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对抗机器学习：贝叶斯视角AI 解读

Adversarial Machine Learning (AML) is emerging as a major field aimed at protecting Machine Learning (ML) systems against security threats: in certain scenarios there may be adversaries that actively manipulate input data to fool learning systems.This creates a new class of security vulnerabilities that ML systems may face, and a new desirable property called adversarial robustness essential to trust operations based on ML outputs.Most work in AML is built upon a…

无效工具变量与 GWAS 汇总数据下的转录组关联研究因果推断AI 解读

Transcriptome-wide association studies (TWAS) have recently emerged as a popular tool to discover (putative) causal genes by integrating an outcome GWAS dataset with another gene expression/transcriptome GWAS (called eQTL) dataset. In our motivating and target application, we'd like to identify causal genes for low-density lipoprotein cholesterol (LDL), which is crucial for developing new treatments for hyperlipidemia and cardiovascular diseases. The statistical principle…

相关网络规模推估模型：识别子群体之间的联系AI 解读

Aggregated relational data (ARD), formed from "How many X's do you know?" questions, is a powerful tool for learning important network characteristics with incomplete network data. Compared to traditional survey methods, ARD is attractive as it does not require a sample from the target population and does not ask respondents to self-reveal their own status. This is helpful for studying hard-to-reach populations like female sex workers who may be hesitant to reveal their…

识别他汀使用相关二型糖尿病风险最高的亚组：电子健康记录证据AI 解读

There have been increased concerns that the use of statins, one of the most commonly prescribed drugs for treating coronary artery disease, is potentially associated with the increased risk of new-onset Type II diabetes (T2D). Nevertheless, to date, there is no robust evidence supporting as to whether and what kind of populations are indeed vulnerable for developing T2D after taking statins. In this case study, leveraging the biobank and electronic health record data in the…

多响应回归与多元方差分析的有效完全分布无关中心向外秩检验AI 解读

Extending rank-based inference to a multivariate setting such as multiple-output regression or MANOVA with unspecified d-dimensional error density has remained an open problem for more than half a century. None of the many solutions proposed so far is enjoying the combination of distribution-freeness and efficiency that makes rank-based inference a successful tool in the univariate setting. A concept of center-outward multivariate ranks and signs based on measure…

个体化决策规则的稳健性AI 解读

With the emergence of precision medicine, estimating optimal individualized decision rules (IDRs) has attracted tremendous attention in many scientific areas. Most existing literature has focused on finding optimal IDRs that can maximize the expected outcome for each individual. Motivated by complex individualized decision making procedures and the popular conditional value at risk (CVaR) measure, we propose a new robust criterion to estimate optimal IDRs in order to control…

基于最大均值差异的 Copula 估计AI 解读

This article deals with robust inference for parametric copula models. Estimation using canonical maximum likelihood might be unstable, especially in the presence of outliers. We propose to use a procedure based on the maximum mean discrepancy (MMD) principle. We derive nonasymptotic oracle inequalities, consistency and asymptotic normality of this new estimator. In particular, the oracle inequality holds without any assumption on the copula family, and can be applied in the…

用于多模态数据整合的广义液态关联分析AI 解读

Multimodal data are now prevailing in scientific research. One of the central questions in multimodal integrative analysis is to understand how two data modalities associate and interact with each other given another modality or demographic variables. The problem can be formulated as studying the associations among three sets of random variables, a question that has received relatively less attention in the literature. In this article, we propose a novel generalized liquid…

通过聚合累积协方差检验高维协变量的影响AI 解读

In this article, we test for the effects of high-dimensional covariates on the response. In many applications, different components of covariates usually exhibit various levels of variation, which is ubiquitous in high-dimensional data. To simultaneously accommodate such heteroscedasticity and high dimensionality, we propose a novel test based on an aggregation of the marginal cumulative covariances, requiring no prior information on the specific form of regression models.…

具有错误发现率控制的大规模高斯图模型迁移学习AI 解读

Transfer learning for high-dimensional Gaussian graphical models (GGMs) is studied. The target GGM is estimated by incorporating the data from similar and related auxiliary studies, where the similarity between the target graph and each auxiliary graph is characterized by the sparsity of a divergence matrix. An estimation algorithm, Trans-CLIME, is proposed and shown to attain a faster convergence rate than the minimax rate in the single-task setting. Furthermore, we…

基于贝叶斯决策树集成的自适应条件分布估计AI 解读

We present a Bayesian nonparametric model for conditional distribution estimation using Bayesian additive regression trees (BART). The generative model we use is based on rejection sampling from a base model. Like other BART models, our model is flexible, has a default prior specification, and is computationally convenient. To address the distinguished role of the response in our BART model, we introduce an approach to targeted smoothing of BART models which is of…

干预目标不确定时的网络结构学习AI 解读

Gaussian Directed Acyclic Graphs (DAGs) represent a powerful tool for learning the network of dependencies among variables, a task which is of primary interest in many fields and specifically in biology. Different DAGs may encode equivalent conditional independence structures, implying limited ability, with observational data, to identify causal relations. In many contexts however, measurements are collected under heterogeneous settings where variables are subject to…

