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Improved Bounds and Inference on Optimal Regimes

最优治疗规则的改进界与推断

Point identification of causal effects requires strong assumptions that are unreasonable in many practical settings. However, informative bounds on these effects can often be derived under plausible assumptions. Even when these bounds are wide or cover null effects, they can guide practical decisions based on formal decision theoretic criteria. Here we derive new results on optimal treatment regimes in settings where the effect of interest is bounded. These results are…

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Balanced Sampling With Inequalities: Application to Category Bounding, Matrix Rounding, and Spread Sampling

带不等式约束的平衡抽样:类别边界、矩阵舍入与空间分散抽样

In this article, we propose a novel algorithm for balanced sample selection with linear inequality constraints, ensuring that estimators remain within fixed bounds. This algorithm extends the cube method of Deville and Tillé, allowing the selection of a sample from a database where Horvitz-Thompson estimators of totals are equal or nearly equal to the true population totals. The new algorithm has several key applications, including imposing minimum sample sizes for small…

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Using Total Margin of Error to Account for Non-Sampling Error in Election Polls

用总误差幅度纳入选举民调的非抽样误差

The potential impact of non-sampling errors on election polls is well known, but measurement has focused on the margin of sampling error. Statisticians have recommended measurement of total survey error by mean square error (MSE), which jointly measures sampling and non-sampling errors. We suggest use of the square root of maximum MSE to measure the total margin of error (TME). We suggest that measurement of TME should be a standard feature in the reporting of polls. Because…

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Statistical Quantile Learning for Large Additive Latent Variable Models

大型加性潜变量模型的统计分位数学习

Large and complex datasets, emerging from technological advancements in fields such as genomics and brain imaging, hold ample promise for gaining new scientific insights. Yet, their inherent nonlinearity and high dimensionality present considerable theoretical, methodological, and application challenges to the statistics and machine learning community. This article introduces Statistical Quantile Learning (SQL), a new nonparametric method for estimating large additive latent…

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Word-Level Maximum Mean Discrepancy Regularization for Word Embedding

用于词嵌入的词级最大均值差异正则化

The technique of word embedding is widely used in natural language processing (NLP) to represent words as numerical vectors in textual datasets. However, the estimation of word embedding may suffer from severe overfitting due to the huge variety of words. To address the issue, this article proposes a novel regularization framework that recognizes and accounts for the “word-level distribution discrepancy”–a common phenomenon in a range of NLP tasks where word distributions…

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Data Thinning for Poisson Factor Models and its Applications

泊松因子模型的数据稀释及其应用

The Poisson factor model is a powerful tool for dimension reduction and visualization of large-scale count datasets across diverse domains. Despite the availability of efficient algorithms for estimating factors and loadings, existing methods either require prior knowledge of the number of factors, or resort to ad hoc criteria for its determination. This article proposes a novel data-driven criterion called Information Criterion via Data Thinning (ICDT), leveraging the…

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Linear-Cost Vecchia Approximation of Multivariate Normal Probabilities

多元正态概率的线性成本 Vecchia 近似

Multivariate normal (MVN) probabilities arise in myriad applications, but they are analytically intractable and need to be evaluated via Monte Carlo-based numerical integration. For the state-of-the-art minimax exponential tilting (MET) method, we show that the complexity of each of its components can be greatly reduced through an integrand parameterization that uses the sparse inverse Cholesky factor produced by the Vecchia approximation, whose approximation error is often…

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A Bayesian Nonparametric Approach to Mediation and Spillover Effects with Multiple Mediators in Cluster-Randomized Trials

整群随机试验中多重中介与溢出效应的贝叶斯非参数方法

Cluster randomized trials (CRTs) with multiple unstructured mediators present significant methodological challenges for causal inference due to within-cluster correlation, interference among units, and the complexity introduced by multiple mediators. Existing causal mediation methods often fall short in simultaneously addressing these complexities, particularly in disentangling mediator-specific effects under interference that are central to studying complex mechanisms. To…

