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Competing Risks Quantile Regression

竞争风险分位数回归

Quantile regression has emerged as a significant extension of traditional linear models and its potential in survival applications has recently been recognized. In this paper we study quantile regression with competing risks data, formulating the model based on conditional quantiles defined using the cumulative incidence function, which includes as a special case an analog to the usual accelerated failure time model. The proposed competing risks quantile regression model…

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Empirical Likelihood in Missing Data Problems

缺失数据问题中的经验似然

Missing data is a ubiquitous problem in medical and social sciences. It is well known that inferences based only on the complete data may not only lose efficiency, but may also lead to biased results if the data is not missing completely at random (MCAR). The inverse-probability weighting method proposed by Horvitz and Thompson (1952) is a popular alternative when the data is not MCAR. The Horvitz–Thompson method, however, is sensitive to the inverse weights and may suffer…

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Multivariate Statistical Process Control Using LASSO

基于 LASSO 的多变量统计过程控制

This article develops a new multivariate statistical process control (SPC) methodology based on adapting the LASSO variable selection method to the SPC problem. The LASSO method has the sparsity property of being able to select exactly the set of nonzero regression coefficients in multivariate regression modeling, which is especially useful in cases where the number of nonzero coefficients is small. In multivariate SPC applications, process mean vectors often shift in a…

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The Analysis of Two-Way Functional Data Using Two-Way Regularized Singular Value Decompositions

利用双向正则化奇异值分解分析双向函数型数据

Two-way functional data consist of a data matrix whose row and column domains are both structured, for example, temporally or spatially, as when the data are time series collected at different locations in space. We extend one-way functional principal component analysis (PCA) to two-way functional data by introducing regularization of both left and right singular vectors in the singular value decomposition (SVD) of the data matrix. We focus on a penalization approach and…

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Modeling and Inference for Measured Crystal Orientations and a Tractable Class of Symmetric Distributions for Rotations in Three Dimensions

晶体取向测量的建模推断与一类易处理的三维旋转对称分布

Electron backscatter diffraction (EBSD) is a technique used in materials science to study the microtexture of metals, producing data that measure the orientations of crystals in a specimen. We examine the precision of such data based on a useful class of distributions on orientations in three dimensions (as represented by 3×3 orthogonal matrices with positive determinants). Although such modeling has received attention in the statistical literature, the approach taken…

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Option Pricing With Model-Guided Nonparametric Methods

模型引导的非参数期权定价方法

Parametric option pricing models are widely used in finance. These models capture several features of asset price dynamics; however, their pricing performance can be significantly enhanced when they are combined with nonparametric learning approaches that learn and correct empirically the pricing errors. In this article we propose a new nonparametric method for pricing derivatives assets. Our method relies on the state price distribution instead of the state price density,…

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Forward Regression for Ultra-High Dimensional Variable Screening

超高维变量筛选中的前向回归

Motivated by the seminal theory of Sure Independence Screening (Fan and Lv 2008, SIS), we investigate here another popular and classical variable screening method, namely, forward regression (FR). Our theoretical analysis reveals that FR can identify all relevant predictors consistently, even if the predictor dimension is substantially larger than the sample size. In particular, if the dimension of the true model is finite, FR can discover all relevant predictors within a…

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Conditional Quantile Estimation for Generalized Autoregressive Conditional Heteroscedasticity Models

GARCH 模型的条件分位数估计

Conditional quantile estimation is an essential ingredient in modern risk management. Although generalized autoregressive conditional heteroscedasticity (GARCH) processes have proven highly successful in modeling financial data, it is generally recognized that it would be useful to consider a broader class of processes capable of representing more flexibly both asymmetry and tail behavior of conditional returns distributions. In this article we study estimation of…

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p -Values for High-Dimensional Regression

高维回归中的 p 值

Assigning significance in high-dimensional regression is challenging. Most computationally efficient selection algorithms cannot guard against inclusion of noise variables. Asymptotically valid p-values are not available. An exception is a recent proposal by Wasserman and Roeder that splits the data into two parts. The number of variables is then reduced to a manageable size using the first split, while classical variable selection techniques can be applied to the remaining…

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What Are the Limits of Posterior Distributions Arising From Nonidentified Models, and Why Should We Care?

非识别模型后验分布的极限是什么,为何值得关注?

In health research and other fields, the observational data available to researchers often fall short of the data that ideally would be available, due to the inherent limitations of study design and data acquisition. Were they available, these ideal data might be readily analyzed via straightforward statistical models with such desirable properties as parameter identifiability. Conversely, realistic models for the available data that incorporate uncertainty about the link…

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Logistic Regression With Brownian-Like Predictors

具有类布朗运动预测变量的逻辑回归

This article introduces a new type of logistic regression model involving functional predictors of binary responses, and provides an extension of this approach to generalized linear models. The predictors are trajectories that have certain sample path properties in common with Brownian motion. Time points are treated as parameters of interest, and confidence intervals are developed under prospective and retrospective (case-control) sampling designs. In an application to…

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Sequential Implementation of Monte Carlo Tests With Uniformly Bounded Resampling Risk

具有一致有界重抽样风险的蒙特卡洛检验序贯实现

This paper introduces an open-ended sequential algorithm for computing the p-value of a test using Monte Carlo simulation. It guarantees that the resampling risk, the probability of a different decision than the one based on the theoretical p-value, is uniformly bounded by an arbitrarily small constant. Previously suggested sequential or nonsequential algorithms, using a bounded sample size, do not have this property. Although the algorithm is open-ended, the expected number…

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Efficient Global Approximation of Generalized Nonlinear ℓ 1 -Regularized Solution Paths and Its Applications

