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Estimation in a simple random effects model with nonnormal distributions

非正态分布下简单随机效应模型的估计

A simple structural model is considered involving the addition of two random variables representing between‐ and within‐group variation. Methods for estimating the cumulants of the two components of variation are proposed, based on homogeneous polynomials in the data. Emphasis is placed on situations in which the number of observations per group is quite small. In some cases an essentially unique estimator is available, whereas in others there is a family of possible…

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Bayesian inference for the uncertainty distribution of computer model outputs

计算机模型输出不确定性分布的贝叶斯推断

We consider a problem of inference for the output of a computationally expensive computer model. We suppose that the model is to be used in a context where the values of one or more inputs are uncertain, so that the input configuration is a random variable. We require to make inference about the induced distribution of the output. This distribution is called the uncertainty distribution, and the general problem is known to users of computer models as uncertainty analysis. To…

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Asymptotic approximations to posterior distributions via conditional moment equations

通过条件矩方程渐近逼近后验分布

We consider asymptotic approximations to joint posterior distributions in situations where the full conditional distributions referred to in Gibbs sampling are asymptotically normal. Our development focuses on problems where data augmentation facilitates simpler calculations, but results hold more generally. Asymptotic mean vectors are obtained as simultaneous solutions to fixed point equations that arise naturally in the development. Asymptotic covariance matrices flow…

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A recursive algorithm for Markov random fields

马尔可夫随机场的递归算法

We propose a recursive algorithm as a more useful alternative to the Brook expansion for the joint distribution of a vector of random variables when the original formulation is in terms of the corresponding full conditional distributions, as occurs for Markov random fields. Usually, in practical applications, the computational load will still be excessive but then the algorithm can be used to obtain the componentwise full conditionals of a system after marginalising over…

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An efficient design for model discrimination and parameter estimation in linear models

兼顾线性模型辨别与参数估计的有效试验设计

We consider experimental designs in a regression set‐up where the unknown regression function belongs to a known family of nested linear models. The objective of our design is to select the correct model from the family of nested models as well as to estimate efficiently the parameters associated with that model. We show that our proposed design is able to choose the true model with probability tending to one as the number of trials grows to infinity. We also establish that…

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Circular regression

圆周回归

A new model for an angular regression link function is introduced. The model employs an angular scale parameter, incorporates proper and improper rotations as special cases, and is equivalent to the Möbius circle mapping for complex variables. Desirable properties of the circle mapping carry over to angular regression. Parameter estimation and inferential methods are developed and illustrated.

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Semiparametric analysis of transformation models with censored data

删失数据变换模型的半参数分析

A unified estimation procedure is proposed for the analysis of censored data using linear transformation models, which include the proportional hazards model and the proportional odds model as special cases. This procedure is easily implemented numerically and its validity does not rely on the assumption of independence between the covariates and the censoring variable. The estimator is the same as the Cox partial likelihood estimator in the case of the proportional hazards…

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Efficient estimation in additive hazards regression with current status data

现状数据下加性风险回归的有效估计

Current status data arise when the exact timing of an event is unobserved, and it is only known at a given point in time whether or not the event has occurred. Recently Lin et al. (1998) studied the additive semiparametric hazards model for current status data. They showed that the analysis of current status data under the additive hazards model reduces to ordinary Cox regression under the assumption that a proportional hazards model may be used to describe the monitoring…

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Estimation of the failure time distribution in the presence of informative censoring

信息性删失下失效时间分布的估计

We present a method for estimating the survival curve of a continuous failure time random variable from right-censored data. Our method allows adjustment for informative censoring due to measured prognostic factors for time-to-event and censoring while simultaneously quantifying the sensitivity of the inference to residual dependence between failure and censoring due to unmeasured factors. We present the results of a simulation study and illustrate our approach using data…

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Estimation in a semiparametric model for longitudinal data with unspecified dependence structure

依赖结构未指定的纵向数据半参数模型估计

This paper considers an extension of M‐estimators in semiparametric models for independent observations to the case of longitudinal data. We approximate the nonparametric function by a regression spline, and any M‐estimation algorithm for the usual linear models can then be used to obtain consistent estimators of the model and valid large‐sample inferences about the regression parameters without any specification of the error distribution and the covariance structure.…

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Analysis of clustered data: A combined estimating equations approach

聚类数据分析:组合估计方程方法

Examples of clustered data include data from longitudinal studies and data sampled within groups. This paper proposes a regression analysis method for clustered data that optimally weights and combines contrasts of the data through a combination of estimating equations. Examples of combining between‐cluster, within‐cluster and longitudinal data contrasts are presented. The method results in increased estimation efficiency relative to generalised estimating equations with…

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Bayesian analysis of covariance matrices and dynamic models for longitudinal data

