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Decomposing Treatment Effect Variation

处理效应变异的分解

Understanding and characterizing treatment effect variation in randomized experiments has become essential for going beyond the “black box” of the average treatment effect. Nonetheless, traditional statistical approaches often ignore or assume away such variation. In the context of randomized experiments, this article proposes a framework for decomposing overall treatment effect variation into a systematic component explained by observed covariates and a remaining…

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Weighted NPMLE for the Subdistribution of a Competing Risk

竞争风险子分布的加权非参数极大似然估计

Direct regression modeling of the subdistribution has become popular for analyzing data with multiple, competing event types. All general approaches so far are based on non-likelihood based procedures and target covariate effects on the subdistribution. We introduce a novel weighted likelihood function that allows for a direct extension of the Fine-Gray model to a broad class of semiparametric regression models. The model accommodates time-dependent covariate effects on the…

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Modeling Spatial Processes with Unknown Extremal Dependence Class

极端依赖类别未知的空间过程建模

Many environmental processes exhibit weakening spatial dependence as events become more extreme. Well-known limiting models, such as max-stable or generalized Pareto processes, cannot capture this, which can lead to a preference for models that exhibit a property known as asymptotic independence. However, weakening dependence does not automatically imply asymptotic independence, and whether the process is truly asymptotically (in)dependent is usually far from clear. The…

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Information-Based Optimal Subdata Selection for Big Data Linear Regression

大数据线性回归中基于信息的最优子数据选择

Extraordinary amounts of data are being produced in many branches of science. Proven statistical methods are no longer applicable with extraordinary large datasets due to computational limitations. A critical step in big data analysis is data reduction. Existing investigations in the context of linear regression focus on subsampling-based methods. However, not only is this approach prone to sampling errors, it also leads to a covariance matrix of the estimators that is…

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Accurate and Efficient P -value Calculation Via Gaussian Approximation: A Novel Monte-Carlo Method

通过高斯近似高效准确计算 p 值:一种蒙特卡洛方法

It is of fundamental interest in statistics to test the significance of a set of covariates. For example, in genome-wide association studies, a joint null hypothesis of no genetic effect is tested for a set of multiple genetic variants. The minimum p-value method, higher criticism, and Berk–Jones tests are particularly effective when the covariates with nonzero effects are sparse. However, the correlations among covariates and the nonGaussian distribution of the response…

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Partially Linear Functional Additive Models for Multivariate Functional Data

多元函数型数据的部分线性函数型可加模型

Raymond K. W. Wonga, Yehua Lib* http://orcid.org/0000-0002-5945-378X & Zhengyuan Zhuca Department of Statistics, Texas A&M University, College Station, TXb Department of Statistics, University of California, Riverside, CAc Department of Statistics & Statistical Laboratory, Iowa State University, Ames, IACONTACT Yehua Li yehuali@ucr.edu Department of Statistics, University of California, Riverside, CA 92521Color versions of one or more of the figures in the article can be…

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Robust Variable and Interaction Selection for Logistic Regression and General Index Models

逻辑回归与一般指数模型的稳健变量及交互项选择

Under the logistic regression framework, we propose a forward-backward method, SODA, for variable selection with both main and quadratic interaction terms. In the forward stage, SODA adds in predictors that have significant overall effects, whereas in the backward stage SODA removes unimportant terms to optimize the extended Bayesian Information Criterion (EBIC). Compared with existing methods for variable selection in quadratic discriminant analysis, SODA can deal with…

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Principal Component Analysis of High-Frequency Data

高频数据的主成分分析

We develop the necessary methodology to conduct principal component analysis at high frequency. We construct estimators of realized eigenvalues, eigenvectors, and principal components, and provide the asymptotic distribution of these estimators. Empirically, we study the high-frequency covariance structure of the constituents of the S&P 100 Index using as little as one week of high-frequency data at a time, and examines whether it is compatible with the evidence accumulated…

