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Principled analysis of crossover designs: Causal effects, efficient estimation and robust inference

交叉设计的因果效应、有效估计与稳健推断

Crossover designs randomly assign each unit to receive a sequence of treatments. By comparing outcomes within the same unit, these designs can effectively eliminate between-unit variation and facilitate the identification of both instantaneous effects of current treatments and carryover effects from past treatments. They are widely used in traditional biomedical studies and are increasingly adopted in modern digital platforms. However, standard analyses of crossover designs…

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SIMPLE-RC: Group network inference with NonSharp nulls and weak signals

SIMPLE-RC:非尖锐原假设与弱信号下的群组网络推断

Large-scale network inference with uncertainty quantification has important applications in natural, social and medical sciences. The recent work of Fan et al. (J. R. Stat. Soc. Ser. B. Stat. Methodol. 84 (2022) 630–653) introduced a general framework of statistical inference on membership profiles in large networks (SIMPLE) for testing the sharp null hypothesis that a pair of given nodes share the same membership profile. In real applications, there are often groups of…

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Sample size and power calculations for causal inference in observational studies

观察性研究中因果推断的样本量与检验力计算

This paper investigates the theoretical foundation and develops analytical formulas for sample size and power calculations for causal inference with observational data. By analyzing the variance of an inverse probability weighting estimator of the average treatment effect, we decompose the power calculation into three components: propensity score distribution, potential outcome distribution and their correlation. We show that to determine the minimal sample size of an…

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Gaussian and bootstrap approximation for matching-based average treatment effect estimators

匹配型平均处理效应估计量的高斯与自助法近似

We establish Gaussian approximation bounds for covariate and rank-matching-based Average Treatment Effect (ATE) estimators. By analyzing these estimators through the lens of stabilization theory, we employ the Malliavin–Stein method to derive our results. Our bounds precisely quantify the impact of key problem parameters, including the number of matches and treatment balance, on the accuracy of the Gaussian approximation. Additionally, we develop multiplier bootstrap…

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Higher-order graphon theory: Fluctuations, degeneracies and inference

高阶图极限函数理论:波动、退化与推断

Exchangeable random graphs, which include some of the most widely studied network models, have emerged as the mainstay of statistical network analysis in recent years. Graphons, which are the central objects in graph limit theory, provide a natural way to sample exchangeable random graphs. It is well known that network moments (motif/subgraph counts) identify a graphon (up to an isomorphism); hence, understanding the sampling distribution of subgraph counts in random graphs…

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Pseudo-maximum likelihood theory for high-dimensional rank one inference

高维秩一推断的伪最大似然理论

We develop a pseudo-likelihood theory for rank one matrix estimation problems in the high-dimensional limit. We prove a variational principle for the limiting pseudo-maximum likelihood, which also characterizes the performance of the corresponding pseudo-maximum likelihood estimator. We show that this variational principle is universal and depends only on four parameters determined by the corresponding null model. Through this universality, we introduce a notion of…

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On the efficiency of highly stratified experiments

高度分层实验的估计效率

This paper studies the use of highly stratified designs for the efficient estimation of a large class of treatment effect parameters that arise in the analysis of experiments. By a “highly stratified” design, we mean experiments in which units are divided into blocks of a fixed size and a proportion within each block is assigned to a binary treatment uniformly at random. The class of parameters considered are those that can be expressed as the solution to a set of moment…

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Uniform estimation and inference for nonparametric partitioning-based M-estimators

基于分割的非参数 M 估计量的一致估计与推断

This paper presents uniform estimation and inference theory for a large class of nonparametric partitioning-based M-estimators. The main theoretical results include: (i) uniform consistency for convex and nonconvex objective functions; (ii) rate-optimal uniform Bahadur representations; (iii) rate-optimal uniform (and mean square) convergence rates; (iv) valid strong approximations and feasible uniform inference methods; and (v) extensions to functional transformations of…

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Towards a unified theory for semiparametric data fusion with individual-level data

迈向个体层面数据融合的统一半参数理论

We consider inference about a finite-dimensional parameter integrating samples from independent sources. A recently developed theory considers scenarios where sources align with subsets of the conditional distributions of a single factorization of the joint target distribution. While this theory applies in many settings, it falls short in important data fusion problems, such as two-sample instrumental variable analysis, settings that integrate data from epidemiological…

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Parameter identification in linear non-Gaussian causal models under general confounding

一般混杂下线性非高斯因果模型的参数识别

Linear non-Gaussian causal models postulate that each random variable is a linear function of parent variables and non-Gaussian exogenous error terms. We study identification of the linear coefficients when such models contain latent variables. Our focus is on the commonly studied acyclic setting, where each model corresponds to a directed acyclic graph (DAG). For this case, prior literature has demonstrated that connections to overcomplete independent component analysis…

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Inferring the dependence graph density of binary graphical models in high dimension

高维二元图模型的依赖图密度推断

We consider a system of binary interacting chains describing the dynamics of a group of N components that, at each time unit, either send some signal to the others or remain silent otherwise. The interactions among the chains are encoded by a directed Erdös–Rényi random graph with unknown parameter p∈(0,1). Moreover, the system is structured within two populations (excitatory chains versus inhibitory ones), which are coupled via a mean field interaction on the underlying…

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Estimation of grouped time-varying network vector autoregressive models

分组时变网络向量自回归模型的估计

This paper introduces a flexible time-varying network vector autoregressive model framework for large-scale time series. A latent group structure is imposed on the heterogeneous and node-specific time-varying momentum and network spillover effects so that the number of unknown time-varying coefficients to be estimated can be reduced considerably. A classic agglomerative clustering algorithm with nonparametrically estimated distance matrix is combined with a ratio criterion…

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Confounder selection via iterative graph expansion

