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Peng Ding’s Contribution to the Discussion of ‘Assumption-Lean Inference for Generalised Linear Model Parameters’ by Vansteelandt and Dukes

彭鼎对《广义线性模型参数的弱假设推断》的讨论

I want to congratulate the authors on a thought-provoking paper on statistical inference with misspecified models. It deepens our understanding of the role of models in causal inference. I offer two comments. Comparison of the conditional and marginal estimands based on 105 Monte Carlo samples. The parameters of the distributions of L and Y are all drawn independently from Uniform(0, 1) The authors provide inspiring derivations of the novel average effect and interaction…

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Seconder of the Vote of thanks to Vansteelandt and Dukes and Contribution to the Discussion of ‘Assumption-Lean Inference for Generalised Linear Model Parameters’

《广义线性模型参数的弱假设推断》讨论与致谢附议

In my view, one of the most important contributions of the field of causal inference has been to place the target of inference, the desired estimand, at the centre of the analysis. The estimand is chosen in view of the research question, and typically reflects what decision problem we need to solve or what our ideal (target) trial would be. Crucially, the (causal) estimand is not automatically a parameter that happens to parametrise a chosen model. The role of models is…

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Assumption-lean Inference for Generalised Linear Model Parameters

广义线性模型参数的弱假设推断

Abstract Inference for the parameters indexing generalised linear models is routinely based on the assumption that the model is correct and a priori specified. This is unsatisfactory because the chosen model is usually the result of a data-adaptive model selection process, which may induce excess uncertainty that is not usually acknowledged. Moreover, the assumptions encoded in the chosen model rarely represent some a priori known, ground truth, making standard inferences…

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High-dimensional Changepoint Estimation with Heterogeneous Missingness

异质缺失下的高维变点估计

Abstract We propose a new method for changepoint estimation in partially observed, high-dimensional time series that undergo a simultaneous change in mean in a sparse subset of coordinates. Our first methodological contribution is to introduce a ‘MissCUSUM’ transformation (a generalisation of the popular cumulative sum statistics), that captures the interaction between the signal strength and the level of missingness in each coordinate. In order to borrow strength across the…

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Robust Generalised Bayesian Inference for Intractable Likelihoods

难处理似然下的稳健广义贝叶斯推断

Abstract Generalised Bayesian inference updates prior beliefs using a loss function, rather than a likelihood, and can therefore be used to confer robustness against possible mis-specification of the likelihood. Here we consider generalised Bayesian inference with a Stein discrepancy as a loss function, motivated by applications in which the likelihood contains an intractable normalisation constant. In this context, the Stein discrepancy circumvents evaluation of the…

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Coupling-based Convergence Assessment of some Gibbs Samplers for High-Dimensional Bayesian Regression with Shrinkage Priors

基于耦合的高维收缩先验贝叶斯回归 Gibbs 采样收敛评估

Abstract We consider Markov chain Monte Carlo (MCMC) algorithms for Bayesian high-dimensional regression with continuous shrinkage priors. A common challenge with these algorithms is the choice of the number of iterations to perform. This is critical when each iteration is expensive, as is the case when dealing with modern data sets, such as genome-wide association studies with thousands of rows and up to hundreds of thousands of columns. We develop coupling techniques…

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On Functional Processes with Multiple Discontinuities

具有多重不连续点的函数型过程

Abstract We consider the problem of estimating multiple change points for a functional data process. There are numerous examples in science and finance in which the process of interest may be subject to some sudden changes in the mean. The process data that are not in a close vicinity of any change point can be analysed by the usual nonparametric smoothing methods. However, the data close to change points and contain the most pertinent information of structural breaks need…

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Supervised Multivariate Learning with Simultaneous Feature Auto-Grouping and Dimension Reduction

Abstract Modern high-dimensional methods often adopt the ‘bet on sparsity’ principle, while in supervised multivariate learning statisticians may face ‘dense’ problems with a large number of nonzero coefficients. This paper proposes a novel clustered reduced-rank learning (CRL) framework that imposes two joint matrix regularizations to automatically group the features in constructing predictive factors. CRL is more interpretable than low-rank modelling and relaxes the…

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The Sceptical Bayes Factor for the Assessment of Replication Success

用于评估重复研究成功的怀疑贝叶斯因子

Abstract Replication studies are increasingly conducted but there is no established statistical criterion for replication success. We propose a novel approach combining reverse-Bayes analysis with Bayesian hypothesis testing: a sceptical prior is determined for the effect size such that the original finding is no longer convincing in terms of a Bayes factor. This prior is then contrasted to an advocacy prior (the reference posterior of the effect size based on the original…

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Empirical Bayes PCA in High Dimensions

高维经验贝叶斯主成分分析

Abstract When the dimension of data is comparable to or larger than the number of data samples, principal components analysis (PCA) may exhibit problematic high-dimensional noise. In this work, we propose an empirical Bayes PCA method that reduces this noise by estimating a joint prior distribution for the principal components. EB-PCA is based on the classical Kiefer–Wolfowitz non-parametric maximum likelihood estimator for empirical Bayes estimation, distributional results…

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False Discovery Rate Control with E-values

使用 e 值控制错误发现率

Abstract E-values have gained attention as potential alternatives to p-values as measures of uncertainty, significance and evidence. In brief, e-values are realized by random variables with expectation at most one under the null; examples include betting scores, (point null) Bayes factors, likelihood ratios and stopped supermartingales. We design a natural analogue of the Benjamini-Hochberg (BH) procedure for false discovery rate (FDR) control that utilizes e-values, called…

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Semiparametric Estimation for Causal Mediation Analysis with Multiple Causally Ordered Mediators

