论文检索

混合表达数据中细胞类型比例估计的统计推断AI 解读

There is a growing interest in cell-type-specific analysis from bulk samples with a mixture of different cell types. A critical first step in such analyses is the accurate estimation of cell-type proportions in a bulk sample. Although many methods have been proposed recently, quantifying the uncertainties associated with the estimated cell-type proportions has not been well studied. Lack of consideration of these uncertainties can lead to missed or false findings in…

稀疏独立成分分析及其在自闭症皮层表面功能磁共振数据中的应用AI 解读

Independent component analysis (ICA) is widely used to estimate spatial resting-state networks and their time courses in neuroimaging studies. It is thought that independent components correspond to sparse patterns of co-activating brain locations. Previous approaches for introducing sparsity to ICA replace the non-smooth objective function with smooth approximations, resulting in components that do not achieve exact zeros. We propose a novel Sparse ICA method that enables…

从历史安慰剂对照试验推广活性对照的意向治疗效应：HPTN 084 案例AI 解读

In many clinical settings, an active-controlled trial design (e.g., a non-inferiority or superiority design) is often used to compare an experimental medicine to an active control (e.g., an FDA-approved, standard therapy). One prominent example is a recent phase 3 efficacy trial, HIV Prevention Trials Network Study 084 (HPTN 084), comparing long-acting cabotegravir, a new HIV pre-exposure prophylaxis (PrEP) agent, to the FDA-approved daily oral tenofovir disoproxil fumarate…

利用Muscle联合张量建模单细胞三维基因组与表观遗传数据AI 解读

Emerging single cell technologies that simultaneously capture long-range interactions of genomic loci together with their DNA methylation levels are advancing our understanding of three-dimensional genome structure and its interplay with the epigenome at the single cell level. While methods to analyze data from single cell high throughput chromatin conformation capture (scHi-C) experiments are maturing, methods that can jointly analyze multiple single cell modalities with…

潜在异质环境中的强化学习AI 解读

Reinforcement Learning holds great promise for data-driven decision-making in various social contexts, including healthcare, education, and business. However, classical methods that focus on the mean of the total return may yield misleading results when dealing with heterogeneous populations typically found in large-scale datasets. To address this issue, we introduce the K-Value Heterogeneous Markov Decision Process, a framework designed to handle sequential decision…

在线学习中最优政策评价的双重稳健区间估计AI 解读

Evaluating the performance of an ongoing policy plays a vital role in many areas such as medicine and economics, to provide crucial instructions on the early-stop of the online experiment and timely feedback from the environment. Policy evaluation in online learning thus attracts increasing attention by inferring the mean outcome of the optimal policy (i.e., the value) in real-time. Yet, such a problem is particularly challenging due to the dependent data generated in the…

异时采样分子数据的高效溯祖模型AI 解读

Molecular sequence variation at a locus informs about the evolutionary history of the sample and past population size dynamics. The Kingman coalescent is used in a generative model of molecular sequence variation to infer evolutionary parameters. However, it is well understood that inference under this model does not scale well with sample size. Here, we build on recent work based on a lower resolution coalescent process, the Tajima coalescent, to model longitudinal samples.…

尖峰噪声协方差下高维多元回归的一般线性假设检验AI 解读

We consider the problem of testing linear hypotheses under a multivariate regression model with a high-dimensional response and spiked noise covariance. The proposed family of tests consists of test statistics based on a weighted sum of projections of the data onto the estimated latent factor directions, with the weights acting as the regularization parameters. We establish asymptotic normality of the test statistics under the null hypothesis. We also establish the power…

噪声下函数局部极值的半参数贝叶斯推断AI 解读

There is a wide range of applications where the local extrema of a function are the key quantity of interest. However, there is surprisingly little work on methods to infer local extrema with uncertainty quantification in the presence of noise. By viewing the function as an infinite-dimensional nuisance parameter, a semiparametric formulation of this problem poses daunting challenges, both methodologically and theoretically, as (i) the number of local extrema may be unknown,…

层间依赖多层网络的一致社群检测AI 解读

Community detection in multi-layer networks, which aims at finding groups of nodes with similar connective patterns among all layers, has attracted tremendous interests in multi-layer network analysis. Most existing methods are extended from those for single-layer networks, which assume that different layers are independent. In this article, we propose a novel community detection method in multi-layer networks with inter-layer dependence, which integrates the stochastic…

动态矩阵恢复AI 解读

Matrix recovery from sparse observations is an extensively studied topic emerging in various applications, such as recommendation system and signal processing, which includes the matrix completion and compressed sensing models as special cases. In this article, we propose a general framework for dynamic matrix recovery of low-rank matrices that evolve smoothly over time. We start from the setting that the observations are independent across time, then extend to the setting…

高斯链图模型的可识别性与一致估计AI 解读

The chain graph model admits both undirected and directed edges in one graph, where symmetric conditional dependencies are encoded via undirected edges and asymmetric causal relations are encoded via directed edges. Though frequently encountered in practice, the chain graph model has been largely under investigated in literature, possibly due to the lack of identifiability conditions between undirected and directed edges. In this paper, we first establish a set of novel…

