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学习最优个体化治疗规则的改进双重稳健估计AI 解读

Individualized treatment rules (ITRs) recommend treatment according to patient characteristics. There is a growing interest in developing novel and efficient statistical methods in constructing ITRs. We propose an improved doubly robust estimator of the optimal ITRs. The proposed estimator is based on a direct optimization of an augmented inverse-probability weighted estimator (AIPWE) of the expected clinical outcome over a class of ITRs. The method enjoys two key…

利用纵向移动健康数据学习个性化干预策略AI 解读

Personalized policy represents a paradigm shift from one-decision-rule-for-all users to an individualized decision rule for each user. Developing personalized policy in mobile health applications imposes challenges. First, for lack of adherence, data from each user are limited. Second, unmeasured contextual factors can potentially impact on decision making. Aiming to optimize immediate rewards, we propose using a generalized linear mixed modeling framework where population…

内生性下最优治疗规则的半参数工具变量方法AI 解读

There is a fast-growing literature on estimating optimal treatment regimes based on randomized trials or observational studies under a key identifying condition of no unmeasured confounding. Because confounding by unmeasured factors cannot generally be ruled out with certainty in observational studies or randomized trials subject to noncompliance, we propose a general instrumental variable (IV) approach to learning optimal treatment regimes under endogeneity. Specifically,…

利用观察数据估计与验证比值型条件平均处理效应AI 解读

While sample sizes in randomized clinical trials are large enough to estimate the average treatment effect well, they are often insufficient for estimation of treatment-covariate interactions critical to studying data-driven precision medicine. Observational data from real world practice may play an important role in alleviating this problem. One common approach in trials is to predict the outcome of interest with separate regression models in each treatment arm, and…

情境老虎机在线决策中的统计推断AI 解读

Online decision making problem requires us to make a sequence of decisions based on incremental information. Common solutions often need to learn a reward model of different actions given the contextual information and then maximize the long-term reward. It is meaningful to know if the posited model is reasonable and how the model performs in the asymptotic sense. We study this problem under the setup of the contextual bandit framework with a linear reward model. The…

利用内部变差成像回归识别与言语推理相关的脑区AI 解读

Brain-imaging data have been increasingly used to understand intellectual disabilities. Despite significant progress in biomedical research, the mechanisms for most of the intellectual disabilities remain unknown. Finding the underlying neurological mechanisms has been proved difficult, especially in children due to the rapid development of their brains. We investigate verbal reasoning, which is a reliable measure of individuals' general intellectual abilities, and develop a…

将动物运动纳入距离抽样AI 解读

Distance sampling is a popular statistical method to estimate the density of wild animal populations. Conventional distance sampling represents animals as fixed points in space that are detected with an unknown probability that depends on the distance between the observer and the animal. Animal movement can cause substantial bias in density estimation. Methods to correct for responsive animal movement exist, but none account for nonresponsive movement independent of the…

稳健 Q 学习AI 解读

Q-learning is a regression-based approach that is widely used to formalize the development of an optimal dynamic treatment strategy. Finite dimensional working models are typically used to estimate certain nuisance parameters, and misspecification of these working models can result in residual confounding and/or efficiency loss. We propose a robust Q-learning approach which allows estimating such nuisance parameters using data-adaptive techniques. We study the asymptotic…

最优给药策略的双重稳健估计AI 解读

The goal of precision medicine is to tailor treatment strategies on an individual patient level. Although several estimation techniques have been developed for determining optimal treatment rules, the majority of methods focus on the case of a dichotomous treatment, an example being the dynamic weighted ordinary least squares regression approach of Wallace and Moodie. We propose an extension to the aforementioned framework to allow for a continuous treatment with the…

利用工具变量方法构建最优个体化决策规则AI 解读

There is an extensive literature on the estimation and evaluation of optimal individualized treatment rules in settings where all confounders of the effect of treatment on outcome are observed. We study the development of individualized decision rules in settings where some of these confounders may not have been measured but a valid binary instrument is available for a binary treatment. We first consider individualized treatment rules, which will naturally be most…

极端降水的层级最大无限可分空间模型AI 解读

Understanding the spatial extent of extreme precipitation is necessary for determining flood risk and adequately designing infrastructure (e.g., stormwater pipes) to withstand such hazards. While environmental phenomena typically exhibit weakening spatial dependence at increasingly extreme levels, limiting max-stable process models for block maxima have a rigid dependence structure that does not capture this type of behavior. We propose a flexible Bayesian model from a…

异质数据中基于协方差的样本选择及自闭症风险基因识别AI 解读

Risk for autism can be influenced by genetic mutations in hundreds of genes. Based on findings showing that genes with highly correlated gene expressions are functionally interrelated, "guilt by association" methods such as DAWN have been developed to identify these autism risk genes. Previous research analyze the BrainSpan dataset, which contains gene expression of brain tissues from varying regions and developmental periods. Since the spatiotemporal properties of brain…

