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利用布尔矩阵逻辑检验中介效应AI 解读

A central question in high-dimensional mediation analysis is to infer the significance of individual mediators. The main challenge is that the total number of potential paths that go through any mediator is super-exponential in the number of mediators. Most existing mediation inference solutions either explicitly impose that the mediators are conditionally independent given the exposure, or ignore any potential directed paths among the mediators. In this article, we propose…

一致稀疏深度学习：理论与计算AI 解读

Deep learning has been the engine powering many successes of data science. However, the deep neural network (DNN), as the basic model of deep learning, is often excessively over-parameterized, causing many difficulties in training, prediction and interpretation. We propose a frequentist-like method for learning sparse DNNs and justify its consistency under the Bayesian framework: the proposed method could learn a sparse DNN with at most O(n/ log (n)) connections and nice…

无需估计非可忽略缺失机制的通用估计程序AI 解读

We consider the estimation problem in a regression setting where the outcome variable is subject to nonignorable missingness and identifiability is ensured by the shadow variable approach. We propose a versatile estimation procedure where modeling of missingness mechanism is completely bypassed. We show that our estimator is easy to implement and we derive the asymptotic theory of the proposed estimator. We also investigate some alternative estimators under different…

普通最小二乘二次泛函的中等维度推断AI 解读

Statistical inferences for quadratic functionals of linear regression parameter have found wide applications including signal detection, global testing, inferences of error variance and fraction of variance explained. Classical theory based on ordinary least squares estimator works perfectly in the low-dimensional regime, but fails when the parameter dimension pn grows proportionally to the sample size n. In some cases, its performance is not satisfactory even when n≥5pn.…

含分类变量的变量选择：模型选择视角AI 解读

In the context of a Gaussian multiple regression model, we address the problem of variable selection when in the list of potential predictors there are factors, that is, categorical variables. We adopt a model selection perspective, that is, we approach the problem by constructing a class of models, each corresponding to a particular selection of active variables. The methodology is Bayesian and proceeds by computing the posterior probability of each of these models. We…

高维线性混合效应模型的推断：拟似然方法AI 解读

Linear mixed-effects models are widely used in analyzing clustered or repeated measures data. We propose a quasi-likelihood approach for estimation and inference of the unknown parameters in linear mixed-effects models with high-dimensional fixed effects. The proposed method is applicable to general settings where the dimension of the random effects and the cluster sizes are possibly large. Regarding the fixed effects, we provide rate optimal estimators and valid inference…

用于分布式估计与推断的一阶牛顿型估计量AI 解读

This article studies distributed estimation and inference for a general statistical problem with a convex loss that could be nondifferentiable. For the purpose of efficient computation, we restrict ourselves to stochastic first-order optimization, which enjoys low per-iteration complexity. To motivate the proposed method, we first investigate the theoretical properties of a straightforward divide-and-conquer stochastic gradient descent approach. Our theory shows that there…

深度复合空间模型AI 解读

Spatial processes with nonstationary and anisotropic covariance structure are often used when modeling, analyzing, and predicting complex environmental phenomena. Such processes may often be expressed as ones that have stationary and isotropic covariance structure on a warped spatial domain. However, the warping function is generally difficult to fit and not constrained to be injective, often resulting in “space-folding.” Here, we propose modeling an injective warping…

利用参数化决策分析实现快速、最优与目标导向预测AI 解读

Prediction is critical for decision-making under uncertainty and lends validity to statistical inference. With targeted prediction, the goal is to optimize predictions for specific decision tasks of interest, which we represent via functionals. Although classical decision analysis extracts predictions from a Bayesian model, these predictions are often difficult to interpret and slow to compute. Instead, we design a class of parameterized actions for Bayesian decision…

含协变量的双成分混合模型AI 解读

In this article, we study a generalization of the two-groups model in the presence of covariates—a problem that has recently received much attention in the statistical literature due to its applicability in multiple hypotheses testing problems. The model we consider allows for infinite dimensional parameters and offers flexibility in modeling the dependence of the response on the covariates. We discuss the identifiability issues arising in this model and systematically study…

主成分分析的分布式估计：扩展特征子空间分析AI 解读

The growing size of modern datasets brings many challenges to the existing statistical estimation approaches, which calls for new distributed methodologies. This article studies distributed estimation for a fundamental statistical machine learning problem, principal component analysis (PCA). Despite the massive literature on top eigenvector estimation, much less is presented for the top-L-dim (L > 1) eigenspace estimation, especially in a distributed manner. We propose a…

