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Latent factor models for density estimation

用于密度估计的潜在因子模型

Abstract: Although discrete mixture modeling has formed the backbone of the literature on Bayesian density estimation, there are some well known disadvantages. We propose an alternative class of priors based on random nonlinear functions of a uniform latent variable with an additive residual. The induced prior for the density is shown to have desirable properties including ease of centering on an initial guess for the density, large support, posterior consistency and…

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Statistical inference methods for recurrent event processes with shape and size parameters

带形状与规模参数的重复事件过程统计推断

This paper proposes a unified framework to characterize the rate function of a recurrent event process through shape and size parameters. In contrast to the intensity function, which is the event occurrence rate conditional on the event history, the rate function is the occurrence rate unconditional on the event history, and thus it can be interpreted as a population-averaged count of events in unit time. In this paper, shape and size parameters are introduced and used to…

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Extended empirical likelihood for estimating equations

估计方程的扩展经验似然

We derive an extended empirical likelihood for parameters defined by estimating equations which generalizes the original empirical likelihood to the full parameter space. Under mild conditions, the extended empirical likelihood has all the asymptotic properties of the original empirical likelihood. The first-order extended empirical likelihood is easy to use and substantially more accurate than the original empirical likelihood.

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Posterior expectation based on empirical likelihoods

基于经验似然的后验期望

Posterior expectation is widely used as a Bayesian point estimator. In this note we extend it from parametric models to nonparametric models using empirical likelihood, and develop a nonparametric analogue of James–Stein estimation. We use the Laplace method to establish asymptotic approximations to our proposed posterior expectations, and show by simulation that they are often more efficient than the corresponding classical nonparametric procedures, especially when the…

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Characterization of the likelihood continual reassessment method

似然连续再评估法的刻画

This paper deals with the design of the likelihood continual reassessment method, which is an increasingly widely used model-based method for dose-finding studies. It is common to implement the method in a two-stage approach, whereby the model-based stage is activated after an initial sequence of patients has been treated. While this two-stage approach is practically appealing, it lacks a theoretical framework, and it is often unclear how the design components should be…

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Estimation from cross-sectional samples under bias and dependence

偏差与依赖并存时的横截面样本估计

A population can be entered at a known sequence of discrete times; it is sampled cross-sectionally, and the sojourn times of individuals in the sample are observed. It is well known that cross-sectioning leads to length-bias, but less well known and often ignored that it may also result in dependence among the observations. We show that observed sojourn times are independent only under a multinomial entrance process. We study asymptotic properties of parametric and…

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Tests for comparing estimated survival functions

比较估计生存函数的检验

We describe a class of statistical tests for the comparison of two or more survival curves, typically estimated using the Kaplan–Meier method. The class is based on the construction of O’Quigley (2003), and some special cases are of particular interest. Underlying the inferential development are the arguments of Efron & Hinkley (1978), leading to a theoretical sampling model that is in some sense closer to the observed data. The log-rank and weighted log-rank tests arise as…

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Nonparametric inference on bivariate survival data with interval sampling: association estimation and testing

区间抽样下二元生存数据的非参数关联估计与检验

In many biomedical applications, interest focuses on the occurrence of two or more consecutive failure events and the relationship between event times, such as age of disease onset and residual lifetime. Bivariate survival data with interval sampling arise frequently when disease registries or surveillance systems collect data based on disease incidence occurring within a specific calendar time interval. The initial event is then retrospectively confirmed and the subsequent…

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Self-consistent nonparametric maximum likelihood estimator of the bivariate survivor function

二元生存函数的自洽非参数最大似然估计

As usually formulated the nonparametric likelihood for the bivariate survivor function is over-parameterized, resulting in uniqueness problems for the corresponding nonparametric maximum likelihood estimator. Here the estimation problem is redefined to include parameters for marginal hazard rates, and for double failure hazard rates only at informative uncensored failure time grid points where there is pertinent empirical information. Double failure hazard rates at other…

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Multivariate functional-coefficient regression models for nonlinear vector time series data

非线性向量时间序列的多元函数系数回归模型

Vector time series data are widely met in practice. In this paper we propose a multivariate functional-coefficient regression model with heteroscedasticity for modelling such data. A local linear smoother is employed to estimate the unknown coefficient matrices. Asymptotic normality of the proposed estimators is established, and bandwidth selection is considered. To deal with the co-integration commonly observed in financial markets, we propose an error-corrected…

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Semiparametric group testing regression models

半参数混样检测回归模型

Group testing, through the use of pooling, has proven to be an efficient method of reducing the time and cost associated with screening for a binary characteristic of interest, such as infection status. A topic of key interest in the statistical literature involves the development of regression models that relate individual-level covariates to testing responses observed from pooled specimens. In this article, we propose a general semiparametric framework that allows for the…

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Bootstrap for the case-cohort design

病例队列设计的自助法

The case-cohort design facilitates economical investigation of risk factors in a large survival study, with covariate data collected only from the cases and a simple random subset of the full cohort. Methods that accommodate the design have been developed for various semiparametric models, but most inference procedures are based on asymptotic distribution theory. Such inference can be cumbersome to derive and implement, and does not permit confidence band construction. While…

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Hypothesis testing for band size detection of high-dimensional banded precision matrices