多个因果有序中介变量下的因果中介分析半参数估计

Abstract Causal mediation analysis concerns the pathways through which a treatment affects an outcome. While most of the mediation literature focuses on settings with a single mediator, a flourishing line of research has examined settings involving multiple mediators, under which path-specific effects (PSEs) are often of interest. We consider estimation of PSEs when the treatment effect operates through K(≥ 1) causally ordered, possibly multivariate mediators. In this…

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Statistical Inference of the Value Function for Reinforcement Learning in Infinite-Horizon Settings

无限时域强化学习中价值函数的统计推断

Abstract Reinforcement learning is a general technique that allows an agent to learn an optimal policy and interact with an environment in sequential decision-making problems. The goodness of a policy is measured by its value function starting from some initial state. The focus of this paper was to construct confidence intervals (CIs) for a policy’s value in infinite horizon settings where the number of decision points diverges to infinity. We propose to model the…

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Bayesian Estimation and Comparison of Conditional Moment Models

条件矩模型的贝叶斯估计与比较

Abstract We consider the Bayesian analysis of models in which the unknown distribution of the outcomes is specified up to a set of conditional moment restrictions. The non-parametric exponentially tilted empirical likelihood function is constructed to satisfy a sequence of unconditional moments based on an increasing (in sample size) vector of approximating functions (such as tensor splines based on the splines of each conditioning variable). For any given sample size,…

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Simple: Statistical Inference on Membership Profiles in Large Networks

SIMPLE:大型网络中社群成员构成的统计推断

Abstract Network data are prevalent in many contemporary big data applications in which a common interest is to unveil important latent links between different pairs of nodes. Yet a simple fundamental question of how to precisely quantify the statistical uncertainty associated with the identification of latent links still remains largely unexplored. In this paper, we propose the method of statistical inference on membership profiles in large networks (SIMPLE) in the setting…

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Functional Structural Equation Model

函数型结构方程模型

Abstract In this article, we introduce a functional structural equation model for estimating directional relations from multivariate functional data. We decouple the estimation into two major steps: directional order determination and selection through sparse functional regression. We first propose a score function at the linear operator level, and show that its minimization can recover the true directional order when the relation between each function and its parental…

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Graphical Criteria for Efficient Total Effect Estimation Via Adjustment in Causal Linear Models

因果线性模型中通过协变量调整高效估计总效应的图判据

Abstract Covariate adjustment is a commonly used method for total causal effect estimation. In recent years, graphical criteria have been developed to identify all valid adjustment sets, that is, all covariate sets that can be used for this purpose. Different valid adjustment sets typically provide total causal effect estimates of varying accuracies. Restricting ourselves to causal linear models, we introduce a graphical criterion to compare the asymptotic variances provided…

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A Kernel-Expanded Stochastic Neural Network

核扩展随机神经网络

Abstract The deep neural network suffers from many fundamental issues in machine learning. For example, it often gets trapped into a local minimum in training, and its prediction uncertainty is hard to be assessed. To address these issues, we propose the so-called kernel-expanded stochastic neural network (K-StoNet) model, which incorporates support vector regression as the first hidden layer and reformulates the neural network as a latent variable model. The former maps the…

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Prediction and Outlier Detection in Classification Problems

分类问题中的预测与离群点检测

Abstract We consider the multi-class classification problem when the training data and the out-of-sample test data may have different distributions and propose a method called BCOPS (balanced and conformal optimized prediction sets). BCOPS constructs a prediction set C(x) as a subset of class labels, possibly empty. It tries to optimize the out-of-sample performance, aiming to include the correct class and to detect outliers x as often as possible. BCOPS returns no…

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The Barker Proposal: Combining Robustness and Efficiency in Gradient-Based MCMC

Barker 提议:结合梯度 MCMC 的稳健性与效率

Abstract There is a tension between robustness and efficiency when designing Markov chain Monte Carlo (MCMC) sampling algorithms. Here we focus on robustness with respect to tuning parameters, showing that more sophisticated algorithms tend to be more sensitive to the choice of step-size parameter and less robust to heterogeneity of the distribution of interest. We characterise this phenomenon by studying the behaviour of spectral gaps as an increasingly poor step-size is…

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Model Identification Via Total Frobenius Norm of Multivariate Spectra

通过多元谱的总Frobenius范数进行模型识别

Abstract We study the integral of the Frobenius norm as a measure of the discrepancy between two multivariate spectra. Such a measure can be used to fit time series models, and ensures proximity between model and process at all frequencies of the spectral density—this is more demanding than Kullback–Leibler discrepancy, which is instead related to one-step ahead forecasting performance. We develop new asymptotic results for linear and quadratic functionals of the…

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Efficient Learning of Optimal Individualized Treatment Rules for Heteroscedastic or Misspecified Treatment-Free Effect Models

异方差或无处理基准效应模型误设下最优个体化处理规则的高效学习

Abstract Recent development in data-driven decision science has seen great advances in individualized decision making. Given data with individual covariates, treatment assignments and outcomes, researchers can search for the optimal individualized treatment rule (ITR) that maximizes the expected outcome. Existing methods typically require initial estimation of some nuisance models. The double robustness property that can protect from misspecification of either the…

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Selective Inference for Effect Modification Via the Lasso

利用Lasso进行效应修饰的选择后推断

Abstract Effect modification occurs when the effect of the treatment on an outcome varies according to the level of other covariates and often has important implications in decision-making. When there are tens or hundreds of covariates, it becomes necessary to use the observed data to select a simpler model for effect modification and then make valid statistical inference. We propose a two-stage procedure to solve this problem. First, we use Robinson's transformation to…

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