Integrative Analysis of Microbial 16S Gene and Shotgun Metagenomic Sequencing Data Improves Statistical Efficiency in Testing Differential Abundance
整合微生物 16S 与宏基因组测序数据以提高差异丰度检验效率
The most widely used technologies for profiling microbial communities are 16S marker-gene sequencing and shotgun metagenomic sequencing. Surprisingly, many microbiome studies have performed both experiments on the same cohort of samples. The two sequencing datasets often reveal consistent patterns of microbial signatures, suggesting that an integrative analysis of both datasets could enhance the testing power for these signatures. However, differential experimental biases,…