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Estimating the Number of Components in Finite Mixture Models via Variational Approximation

通过变分近似估计有限混合模型的成分数

This work introduces a new method for selecting the number of components in finite mixture models (FMMs) using variational Bayes, inspired by the large-sample properties of the Evidence Lower Bound (ELBO) derived from mean-field (MF) variational approximation. Specifically, we establish matching upper and lower bounds for the ELBO without assuming conjugate priors, suggesting the consistency of model selection for FMMs based on maximizing the ELBO. As a by-product, we show…

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Second-Order Sparse Sufficient Dimension Reduction with Applications to Quadratic Discriminant Analysis

二阶稀疏充分降维及其在二次判别分析中的应用

Motivated by exploratory data analysis, sufficient dimension reduction (SDR) methods, especially inverse regression methods such as sliced inverse regression (SIR) and sliced averaged variance estimation (SAVE), have been central to multivariate analysis for more than three decades. Despite their popularity, the extension of these methods to high-dimensional settings remains challenging. This paper addresses the computational and theoretical limitations of the less explored…

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Group Sequential Design with Posterior and Posterior Predictive Probabilities

基于后验与后验预测概率的组序贯设计

Group sequential designs drive innovation in clinical, industrial, and corporate settings. Early stopping for failure in sequential designs conserves experimental resources, whereas early stopping for success accelerates access to improved interventions. Bayesian decision procedures provide a formal and intuitive framework for early stopping using posterior and posterior predictive probabilities. Design parameters including decision thresholds and sample sizes are chosen to…

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Enhanced Marginal Sensitivity Model and Bounds

增强边际敏感性模型及其界限

Sensitivity analysis is important to assess the impact of unmeasured confounding in causal inference from observational studies. The marginal sensitivity model (MSM) provides a useful approach in quantifying the influence of unmeasured confounders on treatment assignment and leading to tractable sharp bounds of common causal parameters. In this paper, to tighten MSM sharp bounds, we propose the enhanced MSM (eMSM) by incorporating another sensitivity constraint which…

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High-Dimensional Inference for Extreme Value Indices

极值指数的高维推断

When applying multivariate extreme value statistics to analyze tail risk in compound events defined by a multivariate random vector, one often assumes that all dimensions share the same extreme value index. While such an assumption can be tested using a Wald-type test, the performance of such a test deteriorates as the dimensionality increases.This paper introduces novel tests for comparing extreme value indices in high-dimensional settings, under both weak and general…

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Anytime-Valid Inference in Linear Models with Applications to Regression-Adjusted Causal Inference

线性模型的随时有效推断及回归调整因果推断应用

Linear models are foundational tools in statistics and ubiquitous across the applied sciences. However, conventional statistical tests, such as t-tests and F-tests, are only valid at fixed sample sizes, making them unsuitable for sequential settings such as online A/B testing. We develop an anytime-valid theory of inference for the linear model, introducing sequential analogues of classical tests and confidence sets that provide Type-I error control and coverage guarantees…

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Channeling Multimodality Through a Unimodalizing Transport: Warp-U Sampler and Stochastic Bridge Sampling Estimator

通过单峰化输运处理多峰分布:Warp-U采样与随机桥采样估计

Monte Carlo integration is a powerful tool for scientific and statistical computation, but faces significant challenges when the integrand is a multi-modal distribution, even when the mode locations are known. This work introduces novel Monte Carlo sampling and integration estimation strategies for the multi-modal context by leveraging a generalized version of the stochastic Warp-U transformation (Wang et al., 2022). We propose two flexible classes of Warp-U transformations,…

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Bayesian Transfer Learning for Enhanced Estimation and Inference

用于改进估计与推断的贝叶斯迁移学习

Transfer learning enhances model performance in a target population with limited samples by leveraging knowledge from related studies. While many works focus on improving predictive performance, challenges persist in statistical inference. Bayesian approaches naturally provide uncertainty quantification for parameter estimates; however, existing Bayesian transfer learning methods are typically limited to single-source scenarios or require individual-level data. We introduce…

