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A Simple Estimator for a Shared Frailty Regression Model

共享脆弱性回归模型的一种简便估计量

Summary We propose a simple estimation procedure for a proportional hazards frailty regression model for clustered survival data in which the dependence is generated by a positive stable distribution. Inferences for the frailty parameter can be obtained by using output from Cox regression analyses. The computational burden is substantially less than that of the other approaches to estimation. The large sample behaviour of the estimator is studied and simulations show that…

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Pattern–Mixture and Selection Models for Analysing Longitudinal Data with Monotone Missing Patterns

单调缺失纵向数据分析中的模式混合模型与选择模型

Summary We examine three pattern–mixture models for making inference about parameters of the distribution of an outcome of interest Y that is to be measured at the end of a longitudinal study when this outcome is missing in some subjects. We show that these pattern–mixture models also have an interpretation as selection models. Because these models make unverifiable assumptions, we recommend that inference about the distribution of Y be repeated under a range of plausible…

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Estimating the Association Parameter for Copula Models Under Dependent Censoring

依赖删失下 Copula 模型关联参数的估计

Summary Many biomedical studies involve the analysis of multiple events. The dependence between the times to these end points is often of scientific interest. We investigate a situation when one end point is subject to censoring by the other. The model assumptions of Day and co-workers and Fine and co-workers are extended to more general structures where the level of association may vary with time. Two types of estimating function are proposed. Asymptotic properties of the…

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Covariate Selection for Estimating the Causal Effect of Control Plans by Using Causal Diagrams

利用因果图选择协变量以估计控制方案的因果效应

Summary Consider a case where cause–effect relationships between variables can be described by a causal path diagram and the corresponding linear structural equation model. The paper proposes a graphical selection criterion for covariates to estimate the causal effect of a control plan. For designing the control plan, it is essential to determine both covariates that are used for control and covariates that are used for identification. The selection of covariates used for…

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Efficiency of Projected Score Methods in Rectangular Array Asymptotics

矩形阵列渐近框架下投影得分方法的效率

Summary The paper considers a rectangular array asymptotic embedding for multistratum data sets, in which both the number of strata and the number of within-stratum replications increase, and at the same rate. It is shown that under this embedding the maximum likelihood estimator is consistent but not efficient owing to a non-zero mean in its asymptotic normal distribution. By using a projection operator on the score function, an adjusted maximum likelihood estimator can be…

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Estimating Variance Components by Using Survey Data

利用调查数据估计方差分量

Summary Inflation-type weighted estimators for variance components can be badly biased. Modified weighted estimators suggested in the literature are also badly biased for certain sampling designs. We propose new estimators for variance components, some of which are approximately unbiased regardless of the sampling design. These estimators require knowledge of the joint inclusion probabilities of the observations. The small sample properties of the estimators are studied via…

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Sequential Classification on Partially Ordered Sets

偏序集上的序贯分类

Summary A general theorem on the asymptotically optimal sequential selection of experiments is presented and applied to a Bayesian classification problem when the parameter space is a finite partially ordered set. The main results include establishing conditions under which the posterior probability of the true state converges to 1 almost surely and determining optimal rates of convergence. Properties of a class of experiment selection rules are explored.

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Building Adaptive Estimating Equations When Inverse of Covariance Estimation is Difficult

协方差逆矩阵难以估计时的自适应估计方程

Summary To construct an optimal estimating function by weighting a set of score functions, we must either know or estimate consistently the covariance matrix for the individual scores. In problems with high dimensional correlated data the estimated covariance matrix could be unreliable. The smallest eigenvalues of the covariance matrix will be the most important for weighting the estimating equations, but in high dimensions these will be poorly determined. Generalized…

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Goodness-of-Fit Tests Based on Maximum Correlations and Their Orthogonal Decompositions

基于最大相关及其正交分解的拟合优度检验

Summary We propose a goodness-of-fit statistic Qn based on the Hoeffding maximum correlation for testing uniformity and we show its relationship to Gini's mean difference. We compute exact and asymptotic critical values and study the power of the test proposed against a representative set of alternatives.

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Comprehensive Definitions of Breakdown Points for Independent and Dependent Observations

独立与相依观测下崩溃点的综合定义

Summary We provide a new definition of breakdown in finite samples, with an extension to asymptotic breakdown. Previous definitions centre on defining a critical region for either the parameter or the objective function. If for a particular outlier configuration the critical region is entered, breakdown is said to occur. In contrast with the traditional approach, we leave the definition of the critical region implicit. Our proposal encompasses previous definitions of…

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Conditional Statistical Inference and Quantification of Relevance

条件统计推断与相关性的量化

Summary We argue that it can be fruitful to take a predictive view on notions such as the precision of a point estimator and the confidence of an interval estimator in frequentist inference. This predictive approach has implications for conditional inference, because it immediately allows a quantification of the concept of relevance for conditional inference. Conditioning on an ancillary statistic makes inference more relevant in this sense, provided that the ancillary is a…

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A Skew Extension of the T -Distribution, with Applications

t 分布的偏斜扩展及其应用

Summary A tractable skew t-distribution on the real line is proposed. This includes as a special case the symmetric t-distribution, and otherwise provides skew extensions thereof. The distribution is potentially useful both for modelling data and in robustness studies. Properties of the new distribution are presented. Likelihood inference for the parameters of this skew t-distribution is developed. Application is made to two data modelling examples.

