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High-dimensional semiparametric bigraphical models

高维半参数双图模型

In multivariate analysis, a Gaussian bigraphical model is commonly used for modelling matrix-valued data. In this paper, we propose a semiparametric extension of the Gaussian bigraphical model, called the nonparanormal bigraphical model. A projected nonparametric rank-based regularization approach is employed to estimate sparse precision matrices and produce graphs under a penalized likelihood framework. Theoretically, our semiparametric procedure achieves the parametric…

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Dimension reduction and predictor selection in semiparametric models

半参数模型中的降维与预测变量选择

Dimension reduction in semiparametric regressions includes construction of informative linear combinations and selection of contributing predictors. To reduce the predictor dimension in semiparametric regressions, we propose an ℓ1-minimization of sliced inverse regression with the Dantzig selector, and establish a non-asymptotic error bound for the resulting estimator. We also generalize the regularization concept to sliced inverse regression with an adaptive Dantzig…

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Species sampling models: consistency for the number of species

物种抽样模型:物种数量的一致性

This paper considers species sampling models using constructions that arise from Bayesian nonparametric prior distributions. A discrete random measure, used to generate a species sampling model, can have either a countable infinite number of atoms, which has been the emphasis in the recent literature, or a finite number of atoms K, while allowing K to be assigned a prior probability distribution on the positive integers. It is the latter class of model we consider here, due…

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Survival analysis without survival data: connecting length-biased and case-control data

没有生存数据的生存分析:连接长度偏倚与病例对照数据

We show that relative mean survival parameters of a semiparametric log-linear model can be estimated using covariate data from an incident sample and a prevalent sample, even when there is no prospective follow-up to collect any survival data. Estimation is based on an induced semiparametric density ratio model for covariates from the two samples, and it shares the same structure as for a logistic regression model for case-control data. Likelihood inference coincides with…

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Continuously additive models for nonlinear functional regression

非线性函数型回归的连续可加模型

We introduce continuously additive models, which can be viewed as extensions of additive regression models with vector predictors to the case of infinite-dimensional predictors. This approach produces a class of flexible functional nonlinear regression models, where random predictor curves are coupled with scalar responses. In continuously additive modelling, integrals taken over a smooth surface along graphs of predictor functions relate the predictors to the responses in a…

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Estimating time-varying effects for overdispersed recurrent events data with treatment switching

治疗转换下过度离散复发事件的时变效应估计

In the analysis of multivariate event times, frailty models assuming time-independent regression coefficients are often considered, mainly due to their mathematical convenience. In practice, regression coefficients are often time dependent and the temporal effects are of clinical interest. Motivated by a phase III clinical trial in multiple sclerosis, we develop a semiparametric frailty modelling approach to estimate time-varying effects for overdispersed recurrent events…

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Estimation with missing data: beyond double robustness

缺失数据估计:超越双重稳健性

We propose an estimator that is more robust than doubly robust estimators, based on weighting complete cases using weights other than inverse probability when estimating the population mean of a response variable subject to ignorable missingness. We allow multiple models for both the propensity score and the outcome regression. Our estimator is consistent if any of the multiple models is correctly specified. Such multiple robustness against model misspecification is a…

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Simple design-efficient calibration estimators for rejective and high-entropy sampling

拒绝式与高熵抽样下简便且设计有效的校准估计量

For survey calibration, consider the situation where the population totals of auxiliary variables are known or where auxiliary variables are measured for all population units. For each situation, we develop design-efficient calibration estimators under rejective or high-entropy sampling. A general approach is to extend efficient estimators for missing-data problems with independent and identically distributed data to the survey setting. We show that this approach effectively…

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On the likelihood ratio test for envelope models in multivariate linear regression

多元线性回归包络模型的似然比检验

We investigate the likelihood ratio test for a hypothesis regarding the dimension of the Σ-envelope of span(β) in a multivariate linear regression model. The asymptotic null distribution of the likelihood ratio statistic is obtained as some nuisance parameters approach infinity. A saddlepoint approximation is also given for this limiting distribution. The accuracy of this approximation and its comparison to the standard chi-squared approximation are assessed via simulation.…

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The optimal power puzzle: scrutiny of the monotone likelihood ratio assumption in multiple testing

最优功效之谜:审视多重检验的单调似然比假设

In single hypothesis testing, power is a non-decreasing function of type I error rate; hence it is desirable to test at the nominal level exactly to achieve optimal power. The puzzle lies in the fact that for multiple testing, under the false discovery rate paradigm, such a monotonic relationship may not hold. In particular, exact false discovery rate control may lead to a less powerful testing procedure if a test statistic fails to fulfil the monotone likelihood ratio…

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Simple tiered classifiers

简单的分层分类器

In this paper we propose simple, general tiered classifiers for relatively complex data. Empirical studies on real and simulated data show that three two-tier classifiers, which are respective extensions of linear discriminant analysis, linear logistic regression and support vector machines, can reduce noticeably the relatively high misclassification error of their original single-tier counterparts, without significantly increasing computational labour.

