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Discussion of “Equi-energy sampler” by Kou, Zhou and Wong

对 Kou、Zhou 与 Wong《等能量采样器》的讨论

Novel sampling algorithms can significantly impact open questions in computational biology, most notably the in silico protein folding problem. By using computational methods, protein folding aims to find the three-dimensional structure of a protein chain given the sequence of its amino acid building blocks. The complexity of the problem strongly depends on the protein representation and its energy function. The more detailed the model, the more complex its corresponding…

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Equi-energy sampler with applications in statistical inference and statistical mechanics

等能量采样器及其在统计推断与统计力学中的应用

We introduce a new sampling algorithm, the equi-energy sampler, for efficient statistical sampling and estimation. Complementary to the widely used temperature-domain methods, the equi-energy sampler, utilizing the temperature–energy duality, targets the energy directly. The focus on the energy function not only facilitates efficient sampling, but also provides a powerful means for statistical estimation, for example, the calculation of the density of states and…

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On the Benjamini–Hochberg method

关于 Benjamini–Hochberg 方法

We investigate the properties of the Benjamini–Hochberg method for multiple testing and of a variant of Storey’s generalization of it, extending and complementing the asymptotic and exact results available in the literature. Results are obtained under two different sets of assumptions and include asymptotic and exact expressions and bounds for the proportion of rejections, the proportion of incorrect rejections out of all rejections and two other proportions used to quantify…

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Resampling methods for spatial regression models under a class of stochastic designs

随机设计下空间回归模型的重抽样方法

In this paper we consider the problem of bootstrapping a class of spatial regression models when the sampling sites are generated by a (possibly nonuniform) stochastic design and are irregularly spaced. It is shown that the natural extension of the existing block bootstrap methods for grid spatial data does not work for irregularly spaced spatial data under nonuniform stochastic designs. A variant of the blocking mechanism is proposed. It is shown that the proposed block…

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The Bernstein–von Mises theorem for the proportional hazard model

比例风险模型的 Bernstein–von Mises 定理

We study large sample properties of Bayesian analysis of the proportional hazard model with neutral to the right process priors on the baseline hazard function. We show that the posterior distribution of the baseline cumulative hazard function and regression coefficients centered at the maximum likelihood estimator is jointly asymptotically equivalent to the sampling distribution of the maximum likelihood estimator.

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Addendum to the discussion of “Breakdown and groups”

《崩溃与群》讨论的补遗

In his discussion of Davies and Gather [Ann. Statist. 33 (2005) 977–1035] Tyler pointed out that the theory developed there could not be applied to the case of directional data. He related the breakdown of directional functionals to the problem of definability. In this addendum we provide a concept of breakdown defined in terms of definability and not in terms of bias. If a group of finite order k acts on the sample space we show that the breakdown point can be bounded above…

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Generalized score test of homogeneity for mixed effects models

混合效应模型同质性的广义得分检验

Many important problems in psychology and biomedical studies require testing for overdispersion, correlation and heterogeneity in mixed effects and latent variable models, and score tests are particularly useful for this purpose. But the existing testing procedures depend on restrictive assumptions. In this paper we propose a class of test statistics based on a general mixed effects model to test the homogeneity hypothesis that all of the variance components are zero. Under…

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Assessing extrema of empirical principal component functions

经验主成分函数极值的评估

The difficulties of estimating and representing the distributions of functional data mean that principal component methods play a substantially greater role in functional data analysis than in more conventional finite-dimensional settings. Local maxima and minima in principal component functions are of direct importance; they indicate places in the domain of a random function where influence on the function value tends to be relatively strong but of opposite sign. We explore…

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Properties of principal component methods for functional and longitudinal data analysis

函数型与纵向数据分析中主成分方法的性质

The use of principal component methods to analyze functional data is appropriate in a wide range of different settings. In studies of “functional data analysis,” it has often been assumed that a sample of random functions is observed precisely, in the continuum and without noise. While this has been the traditional setting for functional data analysis, in the context of longitudinal data analysis a random function typically represents a patient, or subject, who is observed…

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Estimation in semiparametric spatial regression

半参数空间回归中的估计

Nonparametric methods have been very popular in the last couple of decades in time series and regression, but no such development has taken place for spatial models. A rather obvious reason for this is the curse of dimensionality. For spatial data on a grid evaluating the conditional mean given its closest neighbors requires a four-dimensional nonparametric regression. In this paper a semiparametric spatial regression approach is proposed to avoid this problem. An estimation…

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Recovering convex boundaries from blurred and noisy observations

从模糊且含噪的观测中恢复凸边界

We consider the problem of estimating convex boundaries from blurred and noisy observations. In our model, the convolution of an intensity function f is observed with additive Gaussian white noise. The function f is assumed to have convex support G whose boundary is to be recovered. Rather than directly estimating the intensity function, we develop a procedure which is based on estimating the support function of the set G. This approach is closely related to the method of…

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Closed form expressions for Bayesian sample size

贝叶斯样本量的闭式表达

Sample size criteria are often expressed in terms of the concentration of the posterior density, as controlled by some sort of error bound. Since this is done pre-experimentally, one can regard the posterior density as a function of the data. Thus, when a sample size criterion is formalized in terms of a functional of the posterior, its value is a random variable. Generally, such functionals have means under the true distribution. We give asymptotic expressions for the…

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Bayesian analysis for reversible Markov chains

We introduce a natural conjugate prior for the transition matrix of a reversible Markov chain. This allows estimation and testing. The prior arises from random walk with reinforcement in the same way the Dirichlet prior arises from Pólya’s urn. We give closed form normalizing constants, a simple method of simulation from the posterior and a characterization along the lines of W. E. Johnson’s characterization of the Dirichlet prior.