三治疗组因果效应的三元匹配：创伤中心等级与死亡率比较AI 解读

Giovanni Nattinoa, Bo Lua*, Junxin Shib , Stanley Lemeshowa & Henry Xiangbca Division of Biostatistics, College of Public Health, The Ohio State University, Columbus, OHb Center for Pediatric Trauma Research, Center for Injury Research and Policy, Abigail Wexner Research Institute at Nationwide Children’s Hospital, Columbus, OHc College of Medicine, The Ohio State University, Columbus, OHSupplementary materials for this article are available online. Please go to…

存在未测量混杂时个体化治疗规则的选择与排序AI 解读

It is common to compare individualized treatment rules based on the value function, which is the expected potential outcome under the treatment rule. Although the value function is not point-identified when there is unmeasured confounding, it still defines a partial order among the treatment rules under Rosenbaum’s sensitivity analysis model. We first consider how to compare two treatment rules with unmeasured confounding in the single-decision setting and then use this…

基于智能电表数据的分层电力需求概率预测AI 解读

Decisions regarding the supply of electricity across a power grid must take into consideration the inherent uncertainty in demand. Optimal decision-making requires probabilistic forecasts for demand in a hierarchy with various levels of aggregation, such as substations, cities, and regions. The forecasts should be coherent in the sense that the forecast of the aggregated series should equal the sum of the forecasts of the corresponding disaggregated series. Coherency is…

对“高维回归的一种免调参、稳健且高效的方法”的讨论AI 解读

Despite considerable progress over the past two decades, a critical gap remains between the theory and applications of penalized estimation procedures for high-dimensional regression. On the one ha...

多元失效时间数据的统计分析：边际建模方法AI 解读

In large studies of public health interventions, individuals are typically at risk of many different types of events. Despite the multitude of events that may arise, a single failure time is often ...

高维回归中免手工调参的稳健高效方法AI 解读

We introduce a novel approach for high-dimensional regression with theoretical guarantees. The new procedure overcomes the challenge of tuning parameter selection of Lasso and possesses several appealing properties. It uses an easily simulated tuning parameter that automatically adapts to both the unknown random error distribution and the correlation structure of the design matrix. It is robust with substantial efficiency gain for heavy-tailed random errors while maintaining…

核方法与筛方法结合：稀疏可加模型正则化后的置信带AI 解读

Junwei Lua, Mladen Kolarb & Han Liuc Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA Booth School of Business, The University of Chicago, Chicago, IL Department of Computer Science, Northwestern University, Evanston, IL Supplementary materials for this article are available online. Please go to www.tandfonline.com/r/JASA. CONTACT Junwei Lu junweilu@hsph.harvard.edu Department of Biostatistics, Harvard T. H. Chan School of Public Health,…

利用树状收缩多结局回归估计细颗粒物与432种心血管疾病的关系AI 解读

The positive relationship between airborne fine particulate matter (PM2.5) and cardiovascular disease (CVD) is established. Little is known about effect size heterogeneity across distinct CVD outcomes. We conducted a multi-outcome case-crossover study of Medicare beneficiaries aged >65 years residing in the mainland USA from 2000 through 2012. The exposure was two-day average PM2.5 in each individual’s residential zipcode. The outcomes were hospitalization for 432 distinct…

基于 IVX-AR 模型检验美国住房价格指数收益的可预测性AI 解读

We use ten common macroeconomic variables to test for the predictability of the quarterly growth rate of house price index (HPI) in the United States during 1975:Q1–2018:Q2. We extend the instrumental variable based Wald statistic (IVX-KMS) proposed by Kostakis, Magdalinos, and Stamatogiannis to a new instrumental variable based Wald statistic (IVX-AR) which accounts for serial correlation and heteroscedasticity in the error terms of the linear predictive regression model.…

桥下的五个巨魔：异步且含噪高频数据的主成分分析AI 解读

We develop a principal component analysis (PCA) for high frequency data. As in Northern fairy tales, there are trolls waiting for the explorer. The first three trolls are market microstructure noise, asynchronous sampling times, and edge effects in estimators. To get around these, a robust estimator of the spot covariance matrix is developed based on the smoothed two-scale realized variance (S-TSRV). The fourth troll is how to pass from estimated time-varying covariance…

非可忽略未响应下的贝叶斯标量对图像回归AI 解读

Medical imaging has become an increasingly important tool in screening, diagnosis, prognosis, and treatment of various diseases given its information visualization and quantitative assessment. The aim of this article is to develop a Bayesian scalar-on-image regression model to integrate high-dimensional imaging data and clinical data to predict cognitive, behavioral, or emotional outcomes, while allowing for nonignorable missing outcomes. Such a nonignorable nonresponse…

合成控制方法所估平均处理效应的统计推断AI 解读

The synthetic control (SC) method, a powerful tool for estimating average treatment effects (ATE), is increasingly popular in fields such as statistics, economics, political science, and marketing. The SC is particularly suitable for estimating ATE with a single (or a few) treated unit(s), a fixed number of control units, and large pre and post-treatment periods (which we refer as “long panels”). To date, there has been no formal inference theory for SC ATE estimator with…