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Bayesian Graphical Regression

贝叶斯图回归

We consider the problem of modeling conditional independence structures in heterogeneous data in the presence of additional subject-level covariates - termed Graphical Regression. We propose a novel specification of a conditional (in)dependence function of covariates - which allows the structure of a directed graph to vary flexibly with the covariates; imposes sparsity in both edge and covariate selection; produces both subject-specific and predictive graphs; and is…

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Matrix Completion With Covariate Information

结合协变量信息的矩阵补全

This article investigates the problem of matrix completion from the corrupted data, when the additional covariates are available. Despite being seldomly considered in the matrix completion literature, these covariates often provide valuable information for completing the unobserved entries of the high-dimensional target matrix A0. Given a covariate matrix X with its rows representing the row covariates of A0, we consider a column-space-decomposition model A0 = Xβ0 + B0,…

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Fisher Exact Scanning for Dependency

用于依赖关系检验的 Fisher 精确扫描

We introduce a method—called Fisher exact scanning (FES)—for testing and identifying variable dependency that generalizes Fisher’s exact test on 2 × 2 contingency tables to R × C contingency tables and continuous sample spaces. FES proceeds through scanning over the sample space using windows in the form of 2 × 2 tables of various sizes, and on each window completing a Fisher’s exact test. Based on a factorization of Fisher’s multivariate hypergeometric (MHG) likelihood into…

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Confidence Sets for Phylogenetic Trees

系统发育树的置信集合

Inferring evolutionary histories (phylogenetic trees) has important applications in biology, criminology, and public health. However, phylogenetic trees are complex mathematical objects that reside in a non-Euclidean space, which complicates their analysis. While our mathematical, algorithmic, and probabilistic understanding of phylogenies in their metric space is mature, rigorous inferential infrastructure is as yet undeveloped. In this manuscript, we unify recent…

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Least Ambiguous Set-Valued Classifiers With Bounded Error Levels

误差水平受限下歧义最小的集合值分类器

In most classification tasks, there are observations that are ambiguous and therefore difficult to correctly label. Set-valued classifiers output sets of plausible labels rather than a single label, thereby giving a more appropriate and informative treatment to the labeling of ambiguous instances. We introduce a framework for multiclass set-valued classification, where the classifiers guarantee user-defined levels of coverage or confidence (the probability that the true…

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Changepoint Detection in the Presence of Outliers

存在异常值时的变点检测

Many traditional methods for identifying changepoints can struggle in the presence of outliers, or when the noise is heavy-tailed. Often they will infer additional changepoints to fit the outliers. To overcome this problem, data often needs to be preprocessed to remove outliers, though this is difficult for applications where the data needs to be analyzed online. We present an approach to changepoint detection that is robust to the presence of outliers. The idea is to adapt…

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Simulation-Based Bias Correction Methods for Complex Models

复杂模型的基于模拟的偏差校正方法

Along with the ever increasing data size and model complexity, an important challenge frequently encountered in constructing new estimators or in implementing a classical one such as the maximum likelihood estimator, is the computational aspect of the estimation procedure. To carry out estimation, approximate methods such as pseudo-likelihood functions or approximated estimating equations are increasingly used in practice as these methods are typically easier to implement…

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Admissibility in Partial Conjunction Testing

部分合取检验中的可容许性

Meta-analysis combines results from multiple studies aiming to increase power in finding their common effect. It would typically reject the null hypothesis of no effect if any one of the studies shows strong significance. The partial conjunction null hypothesis is rejected only when at least r of n component hypotheses are nonnull with r = 1 corresponding to a usual meta-analysis. Compared with meta-analysis, it can encourage replicable findings across studies. A by-product…

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Diagnostic Checking in Multivariate ARMA Models With Dependent Errors Using Normalized Residual Autocorrelations

