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分位数关联回归模型AI 解读

It is often important to study the association between two continuous variables. In this work, we propose a novel regression framework for assessing conditional associations on quantiles. We develop general methodology which permits covariate effects on both the marginal quantile models for the two variables and their quantile associations. The proposed quantile copula models have straightforward interpretation, facilitating a comprehensive view of association structure…

识别个体多发性硬化患者 MRI 病灶计数的异常增加AI 解读

Data Safety and Monitoring Boards (DSMBs) for multiple sclerosis clinical trials consider an increase of contrast-enhancing lesions on repeated magnetic resonance imaging an indicator for potential adverse events. However, there are no published studies that clearly identify what should be considered an “unexpected increase” of lesion activity for a patient. To address this problem, we consider as an index the likelihood of observing lesion counts as large as those observed…

高维元椭圆数据的尺度不变稀疏主成分分析AI 解读

We propose a semiparametric method for conducting scale-invariant sparse principal component analysis (PCA) on high dimensional non-Gaussian data. Compared with sparse PCA, our method has weaker modeling assumption and is more robust to possible data contamination. Theoretically, the proposed method achieves a parametric rate of convergence in estimating the parameter of interests under a flexible semiparametric distribution family; Computationally, the proposed method…

存在干扰时因果效应的大样本随机化推断AI 解读

Recently, increasing attention has focused on making causal inference when interference is possible. In the presence of interference, treatment may have several types of effects. In this paper, we consider inference about such effects when the population consists of groups of individuals where interference is possible within groups but not between groups. A two stage randomization design is assumed where in the first stage groups are randomized to different treatment…

利用正交条件估计常微分方程参数AI 解读

Differential equations are commonly used to model dynamical deterministic systems in applications. When statistical parameter estimation is required to calibrate theoretical models to data, classical statistical estimators are often confronted to complex and potentially ill-posed optimization problem. As a consequence, alternative estimators to classical parametric estimators are needed for obtaining reliable estimates. We propose a gradient matching approach for the…

两阶段队列研究中半参数变换模型的有效估计AI 解读

Under two-phase cohort designs, such as case-cohort and nested case-control sampling, information on observed event times, event indicators, and inexpensive covariates is collected in the first phase, and the first-phase information is used to select subjects for measurements of expensive covariates in the second phase; inexpensive covariates are also used in the data analysis to control for confounding and to evaluate interactions. This paper provides efficient estimation…

随机临床试验中生存率与治疗效应的界标估计AI 解读

In many studies with a survival outcome, it is often not feasible to fully observe the primary event of interest. This often leads to heavy censoring and thus, difficulty in efficiently estimating survival or comparing survival rates between two groups. In certain diseases, baseline covariates and the event time of nonfatal intermediate events may be associated with overall survival. In these settings, incorporating such additional information may lead to gains in efficiency…

单位区间核密度估计的Probit变换方法AI 解读

Kernel estimation of a probability density function supported on the unit interval has proved difficult, because of the well-known boundary bias issues a conventional kernel density estimator would necessarily face in this situation. Transforming the variable of interest into a variable whose density has unconstrained support, estimating that density, and obtaining an estimate of the density of the original variable through back-transformation, seems a natural idea to easily…

高维回归的模型平均方法AI 解读

This article considers high-dimensional regression problems in which the number of predictors p exceeds the sample size n. We develop a model-averaging procedure for high-dimensional regression problems. Unlike most variable selection studies featuring the identification of true predictors, our focus here is on the prediction accuracy for the true conditional mean of y given the p predictors. Our method consists of two steps. The first step is to construct a class of…

基于梯度的核回归充分降维AI 解读

This article proposes a novel approach to linear dimension reduction for regression using nonparametric estimation with positive-definite kernels or reproducing kernel Hilbert spaces (RKHSs). The purpose of the dimension reduction is to find such directions in the explanatory variables that explain the response sufficiently: this is called sufficient dimension reduction. The proposed method is based on an estimator for the gradient of the regression function considered for…

分位数回归模型的贝叶斯信息准则选择AI 解读

Bayesian information criterion (BIC) is known to identify the true model consistently as long as the predictor dimension is finite. Recently, its moderate modifications have been shown to be consistent in model selection even when the number of variables diverges. Those works have been done mostly in mean regression, but rarely in quantile regression. The best-known results about BIC for quantile regression are for linear models with a fixed number of variables. In this…

二次距离拟合优度检验的核、自由度与功效性质AI 解读

In this article, we study the power properties of quadratic-distance-based goodness-of-fit tests.First, we introduce the concept of a root kernel and discuss the considerations that enter the selection of this kernel.We derive an easy to use normal approximation to the power of quadratic distance goodness-of-fit tests and base the construction of a noncentrality index, an analogue of the traditional noncentrality parameter, on it.This leads to a method akin to the…