纵向数据协方差矩阵与动态模型的贝叶斯分析

Parsimonious modelling of the within‐subject covariance structure while heeding its positive‐definiteness is of great importance in the analysis of longitudinal data. Using the Cholesky decomposition and the ensuing unconstrained and statistically meaningful reparameterisation, we provide a convenient and intuitive framework for developing conditionally conjugate prior distributions for covariance matrices and show their connections with generalised inverse Wishart priors.…

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Bayesian nonparametric multiple imputation of partially observed data with ignorable nonresponse

可忽略无响应下部分观测数据的贝叶斯非参数多重插补

We present a new, nonparametric Bayesian method for multiple imputation of partially observed data for which the pattern of missingness is arbitrary and the data are missing at random with ignorable nonresponse with respect to the model specification. Motivation for the method is provided, followed by an overview of Pólya trees and their application to multiple imputation, and a comparison of the new method to existing approaches is presented. The method is illustrated on a…

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Bayesian mixture of splines for spatially adaptive nonparametric regression

用于局部自适应非参数回归的贝叶斯样条混合

A Bayesian approach is presented for spatially adaptive nonparametric regression where the regression function is modelled as a mixture of splines. Each component spline in the mixture has associated with it a smoothing parameter which is defined over a local region of the covariate space. These local regions overlap such that individual data points may lie simultaneously in multiple regions. Consequently each component spline has attached to it a weight at each point of the…

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Expected-posterior prior distributions for model selection

用于模型选择的期望后验先验分布

We consider the problem of comparing parametric models using a Bayesian approach. A new method of developing prior distributions for the model parameters is presented, called the expected‐posterior prior approach. The idea is to define the priors for all models from a common underlying predictive distribution, in such a way that the resulting priors are amenable to modern Markov chain Monte Carlo computational techniques. The approach has subjective Bayesian and default…

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Probabilistic model for two dependent circular variables

两个相依圆周变量的概率模型

Motivated by problems in molecular biology and molecular physics, we propose a five‐parameter torus analogue of the bivariate normal distribution for modelling the distribution of two circular random variables. The conditional distributions of the proposed distribution are von Mises. The marginal distributions are symmetric around their means and are either unimodal or bimodal. The type of shape depends on the configuration of parameters, and we derive the conditions that…

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Sequential tests and estimators after overrunning based on maximum-likelihood ordering

基于最大似然排序的停止后追加数据序贯检验与估计

SUMMARY Often in sequential trials some additional data become available after a stopping boundary has been reached. A method for incorporating such information from overrunning is developed, based on a maximum-likelihood ordering of the sample space after overrunning. This yields a p-value for the primary test and a median-unbiased estimator and confidence intervals for the parameter under test. The context is that of observing a Brownian motion with drift, with either…

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A Poisson model for the coverage problem with a genomic application

覆盖问题的 Poisson 模型及其基因组应用

Suppose a population has infinitely many individuals and is partitioned into unknown N disjoint classes. The sample coverage of a random sample from the population is the total proportion of the classes observed in the sample. This paper uses a nonparametric Poisson mixture model to give new understanding and results for inference on the sample coverage. The Poisson mixture model provides a simplified framework for inferring any general abundance‐K coverage, the sum of the…

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Comparing nonnested Cox models

非嵌套 Cox 模型的比较

We derive the limiting distribution of the partial likelihood ratio under general conditions. The multiplicative hazards models being fitted may be nonnested and misspecified. The true model is not assumed to contain either model under consideration. The null hypothesis is that the models are equidistant in Kullback–Leibler metric applied to the rank likelihood. The statistic is consistent for the model which is closer to the truth. Its distribution depends on the unknown…

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A simple and efficient simulation smoother for state space time series analysis

状态空间时间序列分析的简便高效模拟平滑器

A simulation smoother in state space time series analysis is a procedure for drawing samples from the conditional distribution of state or disturbance vectors given the observations. We present a new technique for this which is both simple and computationally efficient. The treatment includes models with diffuse initial conditions and regression effects. Computational comparisons are made with the previous standard method. Two applications are provided to illustrate the use…

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Testing model adequacy for dynamic panel data with intercorrelation

具有相互相关性的动态面板模型适合性检验

We give several definitions of residual autocorrelations and derive their joint asymptotic distribution for the panel time series model of Hjellvik & Tjøstheim (1999a). A portmanteau goodness‐of‐fit test arises naturally from the asymptotic distribution. Simulation results show that the asymptotic standard errors compared satisfactorily with the empirical standard errors, that the goodness‐of‐fit test has reasonable empirical size, and that it is powerful enough to be useful…

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A note on approximate Bayesian bootstrap imputation

近似贝叶斯自助法插补的一则说明

The approximate Bayesian bootstrap is suggested by Rubin & Schenker (1986) as a way of generating multiple imputations when the original sample can be regarded as independently and identically distributed and the response mechanism is ignorable. We investigate the finite sample properties of the variance estimator when the approximate Bayesian bootstrap method is used and show that the bias is not negligible for moderate sample sizes. A modification of the method is proposed…

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