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Locally Private Nonparametric Contextual Multi-armed Bandits with Transfer Learning

局部隐私下非参数情境多臂老虎机的迁移学习

Motivated by privacy concerns in sequential decision-making on sensitive data, we address the challenging problem of nonparametric contextual multi-armed bandits (MAB) under local differential privacy (LDP). Via a novelly designed LDP-compatible confidence bound, we propose an algorithm that achieves near-optimal regret performance, whose optimality is further supported by a first-seen minimax lower bound. We further consider the case of private transfer learning where…

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Fréchet Cumulative Covariance Net for Deep Nonlinear Sufficient Dimension Reduction with Random Objects

Fréchet累积协方差网络:随机对象的深度非线性充分降维

Nonlinear sufficient dimension reduction\citep{libing_generalSDR}, which constructs nonlinear low-dimensional representations to summarize essential features of high-dimensional data, is an important branch of representation learning. However, most existing methods are not applicable when the response variables are complex non-Euclidean random objects, which are frequently encountered in many recent statistical applications. In this paper, we introduce a new statistical…

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Incremental effects for continuous exposures

连续暴露的增量干预效应

Causal inference problems often involve continuous treatments, such as dose, duration, or frequency. However, identifying and estimating standard dose-response estimands requires that everyone has some chance of receiving any level of the exposure (i.e., positivity). To avoid this assumption, we consider stochastic interventions based on exponentially tilting the treatment distribution by some parameter $δ$ (an incremental effect); this increases or decreases the likelihood…

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High-dimensional Spectrum Matching: Covariance Inference Based on Universality

高维谱匹配:基于普适性的协方差推断

We propose a new spectrum matching framework based on universality for high-dimensional covariance inference. The method constructs reference distributions for a broad class of spectral statistics by generating an auxiliary Gaussian matrix whose covariance spectrum matches that of the target covariance, with validity justified by universality. This framework accommodates both known and unknown covariance settings and adapts to different inferential targets, including…

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Penalized Network Cross-Validation for Nested Models by Edge-Sampling

基于边抽样的嵌套网络模型惩罚交叉验证

In the network literature, a wide range of statistical models has been proposed to exploit structural patterns in the data. Therefore, model selection between different models is a fundamental problem. However, systematic theoretical understanding remains limited when comparisons involve different model classes. To address this challenging issue, we propose a penalized edge-sampling cross-validation framework for nested network model selection. By incorporating a model…

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Longitudinal weighted and trimmed treatment effects with flip interventions

翻转干预下的纵向加权与修剪处理效应

Weighting and trimming are popular methods for addressing positivity violations in causal inference. While well-studied with single-timepoint data, standard methods do not easily generalize to longitudinal data and remain vulnerable to time-varying positivity violations. We extend weighting and trimming to longitudinal settings via stochastic “flip” interventions, which maintain the treatment status of subjects who would have received the target treatment, and flip others’…

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Transfer Learning of CATE with Kernel Ridge Regression

基于核岭回归的条件平均处理效应迁移学习

The proliferation of data has sparked significant interest in leveraging findings from one study to estimate treatment effects in a different target population without direct outcome observations. However, the transfer learning process is frequently hindered by substantial covariate shift and limited overlap between (i) the source and target populations, as well as (ii) the treatment and control groups within the source. We propose a novel method for overlap-adaptive…

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A Simple and Adaptive Confidence Interval when Nuisance Parameters Satisfy an Inequality

干扰参数满足不等式约束时的简单自适应置信区间

Inequalities may appear in many models. They can be as simple as assuming a parameter is nonnegative, possibly a regression coefficient or a treatment effect. This paper focuses on models with one inequality and proposes an inequality-imposed confidence interval (IICI) that has particularly attractive features. The IICI is simple in that it does not require simulations or tuning parameters. Also, the IICI is adaptive to the slackness of the inequality, uniformly valid, and…

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Nonparametric Predictive Inference for Discrete Data via Metropolis-Adjusted Dirichlet Sequences

