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Quantile-Regression Inference With Adaptive Control of Size

自适应控制检验尺寸的分位数回归推断

Regression quantiles have asymptotic variances that depend on the conditional densities of the response variable given regressors. This article develops a new estimate of the asymptotic variance of regression quantiles that leads any resulting Wald-type test or confidence region to behave as well in large samples as its infeasible counterpart in which the true conditional response densities are embedded. We give explicit guidance on implementing the new variance estimator to…

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Extremiles: A New Perspective on Asymmetric Least Squares

Extremiles:非对称最小二乘的新视角

Quantiles and expectiles of a distribution are found to be useful descriptors of its tail in the same way as the median and mean are related to its central behavior. This article considers a valuable alternative class to expectiles, called extremiles, which parallels the class of quantiles and includes the family of expected minima and expected maxima. The new class is motivated via several angles, which reveals its specific merits and strengths. Extremiles suggest better…

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Covariate-Adjusted Tensor Classification in High Dimensions

高维协变量调整的张量分类

In contemporary scientific research, it is often of great interest to predict a categorical response based on a high-dimensional tensor (i.e., multi-dimensional array) and additional covariates. Motivated by applications in science and engineering, we propose a comprehensive and interpretable discriminant analysis model, called the CATCH model (short for covariate-adjusted tensor classification in high-dimensions). The CATCH model efficiently integrates the covariates and…

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Sparse Minimum Discrepancy Approach to Sufficient Dimension Reduction with Simultaneous Variable Selection in Ultrahigh Dimension

超高维充分降维与同步变量选择的稀疏最小差异方法

Sufficient dimension reduction (SDR) is known to be a powerful tool for achieving data reduction and data visualization in regression and classification problems. In this work, we study ultrahigh-dimensional SDR problems and propose solutions under a unified minimum discrepancy approach with regularization. When p grows exponentially with n, consistency results in both central subspace estimation and variable selection are established simultaneously for important SDR…

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Estimation and Identification of a Varying-Coefficient Additive Model for Locally Stationary Processes

局部平稳过程变系数可加模型的估计与模型识别

The additive model and the varying-coefficient model are both powerful regression tools, with wide practical applications. However, our empirical study on a financial data has shown that both of these models have drawbacks when applied to locally stationary time series. For the analysis of functional data, Zhang and Wang have proposed a flexible regression method, called the varying-coefficient additive model (VCAM), and presented a two-step spline estimation method.…

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Toward Computerized Efficient Estimation in Infinite-Dimensional Models

迈向无限维模型中的计算机化有效估计

Despite the risk of misspecification they are tied to, parametric models continue to be used in statistical practice because they are simple and convenient to use. In particular, efficient estimation procedures in parametric models are easy to describe and implement. Unfortunately, the same cannot be said of semiparametric and nonparametric models. While the latter often reflect the level of available scientific knowledge more appropriately, performing efficient inference in…

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Semiparametric Regression Analysis of Multiple Right- and Interval-Censored Events

多个右删失与区间删失事件的半参数回归分析

Health sciences research often involves both right- and interval-censored events because the occurrence of a symptomatic disease can only be observed up to the end of follow-up, while the occurrence of an asymptomatic disease can only be detected through periodic examinations. We formulate the effects of potentially time-dependent covariates on the joint distribution of multiple right- and interval-censored events through semiparametric proportional hazards models with…

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New Tests for Equality of Several Covariance Functions for Functional Data

多个函数总体协方差函数相等性的新检验

In this article, we propose two new tests for the equality of the covariance functions of several functional populations, namely, a quasi-GPF test and a quasi-Fmax test whose test statistics are obtained via globalizing a pointwise quasi-F-test statistic with integration and taking its supremum over some time interval of interest, respectively. Unlike several existing tests, they are scale-invariant in the sense that their test statistics will not change if we multiply each…

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Bayesian Regularization for Graphical Models With Unequal Shrinkage