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On the Poor Statistical Properties of the P -Curve Meta-Analytic Procedure

P-curve 元分析程序的不良统计性质

The P-curve is a widely used suite of meta-analytic tests advertised for detecting problems in sets of studies. They are based on nonparametric combinations of p values (e.g., Marden) across significant (p < .05) studies and are variously claimed to detect “evidential value”, “lack of evidential value”, and “left skew” in p values. We show that these tests do not have the properties ascribed to them. Moreover, they fail basic desiderata for tests, including admissibility and…

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The Effect of Alcohol Intake on Brain White Matter Microstructural Integrity: A New Causal Inference Framework for Incomplete Phenomic Data

饮酒对白质微结构完整性的影响:不完整表型数据的因果推断框架

Although substance use, such as alcohol intake, is known to be associated with cognitive decline during aging, its direct influence on the central nervous system remains incompletely understood. In this study, we investigate the influence of alcohol intake frequency on reduction of brain white matter microstructural integrity in the fornix, a brain region considered a promising marker of age-related microstructural degeneration, using a large UK Biobank (UKB) cohort with…

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Inference for Low-Rank Models Without Estimating the Rank

无需估计秩的低秩模型推断

This paper studies the inference about linear functionals of high-dimensional low-rank matrices. While most existing inference methods would require consistent estimation of the true rank, our procedure is robust to rank misspecification, making it a promising approach in applications where rank estimation can be unreliable. We estimate the low-rank spaces using pre-specified weighting matrices, known as diversified projections. A novel statistical insight is that, unlike…

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Inference on the Proportion of Variance Explained in Principal Component Analysis

主成分分析中方差解释比例的统计推断

Principal component analysis (PCA) is a longstanding approach for dimension reduction. It rests upon the assumption that the underlying signal has low rank, and thus can be well-summarized using a small number of dimensions. The output of PCA is typically represented using a scree plot, which displays the proportion of variance explained (PVE) by each principal component. While the PVE is extensively reported in routine analyses, to the best of our knowledge the notion of…

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A Powerful Transformation of Quantitative Responses for Biobank-Scale Association Studies

面向生物样本库规模关联研究的高功效定量响应变换

In linear regression models with non-Gaussian errors, transformations of the response variable are widely used in a broad range of applications. Motivated by various genetic association studies, transformation methods for hypothesis testing have received substantial interest. In recent years, the rise of biobank-scale genetic studies, which feature a vast number of participants that could be around half a million, spurred the need for new transformation methods that are both…

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Effect Aliasing in Observational Studies

观察性研究中的效应混杂

In experimental design, aliasing of effects occurs in fractional factorial experiments, where certain low order factorial effects are indistinguishable from certain high order interactions: low order contrast weights may be orthogonal to one another, while their higher order interactions are aliased and not identified. In observational studies, aliasing occurs when certain combinations of covariates—for example, time period and various eligibility criteria for…

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Confidence Sets for Causal Orderings

因果顺序的置信集合

Causal discovery procedures aim to deduce causal relationships among variables in a multivariate dataset. While various methods have been proposed for estimating a single causal model or a single equivalence class of models, less attention has been given to quantifying uncertainty in causal discovery in terms of confidence statements. A primary challenge in causal discovery of directed acyclic graphs is determining a causal ordering among the variables, and our work offers a…

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A Minimax Two-Sample Test for Functional Data via Grothendieck’s Divergence

基于 Grothendieck 散度的函数型数据极小极大两样本检验

Our proposed approach addresses the challenges associated with nonparametric two-sample testing for densely measured functional data. These challenges stem from the high dimensionality of data and the nature of the observation scheme. We introduce a novel metric concept for random functions known as Grothendieck’s divergence to overcome these challenges, which satisfies the homogeneity-zero equivalence property. Our approach uses a pre-smoothing technique on densely measured…

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Online Policy Learning and Inference by Matrix Completion

