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Estimation under matrix quadratic loss and matrix superharmonicity

矩阵二次损失下的估计与矩阵超调和性

Summary We investigate estimation of a normal mean matrix under the matrix quadratic loss. Improved estimation under the matrix quadratic loss implies improved estimation of any linear combination of the columns under the quadratic loss. First, an unbiased estimate of risk is derived and the Efron–Morris estimator is shown to be minimax. Next, a notion of matrix superharmonicity for matrix-variate functions is introduced and shown to have properties analogous to those of the…

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Asymptotics of sample tail autocorrelations for tail-dependent time series: phase transition and visualization

尾部依赖时间序列的样本尾部自相关:相变与可视化

Summary In this article we develop an asymptotic theory for sample tail autocorrelations of time series data that can exhibit serial dependence in both tail and non-tail regions. Unlike with the traditional autocorrelation function, the study of tail autocorrelations requires a double asymptotic scheme to capture the tail phenomena, and our results do not impose any restrictions on the dependence structure in non-tail regions and allow processes that are not necessarily…

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Fast and powerful conditional randomization testing via distillation

通过蒸馏实现快速且有力的条件随机化检验

Summary We consider the problem of conditional independence testing: given a response $Y$ and covariates $(X,Z)$, we test the null hypothesis that $Y {\perp\!\!\!\perp} X \mid Z$. The conditional randomization test was recently proposed as a way to use distributional information about $X\mid Z$ to exactly and nonasymptotically control Type-I error using any test statistic in any dimensionality without assuming anything about $Y\mid (X,Z)$. This flexibility, in principle,…

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Smoothed nested testing on directed acyclic graphs

有向无环图上的平滑嵌套检验

Summary We consider the problem of multiple hypothesis testing when there is a logical nested structure to the hypotheses. When one hypothesis is nested inside another, the outer hypothesis must be false if the inner hypothesis is false. We model the nested structure as a directed acyclic graph, including chain and tree graphs as special cases. Each node in the graph is a hypothesis and rejecting a node requires also rejecting all of its ancestors. We propose a general…

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Inverse moment methods for sufficient forecasting using high-dimensional predictors

利用高维预测变量进行充分预测的逆矩方法

Summary We consider forecasting a single time series using a large number of predictors in the presence of a possible nonlinear forecast function. Assuming that the predictors affect the response through the latent factors, we propose to first conduct factor analysis and then apply sufficient dimension reduction on the estimated factors to derive the reduced data for subsequent forecasting. Using directional regression and the inverse third-moment method in the stage of…

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Testing for unit roots based on sample autocovariances

基于样本自协方差的单位根检验

Summary We propose a new unit-root test for a stationary null hypothesis $H_0$ against a unit-root alternative $H_1$. Our approach is nonparametric as $H_0$ assumes only that the process concerned is $I(0)$, without specifying any parametric forms. The new test is based on the fact that the sample autocovariance function converges to the finite population autocovariance function for an $I(0)$ process, but diverges to infinity for a process with unit roots. Therefore, the new…

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Estimation of genetic correlation with summary association statistics

利用汇总关联统计量估计遗传相关性

Summary Genome-wide association studies have identified thousands of genetic variants that are associated with complex traits. Many complex traits are shown to share genetic etiology. Although various genetic correlation measures and their estimators have been developed, rigorous statistical analysis of their properties, including their robustness to model assumptions, is still lacking. We develop a method of moments estimator of genetic correlation between two traits in the…

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Scalar-on-function local linear regression and beyond

标量对函数的局部线性回归及其扩展

Summary It is common to want to regress a scalar response on a random function. This paper presents results that advocate local linear regression based on a projection as a nonparametric approach to this problem. Our asymptotic results demonstrate that functional local linear regression outperforms its functional local constant counterpart. Beyond the estimation of the regression operator itself, local linear regression is also a useful tool for predicting the functional…

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Confidence regions in Wasserstein distributionally robust estimation

Wasserstein 分布稳健估计中的置信域

Summary Estimators based on Wasserstein distributionally robust optimization are obtained as solutions of min-max problems in which the statistician selects a parameter minimizing the worst-case loss among all probability models within a certain distance from the underlying empirical measure in a Wasserstein sense. While motivated by the need to identify optimal model parameters or decision choices that are robust to model misspecification, these distributionally robust…

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High-dimensional log-error-in-variable regression with applications to microbial compositional data analysis

高维对数变量测量误差回归及其在微生物组成数据分析中的应用

Summary In microbiome and genomic studies, the regression of compositional data has been a crucial tool for identifying microbial taxa or genes that are associated with clinical phenotypes. To account for the variation in sequencing depth, the classic log-contrast model is often used where read counts are normalized into compositions. However, zero read counts and the randomness in covariates remain critical issues. We introduce a surprisingly simple, interpretable and…

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Inverses of Matérn covariances on grids

规则网格上 Matérn 协方差的逆

Summary We conduct a study of the aliased spectral densities of Matérn covariance functions on a regular grid of points, elucidating the properties of a popular approximation based on stochastic partial differential equations. While other researchers have shown that this approximation can work well for the covariance function, we find that it assigns too much power at high frequencies and does not provide increasingly accurate approximations to the inverse as the grid…

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A discrete bouncy particle sampler

离散弹跳粒子采样器

Summary Most Markov chain Monte Carlo methods operate in discrete time and are reversible with respect to the target probability. Nevertheless, it is now understood that the use of nonreversible Markov chains can be beneficial in many contexts. In particular, the recently proposed bouncy particle sampler leverages a continuous-time and nonreversible Markov process, and empirically shows state-of-the-art performance when used to explore certain probability densities; however,…