通过迭代扩展因果图选择混杂变量

Confounder selection, namely choosing a set of covariates to control for confounding between a treatment and an outcome, is arguably the most important step in the design of an observational study. Previous methods, such as Pearl's back-door criterion, typically require pre-specifying a causal graph, which can often be difficult in practice. We propose an interactive procedure for confounder selection that does not require pre-specifying the graph or the set of observed…

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Communication-efficient and distributed-oracle estimation for high-dimensional quantile regression

高维分位数回归的通信高效估计与分布式预言机估计

In this article, we present a novel communication-efficient estimator for distributed high-dimensional quantile regression with folded-concave penalties. An Iterative Multi-Step Algorithm (IMSA) is employed to tackle the nonconvex challenge of the objective function, taking into account both the statistical accuracy and the communication constraints. We demonstrate that the proposed IMSA estimators share similar properties with the global folded-concave penalized estimator.…

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Berry–Esseen bounds for design-based causal inference with possibly diverging treatment levels and varying group sizes

处理水平可能增长且组规模不等时设计型因果推断的 Berry–Esseen 界

Neyman (1923/1990) introduced the randomization model, which contains the notation of potential outcomes to define causal effects and a framework for large-sample inference based on the design of the experiment. However, the existing theory for this framework is far from complete, especially when the number of treatment levels diverges and the treatment group sizes vary. We provide a unified discussion of statistical inference under the randomization model with general…

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Multivariate root-n-consistent smoothing parameter-free matching estimators and estimators of inverse density weighted expectations

无需平滑参数的多元根号样本量一致匹配与逆密度加权期望估计

Expected values weighted by the inverse of a multivariate density or, equivalently, Lebesgue integrals of regression functions with multivariate regressors occur in various areas of applications, including estimating average treatment effects, nonparametric estimators in random coefficient regression models or deconvolution estimators in Berkson errors-in-variables models. The frequently used nearest-neighbor and matching estimators suffer from bias problems in multiple…

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A computational transition for detecting correlated stochastic block models by low-degree polynomials

低阶多项式检测相关随机块模型的计算转变

Detection of correlation in a pair of random graphs is a fundamental statistical and computational problem that has been extensively studied in recent years. In this work, we consider a pair of correlated (sparse) stochastic block models S(n,λn;k,ϵ;s) that are subsampled from a common parent stochastic block model S(n,λn;k,ϵ) with k=O(1) symmetric communities, average degree λ=O(1), divergence parameter ϵ, and subsampling probability s. For the detection problem of…

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Pseudo-likelihood-based M-estimation of random graphs with dependent edges and parameter vectors of increasing dimension

依赖边随机图中参数维数增长的伪似然 M 估计

An important question in statistical network analysis is how to estimate models of discrete and dependent network data with intractable likelihood functions, without sacrificing computational scalability and statistical guarantees. We demonstrate that scalable estimation of random graph models with dependent edges is possible, by establishing convergence rates of pseudo-likelihood-based M-estimators for discrete undirected graphical models with exponential parameterizations…

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A two-way heterogeneity model for dynamic networks

动态网络的双重异质性模型

Analysis of networks that evolve dynamically requires the joint modelling of individual snapshots and time dynamics. This paper proposes a new flexible two-way heterogeneity model towards this goal. The new model equips each node of the network with two heterogeneity parameters, one to characterize the propensity to form ties with other nodes statically and the other to differentiate the tendency to retain existing ties over time. With n observed networks each having p…

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Causal effect estimation under network interference with mean-field methods

网络干扰下基于平均场方法的因果效应估计

We study causal effect estimation from observational data under interference. The interference pattern is captured by an observed network. We adopt the chain graph framework of (J. Amer. Statist. Assoc. 116 (2021) 833–844), which allows (i) interaction among the outcomes of distinct study units connected along the graph and (ii) long range interference, whereby the outcome of an unit may depend on the treatments assigned to distant units connected along the interference…

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Counterfactual inference in sequential experiments

序贯实验中的反事实推断

We consider after-study statistical inference for sequentially designed experiments wherein multiple units are assigned treatments for multiple time points using treatment policies that adapt over time. Our goal is to provide inference guarantees for the counterfactual mean at the smallest possible scale—mean outcome under different treatments for each unit and each time—with minimal assumptions on the adaptive treatment policy. Without any structural assumptions on the…

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Asymptotically-exact selective inference for quantile regression

分位数回归的渐近精确选择后推断

In modern data analysis, it is common to select a model before performing statistical inference. Selective inference tools make adjustments for the model selection process in order to ensure reliable inference post selection. In this paper, we introduce an asymptotic pivot to infer about the effects of selected variables on conditional quantile functions. Utilizing estimators from smoothed quantile regression, our proposed pivot is easy to compute and yields…

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A common-cause principle for eliminating selection bias in causal estimands through covariate adjustment

通过协变量调整消除因果目标选择偏差的共同原因原则

Average treatment effects (ATEs) may be subject to selection bias when they are estimated among only a nonrepresentative subset of the target population. Selection bias can sometimes be eliminated by conditioning on a “sufficient adjustment set” of covariates, even for some forms of missingness not at random (MNAR). Without requiring full specification of the causal structure, we consider sufficient adjustment sets to allow nonparametric identification of conditional ATEs in…

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Causality pursuit from heterogeneous environments via neural adversarial invariance learning

通过神经对抗不变性学习从异质环境中追寻因果关系

Pursuing causality from data is a fundamental problem in scientific discovery, treatment intervention, and transfer learning. This paper introduces a novel algorithmic method for addressing nonparametric invariance and causality learning in regression models across multiple environments, where the joint distribution of response variables and covariates varies, but the conditional expectations of outcome given an unknown set of quasi-causal variables are invariant. The…

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