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皮层下结构中轴表示的内蕴回归模型AI 解读

The aim of this paper is to develop a semiparametric model for describing the variability of the medial representation of subcortical structures, which belongs to a Riemannian manifold, and establishing its association with covariates of interest, such as diagnostic status, age and gender. We develop a two-stage estimation procedure to calculate the parameter estimates. The first stage is to calculate an intrinsic least squares estimator of the parameter vector using the…

基于广义 Kendall’s tau 的非参数协变量调整关联检验AI 解读

Identifying the risk factors for comorbidity is important in psychiatric research. Empirically, studies have shown that testing multiple, correlated traits simultaneously is more powerful than testing a single trait at a time in association analysis. Furthermore, for complex diseases, especially mental illnesses and behavioral disorders, the traits are often recorded in different scales such as dichotomous, ordinal and quantitative. In the absence of covariates,…

适用于任意分量数多元随机场的有效 Matérn 交叉协方差函数族AI 解读

We introduce a valid parametric family of cross-covariance functions for multivariate spatial random fields where each component has a covariance function from a well-celebrated Matérn class. Unlike previous attempts, our model indeed allows for various smoothnesses and rates of correlation decay for any number of vector components. We present the conditions on the parameter space that result in valid models with varying degrees of complexity. We discuss practical…

有理函数回归的最优设计AI 解读

We consider the problem of finding optimal nonsequential designs for a large class of regression models involving polynomials and rational functions with heteroscedastic noise also given by a polynomial or rational weight function. Since the design weights can be found easily by existing methods once the support is known, we concentrate on determining the support of the optimal design. The proposed method treats D-, E-, A-, and Φ p -optimal designs in a unified manner, and…

Heckman样本选择t模型AI 解读

Sample selection arises often in practice as a result of the partial observability of the outcome of interest in a study. In the presence of sample selection, the observed data do not represent a random sample from the population, even after controlling for explanatory variables. That is, data are missing not at random. Thus, standard analysis using only complete cases will lead to biased results. Heckman introduced a sample selection model to analyze such data and proposed…

多元无序分类数据的单纯形因子模型AI 解读

Gaussian latent factor models are routinely used for modeling of dependence in continuous, binary, and ordered categorical data. For unordered categorical variables, Gaussian latent factor models lead to challenging computation and complex modeling structures. As an alternative, we propose a novel class of simplex factor models. In the single-factor case, the model treats the different categorical outcomes as independent with unknown marginals. The model can characterize…

回归中协变量的分位位置变换AI 解读

The need for comparing two regression functions arises frequently in statistical applications. Comparison of the usual regression functions is not very meaningful in situations where the distributions and the ranges of the covariates are different for the populations. For instance, in econometric studies, the prices of commodities and people's incomes observed at different time points may not be on comparable scales due to inflation and other economic factors. In this…

动态处理方案的贝叶斯推断：学生分层中的流动、公平与效率AI 解读

Policies in health, education, and economics often unfold sequentially and adapt to changing conditions. Such time-varying treatments pose problems for standard program evaluation methods because intermediate outcomes are simultaneously pretreatment confounders and posttreatment outcomes. This article extends the Bayesian perspective on causal inference and optimal treatment to these types of dynamic treatment regimes. A unifying idea remains ignorable treatment assignment,…

利用条件核密度估计进行风电功率密度预测AI 解读

Of the various renewable energy resources, wind power is widely recognized as one of the most promising. The management of wind farms and electricity systems can benefit greatly from the availability of estimates of the probability distribution of wind power generation. However, most research has focused on point forecasting of wind power. In this article, we develop an approach to producing density forecasts for the wind power generated at individual wind farms. Our…

基于高维特征筛选子集的偏差校正层级贝叶斯分类AI 解读

Class prediction based on high-dimensional features has received a great deal of attention in many areas of application. For example, biologists are interested in using microarray gene expression profiles for diagnosis or prognosis of a certain disease (e.g., cancer). For computational and other reasons, it is necessary to select a subset of features before fitting a statistical model, by evaluating how strongly the features are related to the response. However, such a…

利用高分辨率贝叶斯隐马尔可夫正态混合模型进行 MRI 组织分类AI 解读

Magnetic resonance imaging (MRI) is used to identify the major tissues within a subject's brain. Classification is usually based on a single image providing one measurement for each volume element, or voxel, in a discretization of the brain. A simple model views each voxel as homogeneous, belonging entirely to one of the three major tissue types: gray matter, white matter, or cerebrospinal fluid. The measurements are normally distributed, with means and variances depending…

稀疏线性判别分析的直接估计方法AI 解读

This article considers sparse linear discriminant analysis of high-dimensional data. In contrast to the existing methods which are based on separate estimation of the precision matrix Ω and the difference δ of the mean vectors, we introduce a simple and effective classifier by estimating the product Ωδ directly through constrained ℓ1 minimization. The estimator can be implemented efficiently using linear programming and the resulting classifier is called the linear…