高维带状精度矩阵带宽识别的假设检验

Many statistical analysis procedures require a good estimator for a high-dimensional covariance matrix or its inverse, the precision matrix. When the precision matrix is banded, the Cholesky-based method often yields a good estimator of the precision matrix. One important aspect of this method is determination of the band size of the precision matrix. In practice, crossvalidation is commonly used; however, we show that crossvalidation not only is computationally intensive…

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Testing equality of a large number of densities

大量密度函数相等性的检验

The problem of testing equality of a large number of densities is considered. The classical k-sample problem compares a small, fixed number of distributions and allows the sample size from each distribution to increase without bound. In our asymptotic analysis the number of distributions tends to infinity but the size of individual samples remains fixed. The proposed test statistic is motivated by the simple idea of comparing kernel density estimators from the various…

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Distances and inference for covariance operators

协方差算子的距离与推断

A framework is developed for inference concerning the covariance operator of a functional random process, where the covariance operator itself is an object of interest for statistical analysis. Distances for comparing positive-definite covariance matrices are either extended or shown to be inapplicable to functional data. In particular, an infinite-dimensional analogue of the Procrustes size-and-shape distance is developed. Convergence of finite-dimensional approximations to…

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Propensity score adjustment with several follow-ups

多轮追访中的倾向得分调整

Propensity score weighting adjustment is commonly used to handle unit nonresponse. When the response mechanism is nonignorable in the sense that the response probability depends directly on the study variable, a follow-up sample is commonly used to obtain an unbiased estimator using the framework of two-phase sampling, where the follow-up sample is assumed to respond completely. In practice, the follow-up sample is also subject to missingness. We consider propensity score…

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Bayes and empirical Bayes: do they merge?

贝叶斯与经验贝叶斯:后验分布会趋同吗?

Bayesian inference is attractive due to its internal coherence and for often having good frequentist properties. However, eliciting an honest prior may be difficult, and common practice is to take an empirical Bayes approach using an estimate of the prior hyperparameters. Although not rigorous, the underlying idea is that, for a sufficiently large sample size, empirical Bayes methods should lead to similar inferential answers as a proper Bayesian inference. However, precise…

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Permuting regular fractional factorial designs for screening quantitative factors

通过水平置换改进定量因子筛选的正规部分因子设计

Fractional factorial designs are widely used in screening experiments. They are often chosen by the minimum aberration criterion, which regards factor levels as symbols. For designs with quan-titative factors, however, permuting the levels for one or more factors could alter their geometrical structures and statistical properties.We provide a justification of theminimum β-aberration crite-rion for quantitative factors and study level permutations for regular fractional…

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Multiscale variance stabilization via maximum likelihood

基于最大似然的多尺度方差稳定化

This article proposes maximum likelihood approaches for multiscale variance stabilization transformations for independently and identically distributed data. For two multiscale variance stabilization transformations we present new unified theoretical results on their Jacobians, a key component of the likelihood. The results provide a deeper understanding of the transformations and the ability to compute the likelihood in linear time. The transformations are shown empirically…

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Measurement bias and effect restoration in causal inference

因果推断中的测量偏差与效应恢复

This paper highlights several areas where graphical techniques can be harnessed to address the problem of measurement errors in causal inference. In particular, it discusses the control of unmeasured confounders in parametric and nonparametric models and the computational problem of obtaining bias-free effect estimates in such models. We derive new conditions under which causal effects can be restored by observing proxy variables of unmeasured confounders with/without…

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Variance estimation in high-dimensional linear models

高维线性模型中的方差估计

The residual variance and the proportion of explained variation are important quantities in many statistical models and model fitting procedures. They play an important role in regression diagnostics and model selection procedures, as well as in determining the performance limits in many problems. In this paper we propose new method-of-moments-based estimators for the residual variance, the proportion of explained variation and other related quantities, such as the ℓ2 signal…

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Logistic regression for spatial Gibbs point processes

空间 Gibbs 点过程的逻辑回归

We propose a computationally efficient technique, based on logistic regression, for fitting Gibbs point process models to spatial point pattern data. The score of the logistic regression is an unbiased estimating function and is closely related to the pseudolikelihood score. Implementation of our technique does not require numerical quadrature, and thus avoids a source of bias inherent in other methods. For stationary processes, we prove that the parameter estimator is…

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A combined estimating function approach for fitting stationary point process models

拟合平稳点过程模型的组合估计函数方法

A composite likelihood technique based on pairwise contributions provides a computationally simple but potentially inefficient approach for fitting spatial point process models. We propose a new estimation procedure that improves the efficiency. Our approach combines estimating functions derived from pairwise composite likelihood estimation and estimating functions that account for correlations among the pairwise contributions. Our method can be used to fit a variety of…

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Bayesian monotone regression using Gaussian process projection

利用高斯过程投影的贝叶斯单调回归

Shape-constrained regression analysis has applications in dose-response modelling, environmental risk assessment, disease screening and many other areas. Incorporating the shape constraints can improve estimation efficiency and avoid implausible results. We propose a novel method, focusing on monotone curve and surface estimation, which uses Gaussian process projections. Our inference is based on projecting posterior samples from the Gaussian process. We develop theory on…

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