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Bayesian Model Selection in High-Dimensional Settings

高维环境下的贝叶斯模型选择

Standard assumptions incorporated into Bayesian model selection procedures result in procedures that are not competitive with commonly used penalized likelihood methods. We propose modifications of these methods by imposing nonlocal prior densities on model parameters. We show that the resulting model selection procedures are consistent in linear model settings when the number of possible covariates p is bounded by the number of observations n, a property that has not been…

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Clustering, Spatial Correlations, and Randomization Inference

聚类、空间相关与随机化推断

It is a standard practice in regression analyses to allow for clustering in the error covariance matrix if the explanatory variable of interest varies at a more aggregate level (e.g., the state level) than the units of observation (e.g., individuals). Often, however, the structure of the error covariance matrix is more complex, with correlations not vanishing for units in different clusters. Here, we explore the implications of such correlations for the actual and estimated…

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Estimating Regression Parameters in an Extended Proportional Odds Model

扩展比例优势模型中的回归参数估计

The proportional odds model may serve as a useful alternative to the Cox proportional hazards model to study association between covariates and their survival functions in medical studies. In this article, we study an extended proportional odds model that incorporates the so-called "external" time-varying covariates. In the extended model, regression parameters have a direct interpretation of comparing survival functions, without specifying the baseline survival odds…

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Estimating Space and Space-Time Covariance Functions for Large Data Sets: A Weighted Composite Likelihood Approach

大型数据集的空间与时空协方差估计:加权复合似然方法

In this article, we propose two methods for estimating space and space-time covariance functions from a Gaussian random field, based on the composite likelihood idea. The first method relies on the maximization of a weighted version of the composite likelihood function, while the second one is based on the solution of a weighted composite score equation. This last scheme is quite general and could be applied to any kind of composite likelihood. An information criterion for…

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A Semiparametric Approach to Dimension Reduction

降维问题的半参数方法

We provide a novel and completely different approach to dimension-reduction problems from the existing literature. We cast the dimension-reduction problem in a semiparametric estimation framework and derive estimating equations. Viewing this problem from the new angle allows us to derive a rich class of estimators, and obtain the classical dimension reduction techniques as special cases in this class. The semiparametric approach also reveals that in the inverse regression…

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Multiple Imputation for M -Regression With Censored Covariates

协变量受删失时 M 回归的多重插补

We develop a new multiple imputation approach for M-regression models with censored covariates. Instead of specifying parametric likelihoods, our method imputes the censored covariates by their conditional quantiles given the observed data, where the conditional quantiles are estimated through fitting a censored quantile regression process. The resulting estimator is shown to be consistent and asymptotically normal, and it improves the estimation efficiency by using…

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One-Sided and Two-Sided Tolerance Intervals in General Mixed and Random Effects Models Using Small-Sample Asymptotics

一般混合与随机效应模型中基于小样本渐近的单侧及双侧容忍区间

The computation of tolerance intervals in mixed and random effects models has not been satisfactorily addressed in a general setting when the data are unbalanced and/or when covariates are present. This article derives satisfactory one-sided and two-sided tolerance intervals in such a general scenario, by applying small-sample asymptotic procedures. In the case of one-sided tolerance limits, the problem reduces to the interval estimation of a percentile, and accurate…

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Recursively Imputed Survival Trees

递归插补生存树

We propose recursively imputed survival tree (RIST) regression for right-censored data. This new nonparametric regression procedure uses a novel recursive imputation approach combined with extremely randomized trees that allows significantly better use of censored data than previous tree based methods, yielding improved model fit and reduced prediction error. The proposed method can also be viewed as a type of Monte Carlo EM algorithm which generates extra diversity in the…

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Vast Volatility Matrix Estimation Using High-Frequency Data for Portfolio Selection

利用高频数据估计大规模波动率矩阵以进行组合选择

Portfolio allocation with gross-exposure constraint is an effective method to increase the efficiency and stability of selected portfolios among a vast pool of assets, as demonstrated in Fan et al (2008). The required high-dimensional volatility matrix can be estimated by using high frequency financial data. This enables us to better adapt to the local volatilities and local correlations among vast number of assets and to increase significantly the sample size for estimating…

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Quantile Regression for Analyzing Heterogeneity in Ultra-High Dimension

用于分析超高维异质性的分位数回归

Ultra-high dimensional data often display heterogeneity due to either heteroscedastic variance or other forms of non-location-scale covariate effects. To accommodate heterogeneity, we advocate a more general interpretation of sparsity which assumes that only a small number of covariates influence the conditional distribution of the response variable given all candidate covariates; however, the sets of relevant covariates may differ when we consider different segments of the…

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Semiparametric Double Balancing Score Estimation for Incomplete Data With Ignorable Missingness

可忽略缺失数据的半参数双平衡得分估计

When estimating the marginal mean response with missing observations, a critical issue is robustness to model misspecification. In this article, we propose a semiparametric estimation method with extended double robustness that attains the optimal efficiency under less stringent requirement for model specifications than the doubly robust estimators. In this semiparametric estimation, covariate information is collapsed into a two-dimensional score S, with one dimension for…

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Bootstrapping for Significance of Compact Clusters in Multidimensional Datasets

多维数据中紧凑聚类显著性的自助法评估

This article proposes a bootstrap approach for assessing significance in the clustering of multidimensional datasets. The procedure compares two models and declares the more complicated model a better candidate if there is significant evidence in its favor. The performance of the procedure is illustrated on two well-known classification datasets and comprehensively evaluated in terms of its ability to estimate the number of components via extensive simulation studies, with…

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Block Bootstraps for Time Series With Fixed Regressors