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Consistency of Bayes estimators of a binary regression function

二元回归函数贝叶斯估计的一致性

When do nonparametric Bayesian procedures “overfit”? To shed light on this question, we consider a binary regression problem in detail and establish frequentist consistency for a certain class of Bayes procedures based on hierarchical priors, called uniform mixture priors. These are defined as follows: let ν be any probability distribution on the nonnegative integers. To sample a function f from the prior πν, first sample m from ν and then sample f uniformly from the set of…

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Semiparametric estimation of a two-component mixture model

两成分混合模型的半参数估计

Suppose that univariate data are drawn from a mixture of two distributions that are equal up to a shift parameter. Such a model is known to be nonidentifiable from a nonparametric viewpoint. However, if we assume that the unknown mixed distribution is symmetric, we obtain the identifiability of this model, which is then defined by four unknown parameters: the mixing proportion, two location parameters and the cumulative distribution function of the symmetric mixed…

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Testing the order of a model

模型阶数的检验

This paper deals with order identification for nested models in the i.i.d. framework. We study the asymptotic efficiency of two generalized likelihood ratio tests of the order. They are based on two estimators which are proved to be strongly consistent. A version of Stein’s lemma yields an optimal underestimation error exponent. The lemma also implies that the overestimation error exponent is necessarily trivial. Our tests admit nontrivial underestimation error exponents.…

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On discriminating between long-range dependence and changes in mean

区分长程依赖与均值变化

We develop a testing procedure for distinguishing between a long-range dependent time series and a weakly dependent time series with change-points in the mean. In the simplest case, under the null hypothesis the time series is weakly dependent with one change in mean at an unknown point, and under the alternative it is long-range dependent. We compute the CUSUM statistic Tn, which allows us to construct an estimator k̂ of a change-point. We then compute the statistic Tn,1…

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Pseudo-maximum likelihood estimation of ARCH(∞) models

ARCH 无穷阶模型的伪极大似然估计

Strong consistency and asymptotic normality of the Gaussian pseudo-maximum likelihood estimate of the parameters in a wide class of ARCH$(\infty)$ processes are established. The conditions are shown to hold in case of exponential and hyperbolic decay in the ARCH weights, though in the latter case a faster decay rate is required for the central limit theorem than for the law of large numbers. Particular parameterizations are discussed.

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High-dimensional graphs and variable selection with the Lasso

高维图与 Lasso 变量选择

The pattern of zero entries in the inverse covariance matrix of a multivariate normal distribution corresponds to conditional independence restrictions between variables. Covariance selection aims at estimating those structural zeros from data. We show that neighborhood selection with the Lasso is a computationally attractive alternative to standard covariance selection for sparse high-dimensional graphs. Neighborhood selection estimates the conditional independence…

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Statistical inference for time-varying ARCH processes

时变 ARCH 过程的统计推断

In this paper the class of ARCH(∞) models is generalized to the nonstationary class of ARCH(∞) models with time-varying coefficients. For fixed time points, a stationary approximation is given leading to the notation “locally stationary ARCH(∞) process.” The asymptotic properties of weighted quasi-likelihood estimators of time-varying ARCH(p) processes (p<∞) are studied, including asymptotic normality. In particular, the extra bias due to nonstationarity of the process is…

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Strong invariance principles for sequential Bahadur–Kiefer and Vervaat error processes of long-range dependent sequences

长程依赖序列的序贯 Bahadur–Kiefer 与 Vervaat 误差过程强不变原理

In this paper we study strong approximations (invariance principles) of the sequential uniform and general Bahadur–Kiefer processes of long-range dependent sequences. We also investigate the strong and weak asymptotic behavior of the sequential Vervaat process, that is, the integrated sequential Bahadur–Kiefer process, properly normalized, as well as that of its deviation from its limiting process, the so-called Vervaat error process. It is well known that the Bahadur–Kiefer…

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Fitting an error distribution in some heteroscedastic time series models

若干异方差时间序列模型中的误差分布拟合

This paper addresses the problem of fitting a known distribution to the innovation distribution in a class of stationary and ergodic time series models. The asymptotic null distribution of the usual Kolmogorov–Smirnov test based on the residuals generally depends on the underlying model parameters and the error distribution. To overcome the dependence on the underlying model parameters, we propose that tests be based on a vector of certain weighted residual empirical…

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Explicit representation of finite predictor coefficients and its applications

有限过去预测系数的显式表示及其应用

We consider the finite-past predictor coefficients of stationary time series, and establish an explicit representation for them, in terms of the MA and AR coefficients. The proof is based on the alternate applications of projection operators associated with the infinite past and the infinite future. Applying the result to long memory processes, we give the rate of convergence of the finite predictor coefficients and prove an inequality of Baxter-type.

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Characterizing Markov equivalence classes for AMP chain graph models

AMP 链图模型的马尔可夫等价类刻画

Chain graphs (CG) (= adicyclic graphs) use undirected and directed edges to represent both structural and associative dependences. Like acyclic directed graphs (ADGs), the CG associated with a statistical Markov model may not be unique, so CGs fall into Markov equivalence classes, which may be superexponentially large, leading to unidentifiability and computational inefficiency in model search and selection. It is shown here that, under the Andersson–Madigan–Perlman (AMP)…

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