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Sparse functional linear discriminant analysis

稀疏函数型线性判别分析

Summary Functional linear discriminant analysis provides a simple yet efficient method for classification, with the possibility of achieving perfect classification. Several methods have been proposed in the literature that mostly address the dimensionality of the problem. On the other hand, there is growing interest in interpretability of the analysis, which favours a simple and sparse solution. In this paper we propose a new approach that incorporates a type of sparsity…

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Efficient adjustment sets in causal graphical models with hidden variables

含隐变量的因果图模型中的高效调整集

Summary We study the selection of adjustment sets for estimating the interventional mean under a point exposure dynamic treatment regime, that is, a treatment rule that depends on the subject’s covariates. We assume a nonparametric causal graphical model with, possibly, hidden variables and at least one adjustment set comprised of observable variables. We provide the definition of a valid adjustment set for a point exposure dynamic treatment regime, which generalizes the…

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Identifiability of causal effects with multiple causes and a binary outcome

多重处理与二元结果下因果效应的可识别性

Summary Unobserved confounding presents a major threat to causal inference in observational studies. Recently, several authors have suggested that this problem could be overcome in a shared confounding setting where multiple treatments are independent given a common latent confounder. It has been shown that under a linear Gaussian model for the treatments, the causal effect is not identifiable without parametric assumptions on the outcome model. In this note, we show that…

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Inference on the average treatment effect under minimization and other covariate-adaptive randomization methods

最小化及其他协变量自适应随机化下的平均处理效应推断

Summary Covariate-adaptive randomization schemes such as minimization and stratified permuted blocks are often applied in clinical trials to balance treatment assignments across prognostic factors. The existing theory for inference after covariate-adaptive randomization is mostly limited to situations where a correct model between the response and covariates can be specified or the randomization method has well-understood properties. Based on stratification with covariate…

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Optimal post-selection inference for sparse signals: a nonparametric empirical Bayes approach

稀疏信号的最优选择后推断:非参数经验贝叶斯方法

Summary Many recently developed Bayesian methods focus on sparse signal detection. However, much less work has been done on the natural follow-up question: how does one make valid inferences for the magnitude of those signals after selection? Ordinary Bayesian credible intervals suffer from selection bias, as do ordinary frequentist confidence intervals. Existing Bayesian methods for correcting this bias produce credible intervals with poor frequentist properties. Further,…

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Heterogeneity-aware and communication-efficient distributed statistical inference

考虑异质性且通信高效的分布式统计推断

Summary In multicentre research, individual-level data are often protected against sharing across sites. To overcome the barrier of data sharing, many distributed algorithms, which only require sharing aggregated information, have been developed. The existing distributed algorithms usually assume the data are homogeneously distributed across sites. This assumption ignores the important fact that the data collected at different sites may come from various subpopulations and…

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More for less: predicting and maximizing genomic variant discovery via Bayesian nonparametrics

以更少资源发现更多基因变异:贝叶斯非参数预测与优化

Summary While the cost of sequencing genomes has decreased dramatically in recent years, this expense often remains nontrivial. Under a fixed budget, scientists face a natural trade-off between quantity and quality: spending resources to sequence a greater number of genomes or spending resources to sequence genomes with increased accuracy. Our goal is to find the optimal allocation of resources between quantity and quality. Optimizing resource allocation promises to reveal…

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Interpoint-ranking sign covariance for the test of independence

用于独立性检验的点间排序符号协方差

Summary We generalize the sign covariance introduced by Bergsma & Dassios (2014) to multivariate random variables and beyond. The new interpoint-ranking sign covariance is applicable to general types of random objects as long as a meaningful similarity measure can be defined, and it is shown to be zero if and only if the two random variables are independent. The test statistic is a $U$-statistic, whose large-sample behaviour guarantees that the proposed test is consistent…

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General ways to improve false coverage rate-adjusted selective confidence intervals

改进错误覆盖率调整的选择性置信区间的一般方法

Summary Post-selection inference on thousands of parameters has attracted considerable research interest in recent years. Specifically, Benjamini & Yekutieli (2005) considered constructing confidence intervals after selection. They proposed adjusting the confidence levels of marginal confidence intervals for the selected parameters to ensure control of the false coverage-statement rate. However, although Benjamini–Yekutieli confidence intervals are widely used, they are…

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Integrated conditional moment test and beyond: when the number of covariates is divergent

协变量维数发散时的积分条件矩检验及其扩展

Summary The classical integrated conditional moment test is a promising method for model checking and its basic idea has been applied to develop several variants. However, in diverging-dimension scenarios, the integrated conditional moment test may break down and has completely different limiting properties from the fixed-dimension case. Furthermore, the related wild bootstrap approximation can also be invalid. To extend this classical test to diverging dimension settings,…

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Statistical inference on shape and size indexes for counting processes

计数过程形状与规模指标的统计推断

Summary Single-index models have gained increased popularity in time-to-event analysis owing to their model flexibility and advantage in dimension reduction. We propose a semiparametric framework for the rate function of a recurrent event counting process by modelling its size and shape components with single-index models. With additional monotone constraints on the two link functions for the size and shape components, the proposed model possesses the desired directional…

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Stratification and optimal resampling for sequential Monte Carlo

序贯蒙特卡洛的分层与最优重采样

Summary Sequential Monte Carlo algorithms are widely accepted as powerful computational tools for making inference with dynamical systems. A key step in sequential Monte Carlo is resampling, which plays the role of steering the algorithm towards the future dynamics. Several strategies have been used in practice, including multinomial resampling, residual resampling, optimal resampling, stratified resampling and optimal transport resampling. In one-dimensional cases, we show…

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