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存在中间混杂变量时的非参数有效因果中介分析AI 解读

Summary Interventional effects for mediation analysis were proposed as a solution to the lack of identifiability of natural (in)direct effects in the presence of a mediator-outcome confounder affected by exposure. We present a theoretical and computational study of the properties of the interventional (in)direct effect estimands based on the efficient influence function in the nonparametric statistical model. We use the efficient influence function to develop two…

用于快速推断的自适应计算机实验复合网格设计AI 解读

Summary Experiments are often used to produce emulators of deterministic computer code. This article introduces composite grid experimental designs and a sequential method for building the designs for accurate emulation. Computational methods are developed that enable fast and exact Gaussian process inference even with large sample sizes. We demonstrate that the proposed approach can produce emulators that are orders of magnitude more accurate than current approximations at…

基于置换单调矩阵的细菌生长率最优估计AI 解读

Summary Motivated by the problem of estimating bacterial growth rates for genome assemblies from shotgun metagenomic data, we consider the permuted monotone matrix model $Y=\Theta\Pi+Z$ where $Y\in \mathbb{R}^{n\times p}$ is observed, $\Theta\in \mathbb{R}^{n\times p}$ is an unknown approximately rank-one signal matrix with monotone rows, $\Pi \in \mathbb{R}^{p\times p}$ is an unknown permutation matrix, and $Z\in \mathbb{R}^{n\times p}$ is the noise matrix. In this article…

刀切经验似然：小带宽、稀疏网络与高维渐近AI 解读

Summary This article aims to shed light on inference problems for statistical models under alternative or nonstandard asymptotic frameworks from the perspective of the jackknife empirical likelihood. Examples include small-bandwidth asymptotics for semiparametric inference and goodness-of-fit testing, sparse-network asymptotics, many-covariates asymptotics for regression models, and many-weak-instruments asymptotics for instrumental variable regression. We first establish…

通过预测变量增广确定降维阶数AI 解读

Summary In many dimension reduction problems in statistics and machine learning, such as in principal component analysis, canonical correlation analysis, independent component analysis and sufficient dimension reduction, it is important to determine the dimension of the reduced predictor, which often amounts to estimating the rank of a matrix. This problem is called order determination. In this article, we propose a novel and highly effective order-determination method based…

利用 ROC 曲线评估生存数据中的治愈状态预测AI 解读

Summary Survival analysis relies on the hypothesis that, if the follow-up is long enough, the event of interest will eventually be observed for all observations. This assumption, however, is often not realistic. The survival data then contain a cure fraction. A common approach to modelling and analysing this type of data consists in using cure models. Two types of information can therefore be obtained: the survival at a given time and the cure status, both possibly modelled…

Wilks 现象的相变AI 解读

Summary Wilks’ theorem, which offers universal chi-squared approximations for likelihood ratio tests, is widely used in many scientific hypothesis testing problems. For modern datasets with increasing dimension, researchers have found that the conventional Wilks’ phenomenon of the likelihood ratio test statistic often fails. Although new approximations have been proposed in high-dimensional settings, there still lacks a clear statistical guideline regarding how to choose…

依赖数据样本分位数的块自助法最优性与经验选块AI 解读

Summary We establish a general theory of optimality for block bootstrap distribution estimation for sample quantiles under mild strong mixing conditions. In contrast to existing results, we study the block bootstrap for varying numbers of blocks. This corresponds to a hybrid between the sub- sampling bootstrap and the moving block bootstrap, in which the number of blocks is between 1 and the ratio of sample size to block length. The hybrid block bootstrap is shown to give…

移动健康中二元结局的时变因果偏离效应估计AI 解读

Summary Advances in digital technology and wearables have made it possible to deliver behavioural mobile health interventions to individuals in their everyday lives. Micro-randomized trials are increasingly used to provide data to inform the construction of these interventions. In a micro-randomized trial, each individual is repeatedly randomized among multiple intervention options, often hundreds or even thousands of times over the course of the trial. The work reported in…

可交换误差下固定设计线性模型的精确检验AI 解读

Summary We propose the cyclic permutation test to test general linear hypotheses for linear models. The test is nonrandomized and valid in finite samples with exact Type I error $\alpha$ for an arbitrary fixed design matrix and arbitrary exchangeable errors, whenever $1 / \alpha$ is an integer and $n / p \geqslant 1 / \alpha - 1$, where $n$ is the sample size and $p$ is the number of parameters. The test involves applying the marginal rank test to $1 / \alpha$ linear…

异质性处理效应的准 Oracle 估计AI 解读

Summary Flexible estimation of heterogeneous treatment effects lies at the heart of many statistical applications, such as personalized medicine and optimal resource allocation. In this article we develop a general class of two-step algorithms for heterogeneous treatment effect estimation in observational studies. First, we estimate marginal effects and treatment propensities to form an objective function that isolates the causal component of the signal. Then, we optimize…

统一广义符号秩检验及其设计敏感度AI 解读

Summary A sensitivity analysis in an observational study tests whether the qualitative conclusions of an analysis would change if we were to allow for the possibility of limited bias due to confounding. The design sensitivity of a hypothesis test quantifies the asymptotic performance of the test in a sensitivity analysis against a particular alternative. We propose a new, nonasymptotic, distribution-free test, the uniform general signed rank test, for observational studies…

