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Sparse Reduced Rank Huber Regression in High Dimensions

高维稀疏降秩 Huber 回归

We propose a sparse reduced rank Huber regression for analyzing large and complex high-dimensional data with heavy-tailed random noise. The proposed method is based on a convex relaxation of a rank- and sparsity-constrained nonconvex optimization problem, which is then solved using a block coordinate descent and an alternating direction method of multipliers algorithm. We establish nonasymptotic estimation error bounds under both Frobenius and nuclear norms in the…

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Survival Analysis via Ordinary Differential Equations

基于常微分方程的生存分析

This article introduces an Ordinary Differential Equation (ODE) notion for survival analysis. The ODE notion not only provides a unified modeling framework, but more importantly, also enables the development of a widely applicable, scalable, and easy-to-implement procedure for estimation and inference. Specifically, the ODE modeling framework unifies many existing survival models, such as the proportional hazards model, the linear transformation model, the accelerated…

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Robust Estimation of Large Panels with Factor Structures

具有因子结构的大型面板的稳健估计

This article studies estimation of linear panel regression models with heterogeneous coefficients using a class of weighted least squares estimators, when both the regressors and the error possibly contain a common latent factor structure. Our theory is robust to the specification of such a factor structure because it does not require any information on the number of factors or estimation of the factor structure itself. Moreover, our theory is efficient, in certain…

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Toward Better Practice of Covariate Adjustment in Analyzing Randomized Clinical Trials

随机临床试验中协变量调整的实践改进

In randomized clinical trials, adjustments for baseline covariates at both design and analysis stages are highly encouraged by regulatory agencies. A recent trend is to use a model-assisted approach for covariate adjustment to gain credibility and efficiency while producing asymptotically valid inference even when the model is incorrect. In this article we present three considerations for better practice when model-assisted inference is applied to adjust for covariates under…

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Marginal and Conditional Multiple Inference for Linear Mixed Model Predictors

线性混合模型预测量的边际与条件多重推断

In spite of its high practical relevance, cluster specific multiple inference for linear mixed model predictors has hardly been addressed so far. While marginal inference for population parameters is well understood, conditional inference for the cluster specific predictors is more intricate. This work introduces a general framework for multiple inference in linear mixed models for cluster specific predictors. Consistent confidence sets for multiple inference are constructed…

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Understanding Implicit Regularization in Over-Parameterized Single Index Model

过参数化单指标模型中的隐式正则化

In this paper, we leverage over-parameterization to design regularization-free algorithms for the high-dimensional single index model and provide theoretical guarantees for the induced implicit regularization phenomenon. Specifically, we study both vector and matrix single index models where the link function is nonlinear and unknown, the signal parameter is either a sparse vector or a low-rank symmetric matrix, and the response variable can be heavy-tailed. To gain a better…

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A Zero-Inflated Logistic Normal Multinomial Model for Extracting Microbial Compositions

用于提取微生物组成的零膨胀逻辑正态多项模型

High throughput sequencing data collected to study the microbiome provide information in the form of relative abundances and should be treated as compositions. Although many approaches including scaling and rarefaction have been proposed for converting raw count data into microbial compositions, most of these methods simply return zero values for zero counts. However, zeros can distort downstream analyses, and they can also pose problems for composition-aware methods. This…

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Optimal Dynamic Treatment Regimes and Partial Welfare Ordering

最优动态处理规则与福利的部分排序

Dynamic treatment regimes are treatment allocations tailored to heterogeneous individuals (e.g., via previous outcomes and covariates).The optimal dynamic treatment regime is a regime that maximizes counterfactual welfare.We introduce a framework in which we can partially learn the optimal dynamic regime from observational data, relaxing the sequential randomization assumption commonly employed in the literature but instead using (binary) instrumental variables.We propose…

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Covariate-Assisted Bayesian Graph Learning for Heterogeneous Data

异质数据的协变量辅助贝叶斯图学习

In a traditional Gaussian graphical model, data homogeneity is routinely assumed with no extra variables affecting the conditional independence. In modern genomic datasets, there is an abundance of auxiliary information, which often gets under-utilized in determining the joint dependency structure. In this article, we consider a Bayesian approach to model undirected graphs underlying heterogeneous multivariate observations with additional assistance from covariates. Building…

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An Automated Approach to Causal Inference in Discrete Settings

离散情形下因果推断的自动化方法

When causal quantities cannot be point identified, researchers often pursue partial identification to quantify the range of possible values. However, the peculiarities of applied research conditions can make this analytically intractable. We present a general and automated approach to causal inference in discrete settings. We show causal questions with discrete data reduce to polynomial programming problems, and we present an algorithm to automatically bound causal effects…

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Statistical Inference for Maximin Effects: Identifying Stable Associations across Multiple Studies

最大最小效应的统计推断:识别跨研究稳定关联

Integrative analysis of data from multiple sources is critical to making generalizable discoveries. Associations consistently observed across multiple source populations are more likely to be generalized to target populations with possible distributional shifts. In this paper, we model the heterogeneous multi-source data with multiple high-dimensional regressions and make inferences for the maximin effect (Meinshausen, Bühlmann, AoS, 43(4), 1801–1830). The maximin effect…

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Factor Augmented Inverse Regression and its Application to Microbiome Data Analysis

因子增强逆回归及其微生物组数据分析应用

We investigate the relationship between count data that inform the relative abundance of features of a composition, and factors that influence the composition. Our work is motivated from microbiome studies aiming to extract microbial signatures that are predictive of host phenotypes based on data collected from a group of individuals harboring radically different microbial communities. We introduce multinomial Factor Augmented Inverse Regression (FAIR) of the count vector…

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On the Estimation of the Number of Communities for Sparse Networks