具有差异化收缩的图模型贝叶斯正则化

We consider a Bayesian framework for estimating a high-dimensional sparse precision matrix, in which adaptive shrinkage and sparsity are induced by a mixture of Laplace priors. Besides discussing our formulation from the Bayesian standpoint, we investigate the MAP (maximum a posteriori) estimator from a penalized likelihood perspective that gives rise to a new nonconvex penalty approximating the ℓ0 penalty. Optimal error rates for estimation consistency in terms of various…

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Covariate-Adjusted Regression for Distorted Longitudinal Data With Informative Observation Times

信息性观测时点下畸变纵向数据的协变量调整回归

In many longitudinal studies, repeated response and predictors are not directly observed, but can be treated as distorted by unknown functions of a common confounding covariate. Moreover, longitudinal data involve an observation process which may be informative with a longitudinal response process in practice. To deal with such complex data, we propose a class of flexible semiparametric covariate-adjusted joint models. The new models not only allow for the longitudinal…

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Skinny Gibbs: A Consistent and Scalable Gibbs Sampler for Model Selection

Skinny Gibbs:一致且可扩展的模型选择 Gibbs 采样器

Naveen N. Narisettya, Juan Shenb* & Xuming Heca Department of Statistics, University of Illinois at Urbana-Champaign, Champaign, ILb Department of Statistics, Fudan University, Shanghai, Chinac Department of Statistics, University of Michigan, Ann Arbor, MICONTACT Juan Shen shenjuan@fudan.edu.cn Department of Statistics, Fudan University, Shanghai, ChinaColor versions of one or more of the figures in the article can be found online at www.tandfonline.com/r/JASA.Supplementary…

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Minimax Estimation of the Volume of a Set Under the Rolling Ball Condition

滚动球条件下集合体积的极小极大估计

We consider the problem of estimating the volume of a compact domain in a Euclidean space based on a uniform sample from the domain. We assume that the domain has a boundary with positive reach. We propose a data-splitting approach to correct the bias of the plug-in estimator based on the sample α-convex hull. We show that this simple estimator achieves a minimax lower bound that we derive. Some numerical experiments corroborate our theoretical findings. Supplementary…

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A Bayesian Hierarchical Summary Receiver Operating Characteristic Model for Network Meta-Analysis of Diagnostic Tests

诊断试验网络荟萃分析的贝叶斯层级汇总ROC模型

In studies evaluating the accuracy of diagnostic tests, three designs are commonly used, crossover, randomized, and non-comparative. Existing methods for meta-analysis of diagnostic tests mainly consider the simple cases in which the reference test in all or none of the studies can be considered a gold standard test, and in which all studies use either a randomized or non-comparative design. The proliferation of diagnostic instruments and the diversity of study designs…

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Factor and Idiosyncratic Empirical Processes

因子成分与特异成分的经验过程

The distributions of the common and idiosyncratic components for an individual variable are important in forecasting and applications. However, they are not identified with low-dimensional observations. Using the recently developed theory for large dimensional approximate factor model for large panel data, the common and idiosyncratic components can be estimated consistently. Based on the estimated common and idiosyncratic components, we construct the empirical processes for…

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Frequentist Consistency of Variational Bayes

变分贝叶斯的频率学一致性

A key challenge for modern Bayesian statistics is how to perform scalable inference of posterior distributions. To address this challenge, variational Bayes (VB) methods have emerged as a popular alternative to the classical Markov chain Monte Carlo (MCMC) methods. VB methods tend to be faster while achieving comparable predictive performance. However, there are few theoretical results around VB. In this article, we establish frequentist consistency and asymptotic normality…

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Robust Bayesian Inference via Coarsening

通过粗化实现稳健贝叶斯推断

The standard approach to Bayesian inference is based on the assumption that the distribution of the data belongs to the chosen model class. However, even a small violation of this assumption can have a large impact on the outcome of a Bayesian procedure. We introduce a novel approach to Bayesian inference that improves robustness to small departures from the model: rather than conditioning on the event that the observed data are generated by the model, one conditions on the…

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Meta-Analysis of Mid- p -Values: Some New Results based on the Convex Order

