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An efficient Markov chain Monte Carlo method for distributions with intractable normalising constants

归一化常数难以计算时的高效马尔可夫链蒙特卡洛方法

Maximum likelihood parameter estimation and sampling from Bayesian posterior distributions are problematic when the probability density for the parameter of interest involves an intractable normalising constant which is also a function of that parameter. In this paper, an auxiliary variable method is presented which requires only that independent samples can be drawn from the unnormalised density at any particular parameter value. The proposal distribution is constructed so…

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A test statistic for graphical modelling of multivariate time series

多元时间序列图模型的检验统计量

A graphical model for multivariate time series is a concept extended by Dahlhaus (2000) from that for a random vector to a multivariate time series. We propose a test statistic for identifying the model based on the Kullback-Leibler divergence between two graphical models. The null distribution is shown to be asymptotically normal with mean and variance which depend just on the dimensions of the graphs.

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Nonparametric estimation with left-truncated semicompeting risks data

左截断半竞争风险数据的非参数估计

Nonparametric estimators for competing risks data can be applied to semicompeting risks data, a type of multi-state data where a terminating event may censor a nonterminating event, after forcing the data into the competing risks format. Complications may arise with left truncation of the terminating event, where the competing risks analysis naively truncates the nonterminating event using the left-truncation time for the terminating event, which may lead to large efficiency…

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A k-sample test with interval censored data

区间删失数据的多样本检验

The problem of testing for the equality of k distribution functions under Case 2 interval censoring is studied and a supremum-type test statistic is proposed based on the differences between the nonparametric maximum likelihood estimator and the so-called leveraged bootstrap estimator of the k underlying distributions. The proposed test is distributionfree and consistent against all alternatives. As the main results hold for a wide range of resampling sizes, a data-driven…

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Linear life expectancy regression with censored data

删失数据下的线性预期剩余寿命回归

In the statistical literature, life expectancy is usually characterised by the mean residual life function. Regression models are thus needed to study the association between the mean residual life functions and their covariates. In this paper, we consider a linear mean residual life model and develop inference procedures in the presence of potential censoring. The new model and inference procedures are applied to the Stanford heart transplant data. Semiparametric efficiency…

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A construction method for orthogonal Latin hypercube designs

正交拉丁超立方设计的构造方法

The Latin hypercube design is a popular choice of experimental design when computer simulation is used to study a physical process. These designs guarantee uniform samples for the marginal distribution of each single input. A number of methods have been proposed for extending the uniform sampling to higher dimensions.We show how to construct Latin hypercube designs in which all main effects are orthogonal. Our method can also be used to construct Latin hypercube designs with…

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Applying the Horvitz-Thompson criterion in complex designs: A computer-intensive perspective for estimating inclusion probabilities

复杂抽样设计中的 Horvitz–Thompson 方法:计算密集型纳入概率估计

A modification of the Horvitz-Thompson estimator is proposed for complex sampling designs. The inclusion probabilities are estimated by means of independent replications of the sampling scheme. The properties of the resulting estimator are derived. Guidelines for choosing the appropriate number of replications are given and some applications are considered. Copyright 2006, Oxford University Press.

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Bayesian alignment using hierarchical models, with applications in protein bioinformatics

基于层级模型的贝叶斯配准及其蛋白质生物信息学应用

An important problem in shape analysis is to match configurations of points in space after filtering out some geometrical transformation. In this paper we introduce hierarchical models for such tasks, in which the points in the configurations are either unlabelled or have at most a partial labelling constraining the matching, and in which some points may only appear in one of the configurations. We derive procedures for simultaneous inference about the matching and the…

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Robust and efficient estimation under data grouping

分组数据下的稳健与有效估计

The minimum Hellinger distance estimator is known to have desirable properties in terms of robustness and efficiency. We propose an approximate minimum Hellinger distance estimator by adapting the approach to grouped data from a continuous distribution. It is easier to compute the approximate version for either the continuous data or the grouped data. Given certain conditions on the model distribution and reasonable grouping rules, the approximate minimum Hellinger distance…

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Latent-model robustness in structural measurement error models

结构测量误差模型中的潜变量模型稳健性

We present methods for diagnosing the effects of model misspecification of the true-predictor distribution in structural measurement error models. We first formulate latent-model robustness theoretically. Then we provide practical techniques for examining the adequacy of an assumed latent predictor model. The methods are illustrated via analytical examples, application to simulated data and with data from a study of coronary heart disease.

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Efficient Bayes factor estimation from the reversible jump output

利用可逆跳跃算法输出高效估计贝叶斯因子

We propose a class of estimators of the Bayes factor which is based on an extension of the bridge sampling identity of Meng & Wong (1996) and makes use of the output of the reversible jump algorithm of Green (1995). Within this class we give the optimal estimator and also a suboptimal one which may be simply computed on the basis of the acceptance probabilities used within the reversible jump algorithm for jumping between models. The proposed estimators are very easily…

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A note on kernel polygons

核多边形估计的一则札记

Jones (1989) has pointed out that piecewise linear interpolated kernel density estimators on a sufficiently fine grid can be visually indistinguishable from the true density. A simple device, the kernel polygon, is proposed for eliminating the evaluation of the normalisation constant of the estimator while retaining its property of being a density function as well as providing practical advantages. The class of uniform and linear kernels of the kernel polygons is given.…

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A note on time-reversibility of multivariate linear processes

