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A nonparametric prior for simultaneous covariance estimation

用于同时协方差估计的非参数先验

In the modeling of longitudinal data from several groups, appropriate handling of the dependence structure is of central importance. Standard methods include specifying a single covariance matrix for all groups or independently estimating the covariance matrix for each group without regard to the others, but when these model assumptions are incorrect, these techniques can lead to biased mean effects or loss of efficiency, respectively. Thus, it is desirable to develop…

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The Kolmogorov filter for variable screening in high-dimensional binary classification

高维二元分类变量筛选的 Kolmogorov 过滤器

Variable screening techniques have been proposed to mitigate the impact of high dimensionality in classification problems, including t-test marginal screening (Fan & Fan, 2008) and maximum marginal likelihood screening (Fan & Song, 2010). However, these methods rely on strong modelling assumptions that are easily violated in real applications. To circumvent the parametric modelling assumptions, we propose a new variable screening technique for binary classification based on…

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Optimal estimation of Poisson intensity with partially observed covariates

协变量部分可观测时泊松强度的最优估计

Rathbun et al. (2007) and Waagepetersen (2008) propose estimating functions for parameters of Poisson point process intensity that may be applied when space- and/or time-varying covariates are sampled from a probability-based sampling design. This paper demonstrates that Waageptersen’s estimating function is optimal in a class of weighted estimating functions.

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Interval estimation of population means under unknown but bounded probabilities of sample selection

样本选择概率未知但有界时总体均值的区间估计

Applying concepts from partial identification to the domain of finite population sampling, we propose a method for interval estimation of a population mean when the probabilities of sample selection lie within a posited interval. The interval estimate is derived from sharp bounds on the Hajek (1971) estimator of the population mean. We demonstrate the method's utility for sensitivity analysis by applying it to a sample of needles collected as part of a syringe tracking and…

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Bias attenuation results for nondifferentially mismeasured ordinal and coarsened confounders

非差异性误测的有序及粗化混杂变量的偏差衰减结果

Suppose we are interested in the effect of a binary treatment on an outcome where that relationship is confounded by an ordinal confounder. We assume that the true confounder is not observed, rather we observe a nondifferentially mismeasured version of it. We show that under certain monotonicity assumptions about its effect on the treatment and on the outcome, an effect measure controlling for the mismeasured confounder will fall between its corresponding crude and the true…

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Covariate-adjusted precision matrix estimation with an application in genetical genomics

协变量调整的精度矩阵估计及其遗传基因组学应用

Motivated by analysis of genetical genomics data, we introduce a sparse high-dimensional multivariate regression model for studying conditional independence relationships among a set of genes adjusting for possible genetic effects. The precision matrix in the model specifies a covariate-adjusted Gaussian graph, which presents the conditional dependence structure of gene expression after the confounding genetic effects on gene expression are taken into account. We present a…

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Conditional simulation of max-stable processes

最大稳定过程的条件模拟

Since many environmental processes are spatial in extent, a single extreme event may affect several locations, and the spatial dependence must be taken into account in an appropriate way. This paper proposes a framework for conditional simulation of max-stable processes and gives closed forms for the regular conditional distributions of Brown–Resnick and Schlather processes. We test the method on simulated data and present applications to extreme rainfall around Zurich and…

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Smoothed nonparametric estimation for current status competing risks data

竞争风险当前状态数据的平滑非参数估计

We study the nonparametric estimation of the cumulative incidence function and the cause-specific hazard function for current status data with competing risks via kernel smoothing. A smoothed naive nonparametric maximum likelihood estimator and a smoothed full nonparametric maximum likelihood estimator are shown to have pointwise asymptotic normality and faster convergence rates than the corresponding unsmoothed nonparametric likelihood estimators. Using the smoothed…

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Benchmarking small area estimators

小区域估计量的基准约束校准

This paper considers benchmarking issues in the context of small area estimation. We find optimal estimators within the class of benchmarked linear estimators under linear constraints. This extends existing results for external and internal benchmarking, and also links the two. Necessary and sufficient conditions for self-benchmarking are found for an augmented model. Most results of this paper are found using ideas of orthogonal projection Copyright 2013, Oxford University…

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Unified inference for sparse and dense longitudinal models

稀疏与密集纵向模型的统一推断

In longitudinal data analysis, statistical inference for sparse data and dense data could be substantially different. For kernel smoothing estimate of the mean function, the convergence rates and limiting variance functions are different under the two scenarios. The latter phenomenon poses challenges for statistical inference as a subjective choice between the sparse and dense cases may lead to wrong conclusions. We develop self-normalization based methods that can adapt to…

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Nuisance parameter elimination for proportional likelihood ratio models with nonignorable missingness and random truncation

不可忽略缺失与随机截断下比例似然比模型的干扰参数消除

We show that the proportional likelihood ratio model proposed recently by Luo & Tsai (2012) enjoys model-invariant properties under certain forms of nonignorable missing mechanisms and randomly double-truncated data, so that target parameters in the population can be estimated consistently from those biased samples. We also construct an alternative estimator for the target parameters by maximizing a pseudo-likelihood that eliminates a functional nuisance parameter in the…

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On p-values for smooth components of an extended generalized additive model

扩展广义可加模型中平滑分量的p值

The problem of testing smooth components of an extended generalized additive model for equality to zero is considered. Confidence intervals for such components exhibit good across-the-function coverage probabilities if based on the approximate result ⁠, where f is the vector of evaluated values for the smooth component of interest and Vf is the covariance matrix for f according to the Bayesian view of the smoothing process. Based on this result, a Wald-type test of f=0 is…