正误差自回归过程的预测器选择AI 解读

Let observations y1, …, yn be generated from a first-order autoregressive (AR) model with positive errors. In both the stationary and unit root cases, we derive moment bounds and limiting distributions of an extreme value estimator, , of the AR coefficient. These results enable us to provide asymptotic expressions for the mean squared error (MSE) of and the mean squared prediction error (MSPE) of the corresponding predictor, , of yn + 1. Based on these expressions, we…

允许多领域归属的多结果贝叶斯模型：塞舌尔儿童发展研究AI 解读

The Seychelles Child Development Study (SCDS) examines the effects of prenatal exposure to methylmercury on the functioning of the central nervous system. The SCDS data include 20 outcomes measured on 9-year old children that can be classified broadly in four outcome classes or "domains": cognition, memory, motor, and social behavior. Previous analyses and scientific theory suggest that these outcomes may belong to more than one of these domains, rather than only a single…

广义线性模型中均值与误差分布的联合估计AI 解读

This article introduces a semiparametric extension of generalized linear models that is based on a full probability model, but does not require specification of an error distribution or variance function for the data. The approach involves treating the error distribution as an infinite-dimensional parameter, which is then estimated simultaneously with the mean-model parameters using a maximum empirical likelihood approach. The resulting estimators are shown to be consistent…

降秩惩罚样条平滑的边际方法及其多层函数数据应用AI 解读

Multilevel functional data is collected in many biomedical studies. For example, in a study of the effect of Nimodipine on patients with subarachnoid hemorrhage (SAH), patients underwent multiple 4-hour treatment cycles. Within each treatment cycle, subjects' vital signs were reported every 10 minutes. This data has a natural multilevel structure with treatment cycles nested within subjects and measurements nested within cycles. Most literature on nonparametric analysis of…

嵌套病例对照研究中的推断重抽样程序AI 解读

The nested case-control (NCC) design have been widely adopted as a cost-effective solution in many large cohort studies for risk assessment with expensive markers, such as the emerging biologic and genetic markers. To analyze data from NCC studies, conditional logistic regression (Goldstein and Langholz, 1992; Borgan et al., 1995) and maximum likelihood (Scheike and Juul, 2004; Zeng et al., 2006) based methods have been proposed. However, most of these methods either cannot…

时间序列的渐进分块经验似然方法AI 解读

This article develops a new blockwise empirical likelihood (BEL) method for stationary, weakly dependent time processes, called the progressive block empirical likelihood (PBEL). In contrast to the standard version of BEL, which uses data blocks of constant length for a given sample size and whose performance can depend crucially on the block length selection, this new approach involves a data-blocking scheme where blocks increase in length by an arithmetic progression.…

通过嵌套高斯过程实现局部自适应贝叶斯非参数回归AI 解读

We propose a nested Gaussian process (nGP) as a locally adaptive prior for Bayesian nonparametric regression. Specified through a set of stochastic differential equations (SDEs), the nGP imposes a Gaussian process prior for the function’s mth-order derivative. The nesting comes in through including a local instantaneous mean function, which is drawn from another Gaussian process inducing adaptivity to locally varying smoothness. We discuss the support of the nGP prior in…

通过递归混合建模进行条件关联的自适应检验AI 解读

In many case-control studies, a central goal is to test for association or dependence between the predictors and the response. Relevant covariates must be conditioned on to avoid false positives and loss in power. Conditioning on covariates is easy in parametric frameworks such as the logistic regression—by incorporating the covariates into the model as additional variables. In contrast, nonparametric methods such as the Cochran-Mantel-Haenszel test accomplish conditioning…

含长期存活群体的删失数据治愈率分位数回归AI 解读

Censored quantile regression offers a valuable complement to the traditional Cox proportional hazards model for survival analysis. Survival times tend to be right-skewed, particularly when there exists a substantial fraction of long-term survivors who are either cured or immune to the event of interest. For survival data with a cure possibility, we propose cure rate quantile regression under the common censoring scheme that survival times and censoring times are…

一般列联表模型的广义残差及其项目反应理论应用AI 解读

Generalized residuals are a tool employed in the analysis of contingency tables to examine possible sources of model error. They have typically been applied to log-linear models and to latent-class models. A general approach to generalized residuals is developed for a very general class of models for contingency tables. To illustrate their use, generalized residuals are applied to models based on item response theory (IRT) models. Such models are commonly applied to analysis…

上位作用聚类：识别簇间联系的模型方法AI 解读

Most clustering methods assume that the data can be represented by mutually exclusive clusters, although this assumption may not be the case in practice. For example, in gene expression microarray studies, investigators have often found that a gene can play multiple functions in a cell and may, therefore, belong to more than one cluster simultaneously, and that gene clusters can be linked to each other in certain pathways. This article examines the effect of the above…

控制错误发现率的两阶段自适应多重检验与组合检验AI 解读

Testing multiple null hypotheses in two stages to decide which of these can be rejected or accepted at the first stage and which should be followed up for further testing having had additional observations is of importance in many scientific studies. We develop two procedures, each with two different combination functions, Fisher's and Simes’, to combine p-values from two stages, given prespecified boundaries on the first-stage p-values in terms of the false discovery rate…