依赖误差下多元 ARMA 模型的诊断:标准化残差自相关方法

In this paper, we derive the asymptotic distribution of normalized residual empirical autocovariances and autocorrelations under weak assumptions on the noise. We propose new portmanteau statistics for vector autoregressive moving average models with uncorrelated but nonindependent innovations by using a self-normalization approach. We establish the asymptotic distribution of the proposed statistics. This asymptotic distribution is quite different from the usual chi-squared…

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Interpretable Dynamic Treatment Regimes

可解释的动态治疗方案

Precision medicine is currently a topic of great interest in clinical and intervention science. A key component of precision medicine is that it is evidence-based, i.e., data-driven, and consequently there has been tremendous interest in estimation of precision medicine strategies using observational or randomized study data. One way to formalize precision medicine is through a treatment regime, which is a sequence of decision rules, one per stage of clinical intervention,…

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A Nonparametric Graphical Model for Functional Data With Application to Brain Networks Based on fMRI

函数数据的非参数图模型及其功能磁共振脑网络应用

We introduce a nonparametric graphical model whose observations on vertices are functions. Many modern applications, such as electroencephalogram and functional magnetic resonance imaging (fMRI), produce data are of this type. The model is based on additive conditional independence (ACI), a statistical relation that captures the spirit of conditional independence without resorting to multi-dimensional kernels. The random functions are assumed to reside in a Hilbert space. No…

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Linear Hypothesis Testing in Dense High-Dimensional Linear Models

稠密高维线性模型中的线性假设检验

We propose a methodology for testing linear hypothesis in high-dimensional linear models. The proposed test does not impose any restriction on the size of the model, that is, model sparsity or the loading vector representing the hypothesis. Providing asymptotically valid methods for testing general linear functions of the regression parameters in high-dimensions is extremely challenging—especially without making restrictive or unverifiable assumptions on the number of…

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Efficient Estimation of the Nonparametric Mean and Covariance Functions for Longitudinal and Sparse Functional Data

纵向与稀疏函数数据中非参数均值和协方差函数的有效估计

We consider the estimation of mean and covariance functions for longitudinal and sparse functional data by using the full quasi-likelihood coupling a modification of the local kernel smoothing method. The proposed estimators are shown to be consistent, asymptotically normal, and semiparametrically efficient in terms of their linear functionals. Their superiority to the competitors is further illustrated numerically through simulation studies. The method is applied to analyze…

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Fast Moment Estimation for Generalized Latent Dirichlet Models

广义潜在 Dirichlet 模型的快速矩估计

We develop a generalized method of moments (GMM) approach for fast parameter estimation in a new class of Dirichlet latent variable models with mixed data types. Parameter estimation via GMM has computational and statistical advantages over alternative methods, such as expectation maximization, variational inference, and Markov chain Monte Carlo. A key computational advantage of our method, Moment Estimation for latent Dirichlet models (MELD), is that parameter estimation…

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Mixtures of g -Priors in Generalized Linear Models

广义线性模型中的 g 先验混合

Mixtures of Zellner’s g-priors have been studied extensively in linear models and have been shown to have numerous desirable properties for Bayesian variable selection and model averaging. Several extensions of g-priors to generalized linear models (GLMs) have been proposed in the literature; however, the choice of prior distribution of g and resulting properties for inference have received considerably less attention. In this article, we unify mixtures of g-priors in GLMs…

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A Bayesian Variable Selection Approach Yields Improved Detection of Brain Activation From Complex-Valued fMRI

复值功能磁共振成像脑激活检测的贝叶斯变量选择方法

Voxel functional magnetic resonance imaging (fMRI) time courses are complex-valued signals giving rise to magnitude and phase data. Nevertheless, most studies use only the magnitude signals and thus discard half of the data that could potentially contain important information. Methods that make use of complex-valued fMRI (CV-fMRI) data have been shown to lead to superior power in detecting active voxels when compared to magnitude-only methods, particularly for small…

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