基于凸序的 mid-p 值元分析新结果

The mid-p-value is a proposed improvement on the ordinary p-value for the case where the test statistic is partially or completely discrete. In this case, the ordinary p-value is conservative, meaning that its null distribution is larger than a uniform distribution on the unit interval, in the usual stochastic order. The mid-p-value is not conservative. However, its null distribution is dominated by the uniform distribution in a different stochastic order, called the convex…

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Fully Bayesian Analysis of RNA-seq Counts for the Detection of Gene Expression Heterosis

用于检测基因表达杂种优势的RNA-seq计数全贝叶斯分析

Heterosis, or hybrid vigor, is the enhancement of the phenotype of hybrid progeny relative to their inbred parents. Heterosis is extensively used in agriculture, and the underlying mechanisms are unclear. To investigate the molecular basis of phenotypic heterosis, researchers search tens of thousands of genes for heterosis with respect to expression in the transcriptome. Difficulty arises in the assessment of heterosis due to composite null hypotheses and non-uniform…

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Batch Effects Correction with Unknown Subtypes

未知亚型情况下的批次效应校正

High-throughput experimental data are accumulating exponentially in public databases. Unfortunately, however, mining valid scientific discoveries from these abundant resources is hampered by technical artifacts and inherent biological heterogeneity. The former are usually termed “batch effects,” and the latter is often modeled by subtypes. Existing methods either tackle batch effects provided that subtypes are known or cluster subtypes assuming that batch effects are absent.…

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Valid Post-Selection Inference in High-Dimensional Approximately Sparse Quantile Regression Models

高维近似稀疏分位数回归模型中的有效选择后推断

This work proposes new inference methods for a regression coefficient of interest in a (heterogeneous) quantile regression model. We consider a high-dimensional model where the number of regressors potentially exceeds the sample size but a subset of them suffice to construct a reasonable approximation to the conditional quantile function. The proposed methods are (explicitly or implicitly) based on orthogonal score functions that protect against moderate model selection…

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Communication-Efficient Distributed Statistical Inference

通信高效的分布式统计推断

We present a communication-efficient surrogate likelihood (CSL) framework for solving distributed statistical inference problems. CSL provides a communication-efficient surrogate to the global likelihood that can be used for low-dimensional estimation, high-dimensional regularized estimation, and Bayesian inference. For low-dimensional estimation, CSL provably improves upon naive averaging schemes and facilitates the construction of confidence intervals. For high-dimensional…

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Joint Indirect Standardization When Only Marginal Distributions are Observed in the Index Population

目标总体仅有边际分布时的联合间接标准化

It is a common interest in medicine to determine whether a hospital meets a benchmark created from an aggregate reference population, after accounting for differences in distributions of multiple covariates. Due to the difficulties of collecting individual-level data, however, it is often the case that only marginal distributions of the covariates are available, making covariate-adjusted comparison challenging. We propose and evaluate a novel approach for conducting indirect…

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Functional Data Analysis of Dynamic PET Data

动态正电子发射断层扫描数据的函数型分析

One application of positron emission tomography (PET), a nuclear imaging technique, in neuroscience involves in vivo estimation of the density of various proteins (often, neuroreceptors) in the brain. PET scanning begins with the injection of a radiolabeled tracer that binds preferentially to the target protein; tracer molecules are then continuously delivered to the brain via the bloodstream. By detecting the radioactive decay of the tracer over time, dynamic PET data are…

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Optimal Forecast Reconciliation for Hierarchical and Grouped Time Series Through Trace Minimization

通过迹最小化协调层级与分组时间序列预测

Large collections of time series often have aggregation constraints due to product or geographical groupings. The forecasts for the most disaggregated series are usually required to add-up exactly to the forecasts of the aggregated series, a constraint we refer to as “coherence.” Forecast reconciliation is the process of adjusting forecasts to make them coherent.The reconciliation algorithm proposed by Hyndman et al. (2011 Hyndman, R. J., Ahmed, R. A., Athanasopoulos, G.,…

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