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Hub Detection in Gaussian Graphical Models

高斯图模型中的枢纽节点检测

Graphical models are popular tools for exploring relationships among a set of variables. The Gaussian graphical model (GGM) is an important class of graphical models, where the conditional dependence among variables is represented by nodes and edges in a graph. In many real applications, we are interested in detecting hubs in graphical models, which refer to nodes with a significant higher degree of connectivity compared to non-hub nodes. A typical strategy for hub detection…

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Efficient Multiple Change Point Detection and Localization For High-Dimensional Quantile Regression with Heteroscedasticity

异方差高维分位数回归的多重变点检测与定位

Data heterogeneity is a challenging issue for modern statistical data analysis. There are different types of data heterogeneity in practice. In this article, we consider potential structural changes and complicated tail distributions. There are various existing methods proposed to handle either structural changes or heteroscedasticity. However, it is difficult to handle them simultaneously. To overcome this limitation, we consider statistically and computationally efficient…

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Nonparametric Prediction Distribution from Resolution-Wise Regression with Heterogeneous Data

异质数据逐分辨率回归的非参数预测分布

Modeling and inference for heterogeneous data have gained great interest recently due to rapid developments in personalized marketing. Most existing regression approaches are based on the conditional mean and may require additional cluster information to accommodate data heterogeneity. In this paper, we propose a novel nonparametric resolution-wise regression procedure to provide an estimated distribution of the response instead of one single value. We achieve this by…

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On Robustness of Individualized Decision Rules

个体化决策规则的稳健性

With the emergence of precision medicine, estimating optimal individualized decision rules (IDRs) has attracted tremendous attention in many scientific areas. Most existing literature has focused on finding optimal IDRs that can maximize the expected outcome for each individual. Motivated by complex individualized decision making procedures and the popular conditional value at risk (CVaR) measure, we propose a new robust criterion to estimate optimal IDRs in order to control…

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Efficient Learning of Optimal Individualized Treatment Rules for Heteroscedastic or Misspecified Treatment-Free Effect Models

异方差或无处理基准效应模型误设下最优个体化处理规则的高效学习

Abstract Recent development in data-driven decision science has seen great advances in individualized decision making. Given data with individual covariates, treatment assignments and outcomes, researchers can search for the optimal individualized treatment rule (ITR) that maximizes the expected outcome. Existing methods typically require initial estimation of some nuisance models. The double robustness property that can protect from misspecification of either the…

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Learning Optimal Distributionally Robust Individualized Treatment Rules

学习最优分布鲁棒个体化治疗规则

Recent development in the data-driven decision science has seen great advances in individualized decision making. Given data with individual covariates, treatment assignments and outcomes, policy makers best individualized treatment rule (ITR) that maximizes the expected outcome, known as the value function. Many existing methods assume that the training and testing distributions are the same. However, the estimated optimal ITR may have poor generalizability when the…

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评论:多阶段化疗方案的 Q-learning 与 O-learning

Xu, Müller, Wahed, and Thall proposed a Bayesian model to analyze an acute leukemia study involving multi-stage chemotherapy regimes. We discuss two alternative methods, Q-learning and O-learning, to solve the same problem from the machine learning point of view. The numerical studies show that these methods can be flexible and have advantages in some situations to handle treatment heterogeneity while being robust to model misspecification.

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Quantile Regression in Reproducing Kernel Hilbert Spaces

再生核希尔伯特空间中的分位数回归

In this article we consider quantile regression in reproducing kernel Hilbert spaces, which we call kernel quantile regression (KQR). We make three contributions: (1) we propose an efficient algorithm that computes the entire solution path of the KQR, with essentially the same computational cost as fitting one KQR model; (2) we derive a simple formula for the effective dimension of the KQR model, which allows convenient selection of the regularization parameter; and (3) we…

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