广义非线性 ℓ1 正则化解路径的高效全局近似及应用

We consider efficient construction of nonlinear solution paths for general ℓ1-regularization. Unlike the existing methods that incrementally build the solution path through a combination of local linear approximation and recalibration, we propose an efficient global approximation to the whole solution path. With the loss function approximated by a quadratic spline, we show that the solution path can be computed using a generalized Lars algorithm. The proposed methodology…

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Semiparametric Efficient Estimation for Incomplete Longitudinal Binary Data, With Application to Smoking Trends

不完整纵向二元数据的半参数有效估计及吸烟趋势应用

Incomplete longitudinal data often are analyzed with estimating equations for inference on a parameter from a marginal mean regression model. Generalized estimating equations, although commonly used for incomplete longitudinal data, are invalid for data that are not missing completely at random. There exists a class of inverse probability weighted estimating equations that are valid under dropouts missing at random, including an easy-to-implement but inefficient member. A…

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Analysis of Multifactor Affine Yield Curve Models

多因子仿射收益率曲线模型分析

In finance and economics much work has been done on the theoretical modeling and statistical estimation of the yield curve, defined as the relationship between (−1/τ) log pt(τ) and τ, where pt(τ) is the time t price of a zero-coupon bond with payoff 1 at maturity date t+τ. Of considerable current interest are models of the yield curve in which a collection of observed and latent factors determine the market price of factor risks, the stochastic discount factor, and the…

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Bayesian Calibration of Microsimulation Models

微观模拟模型的贝叶斯校准

Microsimulation models that describe disease processes synthesize information from multiple sources and can be used to estimate the effects of screening and treatment on cancer incidence and mortality at a population level. These models are characterized by simulation of individual event histories for an idealized population of interest. Microsimulation models are complex and invariably include parameters that are not well informed by existing data. Therefore, a key…

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Nonparametric Transition-Based Tests for Jump Diffusions

基于转移分布的跳跃扩散非参数检验

We develop a specification test for the transition density of a discretely sampled continuous-time jump-diffusion process, based on a comparison of a nonparametric estimate of the transition density or distribution function with their corresponding parametric counterparts assumed by the null hypothesis. As a special case, our method applies to pure diffusions. We provide a direct comparison of the two densities for an arbitrary specification of the null parametric model…

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Cox Models With Smooth Functional Effect of Covariates Measured With Error

含测量误差协变量平滑效应的 Cox 模型

We propose, develop, and implement a fully Bayesian inferential approach for the Cox model when the log hazard function contains unknown smooth functions of the variables measured with error. Our approach is to model nonparametrically both the log-baseline hazard and the smooth components of the log-hazard functions using low-rank penalized splines. Careful implementation of the Bayesian inferential machinery is shown to produce remarkably better results than the naive…

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Nonparametric Prediction in Measurement Error Models

测量误差模型中的非参数预测

Predicting the value of a variable Y corresponding to a future value of an explanatory variable X, based on a sample of previously observed independent data pairs (X(1), Y(1)), …, (X(n), Y(n)) distributed like (X, Y), is very important in statistics. In the error-free case, where X is observed accurately, this problem is strongly related to that of standard regression estimation, since prediction of Y can be achieved via estimation of the regression curve E(Y|X). When the…

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Constructing Confidence Regions of Optimal Expected Size

构造具有最优期望大小的置信区域

This article presents a Monte Carlo method for approximating the minimax expected size (MES) confidence set for a parameter known to lie in a compact set. The algorithm is motivated by problems in the physical sciences in which parameters are unknown physical constants related to the distribution of observable phenomena through complex numerical models. The method repeatedly draws parameters at random from the parameter space and simulates data as if each of those values…

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Weighted Normal Spatial Scan Statistic for Heterogeneous Population Data

异质总体数据的加权正态空间扫描统计量

In geographical spatial epidemiology and disease surveillance, all the existing spatial scan methods for cluster detection using continuous data are designed for evaluating clusters of individuals and analyzing individual-level data. Motivated by growing demands to study the spatial heterogeneity of continuous measures in population data, such as mortality rates, survival rates, average body mass indexes and pollution at state, county, and census tract levels, we propose a…

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Analyzing Length-Biased Data With Semiparametric Transformation and Accelerated Failure Time Models

利用半参数变换与加速失效时间模型分析长度偏倚数据

Right-censored time-to-event data are often observed from a cohort of prevalent cases that are subject to length-biased sampling. Informative right censoring of data from the prevalent cohort within the population often makes it difficult to model risk factors on the unbiased failure times for the general population, because the observed failure times are length biased. In this paper, we consider two classes of flexible semiparametric models: the transformation models and…

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Empirical Bayes Estimates for Large-Scale Prediction Problems

大规模预测问题的经验贝叶斯估计

Classical prediction methods such as Fisher's linear discriminant function were designed for small-scale problems, where the number of predictors N is much smaller than the number of observations n. Modern scientific devices often reverse this situation. A microarray analysis, for example, might include n = 100 subjects measured on N = 10,000 genes, each of which is a potential predictor. This paper proposes an empirical Bayes approach to large-scale prediction, where the…

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An Incomplete-Data Quasi-Likelihood Approach to Haplotype-Based Genetic Association Studies on Related Individuals

相关个体单倍型遗传关联研究的不完整数据准似然方法

We propose an incomplete-data, quasi-likelihood framework, for estimation and score tests, which accommodates both dependent and partially-observed data. The motivation comes from genetic association studies, where we address the problems of estimating haplotype frequencies and testing association between a disease and haplotypes of multiple tightly-linked genetic markers, using case-control samples containing related individuals. We consider a more general setting in which…

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