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非高斯条件下的高维因果发现AI 解读

Summary We consider graphical models based on a recursive system of linear structural equations. This implies that there is an ordering, $\sigma$, of the variables such that each observed variable $Y_v$ is a linear function of a variable-specific error term and the other observed variables $Y_u$ with $\sigma(u) < \sigma (v)$. The causal relationships, i.e., which other variables the linear functions depend on, can be described using a directed graph. It has previously been…

利用共轭广义线性混合模型分析分组数据AI 解读

Summary This article concerns a class of generalized linear mixed models for two-level grouped data, where the random effects are uniquely indexed by groups and are independent. We derive necessary and sufficient conditions for the marginal likelihood to be expressed in explicit form. These models are unified under the conjugate generalized linear mixed models framework, where conjugate refers to the fact that the marginal likelihood can be expressed in closed form, rather…

最小离散度近似平衡权重：渐近性质与实践问题AI 解读

Summary Weighting methods are widely used to adjust for covariates in observational studies, sample surveys, and regression settings. In this paper, we study a class of recently proposed weighting methods, which find the weights of minimum dispersion that approximately balance the covariates. We call these weights ‘minimal weights’ and study them under a common optimization framework. Our key observation is that finding weights which achieve approximate covariate balance is…

对《删失下生存函数的非参数广义置信推断》的回复AI 解读

We are very grateful to Professors Taraldsen, Lindqvist and Martin for providing stimulating and thoughtful discussions about our paper (Cui & Hannig, 2019). Several important questions are raised by the discussants. We respond to their comments in turn, omitting those points we agree with or to which we have nothing insightful to add. Thank you for the thorough review of fiducial inference in the first part of your discussion (Taraldsen & Lindqvist, 2019). An interesting…

关于删失下生存函数非参数广义信赖推断的讨论AI 解读

We expect that many readers will not be familiar with fiducial inference. This is in contrast to the well-founded alternatives given by Bayesian and classical inference known to every statistician today. Fiducial inference has not yet been established as a general theory, but there has been considerable progress over the past few decades, as demonstrated by the paper of Cui & Hannig (2019). To discuss their contribution, we first provide a context for fiducial inference as…

《删失下生存函数的非参数广义 fiducial 推断》讨论AI 解读

It is a pleasure to participate in the discussion of the article by Cui & Hannig (2019). The authors are to be congratulated for their efforts and ingenuity in developing what is, to my knowledge, the first fiducial solution to a problem involving an infinite-dimensional parameter of interest. Specifically, the authors build on some existing machinery, summarized recently in Hannig et al. (2016) and the references therein, to construct a generalized fiducial distribution for…

频率学派模型平均的最优实验设计AI 解读

Summary We consider the problem of designing experiments for estimating a target parameter in regression analysis when there is uncertainty about the parametric form of the regression function. A new optimality criterion is proposed that chooses the experimental design to minimize the asymptotic mean squared error of the frequentist model averaging estimate. Necessary conditions for the optimal solution of a locally and Bayesian optimal design problem are established. The…

高维遗传通路分析的统计推断AI 解读

Summary Genetic pathway analysis has become an important tool for investigating the association between a group of genetic variants and traits. With dense genotyping and extensive imputation, the number of genetic variants in biological pathways has increased considerably and sometimes exceeds the sample size $n$. Conducting genetic pathway analysis and statistical inference in such settings is challenging. We introduce an approach that can handle pathways whose dimension $p$…

协变量信息不一致研究的多元回归广义元分析AI 解读

Summary Meta-analysis is widely popular for synthesizing information on common parameters of interest across multiple studies because of its logistical convenience and statistical efficiency. We develop a generalized meta-analysis approach to combining information on multivariate regression parameters across multiple studies that have varying levels of covariate information. Using algebraic relationships among regression parameters in different dimensions, we specify a set…

基于置换的错误发现比例同时置信界AI 解读

Summary When multiple hypotheses are tested, interest is often in ensuring that the proportion of false discoveries is small with high confidence. In this paper, confidence upper bounds for the false discovery proportion are constructed, which are simultaneous over all rejection cut-offs. In particular, this allows the user to select a set of hypotheses post hoc such that the false discovery proportion lies below some constant with high confidence. Our method uses…

高维极值依赖的分解AI 解读

Summary We propose two decompositions that help to summarize and describe high-dimensional tail dependence within the framework of regular variation. We use a transformation to define a vector space on the positive orthant and show that transformed-linear operations applied to regularly-varying random vectors preserve regular variation. We summarize tail dependence via a matrix of pairwise tail dependence metrics that is positive semidefinite; eigendecomposition allows one…

删失下生存函数的非参数广义信赖推断AI 解读

Summary Since the introduction of fiducial inference by Fisher in the 1930s, its application has been largely confined to relatively simple, parametric problems. In this paper, we present what might be the first time fiducial inference is systematically applied to estimation of a nonparametric survival function under right censoring. We find that the resulting fiducial distribution gives rise to surprisingly good statistical procedures applicable to both one-sample and…

