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Contrastive Learning on Multimodal Analysis of Electronic Health Records

电子健康记录多模态分析中的对比学习

Electronic health record (EHR) systems capture a wealth of multimodal clinical data, encompassing both structured clinical codes and unstructured clinical notes. Yet, many EHR-focused studies have traditionally examined these modalities in isolation or combined them using simplistic methods, overlooking the intrinsic synergy between them. In reality, these modalities are deeply interconnected, each containing clinically relevant and complementary information that, when…

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Extreme Value Statistics for General Heterogeneous Data through the Average Tail

通过平均分布尾部分析一般异质数据的极值统计

In the general setting of independent data with possibly very different distributions, extreme value estimators inevitably target the tail of the average distribution function. We consider all possible cases, that is, the extreme value index of the average distribution can be negative, zero, or positive, and we present novel asymptotic theory for the moment estimator. Our results require a different and much more challenging proof than those for the power-law case and are…

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A Semi-Parametric Model for Assessing the Effect of Temperature on Ice Accumulation Rate From Antarctic Ice Core Data

利用南极冰芯数据评估温度与冰积累速率的半参数模型

In this paper, we present a semiparametric model for describing the effect of temperature on Antarctic ice accumulation on a paleoclimatic time scale. The model is motivated by sharp ups and downs in the rate of ice accumulation apparent from ice core data records, which are synchronous with movements of temperature. We prove consistency of the estimators under reasonable conditions. We conduct extensive simulations to assess the performance of the estimators and their…

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GS-BART: Bayesian Additive Regression Trees with Graph-Split Decision Rules

GS-BART:采用图分裂决策规则的贝叶斯加性回归树

Ensemble decision tree methods such as XGBoost, Random Forest, and Bayesian Additive Regression Trees (BART) have gained enormous popularity in data science for their superior performance in machine learning regression and classification tasks. In this paper, we introduce a new Bayesian graph-split additive decision tree method, GS-BART, designed to enhance the performance of axis-parallel split-based BART for dependent data with graph structures. The proposed approach…

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Statistical Inference for Mediation Models with High Dimensional Exposures and Mediators

高维暴露与高维中介模型的统计推断

High-dimensional mediation analysis has gained increasing interest in various fields, particularly in genetic and medical research. Compared with existing works that focus mainly on high-dimensional mediators, this paper advocates a new framework of Partial Regularization-based Inference for Mediation Effects (PRIME) when both exposures and mediators are high-dimensional. Estimated direct and indirect effects are established using a group-wise partially penalized least…

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Tail Postcoloring in Long-Run Variance Estimation of Time Series

时间序列长期方差估计中的尾部后着色

Prewhitening is a common approach to deal with strong autocorrelation. In this article, we propose a new approach called tail postcoloring, motivated by it. It uses parametric models to project, or color back, the neglected tail autocovariances in nonparametric estimators onto the final estimator. This approach bridges the non-parametric variance estimator and the parametric coloring model through a scaling factor. It automatically switches between these two arms using a…

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Exact inference via quasi-conjugacy in two-parameter Poisson–Dirichlet hidden Markov models

双参数泊松–狄利克雷隐马尔可夫模型的准共轭精确推断

We introduce a nonparametric model for inferring time-evolving, unobserved probability distributions from discrete-time data consisting of unlabelled partitions. The latent process is a two-parameter Poisson–Dirichlet diffusion, and observations arise via exchangeable sampling. Applications include social and genetic data where only aggregate clustering summaries are observed.To address the intractable likelihood, we develop a tractable inferential framework that avoids…

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Inferences on Mixing Probabilities and Ranking in Mixed-Membership Models

混合成员模型中混合概率与排序的统计推断

Network data is prevalent in numerous big data applications, including economics and health networks, where understanding the latent structure of the network is of prime importance. In this paper, we model the network using the Degree-Corrected Mixed Membership (DCMM) model. In the DCMM model, for each node i, there exists a membership vector πi=(πi(1),πi(2),…,πi(K)), where πi(k) denotes the weight that node i puts in community k. We derive a novel finite-sample expansion…

