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Statistical inference for streamed longitudinal data

流式纵向数据的统计推断

Summary Modern longitudinal data, for example from wearable devices, may consist of measurements of biological signals on a fixed set of participants at a diverging number of time-points. Traditional statistical methods are not equipped to handle the computational burden of repeatedly analysing the cumulatively growing dataset each time new data are collected. We propose a new estimation and inference framework for dynamic updating of point estimates and their standard…

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Semiparametric efficient G-estimation with invalid instrumental variables

含无效工具变量的半参数有效G估计

Summary The instrumental variable method is widely used in the health and social sciences for identification and estimation of causal effects in the presence of potential unmeasured confounding. To improve efficiency, multiple instruments are routinely used, raising concerns about bias due to possible violation of the instrumental variable assumptions. To address such concerns, we introduce a new class of G-estimators that are guaranteed to remain consistent and…

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Sampling distribution for single-regression Granger causality estimators

单回归Granger因果估计量的抽样分布

Summary The single-regression Granger–Geweke causality estimator has previously been shown to solve known problems associated with the more conventional likelihood ratio estimator; however, its sampling distribution has remained unknown. We show that, under the null hypothesis of vanishing Granger causality, the single-regression estimator converges to a generalized χ2 distribution, which is well approximated by a Γ distribution. We show that this holds too for Geweke’s…

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Efficient estimation under data fusion

数据融合下的有效估计

Summary We aim to make inferences about a smooth, finite-dimensional parameter by fusing together data from multiple sources. Previous works have studied the estimation of a variety of parameters in similar data fusion settings, including estimation of the average treatment effect and average reward under a policy, with the majority of them merging one historical data source with covariates, actions and rewards, and one data source of the same covariates. In this article, we…

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A subsampling perspective for extending the validity of state-of-the-art bootstraps in the frequency domain

以子抽样扩展频域自助法的有效性

Summary Bootstrapping spectral mean statistics has been a notoriously difficult problem over the past 25 years. Many frequency domain bootstraps are valid only for certain time series structures, e.g., linear processes, or for special types of statistics, i.e., ratio statistics, because such bootstraps fail to capture the limiting variance of spectral statistics in general settings. We address this issue with a different form of resampling, namely, subsampling. While not…

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An instrumental variable method for point processes: generalized Wald estimation based on deconvolution

点过程的工具变量方法:基于反卷积的广义 Wald 估计

Summary Point processes are probabilistic tools for modelling event data. While there exists a fast-growing literature on the relationships between point processes, how such relationships connect to causal effects remains unexplored. In the presence of unmeasured confounders, parameters from point process models do not necessarily have causal interpretations. We propose an instrumental variable method for causal inference with point process treatment and outcome. We define…

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A generalized Bayes framework for probabilistic clustering

概率聚类的广义贝叶斯框架

Summary Loss-based clustering methods, such as k-means clustering and its variants, are standard tools for finding groups in data. However, the lack of quantification of uncertainty in the estimated clusters is a disadvantage. Model-based clustering based on mixture models provides an alternative approach, but such methods face computational problems and are highly sensitive to the choice of kernel. In this article we propose a generalized Bayes framework that bridges…

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High-dimensional analysis of variance in multivariate linear regression

多元线性回归中的高维方差分析

Summary In this paper, we develop a systematic theory for high-dimensional analysis of variance in multivariate linear regression, where the dimension and the number of coefficients can both grow with the sample size. We propose a new U-type statistic to test linear hypotheses and establish a high-dimensional Gaussian approximation result under fairly mild moment assumptions. Our general framework and theory can be used to deal with the classical one-way multivariate…

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Median regularity and honest inference

中位数正则性与诚实推断

Summary We introduce a new notion of regularity of an estimator called median regularity. We prove that uniformly valid honest inference for a functional is possible if and only if there exists a median regular estimator of that functional. To the best of our knowledge, such a notion of regularity that is necessary for uniformly valid inference is unavailable in the literature.

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Splitting strategies for post-selection inference

选择后推断中的分割策略

Summary We consider the problem of providing valid inference for a selected parameter in a sparse regression setting. It is well known that classical regression tools can be unreliable in this context because of the bias generated in the selection step. Many approaches have been proposed in recent years to ensure inferential validity. In this article we consider a simple alternative to data splitting based on randomizing the response vector, which allows for higher selection…

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Spectral adjustment for spatial confounding

空间混杂的谱域调整

Summary Adjusting for an unmeasured confounder is generally an intractable problem, but in the spatial setting it may be possible under certain conditions. We derive necessary conditions on the coherence between the exposure and the unmeasured confounder that ensure the effect of exposure is estimable. We specify our model and assumptions in the spectral domain to allow for different degrees of confounding at different spatial resolutions. One assumption that ensures…

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Dependent censoring based on parametric copulas

基于参数 Copula 的依赖删失模型

Summary Consider a survival time $T$ that is subject to random right censoring, and suppose that $T$ is stochastically dependent on the censoring time $C$. We are interested in the marginal distribution of $T$. This situation is often encountered in practice. Consider, for example, the case where $T$ is a patient’s time to death from a certain disease. Then the censoring time $C$ could be the time until the patient leaves the study or the time until death from another cause.…

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Honest calibration assessment for binary outcome predictions