基于互信息的非参数独立性检验AI 解读

Summary We propose a test of independence of two multivariate random vectors, given a sample from the underlying population. Our approach is based on the estimation of mutual information, whose decomposition into joint and marginal entropies facilitates the use of recently developed efficient entropy estimators derived from nearest neighbour distances. The proposed critical values may be obtained by simulation in the case where an approximation to one marginal is available…

大幅改善协变量平衡的近随机实验设计AI 解读

Summary We present a procedure that divides a set of experimental units into two groups that are similar on a prespecified set of covariates and are almost as random as with a complete randomization. Under complete randomization, the difference in the standardized average between treatment and control is $O_{\rm p}(n^{-1/2})$, which may be material in small samples. We present an algorithm that reduces imbalance to $O_{\rm p}(n^{-3})$ for one covariate and $O_{\rm p}\{n^{-(1 + 2/p)}\}$…

高维纵向数据协方差矩阵的同质性检验AI 解读

Summary This paper deals with the detection and identification of changepoints among covariances of high-dimensional longitudinal data, where the number of features is greater than both the sample size and the number of repeated measurements. The proposed methods are applicable under general temporal-spatial dependence. A new test statistic is introduced for changepoint detection, and its asymptotic distribution is established. If a changepoint is detected, an estimate of…

高维线性模型中的误差方差估计AI 解读

Summary The lasso has been studied extensively as a tool for estimating the coefficient vector in the high-dimensional linear model; however, considerably less is known about estimating the error variance in this context. In this paper, we propose the natural lasso estimator for the error variance, which maximizes a penalized likelihood objective. A key aspect of the natural lasso is that the likelihood is expressed in terms of the natural parameterization of the…

高维回归中的条件性原则AI 解读

Summary Consider a high-dimensional linear regression problem, where the number of covariates is larger than the number of observations and the interest is in estimating the conditional variance of the response variable given the covariates. A conditional and an unconditional framework are considered, where conditioning is with respect to the covariates, which are ancillary to the parameter of interest. In recent papers, a consistent estimator was developed in the…

截断数据中存在分解条件时的不可识别性AI 解读

Summary A time to event, $X$, is left-truncated by $T$ if $X$ can be observed only if $T<X$. This often results in oversampling of large values of $X$, and necessitates adjustment of estimation procedures to avoid bias. Simple risk-set adjustments can be made to standard risk-set-based estimators to accommodate left truncation when $T$ and $X$ are quasi-independent. We derive a weaker factorization condition for the conditional distribution of $T$ given $X$ in the observable…

逻辑回归模型中的边际参数与条件参数AI 解读

Summary We derive the exact formula linking the parameters of marginal and conditional logistic regression models with binary mediators when no conditional independence assumptions can be made. The formula has the appealing property of being the sum of terms that vanish whenever parameters of the conditional models vanish, thereby recovering well-known results as particular cases. It also permits the disentangling of direct and indirect effects as well as quantifying the…

异质面板中个体球形性的检验AI 解读

Summary This manuscript considers locally best invariant tests for sphericity in heterogeneous panels. A new integral representation for the characteristic function of the test statistic under the null is presented, along with an algorithm for inverting it to obtain the distribution function. A saddlepoint approximation to the null distribution addresses the need to quickly compute approximate $p$-values in empirical work. The approximation shows substantial improvements…

稀疏尺度与协方差矩阵变换AI 解读

Summary We develop a theory of covariance and concentration matrix estimation on any given or estimated sparsity scale when the matrix dimension is larger than the sample size. Nonstandard sparsity scales are justified when such matrices are nuisance parameters, distinct from interest parameters, which should always have a direct subject-matter interpretation. The matrix logarithmic and inverse scales are studied as special cases, with the corollary that a constrained…

Pearson 卡方统计量：近似理论及其扩展AI 解读

Summary We establish an approximation theory for Pearson’s chi-squared statistics in situations where the number of cells is large, by using a high-dimensional central limit theorem for quadratic forms of random vectors. Our high-dimensional central limit theorem is proved under Lyapunov-type conditions that involve a delicate interplay between the dimension, the sample size, and the moment conditions. We propose a modified chi-squared statistic and introduce an adjusted…

期望乘积的无偏近似AI 解读

Summary We consider the problem of approximating the product of $n$ expectations with respect to a common probability distribution $\mu$. Such products routinely arise in statistics as values of the likelihood in latent variable models. Motivated by pseudo-marginal Markov chain Monte Carlo schemes, we focus on unbiased estimators of such products. The standard approach is to sample $N$ particles from $\mu$ and assign each particle to one of the expectations; this is wasteful…

充分方向因子模型及其在基因表达数量性状位点发现中的应用AI 解读

Rapid improvement in technology has made it relatively cheap to collect genetic data, however statistical analysis of existing data is still much cheaper. Thus, secondary analysis of single-nucleotide polymorphism, SNP, data, i.e., reanalysing existing data in an effort to extract more information, is an attractive and cost-effective alternative to collecting new data. We study the relationship between gene expression and SNPs through a combination of factor analysis and…