Wald 检验中的 Hauck–Donner 效应：检测、临界点与参数空间刻画AI 解读

The Wald test remains ubiquitous in statistical practice despite shortcomings such as its inaccuracy in small samples and lack of invariance under reparameterization. This article develops on another but lesser-known shortcoming called the Hauck–Donner effect (HDE) whereby a Wald test statistic is no longer monotone increasing as a function of increasing distance between the parameter estimate and the null value. Resulting in an upward biased p-value and loss of power, the…

含噪、稀疏及片段化函数数据的同步配准与估计：贝叶斯框架AI 解读

In many applications, smooth processes generate data that is recorded under a variety of observational regimes, including dense sampling and sparse or fragmented observations that are often contaminated with error. The statistical goal of registering and estimating the individual underlying functions from discrete observations has thus far been mainly approached sequentially without formal uncertainty propagation, or in an application-specific manner by pooling information…

结合网络嵌入的有向社区检测AI 解读

Community detection in network data aims at grouping similar nodes sharing certain characteristics together. Most existing methods focus on detecting communities in undirected networks, where similarity between nodes is measured by their node features and whether they are connected. In this article, we propose a novel method to conduct network embedding and community detection simultaneously in a directed network. The network embedding model introduces two sets of vectors to…

结构化收缩估计的回归建模方法AI 解读

Problems involving the simultaneous estimation of multiple parameters arise in many areas of theoretical and applied statistics. A canonical example is the estimation of a vector of normal means. Frequently, structural information about relationships between the parameters of interest is available. For example, in a gene expression denoising problem, genes with similar functions may have similar expression levels. Despite its importance, structural information has not been…

非参数经验贝叶斯预测AI 解读

Henceforth, the Journal of the American Statistical Association 2022 Theory and Methods Invited Paper by Nikolaos Ignatiadis and Stefan Wager, “Nonparametric Empirical Bayes Analysis,” will be refe...

对《非参数经验贝叶斯分析的置信区间》的讨论AI 解读

We would like to start with congratulating the authors. Empirical Bayes estimation is a very old, well studied problem. However, construction of confidence intervals in empirical Bayes setting has ...

作者回复：非参数经验贝叶斯分析的置信区间AI 解读

In our article, we introduced two general methods for conducting inference for empirical Bayes estimands. The discussants have contributed to our work by clarifying and raising important issues reg...

经验贝叶斯区间的覆盖性质：对非参数经验贝叶斯置信区间研究的讨论AI 解读

Empirical Bayes methods are commonly used in the analysis of data coming from multiple related populations or groups, where often the goal is to obtain a parameter estimate for each individual grou...

关于“非参数经验贝叶斯分析的置信区间”的讨论AI 解读

We congratulate Ignatiadis and Wager (IW) on this significant step forward, incorporating uncertainty in the estimated prior into empirical Bayes (EB) analysis. EB analyses have traditionally ignor...

关于非参数经验贝叶斯分析置信区间的讨论AI 解读

I congratulate the authors for a fantastic piece of work about confidence intervals in an inverse problem involving a mixing distribution under an empirical Bayes setup. We can regard the problem a...

高维中介分析：筛选连接童年创伤与皮质醇应激反应的 DNA 甲基化位点AI 解读

Childhood trauma tends to influence cortisol stress reactivity through the mediating effects of DNA methylation. Houtepen et al. conducted a study to investigate the role of DNA methylation in cortisol stress reactivity and its relationship with childhood trauma. The study collected a dataset consisting of 385,882 DNA methylation loci, cortisol stress reactivity, one-dimensional score on a childhood trauma questionnaire and several covariates for 85 healthy individuals. Of…

含内生协变量的复合分布 Copula 回归及保险免赔额定价应用AI 解读

This article concerns deductible pricing in nonlife insurance contracts. The primary interest of insurers is the effect of the contract deductible on a policyholder’s aggregate loss that is determined by a compound distribution where the sum of individual claim amount is stopped by the number of claims. Policyholders choose the deductible level based on their hidden risks, which makes deductible endogenous in the regressions for both claim frequency and claim severity. To…

脑电脑机接口中神经活动的贝叶斯推断AI 解读

A brain-computer interface (BCI) is a system that translates brain activity into commands to operate technology. A common design for an electroencephalogram (EEG) BCI relies on the classification of the P300 event-related potential (ERP), which is a response elicited by the rare occurrence of target stimuli among common non-target stimuli. Few existing ERP classifiers directly explore the underlying mechanism of the neural activity. To this end, we perform a novel Bayesian…