二元结果概率预测的诚实校准评估

Summary Probability predictions from binary regressions or machine learning methods ought to be calibrated: if an event is predicted to occur with probability $x$, it should materialize with approximately that frequency, which means that the so-called calibration curve $p(\cdot)$ should equal the identity, i.e., $p(x) = x$ for all $x$ in the unit interval. We propose honest calibration assessment based on novel confidence bands for the calibration curve, which are valid…

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On the statistical role of inexact matching in observational studies

观察性研究中非精确匹配的统计作用

Summary In observational causal inference, exact covariate matching plays two statistical roles: (i) it effectively controls for bias due to measured confounding; (ii) it justifies assumption-free inference based on randomization tests. In this paper we show that inexact covariate matching does not always play these same roles. We find that inexact matching often leaves behind statistically meaningful bias, and that this bias renders standard randomization tests…

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Assessing time-varying causal effect moderation in the presence of cluster-level treatment effect heterogeneity and interference

群组效应异质性与干扰下的时变因果效应调节

Summary The micro-randomized trial is a sequential randomized experimental design to empirically evaluate the effectiveness of mobile health intervention components that may be delivered at hundreds or thousands of decision points. Micro-randomized trials have motivated a new class of causal estimands, termed causal excursion effects, for which semiparametric inference can be conducted via a weighted, centred least-squares criterion (Boruvka et al., 2018). Causal excursion…

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Existence of matching priors on compact spaces

紧空间上匹配先验的存在性

Summary A matching prior at level $1-\alpha$ is a prior such that an associated $1-\alpha$ credible region is also a $1-\alpha$ confidence set. We study the existence of matching priors for general families of credible regions. Our main result gives topological conditions under which matching priors for specific families of credible regions exist. Informally, we prove that, on compact parameter spaces, a matching prior exists if the so-called rejection-probability function…

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Variable elimination, graph reduction and the efficient g-formula

变量消除、图约简与有效 g 公式

Summary We study efficient estimation of an interventional mean associated with a point exposure treatment under a causal graphical model represented by a directed acyclic graph without hidden variables. Under such a model, a subset of the variables may be uninformative, in that failure to measure them neither precludes identification of the interventional mean nor changes the semiparametric variance bound for regular estimators of it. We develop a set of graphical criteria…

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Testing Kronecker product covariance matrices for high-dimensional matrix-variate data

高维矩阵数据的 Kronecker 积协方差检验

Summary The Kronecker product covariance structure provides an efficient way to model the inter-correlations of matrix-variate data. In this paper, we propose test statistics for the Kronecker product covariance matrix based on linear spectral statistics of renormalized sample covariance matrices. A central limit theorem is proved for the linear spectral statistics, with explicit formulas for the mean and covariance functions, thereby filling a gap in the literature. We then…

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Thresholded graphical lasso adjusts for latent variables

利用阈值化 graphical lasso 处理潜变量

Summary Structural learning of Gaussian graphical models in the presence of latent variables has long been a challenging problem. Chandrasekaran et al. (2012) proposed a convex program for estimating a sparse graph plus a low-rank term that adjusts for latent variables; however, this approach poses challenges from both computational and statistical perspectives. We propose an alternative, simple solution: apply a hard-thresholding operator to existing graph selection…

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Marginal proportional hazards models for multivariate interval-censored data

多元区间删失数据的边际比例风险模型

Summary Multivariate interval-censored data arise when there are multiple types of events or clusters of study subjects, such that the event times are potentially correlated and when each event is only known to occur over a particular time interval. We formulate the effects of potentially time-varying covariates on the multivariate event times through marginal proportional hazards models while leaving the dependence structures of the related event times unspecified. We…

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On the implied weights of linear regression for causal inference

用于因果推断的线性回归隐含权重

Summary A basic principle in the design of observational studies is to approximate the randomized experiment that would have been conducted under ideal circumstances. At present, linear regression models are commonly used to analyse observational data and estimate causal effects. How do linear regression adjustments in observational studies emulate key features of randomized experiments, such as covariate balance, self-weighted sampling and study representativeness? In this…

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Optimal design of the Barker proposal and other locally balanced Metropolis–Hastings algorithms

Barker 提议与局部平衡 Metropolis–Hastings 算法的最优设计

Summary We study the class of first-order locally balanced Metropolis–Hastings algorithms introduced in Livingstone & Zanella (2022). To choose a specific algorithm within the class, the user must select a balancing function $g:{\mathbb{R}}_+ \to {\mathbb{R}}_+$ satisfying $g(t) = tg(1/t)$ and a noise distribution for the proposal increment. Popular choices within the class are the Metropolis-adjusted Langevin algorithm and the recently introduced Barker proposal. We first…

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Gaussian universal likelihood ratio testing

高斯模型中的通用似然比检验

Summary The classical likelihood ratio test based on the asymptotic chi-squared distribution of the log-likelihood is one of the fundamental tools of statistical inference. A recent universal likelihood ratio test approach based on sample splitting provides valid hypothesis tests and confidence sets in any setting for which we can compute the split likelihood ratio statistic, or, more generally, an upper bound on the null maximum likelihood. The universal likelihood ratio…

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Additive models for symmetric positive-definite matrices and Lie groups

对称正定矩阵与李群上的加性模型

Summary We propose and investigate an additive regression model for symmetric positive-definite matrix-valued responses and multiple scalar predictors. The model exploits the Abelian group structure inherited from either of the log-Cholesky and log-Euclidean frameworks for symmetric positive-definite matrices and naturally extends to general Abelian Lie groups. The proposed additive model is shown to connect to an additive model on a tangent space. This connection not only…

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