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Enhanced Marginal Sensitivity Model and Bounds

增强边际敏感性模型及其界限

Sensitivity analysis is important to assess the impact of unmeasured confounding in causal inference from observational studies. The marginal sensitivity model (MSM) provides a useful approach in quantifying the influence of unmeasured confounders on treatment assignment and leading to tractable sharp bounds of common causal parameters. In this paper, to tighten MSM sharp bounds, we propose the enhanced MSM (eMSM) by incorporating another sensitivity constraint which…

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Sensitivity models and bounds under sequential unmeasured confounding in longitudinal studies

纵向研究中序贯未测混杂下的敏感性模型与界限

Abstract We consider sensitivity analysis for causal inference in a longitudinal study with time-varying treatments and covariates. It is of interest to assess the worst-case possible values of counterfactual outcome means and average treatment effects under sequential unmeasured confounding. We formulate several multi-period sensitivity models to relax the corresponding versions of the assumption of sequential non-confounding. The primary sensitivity model involves only…

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Model-assisted sensitivity analysis for treatment effects under unmeasured confounding via regularized calibrated estimation

未观测混杂下处理效应的模型辅助敏感性分析:正则化校准估计

Abstract Consider sensitivity analysis for estimating average treatment effects under unmeasured confounding, assumed to satisfy a marginal sensitivity model. At the population level, we provide new representations for the sharp population bounds and doubly robust estimating functions. We also derive new, relaxed population bounds, depending on weighted linear outcome quantile regression. At the sample level, we develop new methods and theory for obtaining not only doubly…

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High-dimensional model-assisted inference for treatment effects with multi-valued treatments

多值处理效应的高维模型辅助推断

Consider estimation of average treatment effects with multi-valued treatments using augmented inverse probability weighted (IPW) estimators, depending on outcome regression and propensity score models in high-dimensional settings. These regression models are often fitted by regularized likelihood-based estimation, while ignoring how the fitted functions are used in the subsequent inference about the treatment parameters. Such separate estimation can be associated with known…

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Hamiltonian-Assisted Metropolis Sampling

哈密顿辅助 Metropolis 抽样

Various Markov chain Monte Carlo (MCMC) methods are studied to improve upon random walk Metropolis sampling, for simulation from complex distributions. Examples include Metropolis-adjusted Langevin algorithms, Hamiltonian Monte Carlo, and other algorithms related to underdamped Langevin dynamics. We propose a broad class of irreversible sampling algorithms, called Hamiltonian-assisted Metropolis sampling (HAMS), and develop two specific algorithms with appropriate tuning and…

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High-Dimensional Model-Assisted Inference for Local Average Treatment Effects With Instrumental Variables

工具变量下局部平均处理效应的高维模型辅助推断

Consider the problem of estimating the local average treatment effect with an instrument variable, where the instrument unconfoundedness holds after adjusting for a set of measured covariates. Several unknown functions of the covariates need to be estimated through regression models, such as instrument propensity score and treatment and outcome regression models. We develop a computationally tractable method in high-dimensional settings where the numbers of regression terms…

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Model-assisted inference for treatment effects using regularized calibrated estimation with high-dimensional data

高维数据下正则化校准估计的处理效应模型辅助推断

Consider the problem of estimating average treatment effects when a large number of covariates are used to adjust for possible confounding through outcome regression and propensity score models. We develop new methods and theory to obtain not only doubly robust point estimators for average treatment effects, which remain consistent if either the propensity score model or the outcome regression model is correctly specified, but also model-assisted confidence intervals, which…

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Doubly penalized estimation in additive regression with high-dimensional data

高维加性回归中的双重惩罚估计

Additive regression provides an extension of linear regression by modeling the signal of a response as a sum of functions of covariates of relatively low complexity. We study penalized estimation in high-dimensional nonparametric additive regression where functional semi-norms are used to induce smoothness of component functions and the empirical $L_{2}$ norm is used to induce sparsity. The functional semi-norms can be of Sobolev or bounded variation types and are allowed to…

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Efficient Sequential Monte Carlo With Multiple Proposals and Control Variates

Sequential Monte Carlo is a useful simulation-based method for online filtering of state-space models. For certain complex state-space models, a single proposal distribution is usually not satisfactory and using multiple proposal distributions is a general approach to address various aspects of the filtering problem. This article proposes an efficient method of using multiple proposals in combination with control variates. The likelihood approach of Tan (2004 Tan, Z. (2004),…

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Two-Stage Importance Sampling With Mixture Proposals

采用混合提议分布的两阶段重要性抽样

For importance sampling (IS), multiple proposals can be combined to address different aspects of a target distribution. There are various methods for IS with multiple proposals, including Hesterberg's stratified IS estimator, Owen and Zhou's regression estimator, and Tan's maximum likelihood estimator. For the problem of efficiently allocating samples to different proposals, it is natural to use a pilot sample to select the mixture proportions before the actual sampling and…

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Marginal and Nested Structural Models Using Instrumental Variables

使用工具变量的边际与嵌套结构模型

The objective of many scientific studies is to evaluate the effect of a treatment on an outcome of interest ceteris paribus. Instrumental variables (IVs) serve as an experimental handle, independent of potential outcomes and potential treatment status and affecting potential outcomes only through potential treatment status. We propose marginal and nested structural models using IVs, in the spirit of marginal and nested structural models under no unmeasured confounding. A…

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Causal Inference in Outcome-Dependent Two-Phase Sampling Designs

结局依赖的两阶段抽样设计中的因果推断

Summary We consider estimation of the causal effect of a treatment on an outcome from observational data collected in two phases. In the first phase, a simple random sample of individuals is drawn from a population. On these individuals, information is obtained on treatment, outcome and a few low dimensional covariates. These individuals are then stratified according to these factors. In the second phase, a random subsample of individuals is drawn from each stratum, with…

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A Distributional Approach for Causal Inference Using Propensity Scores

利用倾向得分进行因果推断的分布方法

Drawing inferences about the effects of treatments and actions is a common challenge in economics, epidemiology, and other fields. We adopt Rubin's potential outcomes framework for causal inference and propose two methods serving complementary purposes. One can be used to estimate average causal effects, assuming no confounding given measured covariates. The other can be used to assess how the estimates might change under various departures from no confounding. Both methods…

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Regression and Weighting Methods for Causal Inference Using Instrumental Variables

利用工具变量进行因果推断的回归与加权方法

Please see the supplementary material for a correction and a new result.Recent researches in econometrics and statistics have gained considerable insights into the use of instrumental variables (IVs) for causal inference. A basic idea is that IVs serve as an experimental handle, the turning of which may change each individual's treatment status and, through and only through this effect, also change observed outcome. The average difference in observed outcome relative to that…

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On a Likelihood Approach for Monte Carlo Integration

蒙特卡洛积分的似然方法

The use of estimating equations has been a common approach for constructing Monte Carlo estimators. Recently, Kong et al. proposed a formulation of Monte Carlo integration as a statistical model, making explicit what information is ignored and what is retained about the baseline measure. From simulated data, the baseline measure is estimated by maximum likelihood, and then integrals of interest are estimated by substituting the estimated measure. For two different situations…

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