稀疏网络中社区数量的估计

Among the nonparametric methods of estimating the number of communities (K) in a community detection problem, methods based on the spectrum of the Bethe Hessian matrices (Hζ with the scalar parameter ζ) have garnered much popularity for their simplicity, computational efficiency, and robustness to the sparsity of data. For certain heuristic choices of ζ, such methods have been shown to be consistent for networks with N nodes with a common expected degree of ω( log N). In…

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DDAC-SpAM: A Distributed Algorithm for Fitting High-dimensional Sparse Additive Models with Feature Division and Decorrelation

DDAC-SpAM:特征划分与去相关的高维稀疏加性模型分布式算法

–Distributed statistical learning has become a popular technique for large-scale data analysis. Most existing work in this area focuses on dividing the observations, but we propose a new algorithm, DDAC-SpAM, which divides the features under a high-dimensional sparse additive model. Our approach involves three steps: divide, decorrelate, and conquer. The decorrelation operation enables each local estimator to recover the sparsity pattern for each additive component without…

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Multivariate Sparse Clustering for Extremes

多元极值的稀疏聚类

Identifying directions where extreme events occur is a significant challenge in multivariate extreme value analysis. In this article, we use the concept of sparse regular variation introduced by Meyer and Wintenberger to infer the tail dependence of a random vector X. This approach relies on the Euclidean projection onto the simplex which better exhibits the sparsity structure of the tail of X than the standard methods. Our procedure based on a rigorous methodology aims at…

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Exact Bayesian Inference for Diffusion-Driven Cox Processes

扩散驱动 Cox 过程的精确贝叶斯推断

In this article, we present a novel methodology to perform Bayesian inference for Cox processes in which the intensity function is driven by a diffusion process.The novelty lies in the fact that no discretization error is involved, despite the non-tractability of both the likelihood function and the transition density of the diffusion.The methodology is based on an MCMC algorithm and its exactness is built on retrospective sampling techniques.The efficiency of the…

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Testing Directed Acyclic Graph via Structural, Supervised and Generative Adversarial Learning

结合结构学习、监督学习与生成对抗学习检验有向无环图

In this article, we propose a new hypothesis testing method for directed acyclic graph (DAG). While there is a rich class of DAG estimation methods, there is a relative paucity of DAG inference solutions. Moreover, the existing methods often impose some specific model structures such as linear models or additive models, and assume independent data observations. Our proposed test instead allows the associations among the random variables to be nonlinear and the data to be…

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Double Negative Control Inference in Test-Negative Design Studies of Vaccine Effectiveness

疫苗有效性检测阴性设计研究中的双负对照推断

The test-negative design (TND) has become a standard approach to evaluate vaccine effectiveness against the risk of acquiring infectious diseases in real-world settings, such as Influenza, Rotavirus, Dengue fever, and more recently COVID-19. In a TND study, individuals who experience symptoms and seek care are recruited and tested for the infectious disease which defines cases and controls. Despite TND's potential to reduce unobserved differences, in healthcare seeking…

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Bahadur Efficiency of Observational Block Designs

观察性区组设计的Bahadur效率

To be convincing, an observational or nonrandomized study of causal effects must demonstrate that its conclusions cannot be readily explained by a small unmeasured bias in the way individuals were assigned to treatment or control. The Bahadur relative efficiency of a sensitivity analysis compares the performance of different test statistics or different research designs when sensitivity to unmeasured bias is appraised: better statistics and better designs exhibit…

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Bayesian Inference Using the Proximal Mapping: Uncertainty Quantification Under Varying Dimensionality

利用近端映射开展贝叶斯推断:维数变化下的不确定性量化

In statistical applications, it is common to encounter parameters supported on a varying or unknown dimensional space. Examples include the fused lasso regression, the matrix recovery under an unknown low rank, etc. Despite the ease of obtaining a point estimate via optimization, it is much more challenging to quantify their uncertainty. In the Bayesian framework, a major difficulty is that if assigning the prior associated with a p-dimensional measure, then there is zero…

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Classified Mixed Model Projections

分类混合模型投影

In many practical problems, there is interest in the estimation of mixed effect projections for new data that are outside the range of the training data. Examples include predicting extreme small area means for rare populations or making treatment decisions for patients who do not fit typical risk profiles. Standard methods have long been known to struggle with such problems since the training data may not provide enough information about potential model changes for these…

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Bootstrap Prediction Bands for Functional Time Series

函数型时间序列的自助法预测带

Efstathios Paparoditisa and Han Lin ShangbaDepartment of Mathematics and Statistics, University of Cyprus, Nicosia, CyprusbDepartment of Actuarial Studies and Business Analytics, Macquarie Universi...

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Assessing Disparities in Americans’ Exposure to PCBs and PBDEs based on NHANES Pooled Biomonitoring Data

基于 NHANES 混合生物监测数据评估美国人的 PCB 与 PBDE 暴露差异

The National Health and Nutrition Examination Survey (NHANES) has been continuously biomonitoring Americans' exposure to two families of harmful environmental chemicals: polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs). However, biomonitoring these chemicals is expensive. To save cost, in 2005, NHANES resorted to pooled biomonitoring; i.e., amalgamating individual specimens to form a pool and measuring chemical levels from pools. Despite being…

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A Scale-Free Approach for False Discovery Rate Control in Generalized Linear Models

广义线性模型中控制错误发现率的无尺度方法

The Generalized Linear Model (GLM) has been widely used in practice to model counts or other types of non-Gaussian data. This article introduces a framework for feature selection in the GLM that can achieve robust False Discovery Rate (FDR) control. The main idea is to construct a mirror statistic based on data perturbation to measure the importance of each feature. FDR control is achieved by taking advantage of the mirror statistic’s property that its sampling distribution…

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