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Robust Sliced Inverse Regression: Optimal Estimation for Heavy-Tailed Data in High Dimensions

稳健切片逆回归:高维重尾数据的最优估计

Sliced inverse regression (SIR) is a flexible modeling tool that effectively reduces dimensions to reveal the complicated mechanism behind data. In recent years, SIR has been generalized to high dimensions in a variety of ways. However, all existing methods rely on the light-tailed assumption for predictors, which is frequently violated in real life. To tackle ubiquitous heavy-tailed data, we propose a novel robust SIR method, referred to as ROSE, that scales well with high…

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Nonparametric Tests of Treatment Effect Homogeneity for Policy-Makers

面向政策制定者的处理效应同质性非参数检验

Recent work has focused on nonparametric estimation of conditional treatment effects, but inference has remained relatively unexplored. We propose a class of nonparametric tests for both quantitative and qualitative treatment effect heterogeneity. The tests can incorporate a variety of structured assumptions on the conditional average treatment effect, allow for both continuous and discrete covariates, and do not require sample splitting to obtain a tractable asymptotic null…

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Clustering Social Media Users Using Categorical-Valued Functional Data Analysis

使用类别值函数型数据分析聚类社交媒体用户

Social media provides more insight into consumer behavior than companies have ever had, and firms can interact with consumers on social media to increase their brand loyalty and address concerns they might have. However, it is critical for companies to evaluate whether the consumers they interact with have the potential to positively promote the firm. This can be challenging, especially when limited information is available about social media users. Our work proposes a…

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An Efficient Monte Carlo Method for Valid Prior-Free Possibilistic Statistical Inference

有效无先验可能性统计推断的高效蒙特卡洛方法

Inferential models (IMs) offer prior-free, Bayesian-like posterior degrees of belief designed for statistical inference, which feature a frequentist-like calibration property that ensures reliability of said inferences. The catch is that IMs’ degrees of belief are possibilistic rather than probabilistic and, since the familiar Monte Carlo methods approximate probabilistic quantities, there are significant computational challenges associated with putting this framework into…

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Robust Microbial Signature Discovery via Post-Selection Inference for Microbiome Compositions

通过选择后推断稳健发现微生物组成特征

Identifying taxa associated with host phenotypes is crucial for understanding host-microbe interactions and their underlying molecular mechanisms. However, analyzing microbiome data presents unique challenges, as the observed abundances of taxa are high-dimensional, compositional, and subject to both sample-specific and taxon-specific biases. Many existing methods for differential abundance testing struggle to balance false discovery rate control with statistical power. In…

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Principled Estimation and Prediction with Competing Risks: a Bayesian Nonparametric Approach

竞争风险的估计与预测:贝叶斯非参数方法

Competing risks occur in survival analysis when multiple causes of death are present. They play a prominent role in several domains extending beyond biostatistics to encompass epidemiology, actuarial sciences, and reliability theory. This paper adopts a multi–state modeling framework to competing risks. We introduce a class of flexible nonparametric priors, defined through hierarchical completely random measures, to model the transition probabilities, and identify the…

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Minimum Volume Conformal Sets for Multivariate Regression

多元回归的最小体积保形预测集

Conformal prediction provides a principled framework for constructing predictive sets with finite-sample validity. While much of the focus has been on univariate response variables, existing multivariate methods either impose rigid geometric assumptions or rely on flexible but computationally expensive approaches that do not explicitly optimize prediction set volume. We propose an optimization-driven framework based on a novel loss function that directly learns…

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Accounting for Measurement Bias: A New Framework for Reliable Country Ranking in Large-Scale Educational Assessments

校正测量偏差:大型教育评估中国家排名的新框架

International Large-scale Assessments (ILSAs), such as the Program for International Student Assessment (PISA) and the Trends in International Mathematics and Science Study (TIMSS), are cornerstone tools for global educational research and policy-making. By benchmarking educational quality and performance trends, these assessments enable countries to evaluate and share effective pedagogical structures. Specifically, ILSAs employ Item Response Theory (IRT) models to rank…