一种新的干扰参数消除方法及其在无序同源染色体对问题中的应用AI 解读

Motivated by applications of the case–control model or exponential tilting model in the unordered homologous chromosome pairs problem in genetic studies and in the interim analysis in double-blinded clinical trials, we develop a new nuisance-parameter elimination method based on the empirical Shannon’s mutual information. The asymptotic behaviors of the maximum empirical Shannon’s mutual information estimation and the empirical Shannon’s mutual information test are similar…

基于非二部匹配的非参数同质性检验AI 解读

Given a sequence of observations, has a change occurred in the underlying probability distribution with respect to observation order? This problem of detecting change points arises in a variety of applications including health prognostics for mechanical systems, syndromic disease surveillance in geographically dispersed populations, anomaly detection in information networks, and multivariate process control in general. Detecting change points in high-dimensional settings is…

超高维数据的无模型特征筛选AI 解读

With the recent explosion of scientific data of unprecedented size and complexity, feature ranking and screening are playing an increasingly important role in many scientific studies. In this article, we propose a novel feature screening procedure under a unified model framework, which covers a wide variety of commonly used parametric and semiparametric models. The new method does not require imposing a specific model structure on regression functions, and thus is…

评估有序与连续测量间广义一致性的框架AI 解读

Conventional agreement studies have been confined to addressing the sense of reproducibility, and therefore are limited to assessing measurements on the same scale. In this work, we propose a new concept, called "broad sense agreement," which extends the classical framework of agreement to evaluate the capability of interpreting a continuous measurement in an ordinal scale. We present a natural measure for broad sense agreement. Nonparametric estimation and inference…

一般高斯图模型的贝叶斯推断及其在多变量格点数据中的应用AI 解读

We introduce efficient Markov chain Monte Carlo methods for inference and model determination in multivariate and matrix-variate Gaussian graphical models. Our framework is based on the G-Wishart prior for the precision matrix associated with graphs that can be decomposable or non-decomposable. We extend our sampling algorithms to a novel class of conditionally autoregressive models for sparse estimation in multivariate lattice data, with a special emphasis on the analysis…

利用复杂抽样数据构建一致的回归树AI 解读

In the past several years a wide range of methods for the construction of regression trees and other estimators based on the recursive partitioning of samples have appeared in the statistics literature. Many applications involve data collected through a complex sample design. At present, however, relatively little is known regarding the properties of these methods under complex designs. This article proposes a method for incorporating information about the complex sample…

长度偏倚数据的最大似然估计与 EM 算法AI 解读

Length-biased sampling has been well recognized in economics, industrial reliability, etiology applications, epidemiological, genetic and cancer screening studies. Length-biased right-censored data have a unique data structure different from traditional survival data. The nonparametric and semiparametric estimations and inference methods for traditional survival data are not directly applicable for length-biased right-censored data. We propose new expectation-maximization…

利用指数平滑预测具有复杂季节模式的时间序列AI 解读

An innovations state space modeling framework is introduced for forecasting complex seasonal time series such as those with multiple seasonal periods, high-frequency seasonality, non-integer seasonality, and dual-calendar effects. The new framework incorporates Box–Cox transformations, Fourier representations with time varying coefficients, and ARMA error correction. Likelihood evaluation and analytical expressions for point forecasts and interval predictions under the…

纵向研究中变化速率函数的半参数随机建模AI 解读

In longitudinal biomedical studies, there is often interest in the rate functions, which describe the functional rates of change of biomarker profiles. This paper proposes a semiparametric approach to model these functions as the realizations of stochastic processes defined by stochastic differential equations. These processes are dependent on the covariates of interest and vary around a specified parametric function. An efficient Markov chain Monte Carlo algorithm is…

用于蛋白质组通路分析的正则化 Hotelling T² 检验AI 解读

Recent proteomic studies have identified proteins related to specific phenotypes. In addition to marginal association analysis for individual proteins, analyzing pathways (functionally related sets of proteins) may yield additional valuable insights. Identifying pathways that differ between phenotypes can be conceptualized as a multivariate hypothesis testing problem: whether the mean vector μ of a p-dimensional random vector X is μ0. Proteins within the same biological…

用于局地校准概率定量降水预测的地统计模型平均AI 解读

Accurate weather benefit many key societal functions and activities, including agriculture, transportation, recreation, and basic human and infrastructural safety. Over the past two decades, ensembles of numerical weather prediction models have been developed, in which multiple estimates of the current state of the atmosphere are used to generate probabilistic forecasts for future weather events. However, ensemble systems are uncalibrated and biased, and thus need to be…

Tweedie 公式与选择偏差AI 解读

We suppose that the statistician observes some large number of estimates z(i), each with its own unobserved expectation parameter μ(i). The largest few of the z(i)'s are likely to substantially overestimate their corresponding μ(i)'s, this being an example of selection bias, or regression to the mean. Tweedie's formula, first reported by Robbins in 1956, offers a simple empirical Bayes approach for correcting selection bias. This paper investigates its merits and…