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Thin Plate Regression Splines

薄板回归样条

Summary I discuss the production of low rank smoothers for d ≥ 1 dimensional data, which can be fitted by regression or penalized regression methods. The smoothers are constructed by a simple transformation and truncation of the basis that arises from the solution of the thin plate spline smoothing problem and are optimal in the sense that the truncation is designed to result in the minimum possible perturbation of the thin plate spline smoothing problem given the dimension…

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Adaptive Varying-Coefficient Linear Models

自适应变系数线性模型

Summary Varying-coefficient linear models arise from multivariate nonparametric regression, non-linear time series modelling and forecasting, functional data analysis, longitudinal data analysis and others. It has been a common practice to assume that the varying coefficients are functions of a given variable, which is often called an index. To enlarge the modelling capacity substantially, this paper explores a class of varying-coefficient linear models in which the index is…

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Inference in Smoothing Spline Analysis of Variance

平滑样条方差分析中的推断

Summary Smoothing spline analysis of variance decomposes a multivariate function into additive components. This decomposition not only provides an efficient way to model a multivariate function but also leads to meaningful inference by testing whether a certain component equals 0. No formal procedure is yet available to test such a hypothesis. We propose an asymptotic method based on the likelihood ratio to test whether a functional component is 0. This test allows us to…

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Estimation of Integrated Squared Density Derivatives from a Contaminated Sample

受噪声污染样本中密度导数平方积分的估计

Summary We propose a kernel estimator of integrated squared density derivatives, from a sample that has been contaminated by random noise. We derive asymptotic expressions for the bias and the variance of the estimator and show that the squared bias term dominates the variance term. This coincides with results that are available for non-contaminated observations. We then discuss the selection of the bandwidth parameter when estimating integrated squared density derivatives…

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A Measure of Disclosure Risk for Microdata

微观数据的一种披露风险度量

Summary Protection against disclosure is important for statistical agencies releasing microdata files from sample surveys. Simple measures of disclosure risk can provide useful evidence to support decisions about release. We propose a new measure of disclosure risk: the probability that a unique match between a microdata record and a population unit is correct. We argue that this measure has at least two advantages. First, we suggest that it may be a more realistic measure…

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Least Squares Variogram Fitting by Spatial Subsampling

利用空间子抽样进行最小二乘变差函数拟合

Summary Least squares methods are popular for fitting valid variogram models to spatial data. The paper proposes a new least squares method based on spatial subsampling for variogram model fitting. We show that the method proposed is statistically efficient among a class of least squares methods, including the generalized least squares method. Further, it is computationally much simpler than the generalized least squares method. The method produces valid variogram estimators…

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Particle Filtering for Partially Observed Gaussian State Space Models

部分观测高斯状态空间模型的粒子滤波

Summary Solving Bayesian estimation problems where the posterior distribution evolves over time through the accumulation of data has many applications for dynamic models. A large number of algorithms based on particle filtering methods, also known as sequential Monte Carlo algorithms, have recently been proposed to solve these problems. We propose a special particle filtering method which uses random mixtures of normal distributions to represent the posterior distributions…

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Bandwidth Selection for Local Linear Regression Smoothers

局部线性回归平滑器的带宽选择

Summary The paper presents a general strategy for selecting the bandwidth of nonparametric regression estimators and specializes it to local linear regression smoothers. The procedure requires the sample to be divided into a training sample and a testing sample. Using the training sample we first compute a family of regression smoothers indexed by their bandwidths. Next we select the bandwidth by minimizing the empirical quadratic prediction error on the testing sample. The…

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Perfect Samplers for Mixtures of Distributions

混合分布的完美采样器

Summary We consider the construction of perfect samplers for posterior distributions associated with mixtures of exponential families and conjugate priors, starting with a perfect slice sampler in the spirit of Mira and co-workers. The methods rely on a marginalization akin to Rao–Blackwellization and illustrate the duality principle of Diebolt and Robert. A first approximation embeds the finite support distribution on the latent variables within a continuous support…

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Assessing Population Differentiation and Isolation from Single-Nucleotide Polymorphism Data

利用单核苷酸多态性数据评估群体分化与隔离

Summary We introduce a new, hierarchical, model for single-nucleotide polymorphism allele frequencies in a structured population, which is naturally fitted via Markov chain Monte Carlo methods. There is one parameter for each population, closely analogous to a population-specific version of Wright's FST, which can be interpreted as measuring how isolated the relevant population has been. Our model includes the effects of single-nucleotide polymorphism ascertainment and is…

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Bayesian Phylogenetic Inference from Animal Mitochondrial Genome Arrangements

基于动物线粒体基因组排列的贝叶斯系统发育推断

Summary The determination of evolutionary relationships is a fundamental problem in evolutionary biology. Genome arrangement data are potentially more informative than deoxyribonucleic acid sequence data for inferring evolutionary relationships between distantly related taxa. We describe a Bayesian framework for phylogenetic inference from mitochondrial genome arrangement data using Markov chain Monte Carlo methods. We apply the method to assess evolutionary relationships…

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A Model Selection Approach for the Identification of Quantitative Trait Loci in Experimental Crosses

实验杂交中数量性状基因座识别的模型选择方法

Summary We consider the problem of identifying the genetic loci (called quantitative trait loci (QTLs)) contributing to variation in a quantitative trait, with data on an experimental cross. A large number of different statistical approaches to this problem have been described; most make use of multiple tests of hypotheses, and many consider models allowing only a single QTL. We feel that the problem is best viewed as one of model selection. We discuss the use of model…

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