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预算约束下利用不规则电子健康记录的强化风险预测AI 解读

Uncontrolled glycated hemoglobin (HbA1c) levels are associated with adverse events among complex diabetic patients. These adverse events present serious health risks to affected patients and are associated with significant financial costs. Thus, a high-quality predictive model that could identify high-risk patients so as to inform preventative treatment has the potential to improve patient outcomes while reducing healthcare costs. Because the biomarker information needed to…

动态治疗方案：精准医疗的统计方法AI 解读

Dynamic treatment regimes (DTRs) are used for managing chronic disease, and fit nicely into the larger paradigm of precision medicine. There is an increasing focus on methodology for dynamic treatm...

学习最优个体化治疗规则的改进双重稳健估计AI 解读

Individualized treatment rules (ITRs) recommend treatment according to patient characteristics. There is a growing interest in developing novel and efficient statistical methods in constructing ITRs. We propose an improved doubly robust estimator of the optimal ITRs. The proposed estimator is based on a direct optimization of an augmented inverse-probability weighted estimator (AIPWE) of the expected clinical outcome over a class of ITRs. The method enjoys two key…

面向个体化医疗的主动临床试验AI 解读

Individualized treatment rules (ITRs) tailor treatments according to individual patient characteristics. They can significantly improve patient care and are thus becoming increasingly popular. The data collected during randomized clinical trials are often used to estimate the optimal ITRs. However, these trials are generally expensive to run, and, moreover, they are not designed to efficiently estimate ITRs. In this article, we propose a cost-effective estimation method from…

估计最优动态治疗方案的新统计学习方法AI 解读

Dynamic treatment regimes (DTRs) are sequential decision rules for individual patients that can adapt over time to an evolving illness. The goal is to accommodate heterogeneity among patients and find the DTR which will produce the best long-term outcome if implemented. We introduce two new statistical learning methods for estimating the optimal DTR, termed backward outcome weighted learning (BOWL), and simultaneous outcome weighted learning (SOWL). These approaches convert…