GENIUS-MAWII: for robust Mendelian randomization with many weak invalid instruments
GENIUS-MAWII:应对大量弱且无效工具变量的稳健孟德尔随机化
Abstract Mendelian randomization (MR) addresses causal questions using genetic variants as instrumental variables. We propose a new MR method, G-Estimation under No Interaction with Unmeasured Selection (GENIUS)-MAny Weak Invalid IV, which simultaneously addresses the 2 salient challenges in MR: many weak instruments and widespread horizontal pleiotropy. Similar to MR-GENIUS, we use heteroscedasticity of the exposure to identify the treatment effect. We derive influence…