通过矩阵补全开展在线策略学习与推断

Is it possible to make online decisions when personalized covariates are unavailable? We take a collaborative-filtering approach for decision-making based on collective preferences. By assuming low-dimensional latent features, we formulate the covariate-free decision-making problem as a matrix completion bandit. We propose a policy learning procedure that combines an ε-greedy policy for decision-making with an online gradient descent algorithm for bandit parameter…

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Dimension Reduction for Large-Scale Federated Data: Statistical Rate and Asymptotic Inference

大规模联邦数据降维:统计误差率与渐近推断

In light of the rapidly growing large-scale data in federated ecosystems, the traditional principal component analysis (PCA) is often not applicable due to privacy protection considerations and large computational burden. Algorithms were proposed to lower the computational cost, but few can handle both high dimensionality and massive sample size under distributed settings. In this paper, we propose the FAst DIstributed (FADI) PCA method for federated data when both the…

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Debiased Calibration Estimation Using Generalized Entropy in Survey Sampling

调查抽样中基于广义熵的去偏校准估计

Incorporating auxiliary information into the survey estimation is a fundamental problem in survey sampling. Calibration weighting is a widely used technique to integrate such information by adjusting design weights to meet benchmarking constraints. Traditional methods, such as those proposed by Deville and Särndal (1992), solve this problem by minimizing a distance between calibrated and design weights. In this paper, we propose a novel calibration framework that instead…

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Estimation of Out-of-Sample Sharpe Ratio for High Dimensional Portfolio Optimization

高维投资组合优化中的样本外夏普比率估计

Portfolio optimization aims at constructing a realistic portfolio with significant out-of-sample performance, which is typically measured by the out-of-sample Sharpe ratio. However, due to in-sample optimism, it is inappropriate to use the in-sample estimated covariance to evaluate the out-of-sample Sharpe, especially in the high dimensional settings. In this paper, we propose a novel method to estimate the out-of-sample Sharpe ratio using only in-sample data, based on…

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A Goodness-of-Fit Assessment for General Learning Procedures in High Dimensions

高维一般学习程序的拟合优度评估

Black-box learners have demonstrated remarkable success across various fields due to their high predictive accuracy. However, the complexity of their learning procedures poses significant challenges in evaluating whether a given learner has achieved optimal performance on datasets with unknown data-generating mechanisms. We propose a general goodness-of-fit test for assessing different learning procedures involving high-dimensional predictors, encompassing methods from…

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SOFARI: High-Dimensional Manifold-Based Inference

SOFARI:基于流形的高维统计推断

Multi-task learning is a widely used technique for harnessing information from various tasks. Recently, the sparse orthogonal factor regression (SOFAR) framework, based on the sparse singular value decomposition (SVD) within the coefficient matrix, was introduced for interpretable multi-task learning, enabling the discovery of meaningful latent feature-response association networks across different layers. However, conducting precise inference on the latent factor matrices…

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Additive Multi-Index Gaussian Process Modeling, with Application to Multi-Physics Surrogate Modeling of the Quark-Gluon Plasma

加性多指标高斯过程及其在夸克—胶子等离子体多物理代理建模中的应用

The Quark-Gluon Plasma (QGP) is a unique phase of nuclear matter, theorized to have filled the Universe shortly after the Big Bang. A critical challenge in studying the QGP is that, to reconcile experimental observables with theoretical parameters, one requires many simulation runs of a complex physics model over a high-dimensional parameter space. Each run is computationally expensive, requiring thousands of CPU hours, thus limiting physicists to only several hundred runs.…

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Design and Analysis of Randomized Trials to Estimate Spatio-Temporally Heterogeneous Treatment Effects

估计时空异质处理效应的随机试验设计与分析

In this article, we consider randomized trial design to evaluate interventions with spatially or spatio-temporally heterogeneous effects. A common approach in this setting is the cluster randomized trial. In many cases, clusters are constituted as discrete subdivisions of a contiguous area of interest. However, cluster trials designed in this way may suffer from issues of spillover and may fail to capture the relevant spatial and temporal effects. We define possible…

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