基于 Metropolis 调整狄利克雷序列的离散数据非参数预测推断

This article is motivated by challenges in conducting Bayesian inferences on unknown discrete distributions, with a particular focus on count data. To avoid the computational disadvantages of traditional mixture models, we develop a novel Bayesian predictive approach. In particular, our Metropolis-adjusted Dirichlet (mad) sequence model characterizes the predictive measure as a mixture of a base measure and Metropolis-Hastings kernels centered on previous data points. The…

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Statistical Modeling of Combinatorial Response Data

组合响应数据的统计建模

There is a rich literature for modeling binary and polychotomous responses. However, existing methods are inadequate for handling combinatorial responses, where each response is an integer array under additional constraints. Such data are increasingly common in modern applications, such as surveys collected under skip logic, event propagation on a network, and observed matching in ecology. Ignoring the combinatorial structure leads to biased estimation and prediction. The…

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Poisson-Process Topic Model for Integrating Knowledge from Pre-trained Language Models

整合预训练语言模型知识的泊松过程主题模型

Topic modeling is traditionally applied to word counts without accounting for the context in which words appear. Recent advances in large language models (LLMs) offer contextualized word embeddings that capture deeper semantic meaning and relationships. We aim to leverage such embeddings to improve topic modeling.We use a pre-trained LLM to convert each document into a sequence of word embeddings. This sequence is then modeled as a Poisson point process, with its intensity…

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A Spectral Confounder Adjustment for Spatial Regression with Multiple Exposures and Outcomes

多暴露与多结局空间回归的谱混杂调整

Characterizing social vulnerability is fundamental to disaster response planning. Numerous vulnerability indicators have been developed, but they are typically not validated for their predictive power over the outcomes of interest. As with many environmental health studies where interventions are impractical or unethical, validation of social vulnerability against public health outcomes is observational and relies on spatially-dependent data. Observational studies are…

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Double/Debiased Machine Learning for Treatment Effects in Dynamic Panels

动态面板处理效应的双重/去偏机器学习

We introduce a novel framework for causal inference in dynamic panel data that extends the cross-sectional Double/Debiased Machine Learning (DML) approach. The method rests on a partially linear dynamic panel model with two-way fixed effects for potential outcomes and readily accommodates binary, multi-valued, or continuous treatments. To translate potential outcome models into an estimable form, we introduce dynamic conditional independence assumptions. By integrating…

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Metropolis–Hastings with Scalable Subsampling

采用可扩展子采样的 Metropolis–Hastings 算法

The Metropolis–Hastings (MH) algorithm is one of the most widely used Markov Chain Monte Carlo schemes for generating samples from Bayesian posterior distributions. The algorithm is asymptotically exact, flexible and easy to implement. However, in the context of Bayesian inference for large datasets, evaluating the likelihood on the full data for thousands of iterations until convergence can be prohibitively expensive. This paper introduces a new subsample MH algorithm that…

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BAP: Bayesian Biomarker-Assisted Platform Design for Dose Ranging in Multi-Agent Multi-Dose Trials

BAP:多药物多剂量试验的贝叶斯生物标志物辅助平台设计

Assessing the long-term benefits of new treatments can be expensive and time-consuming, particularly in disease areas with unmet medical needs. While platform trials enable the evaluation of multiple interventions simultaneously, they currently cannot assess studies involving multiple agents and doses or utilize longitudinal biomarkers in decision-making. We propose a Bayesian biomarker-assisted platform design that offers a unified framework for evaluating multiple…

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Safe, Always-Valid Alpha-Investing Rules For Doubly Sequential Online Inference

双重序贯在线推断中的安全且随时有效的Alpha投资规则

Dynamic decision-making in rapidly evolving research domains, including marketing, finance, and pharmaceutical development, presents a significant challenge. Researchers frequently confront the need for real-time action within a doubly sequential framework characterized by the continuous influx of high-volume data streams and the intermittent arrival of novel tasks. This calls for the development and implementation of new online inference protocols capable of handling both…

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