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Simultaneous supervised clustering and feature selection over a graph

给定图上的同时监督聚类与特征选择

In this article, we propose a regression method for simultaneous supervised clustering and feature selection over a given undirected graph, where homogeneous groups or clusters are estimated as well as informative predictors, with each predictor corresponding to one node in the graph and a connecting path indicating a priori possible grouping among the corresponding predictors. The method seeks a parsimonious model with high predictive power through identifying and…

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Statistical properties of an early stopping rule for resampling-based multiple testing

重抽样多重检验早停规则的统计性质

Resampling-based methods for multiple hypothesis testing often lead to long run times when the number of tests is large. This paper presents a simple rule that substantially reduces computation by allowing resampling to terminate early on a subset of tests. We prove that the method has a low probability of obtaining a set of rejected hypotheses different from those rejected without early stopping, and obtain error bounds for multiple hypothesis testing. Simulation shows that…

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Proportional mean residual life model for right-censored length-biased data

右删失长度偏倚数据的比例平均剩余寿命模型

To study disease association with risk factors in epidemiologic studies, cross-sectional sampling is often more focused and less costly for recruiting study subjects who have already experienced initiating events. For time-to-event outcome, however, such a sampling strategy may be length biased. Coupled with censoring, analysis of length-biased data can be quite challenging, due to induced informative censoring in which the survival time and censoring time are correlated…

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Finite population estimators in stochastic search variable selection

随机搜索变量选择中的有限总体估计量

Monte Carlo algorithms are commonly used to identify a set of models for Bayesian model selection or model averaging. Because empirical frequencies of models are often zero or one in high-dimensional problems, posterior probabilities calculated from the observed marginal likelihoods, renormalized over the sampled models, are often employed. Such estimates are the only recourse in several newer stochastic search algorithms. In this paper, we prove that renormalization of…

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Two-stage testing procedures with independent filtering for genome-wide gene-environment interaction

基因组范围基因—环境交互的独立筛选两阶段检验

Several two-stage multiple testing procedures have been proposed to detect gene-environment interaction in genome-wide association studies. In this article, we elucidate general conditions that are required for validity and power of these procedures, and we propose extensions of two-stage procedures using the case-only estimator of gene-treatment interaction in randomized clinical trials. We develop a unified estimating equation approach to proving asymptotic independence…

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Scaled sparse linear regression

尺度化稀疏线性回归

Scaled sparse linear regression jointly estimates the regression coefficients and noise level in a linear model. It chooses an equilibrium with a sparse regression method by iteratively estimating the noise level via the mean residual square and scaling the penalty in proportion to the estimated noise level. The iterative algorithm costs little beyond the computation of a path or grid of the sparse regression estimator for penalty levels above a proper threshold. For the…

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An efficient empirical likelihood approach for estimating equations with missing data

缺失数据估计方程的高效经验似然方法

We explore the use of estimating equations for efficient statistical inference in case of missing data. We propose a semiparametric efficient empirical likelihood approach, and show that the empirical likelihood ratio statistic and its profile counterpart asymptotically follow central chi-square distributions when evaluated at the true parameter. The theoretical properties and practical performance of our approach are demonstrated through numerical simulations and data…

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Orthogonalization of vectors with minimal adjustment

以最小调整实现向量正交化

Two transformations are proposed that give orthogonal components with a one-to-one correspondence between the original vectors and the components. The aim is that each component should be close to the vector with which it is paired, orthogonality imposing a constraint. The transformations lead to a variety of new statistical methods, including a unified approach to the identification and diagnosis of collinearities, a method of setting prior weights for Bayesian model…

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On the sparsity of signals in a random sample

随机样本中信号的稀疏程度估计

This article proposes a method of moments technique for estimating the sparsity of signals in a random sample. This involves estimating the largest eigenvalue of a large Hermitian trigonometric matrix under mild conditions. As illustration, the method is applied to two well-known problems. The first focuses on the sparsity of a large covariance matrix and the second investigates the sparsity of a sequence of signals observed with stationary, weakly dependent noise.…

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Dispersion operators and resistant second-order functional data analysis

离散度算子与抗异常的二阶函数型数据分析

Inferences related to the second-order properties of functional data, as expressed by covariance structure, can become unreliable when the data are non-Gaussian or contain unusual observations. In the functional setting, it is often difficult to identify atypical observations, as their distinguishing characteristics can be manifold but subtle. In this paper, we introduce the notion of a dispersion operator, investigate its use in probing the second-order structure of…

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Bootstrap confidence bands for sojourn distributions in multistate semi-Markov models with right censoring

右删失多状态半马尔可夫模型中停留分布的自助法置信带

Transient semi-Markov processes have traditionally been used to describe the transitions of a patient through the various states of a multistate survival model. A survival distribution in this context is a sojourn through the states until passage to a fatal absorbing state or certain endpoint states. Using complete sojourn data, this paper shows how such survival distributions and associated hazard functions can be estimated nonparametrically and also how nonparametric…

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Penalized balanced sampling

惩罚平衡抽样

Linear mixed models cover a wide range of statistical methods, which have found many uses in the estimation for complex surveys. The purpose of this work is to consider methods by which linear mixed models may be used at the design stage of a survey to incorporate available auxiliary information. This paper reviews the ideas of balanced sampling and the cube algorithm, and proposes an implementation of the latter by which penalized balanced samples can be selected. Such…

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