多元线性过程时间可逆性札记

We derive some readily verifiable necessary and sufficient conditions for a multivariate non-Gaussian linear process to be time-reversible, under two sets of conditions on the contemporaneous dependence structure of the innovations. One set of conditions concerns the case of independent-component innovations, in which case a multivariate non-Gaussian linear process is time-reversible if and only if the coefficients consist of essentially asymmetric columns with…

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On Bartlett correction of empirical likelihood in the presence of nuisance parameters

存在干扰参数时经验似然的 Bartlett 校正

Lazar & Mykland (1999) showed that an empirical likelihood defined by two estimating equations with a nuisance parameter need not be Bartlett-correctable. This paper shows that Bartlett correction of empirical likelihood in the presence of a nuisance parameter depends critically on the way the nuisance parameter is removed when formulating the likelihood for the parameter of interest. We establish in the broad framework of estimating functions that the empirical likelihood…

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Semiparametric transformation models for the case-cohort study

病例队列研究的半参数变换模型

A general class of semiparametric transformation models is studied for analysing survival data from the case-cohort design, which was introduced by Prentice (1986). Weighted estimating equations are proposed for simultaneous estimation of the regression parameters and the transformation function. It is shown that the resulting regression estimators are asymptotically normal, with variance-covariance matrix that has a closed form and can be consistently estimated by the usual…

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Range of correlation matrices for dependent Bernoulli random variables

相依伯努利随机变量相关矩阵的可行范围

We say that a pair (p, R) is compatible if there exists a multivariate binary distribution with mean vector p and correlation matrix R. In this paper we study necessary and sufficient conditions for compatibility for structured and unstructured correlation matrices. We give examples of correlation matrices that are incompatible with any p. Using our results we show that the parametric binary models of Emrich & Piedmonte (1991) and Qaqish (2003) allow a good range of…

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A shrinkage estimator for spectral densities

谱密度的收缩估计量

We propose a shrinkage estimator for spectral densities based on a multilevel normal hierarchical model. The first level captures the sampling variability via a likelihood constructed using the asymptotic properties of the periodogram. At the second level, the spectral density is shrunk towards a parametric time series model. To avoid selecting a particular parametric model for the second level, a third level is added which induces an estimator that averages over a class of…

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Semiparametric efficient estimation of survival distributions in two-stage randomisation designs in clinical trials with censored data

删失临床数据中两阶段随机化设计的生存分布半参数有效估计

Two-stage randomisation designs are useful in the evaluation of combination therapies where patients are initially randomised to an induction therapy and then, depending upon their response and consent, are randomised to a maintenance therapy. In this paper we derive the best regular asymptotically linear estimator for the survival distribution and related quantities of treatment regimes. We propose an estimator which is easily computable and is more efficient than existing…

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Covariance matrix selection and estimation via penalised normal likelihood

通过惩罚正态似然选择与估计协方差矩阵

We propose a nonparametric method for identifying parsimony and for producing a statistically efficient estimator of a large covariance matrix. We reparameterise a covariance matrix through the modified Cholesky decomposition of its inverse or the one-step-ahead predictive representation of the vector of responses and reduce the nonintuitive task of modelling covariance matrices to the familiar task of model selection and estimation for a sequence of regression models. The…

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Efficient semiparametric estimator for heteroscedastic partially linear models

异方差部分线性模型的有效半参数估计量

We study the heteroscedastic partially linear model with an unspecified partial baseline component and a nonparametric variance function. An interesting finding is that the performance of a naive weighted version of the existing estimator could deteriorate when the smooth baseline component is badly estimated. To avoid this, we propose a family of consistent estimators and investigate their asymptotic properties. We show that the optimal semiparametric efficiency bound can…

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Using intraslice covariances for improved estimation of the central subspace in regression

利用片内协方差改进回归中心子空间估计

Popular methods for estimating the central subspace in regression require slicing a continuous response. However, slicing can result in loss of information and in some cases that loss can be substantial. We use intraslice covariances to construct improved inference methods for the central subspace. These methods are optimal within a class of quadratic inference functions and permit chi-squared tests of conditional independence hypotheses involving the predictors. Our…

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On least-squares regression with censored data

删失数据的最小二乘回归

The semiparametric accelerated failure time model relates the logarithm of the failure time linearly to the covariates while leaving the error distribution unspecified. The present paper describes simple and reliable inference procedures based on the least-squares principle for this model with right-censored data. The proposed estimator of the vector-valued regression parameter is an iterative solution to the Buckley–James estimating equation with a preliminary consistent…

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Spatially adaptive smoothing splines

随设计位置自适应的平滑样条

We use a reproducing kernel Hilbert space representation to derive the smoothing spline solution when the smoothness penalty is a function λ(t) of the design space t, thereby allowing the model to adapt to various degrees of smoothness in the structure of the data. We propose a convenient form for the smoothness penalty function and discuss computational algorithms for automatic curve fitting using a generalised crossvalidation measure.

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The optimal confidence region for a random parameter

随机参数的最优置信区域

Suppose that, under a two-level hierarchical model, the distribution of the vector of random parameters is known or can be estimated well. The data are generated via a fixed, but unobservable, realisation of the vector. We derive the smallest confidence region for a specific component of this random vector under a joint Bayesian/frequentist paradigm. On average this optimal region can be much smaller than the corresponding Bayesian highest posterior density region. The new…

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