlo…

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