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Data augmentation for non-Gaussian regression models using variance-mean mixtures

利用方差—均值混合进行非高斯回归的数据增广

We use the theory of normal variance-mean mixtures to derive a data-augmentation scheme for a class of common regularization problems. This generalizes existing theory on normal variance mixtures for priors in regression and classification. It also allows variants of the expectation-maximization algorithm to be brought to bear on a wider range of models than previously appreciated. We demonstrate the method on several examples, focusing on the case of binary logistic…

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Estimation of a sparse group of sparse vectors

稀疏向量组的双层稀疏估计

We consider estimating a sparse group of sparse normal mean vectors, based on penalized likelihood estimation with complexity penalties on the number of nonzero mean vectors and the numbers of their significant components, which can be performed by a fast algorithm. The resulting estimators are developed within a Bayesian framework and can be viewed as maximum a posteriori estimators. We establish their adaptive minimaxity over a wide range of sparse and dense settings. A…

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Using shared genetic controls in studies of gene-environment interactions

基因与环境交互作用研究中共享遗传对照的使用

With the advent of modern genomic methods to adjust for population stratification, the use of external or publicly available controls has become an attractive option for reducing the cost of large-scale case-control genetic association studies. In this article, we study the estimation of joint effects of genetic and environmental exposures from a case-control study where data on genome-wide markers are available on the cases and a set of external controls while data on…

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A central limit theorem in the -model for undirected random graphs with a diverging number of vertices

顶点数增长的无向随机图 β 模型中心极限定理

Chatterjee et al. (2011) established the consistency of the maximum likelihood estimator in the β-model for undirected random graphs when the number of vertices goes to infinity. By approximating the inverse of the Fisher information matrix, we prove asymptotic normality of the maximum likelihood estimator under mild conditions. Simulation studies and a data example illustrate the theoretical results.

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Penalized multivariate Whittle likelihood for power spectrum estimation

用于功率谱估计的惩罚多元 Whittle 似然

Nonparametric estimation procedures that can flexibly account for varying levels of smoothness among different functional parameters, such as penalized likelihoods, have been developed in a variety of settings. However, geometric constraints on power spectra have limited the development of such methods when estimating the power spectrum of a vector-valued time series. This article introduces a penalized likelihood approach to nonparametric multivariate spectral analysis…

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Composite likelihood estimation for the Brown-Resnick process

Brown–Resnick 过程的复合似然估计

Genton et al. (2011) investigated the gain in efficiency when triplewise, rather than pairwise, likelihood is used to fit the popular Smith max-stable model for spatial extremes. We generalize their results to the Brown–Resnick model and show that the efficiency gain is substantial only for very smooth processes, which are generally unrealistic in applications.

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Weighting in survey analysis under informative sampling

信息性抽样下调查分析的权重构造

Sampling related to the outcome variable of a regression analysis conditional on covariates is called informative sampling and may lead to bias in ordinary least squares estimation. Weighting by the reciprocal of the inclusion probability approximately removes such bias but may inflate variance. This paper investigates two ways of modifying such weights to improve efficiency while retaining consistency. One approach is to multiply the inverse probability weights by functions…

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Simultaneous confidence intervals uniformly more likely to determine signs

更易判定符号的同时置信区间

Many studies draw inferences about multiple endpoints but ignore the statistical implications of multiplicity. Effects inferred to be positive when there is no adjustment for multiplicity can lose their statistical significance when multiplicity is taken into account, perhaps explaining why such adjustments are so often omitted. We develop new simultaneous confidence intervals that mitigate this problem; these are uniformly more likely to determine signs than are standard…

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The role of the range parameter for estimation and prediction in geostatistics

地统计估计与预测中范围参数的作用

Two canonical problems in geostatistics are estimating the parameters in a specified family of stochastic process models and predicting the process at new locations. We show that asymptotic results for a Gaussian process over a fixed domain with Matérn covariance function, previously proven only in the case of a fixed range parameter, can be extended to the case of jointly estimating the range and the variance of the process. Moreover, we show that intuition and…

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Efficient estimation of the censored linear regression model

删失线性回归模型的有效估计

In linear regression or accelerated failure time models, complications in efficient estimation arise from the multiple roots of the efficient score and density estimation. This paper proposes a one-step efficient estimation method based on a counting process martingale, which has several advantages: it avoids the multiple-root problem, the initial estimator is easily available and the variance estimator can be obtained by employing plug-in rules. A simple and effective…

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A consistent multivariate test of association based on ranks of distances

基于距离秩的一致多元关联检验

We consider the problem of detecting associations between random vectors of any dimension. Few tests of independence exist that are consistent against all dependent alternatives. We propose a powerful test that is applicable in all dimensions and consistent against all alternatives. The test has a simple form, is easy to implement, and has good power.

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Sampling decomposable graphs using a Markov chain on junction trees

基于联结树马尔可夫链的可分解图抽样

Full Bayesian computational inference for model determination in undirected graphical models is currently restricted to decomposable graphs or other special cases, except for small-scale problems, say up to 15 variables. In this paper we develop new, more efficient methodology for such inference, by making two contributions to the computational geometry of decomposable graphs. The first of these provides sufficient conditions under which it is possible to completely connect…

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Efficient Gaussian process regression for large datasets

大规模数据的高效高斯过程回归

Gaussian processes are widely used in nonparametric regression, classification and spatiotemporal modelling, facilitated in part by a rich literature on their theoretical properties. However, one of their practical limitations is expensive computation, typically on the order of n3 where n is the number of data points, in performing the necessary matrix inversions. For large datasets, storage and processing also lead to computational bottlenecks, and numerical stability of…

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