稀疏广义线性模型中的后验收缩AI 解读

Summary We study posterior contraction rates in sparse high-dimensional generalized linear models using priors incorporating sparsity. A mixture of a point mass at zero and a continuous distribution is used as the prior distribution on regression coefficients. In addition to the usual posterior, the fractional posterior, which is obtained by applying Bayes theorem with a fractional power of the likelihood, is also considered. The latter allows uniformity in posterior…

高维统计模型中协方差结构的设定检验AI 解读

Summary We consider testing the covariance structure in statistical models. We focus on developing such tests when the random vectors of interest are not directly observable and have to be derived via estimated models. Additionally, the covariance specification may involve extra nuisance parameters which also need to be estimated. In a generic additive model setting, we develop and investigate test statistics based on the maximum discrepancy measure calculated from the…

可能误设的高维模型中处理效应参数的推断AI 解读

Summary Eliminating the effect of confounding in observational studies typically involves fitting a model for an outcome adjusted for covariates. When, as often, these covariates are high-dimensional, this necessitates the use of sparse estimators, such as the lasso, or other regularization approaches. Naïve use of such estimators yields confidence intervals for the conditional treatment effect parameter that are not uniformly valid. Moreover, as the number of covariates…

差异潜变量图模型估计及其脑连接应用AI 解读

Summary Differential graphical models are designed to represent the difference between the conditional dependence structures of two groups, and thus are of particular interest for scientific investigations. Motivated by modern applications, this manuscript considers an extended setting where each group is generated by a latent variable Gaussian graphical model. Due to the existence of latent factors, the differential network is decomposed into sparse and low-rank components,…

广义线性混合模型的惩罚拟似然信息准则AI 解读

Summary Information criteria are commonly used for joint fixed and random effects selection in mixed models. While information criteria are straightforward to implement, a major difficulty in applying them is that they are typically based on maximum likelihood estimates, but calculating such estimates for one candidate mixed model, let alone multiple models, presents a major computational challenge. To overcome this hurdle, we study penalized quasilikelihood estimation and…

通过积分旋转高斯近似处理高维干扰参数的后验近似AI 解读

Summary Posterior computation for high-dimensional data with many parameters can be challenging. This article focuses on a new method for approximating posterior distributions of a low- to moderate-dimensional parameter in the presence of a high-dimensional or otherwise computationally challenging nuisance parameter. The focus is on regression models and the key idea is to separate the likelihood into two components through a rotation. One component involves only the…

多元广义双曲随机向量的二次型AI 解读

Summary This article presents exact and approximate expressions for tail probabilities and partial moments of quadratic forms in multivariate generalized hyperbolic random vectors. The derivations involve a generalization of the classic inversion formula for distribution functions (Gil-Pelaez, 1951). Two numerical applications are considered: the distribution of the two-stage least squares estimator and the expected shortfall of a quadratic portfolio.

线性约束下向量自回归模型的有限时间分析AI 解读

Summary This paper develops a unified finite-time theory for the ordinary least squares estimation of possibly unstable and even slightly explosive vector autoregressive models under linear restrictions, with the applicable region $\rho(A)\leqslant 1+c/n$, where $\rho(A)$ is the spectral radius of the transition matrix $A$ in the var(1) representation, $n$ is the time horizon and $c>0$ is a universal constant. The linear restriction framework encompasses various existing…

结构约束下控制错误发现率的一般交互框架AI 解读

Summary We propose a general framework based on selectively traversed accumulation rules for interactive multiple testing with generic structural constraints on the rejection set. It combines accumulation tests from ordered multiple testing with data-carving ideas from post-selection inference, allowing highly flexible adaptation to generic structural information. Our procedure defines an interactive protocol for gradually pruning a candidate rejection set, beginning with…

泊松降秩模型及其在政治文本数据中的应用AI 解读

Summary We discuss Poisson reduced-rank models for low-dimensional summaries of high-dimensional Poisson vectors that allow inference on the location of individuals in a low-dimensional space. We show that under weak dependence conditions, which allow for certain correlations between the Poisson random variables, the locations can be consistently estimated using Poisson maximum likelihood estimation. Moreover, we develop consistent rules for determining the dimension of the…

随机压缩算法的统计性质AI 解读

Summary Sketching is a probabilistic data compression technique that has been largely developed by the computer science community. Numerical operations on big datasets can be intolerably slow; sketching algorithms address this issue by generating a smaller surrogate dataset. Typically, inference proceeds on the compressed dataset. Sketching algorithms generally use random projections to compress the original dataset, and this stochastic generation process makes them amenable…

双生存时间尺度超额风险加性回归的非平滑反向拟合AI 解读

Summary We consider an extension of Aalen’s additive regression model that allows covariates to have effects that vary on two different time scales. The two time scales considered are equal up to a constant for each individual and vary across individuals, such as follow-up time and age in medical studies or calendar time and age in longitudinal studies. The model was introduced in Scheike (2001), where it was solved using smoothing techniques. We present a new backfitting…