固定回归变量时间序列的区块自助法

This article examines block bootstrap methods in linear regression models with weakly dependent error variables and nonstochastic regressors. Contrary to intuition, the tapered block bootstrap (TBB) with a smooth taper not only loses its superior bias properties but may also fail to be consistent in the regression problem. A similar problem, albeit at a smaller scale, is shown to exist for the moving and the circular block bootstrap (MBB and CBB, respectively). As a remedy,…

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Modeling Nonstationary Processes Through Dimension Expansion

通过维度扩展建模非平稳空间过程

In this article, we propose a novel approach to modeling nonstationary spatial fields. The proposed method works by expanding the geographic plane over which these processes evolve into higher-dimensional spaces, transforming and clarifying complex patterns in the physical plane. By combining aspects of multidimensional scaling, group lasso, and latent variable models, a dimensionally sparse projection is found in which the originally nonstationary field exhibits…

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Information Ratio Test for Model Misspecification in Quasi-Likelihood Inference

拟似然推断中检验模型错设的信息比率检验

In this article, we focus on the circumstances in quasi-likelihood inference that the estimation accuracy of mean structure parameters is guaranteed by correct specification of the first moment, but the estimation efficiency could be diminished due to misspecification of the second moment. We propose an information ratio (IR) statistic to test for model misspecification of the variance/covariance structure through a comparison between two forms of information matrix: the…

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Likelihood-Based Selection and Sharp Parameter Estimation

基于似然的变量选择与精确参数估计

In high-dimensional data analysis, feature selection becomes one means for dimension reduction, which proceeds with parameter estimation. Concerning accuracy of selection and estimation, we study nonconvex constrained and regularized likelihoods in the presence of nuisance parameters. Theoretically, we show that constrained L(0)-likelihood and its computational surrogate are optimal in that they achieve feature selection consistency and sharp parameter estimation, under one…

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Cross-Dimensional Inference of Dependent High-Dimensional Data

依赖高维数据的跨维度推断

A growing number of modern scientific problems in areas such as genomics, neurobiology, and spatial epidemiology involve the measurement and analysis of thousands of related features that may be stochastically dependent at arbitrarily strong levels. In this work, we consider the scenario where the features follow a multivariate Normal distribution. We demonstrate that dependence is manifested as random variation shared among features, and that standard methods may yield…

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Estimation of Copula Models With Discrete Margins via Bayesian Data Augmentation

通过贝叶斯数据增广估计离散边际 Copula 模型

Estimation of copula models with discrete margins can be difficult beyond the bivariate case. We show how this can be achieved by augmenting the likelihood with continuous latent variables, and computing inference using the resulting augmented posterior. To evaluate this, we propose two efficient Markov chain Monte Carlo sampling schemes. One generates the latent variables as a block using a Metropolis–Hastings step with a proposal that is close to its target distribution,…

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Sparse Estimation of Conditional Graphical Models With Application to Gene Networks

条件图模型的稀疏估计及其基因网络应用

In many applications the graph structure in a network arises from two sources: intrinsic connections and connections due to external effects. We introduce a sparse estimation procedure for graphical models that is capable of isolating the intrinsic connections by removing the external effects. Technically, this is formulated as a conditional graphical model, in which the external effects are modeled as predictors, and the graph is determined by the conditional precision…

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Bayesian Estimation and Prediction for Inhomogeneous Spatiotemporal Log-Gaussian Cox Processes Using Low-Rank Models, With Application to Criminal Surveillance

基于低秩模型的非齐次时空对数高斯 Cox 过程贝叶斯估计与预测:犯罪监测应用

In this article, we propose a method for conducting likelihood-based inference for a class of nonstationary spatiotemporal log-Gaussian Cox processes. The method uses convolution-based models to capture spatiotemporal correlation structure, is computationally feasible even for large datasets, and does not require knowledge of the underlying spatial intensity of the process. We describe an application to a surveillance system for detecting emergent spatiotemporal clusters of…

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Interim Design Modifications in Time-to-Event Studies

事件时间研究中的期中设计修改

We propose a flexible method for interim design modifications in time-to-event studies. With this method, it is possible to inspect the data at any time during the course of the study, without the need for prespecification of a learning phase, and to make certain types of design modifications depending on the interim data without compromising the Type I error risk. The method can be applied to studies designed with a conventional statistical test, fixed sample, or group…

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Sliced Latin Hypercube Designs

切片拉丁超立方设计

This article proposes a method for constructing a new type of space-filling design, called a sliced Latin hypercube design, intended for running computer experiments. Such a design is a special Latin hypercube design that can be partitioned into slices of smaller Latin hypercube designs. It is desirable to use the constructed designs for collective evaluations of computer models and ensembles of multiple computer models. The proposed construction method is easy to implement,…

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Partially Hidden Markov Model for Time-Varying Principal Stratification in HIV Prevention Trials

HIV预防试验中时变主分层的部分隐马尔可夫模型

It is frequently of interest to estimate the intervention effect that adjusts for post-randomization variables in clinical trials. In the recently completed HPTN 035 trial, there is differential condom use between the three microbicide gel arms and the No Gel control arm, so that intention to treat (ITT) analyses only assess the net treatment effect that includes the indirect treatment effect mediated through differential condom use. Various statistical methods in causal…

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Modeling Waves of Extreme Temperature: The Changing Tails of Four Cities

极端温度波动建模:四座城市变化中的尾部

Heat waves are a serious threat to society, the environment, and the economy. Estimates of the recurrence probabilities of heat waves may be obtained following the successful modeling of daily maximum temperature, but working with the latter is difficult as we have to recognize, and allow for, not only a time trend but also seasonality in the mean and in the variability, as well as serial correlation. Furthermore, as the extreme values of daily maximum temperature have a…

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