网络社区数量的最优估计AI 解读

In network analysis, how to estimate the number of communities K is a fundamental problem. We consider a broad setting where we allow severe degree heterogeneity and a wide range of sparsity levels, and propose Stepwise Goodness of Fit (StGoF) as a new approach. This is a stepwise algorithm, where for m=1,2,…, we alternately use a community detection step and a goodness of fit (GoF) step. We adapt SCORE Jin for community detection, and propose a new GoF metric. We show that…

非参数加性模型的核 Knockoffs 变量选择AI 解读

Thanks to its fine balance between model flexibility and interpretability, the nonparametric additive model has been widely used, and variable selection for this type of model has been frequently studied. However, none of the existing solutions can control the false discovery rate (FDR) unless the sample size tends to infinity. The knockoff framework is a recent proposal that can address this issue, but few knockoff solutions are directly applicable to nonparametric models.…

含协变量的高维高斯图回归模型AI 解读

Though Gaussian graphical models have been widely used in many scientific fields, relatively limited progress has been made to link graph structures to external covariates. We propose a Gaussian graphical regression model, which regresses both the mean and the precision matrix of a Gaussian graphical model on covariates. In the context of co-expression quantitative trait locus (QTL) studies, our method can determine how genetic variants and clinical conditions modulate the…

超越 Matérn：一类可解释的合流超几何协方差函数AI 解读

The Matérn covariance function is a popular choice for prediction in spatial statistics and uncertainty quantification literature. A key benefit of the Matérn class is that it is possible to get precise control over the degree of mean-square differentiability of the random process. However, the Matérn class possesses exponentially decaying tails, and thus, may not be suitable for modeling polynomially decaying dependence. This problem can be remedied using polynomial…

可能含异常批次的流式聚类数据实时回归分析AI 解读

This paper develops an incremental learning algorithm based on quadratic inference function (QIF) to analyze streaming datasets with correlated outcomes such as longitudinal data and clustered data. We propose a renewable QIF (RenewQIF) method within a paradigm of renewable estimation and incremental inference, in which parameter estimates are recursively renewed with current data and summary statistics of historical data, but with no use of any historical subject-level raw…

强化学习框架下A/B测试的动态因果效应评估AI 解读

A/B testing, or online experiment is a standard business strategy to compare a new product with an old one in pharmaceutical, technological, and traditional industries. Major challenges arise in online experiments of two-sided marketplace platforms (e.g., Uber) where there is only one unit that receives a sequence of treatments over time. In those experiments, the treatment at a given time impacts current outcome as well as future outcomes. The aim of this article is to…

基于小波的函数型数据独立性检验及脑磁图连接应用AI 解读

Measuring and testing the dependency between multiple random functions is often an important task in functional data analysis. In the literature, a model-based method relies on a model which is subject to the risk of model misspecification, while a model-free method only provides a correlation measure which is inadequate to test independence. In this paper, we adopt the Hilbert–Schmidt Independence Criterion (HSIC) to measure the dependency between two random functions. We…

贝叶斯 Bootstrap 尖峰厚尾 LASSOAI 解读

The impracticality of posterior sampling has prevented the widespread adoption of spike-and-slab priors in high-dimensional applications. To alleviate the computational burden, optimization strategies have been proposed that quickly find local posterior modes. Trading off uncertainty quantification for computational speed, these strategies have enabled spike-and-slab deployments at scales that would be previously unfeasible. We build on one recent development in this strand…

具有形状约束成对相关函数的聚集点过程半参数拟合优度检验AI 解读

Specification of a parametric model for the intensity function is a fundamental task in statistics for spatial point processes. It is, therefore, crucial to be able to assess the appropriateness of a suggested model for a given point pattern dataset. For this purpose, we develop a new class of semiparametric goodness-of-fit tests for the specified parametric first-order intensity, without assuming a full data generating mechanism that is needed for the existing popular Monte…

组成分布的得分匹配估计AI 解读

Compositional data are challenging to analyse due to the non-negativity and sum-to-one constraints on the sample space. With real data, it is often the case that many of the compositional components are highly right-skewed, with large numbers of zeros. Major limitations of currently available models for compositional data include one or more of the following: insufficient flexibility in terms of distributional shape; difficulty in accommodating zeros in the data in…

通过纵向生物标志物曲线配准分析未知起点的事件时间AI 解读

In observational studies, the time origin of interest for time-to-event analysis is often unknown, such as the time of disease onset. Existing approaches to estimating the time origins are commonly built on extrapolating a parametric longitudinal model, which rely on rigid assumptions that can lead to biased inferences. In this paper, we introduce a flexible semiparametric curve registration model. It assumes the longitudinal trajectories follow a flexible common shape…

存在局部最优解时的统计推断AI 解读

We study the statistical properties of an estimator derived by applying a gradient ascent method with multiple initializations to a multi-modal likelihood function. We derive the population quantity that is the target of this estimator and study the properties of confidence intervals (CIs) constructed from asymptotic normality and the bootstrap approach. In particular, we analyze the coverage deficiency due to finite number of random initializations. We also investigate the…