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Edgeworth Accountant: An Analytical Approach to Differential Privacy Composition

Edgeworth 隐私核算器:差分隐私组合的解析方法

In privacy-preserving data analysis, many procedures and algorithms are structured as compositions of multiple private building blocks. As such, an important question is how to efficiently compute the overall privacy loss under composition. This paper introduces the Edgeworth Accountant, an analytical approach to composing differential privacy guarantees for private algorithms. Leveraging the f-differential privacy framework (Dong et al., 2022), the Edgeworth Accountant…

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Robust Unsupervised Multi-Task and Transfer Learning on Gaussian Mixture Models

高斯混合模型的稳健无监督多任务与迁移学习

Unsupervised learning has been widely used in many real-world applications. One of the simplest and most important unsupervised learning models is the Gaussian mixture model (GMM). In this work, we study the multi-task learning problem on GMMs, which aims to leverage potentially similar GMM parameter structures among tasks to obtain improved learning performance compared to single-task learning. We propose a multi-task GMM learning procedure based on the EM algorithm that…

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Generalized Grade-of-Membership Estimation for High-Dimensional Locally Dependent Data

高维局部依赖数据的广义隶属度估计

This work focuses on the mixed membership models for multivariate categorical data widely used for analyzing survey responses and population genetics data. These grade of membership (GoM) models offer rich modeling power but present significant estimation challenges for high-dimensional polytomous data. Popular existing approaches, such as Bayesian MCMC inference, are not scalable and lack theoretical guarantees in high-dimensional settings. To address this, we first observe…

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Successive Classification Learning for Estimating Quantile Optimal Treatment Regimes

估计分位数最优处理规则的序贯分类学习

Quantile optimal treatment regimes (OTRs) aim to assign treatments that maximize a specified quantile of patients’ outcomes. Compared to treatment regimes that target the mean outcomes, quantile OTRs offer fairer regimes when a lower quantile is selected, as it improves outcomes for vulnerable patients. In this paper, we propose a novel method for estimating quantile OTRs by reformulating the problem as a successive classification task, solvable via training a sequence of…

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Conformal Prediction After Data-Dependent Model Selection

数据依赖模型选择后的保形预测

Given a family of pretrained models and a hold-out set, how can we construct a valid conformal prediction set while selecting a model that minimizes the width of the set? If we use the same hold-out data set both to select a model (the model that yields the smallest conformal prediction sets) and then to construct a conformal prediction set based on that selected model, we suffer a loss of coverage due to selection bias. Alternatively, we could further split the data to…

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Domain-Specific Nonparametric Regression for Domain Generalization

用于域泛化的域特定非参数回归

We propose a domain-specific regression approach for domain generalization, taking into account possible heterogeneity among the datasets from different sources. In the proposed model, the domain-specific features are characterized through linear functionals of the marginal source distributions. The predictors are combined with the domain-specific linear functionals as inputs in the model. Using the source data sets, we estimate the domain-index function and the regression…

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Mixture Modeling for Temporal Point Processes with Memory

具有记忆的时间点过程混合建模

We propose a constructive approach to building temporal point processes that incorporate dependence on their history. The dependence is modeled through the conditional density of the duration, i.e., the interval between successive event times, using a mixture of first-order conditional densities for each one of a specific number of lagged durations. Such a formulation for the conditional duration density accommodates high-order dynamics, and it thus enables flexible modeling…

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Extracting Interpretable Models from Tree Ensembles: Computational and Statistical Perspectives

从树集成中提取可解释模型:计算与统计视角

Tree ensembles are non-parametric methods widely recognized for their accuracy and ability to capture complex interactions. While these models excel at prediction, they are difficult to interpret and may fail to uncover useful relationships in the data. We propose an estimator to extract compact sets of decision rules from tree ensembles. The extracted models are accurate and can be manually examined to reveal relationships between the predictors and the response. A key…

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