极值随机森林AI 解读

Classical methods for quantile regression fail in cases where the quantile of interest is extreme and only few or no training data points exceed it. Asymptotic results from extreme value theory can be used to extrapolate beyond the range of the data, and several approaches exist that use linear regression, kernel methods or generalized additive models. Most of these methods break down if the predictor space has more than a few dimensions or if the regression function of…

具有非对称反事实效用的政策学习AI 解读

Data-driven decision making plays an important role even in high stakes settings like medicine and public policy. Learning optimal policies from observed data requires a careful formulation of the utility function whose expected value is maximized across a population. Although researchers typically use utilities that depend on observed outcomes alone, in many settings the decision maker’s utility function is more properly characterized by the joint set of potential outcomes…

基于复合似然的时空过程变点检测AI 解读

This article develops a unified and computationally efficient method for change-point estimation along the time dimension in a nonstationary spatio-temporal process. By modeling a nonstationary spatio-temporal process as a piecewise stationary spatio-temporal process, we consider simultaneous estimation of the number and locations of change-points, and model parameters in each segment. A composite likelihood-based criterion is developed for change-point and parameter…

利用变分贝叶斯与拉普拉斯近似拟合潜在非高斯模型AI 解读

Latent Gaussian models (LGMs) are perhaps the most commonly used class of models in statistical applications. Nevertheless, in areas ranging from longitudinal studies in biostatistics to geostatistics, it is easy to find datasets that contain inherently non-Gaussian features, such as sudden jumps or spikes, that adversely affect the inferences and predictions made using an LGM. These datasets require more general latent non-Gaussian models (LnGMs) that can handle…

多元函数型时间序列的图主成分分析AI 解读

In this paper, we consider multivariate functional time series with a two-way dependence structure: a serial dependence across time points and a graphical interaction among the multiple functions within each time point. We develop the notion of dynamic weak separability, a more general condition than those assumed in literature, and use it to characterize the two-way structure in multivariate functional time series. Based on the proposed weak separability, we develop a…

稳健验证：分布漂移下的预测不确定性保障AI 解读

While the traditional viewpoint in machine learning and statistics assumes training and testing samples come from the same population, practice belies this fiction. One strategy—coming from robust statistics and optimization—is thus to build a model robust to distributional perturbations. In this article, we take a different approach to describe procedures for robust predictive inference, where a model provides uncertainty estimates on its predictions rather than point…

多个分布之间的核差异度量AI 解读

Given M≥2 distributions defined on a general measurable space, we introduce a nonparametric (kernel) measure of multi-sample dissimilarity (KMD)—a parameter that quantifies the difference between the M distributions. The population KMD, which takes values between 0 and 1, is 0 if and only if all the M distributions are the same, and 1 if and only if all the distributions are mutually singular. Moreover, KMD possesses many properties commonly associated with f-divergences…

基于 Kiefer–Wolfowitz 方法的随机优化在线统计推断AI 解读

This article investigates the problem of online statistical inference of model parameters in stochastic optimization problems via the Kiefer-Wolfowitz algorithm with random search directions. We first present the asymptotic distribution for the Polyak-Ruppert-averaging type Kiefer-Wolfowitz (AKW) estimators, whose asymptotic covariance matrices depend on the distribution of search directions and the function-value query complexity. The distributional result reflects the…

高维含噪类别数据的聚类AI 解读

Clustering is a widely used unsupervised learning technique that groups data into homogeneous clusters. However, when dealing with real-world data that contain categorical values, existing algorithms can be computationally costly in high dimensions and can struggle with noisy data that has missing values. Furthermore, except for one algorithm, no others provide theoretical guarantees of clustering accuracy. In this article, we propose a general categorical data encoding…

多重比较的分割 Knockoff：控制方向性错误发现率AI 解读

Multiple comparisons in hypothesis testing often encounter structural constraints in various applications. For instance, in structural Magnetic Resonance Imaging for Alzheimer’s Disease, the focus extends beyond examining atrophic brain regions to include comparisons of anatomically adjacent regions. These constraints can be modeled as linear transformations of parameters, where the sign patterns play a crucial role in estimating directional effects. This class of problems,…

集群随机实验中模型稳健且有效的协变量调整AI 解读

Cluster-randomized experiments are increasingly used to evaluate interventions in routine practice conditions, and researchers often adopt model-based methods with covariate adjustment in the statistical analyses. However, the validity of model-based covariate adjustment is unclear when the working models are misspecified, leading to ambiguity of estimands and risk of bias. In this article, we first adapt two conventional model-based methods, generalized estimating equations…

利用 Gram–Schmidt Walk 设计平衡随机实验协变量AI 解读

The design of experiments involves a compromise between covariate balance and robustness.This article provides a formalization of this tradeoff and describes an experimental design that allows experimenters to navigate it.The design is specified by a robustness parameter that bounds the worst-case mean squared error of an estimator of the average treatment effect.Subject to the experimenter's desired level of robustness, the design aims to simultaneously balance all linear…